binned metagenome: spire_mag_02261764
Phocaeicola vulgatus
ENA first public
2024-09-20
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_02261764
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
missing: third party data
completeness score
91.78
completeness software
checkm2 0.1.3
contamination score
1.47
environmental medium
stool
geographic location (country and/or sea)
New Zealand
geographic location (latitude)
missing: third party data
geographic location (longitude)
missing: third party data
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
The gut microbiome is a contributing factor in the development of metabolic disorders. The overarching goal of this study was to assess the efficacy of using lean multi-donor FMT to treat adolescents with severe obesity. The Gut Bugs Trial recruited 87 adolescents with severe obesity and randomised them 1:1 to receive a single dose of either FMT or placebo capsules. FMT capsules contained concentrated fecal material derived from 4 sex-matched lean donors. Placebo capsules contained saline. Recipients were clinically assessed at baseline, and at 6-, 12-, and 26-weeks post-treatment. The primary objective was a change in BMI SDS at week 6. Secondary objectives included a variety of metabolic health parameters, body composition, and gut microbiome alterations.
sample derived from
SAMN15156609
sample name
spire_mag_02261764
scientific_name
Phocaeicola vulgatus
sequencing method
Illumina NovaSeq 6000
taxonomic identity marker
multi-marker approach