spatial
In a murine orthotopic hepatocellular carcinoma model, mice in the combination therapy group received intraperitoneal injections of V-9302 (a glutamine uptake inhibitor, 30 mg/kg; #HY-112683, MCE) and AdOx (an arginine methylation inhibitor, 10 mol/kg; #A7154, Sigma-Aldrich). Liver tissues were collected upon euthanasia and subjected to single-cell spatial transcriptomic profiling.