Stimulation of soluble Guanylate Cyclase by riociguat attenuates pathological cardiac hypertrophy and heart failure in response to chronic pressure overload.
Mus musculus
Aim of the study was to examine the cardioprotective potential of the soluble guanylate cyclase (sGC) activator riociguat in an in vivo mouse model of chronic pressure overload by transverse aortic constriction (TAC). To determine whether riociguat reverses the molecular changes caused by TAC, the left ventricular gene expression profile of TAC operated mice treated with and without riociguat was analysed by RNA sequencing.
strain
C57BL/6N
age
112
dev_stage
adult
sex
male
tissue
left ventricle w/o septum (heart)
BioSampleModel
Model organism or animal