Single-cell RNA-seq from bone marrow samples drawn from patients with high-risk MGUS and low-risk SMM enrolled in the Phase II D-PRISM trial of Daratumumab monotherapy.
Libraries were prepared using the Chromium Next GEM Single Cell 5` Reagent Kit v2 (Dual Index) and Library Construction Kits (10X Genomics), according to the manufacturer's instructions. Libraries were sequenced on a NovaSeq 6000 S4 flow cell at the Genomics Platform of the Broad Institute of MIT and Harvard (Cambridge, MA).