Small skin biopsies (3mm) were collected from the inner area of the upper left and right arms (LA1 and RA1, respectively) and the front upper left and right thighs (LT and RT, respectively). Primary cultures of fibroblasts were derived from the biopsies using the standard explant procedure and cultured.  The fibroblast cell lines were reprogrammed into iPSC lines by a viral-free episomal reprogramming method using the Epi5 kit (Life Technologies) following the manufacturer recommendations. The iPSC lines were propagated using mTESR plus medium (StemCell Technologies) on dishes coated with Geltrex LDEV-Free Reduced Growth Factor Basement Membrane Matrix (Life Technologies) and propagated using Gentle Cell Dissociation Reagent (StemCell Technologies). For ResolveOme library sequencing, 4nM pool of all libraries was prepared combining each sample (genome and transcriptome libraries) at a 19:1 ratio DNA: RNA fractions, rather than a 4:1 ratio DNA:cDNA suggested by standard protocols. Sequencing (2×150bp) was performed on the Novogene 6000 instrument S4 chip, with a loading concentration of 1.8pM.