GSM9257939: OVCAR3-DDP-1; Homo sapiens; RNA-Seq
The transcriptomes of A2780 and OVCAR3 resistant cells, along with their parental counterparts, were subjected to RNA sequencing (RNA-seq) to identify genome-wide editing events. Furthermore, ADAR1 was knocked down in the OV cisplatin-resistant cells. Subsequent RNA-seq analysis of the ADAR1-knockdown cells was performed to specifically assess the contribution of ADAR1-dependent editing to the drug-resistant phenotype. Total RNA was isolated with Trizol reagent, cDNA was synthesised for library establish.