Metagenome-assembled genome: SRR3737021_bin.10_CONCOCT_v1.1_MAG
uncultured Clostridia bacterium
This sample represents a Third Party Annotation (TPA) Metagenome-Assembled Genome (MAG) assembled from the metagenomic run SRR3737021 of study SRP076119.
ENA-FIRST-PUBLIC
2023-01-03
ENA-LAST-UPDATE
2023-01-03
External Id
SAMEA14085722
INSDC center alias
EBI
INSDC center name
European Bioinformatics Institute
INSDC first public
2023-01-03T00:33:08Z
INSDC last update
2023-01-03T00:33:08Z
INSDC status
public
Submitter Id
SRR3737021_bin.10_CONCOCT_v1.1_MAG
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
metaspadesv3.10.0
binning parameters
Default
binning software
CONCOCT v1.1
broker name
EMG broker account, EMBL-EBI
collection date
2012-08-24
completeness score
77.17
completeness software
CheckM
contamination score
0.0
environment (biome)
Host-associated
environment (feature)
Human
environment (material)
Digestive system
geographic location (country and/or sea)
USA
geographic location (latitude)
40.829
geographic location (longitude)
-96.667
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
metagenomic source
human gut metagenome
project name
Live bacteria have been used for decades in an attempt to modulate the human gut microbiota, but their colonization is mostly transient, and a conceptual understanding of the ecological role of exogenous microbes in gut ecosystems is lacking. Here we show that Bifidobacterium longum AH1206 stably persists in the gut of one third of human individuals for at least six months after being orally administered without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. Engraftment of AH1206 was associated with low abundance of B. longum and specific carbohydrate utilization genes of this species in the pre-treatment microbiome. This pointed to inter-individual differences in the availability of resources that constitute a niche opportunity for colonization. The findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precision microbiome reconstitution and a personalization of such strategies.
sample derived from
SAMN05194694
sample name
SRR3737021_bin.10_CONCOCT_v1.1_MAG
scientific_name
uncultured Clostridia bacterium
sequencing method
Illumina HiSeq 2500
taxonomic identity marker
multi-marker approach