Uninfected H376 oral keratinocytes, replicate 2
Homo sapiens
Cell line description: Established from a squamous cell carcinoma (SCC) of the floor of the mouth (20mm-40mm) of a 40 year-old female patient. STNMP stage III, well differentiated, node positive tumour. Mutant p53, codon 266 exon 8, G to T; wild type K-, N-, and Ha-ras. This cell line is highly responsive to TGFbeta. H376 cells in culture scatter, i.e. the cells redistribute on the substrate, in response to Hepatocyte Growth Factor. Non-tumourigenic in athymic nude mice by subcutaneous injection and on injection into the floor of the mouth (orthotopic). Haplotype information: A*03,A*24; B*27,B*35; Cw*04,Cw*12
isolate
Uninfected H376 oral keratinocytes, replicate 2
age
40
biomaterial_provider
European Collection of Authenticated Cell Cultures
collection_date
1990
geo_loc_name
United Kingdom: Bristol
sex
female
tissue
Floor of mouth
cell_line
H376
cell_type
oral keratinocyte
culture_collection
ECACC:06092005
disease
Oral Squamous Cell Carcinoma
disease_stage
Grade 3 tumor
ethnicity
not collected
sample_type
Cell Culture
BioSampleModel
Human