Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_01769208
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
missing: third party data
completeness score
95.32
completeness software
checkm2 0.1.3
contamination score
1.44
environmental medium
stool
geographic location (country and/or sea)
not provided
geographic location (latitude)
missing: third party data
geographic location (longitude)
missing: third party data
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Bacterial community acquisition in the infant gut impacts immune education and disease susceptibility. We compared bacterial strains across and within families in a prospective birth cohort of 44 infants and their mothers, sampled longitudinally in the first months of each child's life. We identified mother-to-child microbial transmission events and describe the incidence of family-specific antibiotic resistance genes. Across multiple species, we identified two inheritance patterns, where often the mother's dominant strain is transmitted to the child, but occasionally her minor strains colonize the infant gut. We observed both inheritance patterns for Bacteroides uniformis strains. In families where the minor strain was inherited, we identified a starch utilization gene cluster that was absent in the mother's dominant strain, suggesting the selective advantage of her minor strain in the infant gut. Our findings reveal mother-to-child bacterial transmission events at high-resolution and give insights into early colonization of the infant gut.
sample derived from
SAMN09382546
sample name
spire_mag_01769208
scientific_name
Bacteroides uniformis
sequencing method
Illumina HiSeq 2500
taxonomic identity marker
multi-marker approach