mouse gut metagenome
The goal is to characterize the gut microbiome in female NOD mice during the development of type 1 diabetes. It is of interest to elucidate the modulation of the gut microbiome in response to treatment with an epigenetic drug that affords protection against type 1 diabetes in NOD mice. The data obtained will have implications for the understanding of the regulation of type 1 diabetes via the gut microbiome. The knowledge gained will be of translational value to treat patients with type 1 diabetes.