RSC-PGE2-1 (CRX2099356)
This project uses RSC96 cells (immortalized rat Schwann cells) to study PDAC perineural invasion via transcriptome profiling and functional experiments. It examines RSC96-PDAC cell interaction effects on markers (c-Jun, Sox2, GDNF) and molecules (LIF, ADAMTS-1), PGE2's impact on RSC96, and RSC96's role in ECM degradation/neural remodeling. It provides data, identifies targets (PTGES, PGE2), and supports therapy development.