GSM9469144: OKIMer-treated MYCN-amplified NB PDX 308; Homo sapiens; OTHER
Mice were euthanised at a tumor volume of 2000 mm³, genomic DNA was extracted from harvested neuroblastoma PDX tumor tissue using the QIACube automated system (QIAGEN), according to the manufacturer's instructions. Exome libraries were constructed from genomic DNA using an Illumina-compatible exome enrichment protocol, including DNA fragmentation, adapter ligation, PCR amplification, and hybrid capture of coding regions according to the manufacturer's guidelines.