Weshomosapiens
Whole-exome sequencing was performed using SureSelect XT HS Human All Exon V6 enrichment and sequenced on an Illumina HiSeq platform (2 150 bp). Reads were quality-checked, adaptor-trimmed, aligned to hg38 using BWA-MEM, and processed into BAM files. Variant calling and filtering were performed using CEQer2, and variants were annotated with public databases including ClinVar, dbSNP, ExAC, and gnomAD.