title: HudsonAlpha_ChipSeq_K562_PML_(SC-71910)_v042211.1
organism: Homo sapiens
attributes.tag: source_name
attributes.value: K562
attributes.tag: biomaterial_provider
attributes.value: ATCC
attributes.tag: datatype
attributes.value: ChipSeq
attributes.tag: datatype description
attributes.value: Chromatin IP Sequencing
attributes.tag: antibody antibodydescription
attributes.value: Mouse monoclonal IgG, N-terminal epitope corresponding to residues 37-51 of PML of human origin. Antibody Target: PML
attributes.tag: antibody targetdescription
attributes.value: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq)
attributes.tag: antibody vendorname
attributes.value: Santa Cruz Biotechnology
attributes.tag: antibody vendorid
attributes.value: sc-71910
attributes.tag: controlid
attributes.value: SL6023
attributes.tag: labexpid
attributes.value: SL7894,SL8137
attributes.tag: softwareversion
attributes.value: MACS
attributes.tag: cell sex
attributes.value: F
attributes.tag: antibody
attributes.value: PML_(SC-71910)
attributes.tag: antibody antibodydescription
attributes.value: Mouse monoclonal IgG, N-terminal epitope corresponding to residues 37-51 of PML of human origin. Antibody Target: PML
attributes.tag: antibody targetdescription
attributes.value: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. (provided by RefSeq)
attributes.tag: antibody vendorname
attributes.value: Santa Cruz Biotechnology
attributes.tag: antibody vendorid
attributes.value: sc-71910
attributes.tag: treatment
attributes.value: None
attributes.tag: treatment description
attributes.value: No special treatment or protocol applies
attributes.tag: protocol
attributes.value: v042211.1
attributes.tag: protocol description
attributes.value: Faster ChIP protocol & AMpure XP size selection for ChIP-seq (Myers)
attributes.tag: controlid
attributes.value: SL6023
attributes.tag: labexpid
attributes.value: SL7894,SL8137
attributes.tag: replicate
attributes.value: 1,2
attributes.tag: softwareversion
attributes.value: MACS