C5_M_LUNG
Male and female C57BL/6 mice (n=10/group) received 10 mg/kg 6:2 Cl-PFESA or 2 mg/kg HFPO-TA or DMSO control via gavage for 28 days after acclimatization. Analyses included histopathology (H&E),  biochemical assays (MDA, CAT, SOD, GSH, ELISA (IL-, IL-6, TNF-, IL-4, IL-10, LPS, 20-HETE)), RNA-seq (Illumina NovaSeq, edgeR/Limma), qRT-PCR/Western blot/ for inflammatory genes (e.g., NLRP-12, CYP4a11), and 16S rRNA sequencing (V3-V4, QIIME2/SILVA) of lung contents with diversity/correlation stats.
SUB16178131
16S-RNA-Control Male 5