Human sample from Homo sapiens
Genomic DNA was extracted using a QIAamp Blood Midi Kit (QIAGEN, Valencia, CA). sheared to approximately 200-500 bp using a Covaris S220 instrument.  Then the libraries were constructed through end-repair, A-tailing, adapter ligation and PCR amplification.Exome capture was performed using GenCap Human All ExonV6 capture kit(MyGenostics Inc, Beijing, China).