title: Metagenome-assembled genome: SRR24315758_bin_15952
organism: uncultured Clostridia bacterium
description: This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome assembled from the metagenomic run SRR24315758 of study SRP434700.
attributes.tag: ENA first public
attributes.value: 2025-11-26
attributes.tag: INSDC center name
attributes.value: EMG
attributes.tag: INSDC status
attributes.value: public
attributes.tag: Submitter Id
attributes.value: SRR24315758_bin_15952
attributes.tag: assembly quality
attributes.value: Many fragments with little to no review of assembly other than reporting of standard assembly statistics
attributes.tag: assembly software
attributes.value: metaspades_v3.15.5
attributes.tag: binning parameters
attributes.value: default
attributes.tag: binning software
attributes.value: MGnify-genomes-generation-pipeline_v2.0.0
attributes.tag: broad-scale environmental context
attributes.value: human
attributes.tag: broker name
attributes.value: EBI-EMG
attributes.tag: collection date
attributes.value: 2017/2018
attributes.tag: completeness score
attributes.value: 69.79
attributes.tag: completeness software
attributes.value: CheckM2_v1.0.1
attributes.tag: contamination score
attributes.value: 3.97
attributes.tag: environmental medium
attributes.value: intestine
attributes.tag: geographic location (country and/or sea)
attributes.value: Spain
attributes.tag: geographic location (latitude)
attributes.value: 43.29206200
attributes.tag: geographic location (longitude)
attributes.value: -1.97045100
attributes.tag: investigation type
attributes.value: metagenome-assembled genome
attributes.tag: isolation_source
attributes.value: human gut metagenome
attributes.tag: local environmental context
attributes.value: digestive system
attributes.tag: metagenomic source
attributes.value: human gut metagenome
attributes.tag: project name
attributes.value: Colorectal cancer (CRC) is a disease of worldwide concern, which has an increasingly established relationship with the intestinal microbiota. Most of the cases of sporadic CRC emerge in patients with polyps, which also are influenced by gut microbiota. In this study, we utilized shotgun metagenomics to analyze the taxonomic diversity of Bacteria present in fecal samples of control, polyps, and CRC patients. The samples were collected between 2017 and 2018 by the Biodonostia Health Research Institute - Donostia Hospital in the city of San Sebastian, Spain, following the 2003 European Guidelines and the 2006 National Strategy against Cancer. The population-based screening of CRC was approved by the Basque Autonomous Government and implemented in 2009. The screening is based on the detection of occult blood in feces (FOB) using a biennial quantitative fecal immunochemical test (FIT), targeting women and men between 50 and 69 years old and a colonoscopy under sedation for FIT positive cases. 90 samples were collected and further divided into three groups based on colonoscopy results: control group (n31-60 stool samples from individuals with colonoscopy showing no intestinal lesions, no history of diarrhea, and no history of previous intestinal infection), polyps group (n1-30 stool samples from individuals with colonoscopy showing polyps on the surface of the colon or rectum), and the CRC group, which consists of individuals with biopsies confirming malignancy of colon or rectum lesions (n61-90).
attributes.tag: sample derived from
attributes.value: SAMN34351582
attributes.tag: sample name
attributes.value: SRR24315758_bin_15952
attributes.tag: scientific_name
attributes.value: uncultured Clostridia bacterium
attributes.tag: sequencing method
attributes.value: Illumina MiSeq
attributes.tag: taxonomic identity marker
attributes.value: multi-marker approach