Census-seq low-coverage WGS of 39-donor neural progenitor cell lead response GWAS village, passage 1, day 9, well 2, 3 uM lead
Thirty-nine human ESC-derived neural progenitor cell donor lines were pooled into cell villages for lead (Pb) response mapping. Each treatment and time-point combination was collected from triplicate wells exposed daily beginning on day 2 to 0, 3, or 10 uM lead; baseline samples were also included. Samples were harvested for DNA extraction and Census-seq low-coverage whole-genome sequencing to estimate donor fractions and Pb sensitivity.