HGSOC patient 2, tumor slices with or without CD3xFAP BsAb (OMTX305)
Living tumor tissue was sliced into 250 M PCTS directly following surgical resection. PCTS were cultured with or without autologous PBMCs and incubated with the CD3xFAP BsAb (OMTX305) for 2 days. PCTS were fixed and dissociated using the Chromium Next GEM Single Cell Fixed RNA Sample Preparation Kit (10X Genomics) and profiled using the 10x Genomics scRNA-seq platform.