Uninfected H357 oral keratinocytes, replicate 1
Homo sapiens
Cell line description: Established from a squamous cell carcinoma (SCC) of the tongue (20mm) of a 74 year-old male patient. STNMP stage I, well differentiated, node negative tumour. Mutant p53, codon 110 exon 4, G to A; the previously reported mutant Ha-ras status of this cell line: codon: 13, G to A, codon 61, A-G is under investigation. This cell line is highly responsive to TGF beta and undergoes epithelial to mesenchymal transition. It expresses high levels of TGF beta1. Fahey et al (1996). Tumourigenic in athymic nude mice on subcutaneous injection and non-tumorigenic on orthotopic injection. Haplotype information: A*02,A*31; B*40,B*44; Cw*03,Cw*05
isolate
Uninfected H357 oral keratinocytes, replicate 1
age
74
biomaterial_provider
European Collection of Authenticated Cell Cultures
collection_date
1990
geo_loc_name
United Kingdom: Bristol
sex
male
tissue
Tongue
cell_line
H357
cell_type
oral keratinocyte
culture_collection
ECACC:06092004
disease
Oral Squamous Cell Carcinoma
disease_stage
Grade 1 Tumor
ethnicity
not collected
sample_type
Cell Culture
BioSampleModel
Human