Nothapodytes nimmoniana
Nothapodytes nimmoniana (J.Graham) Mabb.(Icacinaceae),an important source of monoterpene indole alkaloid, camptothecin(CPT). Primary cellular target of CPT is DNA topoisomerase I (topo I). However, number of reports have indicated its therapeutic potential against colon cancer , uterine cervical cancer, ovarian cancer, AIDS and malaria . Two clinically used anti-tumor compounds, topotecan and irinotecan, are currently semi-synthesized using natural camptothecins. Biosynthetic pathway of CPT is yet to be fully enunciated. Transcriptome analysis offers a powerful platform for pathway elucidation and determining the expression profile of genes involved in CPT biosynthesis at the molecular level.
cultivar
Nothapodytes
ecotype
India
collection_date
2014-06-25
env_biome
Sub-tropical
env_feature
Terrestrial Subtropical
env_material
soil
estimated_size
365mbp
geo_loc_name
India:jammu
host
Nothapodytes
isol_growth_condt
Cultivated in the field and RNA isolation from Nacent root wood
lat_lon
33.44 N 74.55 E
num_replicons
1
ploidy
diploid
propagation
Sexual/asexual
BioSampleModel
MIGS.eu
BioSampleModel
MIGS/MIMS/MIMARKS.plant-associated