Mehtilome Bus taurus control3
In this study we examined the metaboloepigenetic adaptations from AKG supplementation during the in vitro culture in a bovine model. AKG during the early stages of development led to the expected increase in the activity of TET family enzymes, resulting in a decrease in nuclear 5mC levels. Additionally, the blastocysts derived from the AKG group exhibited reduced mitochondrial activity in the inner cell mass (ICM), along with increased methylation levels of mitochondrial DNA which, surprisingly, led to hypomethylation and upregulation of genes related to the trophectoderm.
SUB14651606
control meth 3