The library for CUT&Tag was prepared with the use of a CUT&Tag-IT Assay Kit (AT53165, Active Motif) according to the manufacturer's protocol. Nuclei were bound to concanavalin A beads, incubated overnight at 4°C with antibodies to SAF-A, and then incubated with secondary antibodies and subjected to tagmentation for 60 min at 37°C. DNA was purified with the use of DNA purification column before library preparation. Library preparation for ATAC-seq was performed with the use of an ATAC-seq kit (AT53150, Active Motif) and the Omni-ATAC protocol (Corces et al. 2017).