Chinese Crested dog with Neuronal Ceroid Lipofuscinosis
Canis lupus familiaris
With written consent from the owner we obtained blood and formalin-fixed brain tissue from a young adult Chinese Crested dog that was euthanized due to progressive neurological decline accompanied by brain atrophy. The clinical signs suggested that neuronal ceroid lipofuscinosis was the underlying disease. DNA was extracted from the blood and used to generate a whole genome sequence(WGS) which provided an opportunity to identify the disease-causing mutation.
breed
Chinese crested
age
1.5
biomaterial_provider
Dr. Gary Johnson
sex
male
tissue
Blood
breeding_history
rescue dog
disease
Neuronal ceroid lipofuscinosis
disease_stage
advanced
BioSampleModel
Model organism or animal