Genomic DNA was purified from Human MCF7 cells or nuclei by using Purelink genomic DNA kit (K182002) from invitrogen. Genomic DNA was digested with excess DpnI and sonicated to ~300 bp fragments. Paired-end libraries were prepared using the New England Biolabs kits and protocols. qDA-seq (Prajapati et al. (2024) NSMB