Mus musculus
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) is largely unknown. We show that MMc induce a preferential differentiation of hematopoietic stem and progenitor cells towards myelopoiesis in bone marrow of fetal mice, and improves resilience against cytomegalovirus infection in neonates. In humans, low MMc counts in cord blood are associated with an increased number of infections in the first year of life primarily in male newborns. Taken together, MMc boost neonatal immunity in mice and humans to mitigate the risk for early life infections.
ENA-FIRST-PUBLIC
2020-06-03T17:04:50Z
ENA-LAST-UPDATE
2020-06-02T11:46:27Z
External Id
SAMEA6870337
INSDC center name
jhuang
INSDC first public
2020-06-03T17:04:50Z
INSDC last update
2020-06-02T11:46:27Z
INSDC status
public
Submitter Id
MMc3
common name
house mouse
sample name
MMc3
scientific_name
Mus musculus