title: Stanford_ChipSeq_SK-N-SH_Nrf1_IgG-rab
organism: Homo sapiens
attributes.tag: source_name
attributes.value: SK-N-SH
attributes.tag: biomaterial_provider
attributes.value: ATCC
attributes.tag: lab
attributes.value: Stanford
attributes.tag: lab description
attributes.value: Snyder - Stanford University
attributes.tag: datatype
attributes.value: ChipSeq
attributes.tag: datatype description
attributes.value: Chromatin IP Sequencing
attributes.tag: cell
attributes.value: SK-N-SH
attributes.tag: cell organism
attributes.value: human
attributes.tag: cell description
attributes.value: neuroblastoma, newly promoted to tier 2: not in 2011 analysis, the SK-N-SH line was established from a neuroblastoma in a 4 year old individual.
attributes.tag: cell karyotype
attributes.value: cancer
attributes.tag: cell lineage
attributes.value: ectoderm
attributes.tag: cell sex
attributes.value: F
attributes.tag: treatment
attributes.value: None
attributes.tag: treatment description
attributes.value: No special treatment or protocol applies
attributes.tag: antibody
attributes.value: Nrf1
attributes.tag: antibody antibodydescription
attributes.value: Mouse monoclonal, Immunogen corresponding to amino acids 201-286 of Human NRF1. Antibody Target: NRF1
attributes.tag: antibody targetdescription
attributes.value: NRF1 is the mammalian homolog to the erect wing (ewg) Drosophila protein that is required for proper development of the central nervous system and indirect flight muscles. In mammals NRF1 functions as a transcription factor that activates the expression of the EIF2S1 (EIF-alpha) gene. This protein links the transcriptional modulation of key metabolic genes to cellular growth and development, and has been implicated in the control of nuclear genes required for respiration, heme biosynthesis and mitochondrialDNA transcription and replication. NRF1 forms a homodimer and binds DNA as a dimer. NRF1 shows a nuclear localization and is expressed widely in embryonic, fetal and adult tissues. Phosphorylation of NRF1 enhances DNA binding.
attributes.tag: antibody vendorname
attributes.value: Abcam
attributes.tag: antibody vendorid
attributes.value: ab55744
attributes.tag: control
attributes.value: IgG-rab
attributes.tag: control description
attributes.value: Input signal from Normal Rabbit IgG ChIP-seq.
attributes.tag: control
attributes.value: IgG-rab
attributes.tag: control description
attributes.value: Input signal from Normal Rabbit IgG ChIP-seq.
attributes.tag: controlid
attributes.value: wgEncodeEH003393