RNA-Seq Analysis of Ovarian Transcriptome in PCOS Rats Treated with Gypenosides
Polycystic ovary syndrome (PCOS) is an endocrine disorder characterized by ovarian dysfunction, hormonal imbalance, and metabolic disturbances. While the ovarian tissue is a primary site of pathology, its underlying molecular mechanisms are not fully elucidated. Gypenosides, bioactive compounds extracted from Gynostemma pentaphyllum, have shown potential in ameliorating PCOS symptoms; however, their direct effects on the ovarian transcriptome and the associated molecular mechanisms remain unclear.This study aimed to elucidate the transcriptomic changes induced by gypenoside treatment in PCOS and to identify potential ovarian-specific therapeutic targets. Ovarian samples were collected from 18 rats divided into three groups: normal control (Control, n=6), PCOS model (PCOS-Model, n=6), and gypenoside-treated PCOS (PCOS-Gyp, n=6).The submitted dataset comprises 18 raw RNA-Seq sequencing files (FASTQ format) and corresponding sample metadata.