RNA-Seq of homo sapiens :  neurons
Dopaminergic neurons were differentiated from induced pluripotent stem cells (iPSCs) derived from LeschNyhan disease (LND) patients, unaffected controls, and CRISPR-engineered isogenic lines carrying the HPRT1c.508C>T mutation. RNA sequencing was performed at four developmental stages to compare transcriptional programs underlying dopaminergic neuron development and to assess whether isogenic control lines recapitulate disease-associated gene expression patterns.
SUB15929121
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