RNA was extracted from cells after 24h, 48h, and 72h of exposure using the RNeasy Mini kit (Qiagen). DNase 1 (Thermo Scientific, EN0521) treatment was used prior to downstream analyses. RNA-Seq libraries were prepared using the Novogene NGS RNA Library Prep Set (PT042) including polyA-tailed mRNA enrichment. RNA-Seq was performed in two batches i.e., the two exposure experiments of bleomycin and TGF-beta, respectively.