title: Broad_ChipSeq_NH-A_EZH2_(39875)
organism: Homo sapiens
attributes.tag: source_name
attributes.value: NH-A
attributes.tag: biomaterial_provider
attributes.value: Lonza
attributes.tag: datatype
attributes.value: ChipSeq
attributes.tag: datatype description
attributes.value: Chromatin IP Sequencing
attributes.tag: antibody antibodydescription
attributes.value: This EZH2 antibody was raised against a recombinant protein corresponding to amino acids 353-451 of human EZH2. Antibody Target: EZH2
attributes.tag: antibody targetdescription
attributes.value: EZH2 (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.
attributes.tag: antibody vendorname
attributes.value: Active Motif
attributes.tag: antibody vendorid
attributes.value: 39875
attributes.tag: controlid
attributes.value: wgEncodeEH001027
attributes.tag: replicate
attributes.value: 1,2
attributes.tag: softwareversion
attributes.value: ScriptureVPaperR3
attributes.tag: cell sex
attributes.value: U
attributes.tag: antibody
attributes.value: EZH2_(39875)
attributes.tag: antibody antibodydescription
attributes.value: This EZH2 antibody was raised against a recombinant protein corresponding to amino acids 353-451 of human EZH2. Antibody Target: EZH2
attributes.tag: antibody targetdescription
attributes.value: EZH2 (Enhancer of Zeste homolog 2, also designated Enx1 and SETDB1) is a human homolog of the Drosophila Polycomb-group protein Enhancer of Zeste protein. It contains a SET domain that catalyzes the methylation of histone H3 at lysine 27 (Histone H3 Lys27 monomethylated, dimethylated and trimethylated). Polycomb-group proteins repress gene expression by binding to chromatin and locally altering chromatin structure. EZH2, BMI-1 and Suz12 are present in the PRC2 and PRC3 protein complexes that function as mediators of epigenetic transcriptional silencing. EZH2 associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. EZH2 may play a role in the hematopoietic and central nervous systems. Deregulation of EZH2 is linked to a variety of cancers.
attributes.tag: antibody vendorname
attributes.value: Active Motif
attributes.tag: antibody vendorid
attributes.value: 39875
attributes.tag: treatment
attributes.value: None
attributes.tag: treatment description
attributes.value: No special treatment or protocol applies
attributes.tag: control
attributes.value: std
attributes.tag: control description
attributes.value: Standard input signal for most experiments.
attributes.tag: controlid
attributes.value: NH-A/Input/std
attributes.tag: softwareversion
attributes.value: ScriptureVPaperR3