Macroscopic LLC tumors and normal adjacent lung tissues were manually dissected using a binocular microscope and a scalpel. The tissues were snap-frozen in liquid nitrogen and stored at -80 ºC until use. The samples were then sectioned into ~1 mg aliquots for nucleic acid extraction. Genomic DNA and total RNA were co-extracted using the AllPrep DNA/RNA Mini Kit (Qiagen, Cat. No. 80204). Tissue was homogenized with PowerTube beads (Cat. No. 13117-50) using the Omni Bead Ruptor 12 (Cat. No. 19-050A). DNA concentration was quantified using the Qubit™ 1X dsDNA HS Assay Kit (Cat. No. Q33231) on the Qubit 4 Fluorometer (Cat. No. Q33226). All DNA and RNA samples had a DNA Integrity Number (DIN) and RNA Integrity Number (RIN), respectively, greater than 6. RNA-seq libraries were constructed by Novogene using a stranded dUTP workflow: total RNA was [poly(A)-selected or rRNA-depleted], fragmented, converted to cDNA, end-repaired, A-tailed, adaptor-ligated, PCR-amplified, and sequenced on Illumina (PE150)