title: Stanford_ChipSeq_ES-E14_ZNF384_(HPA004051)_std
organism: Mus musculus
attributes.tag: source_name
attributes.value: ES-E14
attributes.tag: biomaterial_provider
attributes.value: Santos lab
attributes.tag: lab
attributes.value: Stanford-m
attributes.tag: lab description
attributes.value: Snyder - Stanford University
attributes.tag: datatype
attributes.value: ChipSeq
attributes.tag: datatype description
attributes.value: Chromatin IP Sequencing
attributes.tag: cell
attributes.value: ES-E14
attributes.tag: cell organism
attributes.value: mouse
attributes.tag: cell description
attributes.value: mouse embryonic stem cell line E14
attributes.tag: cell sex
attributes.value: M
attributes.tag: antibody
attributes.value: ZNF384_(HPA004051)
attributes.tag: antibody antibodydescription
attributes.value: Rabbit polyclonal generated using the immunogen: Zinc finger protein 384 recombinant protein epitope signature tag (PrEST)
attributes.tag: antibody targetdescription
attributes.value: This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7.
attributes.tag: antibody vendorname
attributes.value: SIGMA
attributes.tag: antibody vendorid
attributes.value: HPA004051
attributes.tag: treatment
attributes.value: None
attributes.tag: treatment description
attributes.value: No special treatment or protocol applies
attributes.tag: control
attributes.value: std
attributes.tag: control description
attributes.value: Standard input signal for most experiments.
attributes.tag: age
attributes.value: E0
attributes.tag: age description
attributes.value: Embryonic day 0 (stem cell)
attributes.tag: control
attributes.value: std
attributes.tag: control description
attributes.value: Standard input signal for most experiments.
attributes.tag: controlid
attributes.value: wgEncodeEM002788
attributes.tag: strain
attributes.value: 129/Ola
attributes.tag: strain description
attributes.value: The mice have yellow coats and late onset severe vacuolation in brain (700+ days). Inbred strain used as a control group to compare with null PrP mice.