The variable environmental conditions of marine habitats, including variations in hydrostatic pressure, temperature, and nutrient availability undoubtedly present significant challenges to the microbiota that live in the world's oceans. How marine bacteria adapt to these fluctuating conditions remains largely enigmatic. We hypothesize that temperature is a major driver of bacterial growth and development and hence adaptation in marine environments. Streptomyces have established inhabitants of marine habitats and well-known producers of bioactive metabolites. We hypothesize that temperature dependant regulation of bioactive metabolite production may represent an important adaptive strategy for marine streptomycetes. Bioactivity screening and metabolomic analysis of a library of streptomycetes isolated from intertidal sediments from Nunavut, Canada revealed several instances of low temperature induction of bioactive metabolite production. To elucidate the molecular mechanism underlying this phenomenon we are sequencing the genomes and transcriptomes of selected streptomycetes. We hypothesize that a novel regulatory mechanism underlies this phenomenon and that the results of this research can be used to access other cryptic natural products.
strain
RKAG290
collection_date
2011-08-31
depth
30 cm
elev
0 cm
env_broad_scale
marine sediment biome
env_local_scale
Shoreline zone
env_medium
sediment
geo_loc_name
Canada: Frobisher Bay, Nunavut
isol_growth_condt
Marine Raffinose Histidine agar, 22dC
lat_lon
63.726118 N 68.424361 W
num_replicons
1
ref_biomaterial
no reference for the biomaterial
isolation_source
marine sediment
BioSampleModel
MIGS.ba
BioSampleModel
MIGS/MIMS/MIMARKS.sediment