Mus musculus domesticus
Whole Exome Sequencing of Small Cell Lung Carcinoma tumor mouse sample from a novel murine model driven by the loss of four tumor suppressors. Deletion of Rb1, p107, Pten, and Trp53 exclusively in basal cells leads to the development of Small Cell Lung Carcinoma, showing that Keratin K5 expressing cells contribute to the development as cell of origin of Small Cell Lung Carcinoma.
breed
mixed breed FVB enriched
age
173
sex
female
tissue
Lung epithelium
biomaterial_provider
CIEMAT, 40th Complutense Av, Madrid, 28043
birth_date
2014-07-30T00:00:00
birth_location
Animal Facilities, CIEMAT, 40th Complutense Av, Madrid, 28043
breeding_history
Rb1 floxed Rbl1 null Pten floxed Trp53 floxed mice were generated by breeding Trp53 floxed Pten floxed (1) mice with Rb1 floxed Rbl1 null mice (2). (1) Costa C, et al. (2012) A novel tumor suppressor network in squamous malignancies. Sci Rep. doi:10.1038/srep00828. (2) Moral M, et al. (2009) Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma. Cancer Res. doi:10.1158/0008-5472.CAN-08-3240.
collected_by
Mirentxu Santos Lafuente, Miriam Perez Crespo, Sara Lazaro Encinas
collection_date
2015-01-19
death_date
2015-01-19T00:00:00
disease
Small Cell Lung Carcinoma (SCLC)
disease_stage
Advanced tumor
genotype
Rb1 floxed Rbl1 null Pten floxed Trp53 floxed
geo_loc_name
Spain: Madrid
health_state
Small Cell Lung Carcinoma (SCLC)
sample_type
Tissue sample
store_cond
Tissue sample was stored in RNAlater at -20 C degrees for not loger than 6 months
treatment
Adenovirus expressing Cre recombinase under K5 promoter (Ad5-K5-cre) by intratracheal administration
BioSampleModel
Model organism or animal