description: In order to characterize different scales of genome organization during cervical cancer development, we have used NHEK normal human epidermal keratinocyte and SiHa tumorigenic cervical cancer cells and performed genome-wide Hi-C, ChIP-seq as well as RNA-seq to identify structural variations, specifically TADs. We interpretated a correlation among chromatin structure, epigenetic landscape, gene expression, and HPV-LINC00393 integrated loci in SiHa cells. The results will help us to get a better insight into HPV-LINC00393 integration in cervical carcinogenesis.
attributes.tag: isolate
attributes.value: Japanese woman
attributes.tag: age
attributes.value: 55
attributes.tag: biomaterial_provider
attributes.value: ATCC
attributes.tag: sex
attributes.value: female
attributes.tag: tissue
attributes.value: cervical cancer
attributes.tag: cell_line
attributes.value: SiHa
attributes.tag: BioSampleModel
attributes.value: Human