Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.
Saccharomyces cerevisiae
Nucleosomes are not distributed randomly over the genomes of eukaryotes, but in general are aligned with respect to regulatory elements. In addition, the spacing between nucleosomes is also not random, with distinct nucleosome-to-nucleosome distances evident in different tissues and in different species. Abnormal inter-nucleosome spacing has been associated with increased intragenic transcription, and changes to nucleosome positioning at promoters results in changes to gene expression. ATP-dependent chromatin remodelling enzymes act to organise nucleosomes over genomes with partial redundancy. For example, the Isw1 and Chd1 enzymes both play a major role in positioning nucleosomes over coding regions.
ENA first public
2016-11-30
ENA last update
2016-11-29
External Id
SAMEA17749918
INSDC center alias
University of Dundee
INSDC center name
University of Dundee
INSDC first public
2016-11-30T17:01:28Z
INSDC last update
2016-11-29T18:19:14Z
INSDC status
public
Submitter Id
intNEGCHD1_repeat3
common name
baker's yeast
sample name
intNEGCHD1_repeat3