title: Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.
organism: Saccharomyces cerevisiae
description: Nucleosomes are not distributed randomly over the genomes of eukaryotes, but in general are aligned with respect to regulatory elements. In addition, the spacing between nucleosomes is also not random, with distinct nucleosome-to-nucleosome distances evident in different tissues and in different species. Abnormal inter-nucleosome spacing has been associated with increased intragenic transcription, and changes to nucleosome positioning at promoters results in changes to gene expression. ATP-dependent chromatin remodelling enzymes act to organise nucleosomes over genomes with partial redundancy. For example, the Isw1 and Chd1 enzymes both play a major role in positioning nucleosomes over coding regions.
attributes.tag: ENA first public
attributes.value: 2016-11-30
attributes.tag: ENA last update
attributes.value: 2016-11-29
attributes.tag: External Id
attributes.value: SAMEA17752168
attributes.tag: INSDC center alias
attributes.value: University of Dundee
attributes.tag: INSDC center name
attributes.value: University of Dundee
attributes.tag: INSDC first public
attributes.value: 2016-11-30T17:01:28Z
attributes.tag: INSDC last update
attributes.value: 2016-11-29T18:19:14Z
attributes.tag: INSDC status
attributes.value: public
attributes.tag: Submitter Id
attributes.value: pRS423CHD1_repeat3
attributes.tag: common name
attributes.value: baker's yeast
attributes.tag: sample name
attributes.value: pRS423CHD1_repeat3