DNA was size-selected to target fragments with an insert size of 200 bp using aPippin Prep Size Selection system (Sage Science, Beverly). A bead cleanupsubsequently followed this process. The selected fragments were then used to create asequencing library using the Nextera XT kit (Illumina, San Diego) before sequencingapproximately 10 Gbp of 150 bp paired-end reads on an Illumina HiSeq4000.