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We used illumina sequence to perform RNA sequence of total lung from mice. We set three groups, one is mice without any treatment(control group); one is mice with ATCC17978 infection;  the last one is mice with ATCC17979 infection and treatment with naproxen (Treatment group). Gene expression level was compared between each other and we found most genes have upregulated when bacteria infection, and also many genes have downregulated with drug treatment.