title: Feline Diffuse Iris Melanoma and Iris Melanosis samples
organism: Felis catus
description: Feline diffuse iris melanoma (FDIM) is the most common primary ocular tumour in cats, with high metastatic potential. Greater intraocular invasion correlates with increased mortality. No effective therapeutics exist for metastatic disease, partly due to a lack of known molecular targets associated with aggressive tumour behaviour. Here, we define the transcriptomic landscape of FDIM in treatment-naive cats using bulk RNA sequencing on laser capture microdissection and core biopsy specimens from formalin-fixed paraffin-embedded tissue. Samples included iris melanosis (dysplastic melanocytes confined to the anterior iris; n=7), early FDIM (neoplastic melanocytes confined to the iris stroma; n=13), and late FDIM (neoplastic infiltration into the ciliary body and sclera; n=13).
attributes.tag: breed
attributes.value: Domestic Shorthair
attributes.tag: age
attributes.value: 5y
attributes.tag: collection_date
attributes.value: 2024-04
attributes.tag: geo_loc_name
attributes.value: United Kingdom
attributes.tag: sex
attributes.value: female
attributes.tag: tissue
attributes.value: Eye
attributes.tag: biomaterial_provider
attributes.value: Cytopath Veterinary Pathology
attributes.tag: cell_type
attributes.value: Melanoma
attributes.tag: disease
attributes.value: Feline diffuse iris melanoma
attributes.tag: disease_stage
attributes.value: Early
attributes.tag: sample_type
attributes.value: Tissue sample
attributes.tag: BioSampleModel
attributes.value: Model organism or animal