ChIP-seq protocol: 2x106 asynchronously growing cells were crosslinked with 1% formaldehyde for 10 min at room temperature, followed by quenching with 125 mM glycine for 10 min, washed twice with 1×phosphate buffered saline (PBS), and resuspended in chromatin immunoprecipitation (ChIP) lysis buffer (150 mM NaCl, 1 % Triton X-100, 0.1 % SDS, 20 mM Tris–HCl pH8.0, 2 mM EDTA). Chromatin was sheared to 200–600 bp and immunoprecipitated with 5 μg of antibody. Immunoprecipitated DNA was purified with QIAquick columns (ZymaResearch). ChIP-seq libraries were prepared using TruSeq ChIP Sample Preparation Kit (Illumina, Inc., USA) or NEBNext UltraII DNA Library Prep Kit for Illumina (BioLabs, catalog # E7645S).  Libraries were amplified using 15 cycles on the thermocycler. Post amplification libraries were size selected at 250-450bp in length using Agencourt AMPure XP beads from Beckman Coulter. Libraries were validated using the Agilent High Sensitivity DNA Kit. ATAC-seq libraries were prepared from 50,000 OVCAR8 cells. Nuclei were isolated by lysis in cold buffer (10 mM Tris-HCl, pH 7.4, 10 mM NaCl, 3 mM MgCl_2, and 0.1% IGEPAL CA-630) and subjected to tagmentation using Tn5 transposase (Illumina) for 40 min at 37°C. Tagmented DNA was purified using DNA Clean & Concentrator-5 columns (Zymo Research), amplified with NEBNext High-Fidelity 2× PCR Master Mix (New England Biolabs), and size-selected using 1.8× AMPure XP beads (Beckman Coulter). RNA-seq: Total RNA was extracted from OVCAR8 cells using TRIzol reagent according to the manufacturer's protocol. RNA-seq libraries were prepared according to the manufacturer's protocol using the NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (New England Biolabs, E7760S). Hi-C libraries were prepared using the Arima-HiC Kit (Arima Genomics) according to the manufacturer's instructions. Briefly, 5 million OVCAR8 cells were crosslinked with 2% formaldehyde in growth medium for 10 min at room temperature, and the reaction was quenched with 0.125 M glycine for 10 min. Cells were washed twice with phosphate-buffered saline (PBS), snap-frozen, and stored at −80°C until nuclei isolation.