Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_01386601
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2015-01-05
completeness score
79.47
completeness software
checkm2 0.1.3
contamination score
1.57
environmental medium
not provided
geographic location (country and/or sea)
China
geographic location (latitude)
39.90000000
geographic location (longitude)
116.05000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Hypertension is one of the most prevalent cardiovascular diseases worldwide. Recent findings have identified a link between gut microbiota and blood pressure, yet the contributions of gut microbes and bacterial metabolites towards hypertension remain largely uncharacterized. We carried out metagenomic and metabonomics analyses, in combination with faecal microbiota transplantation, and elucidate that dysbiosis of gut microbiome triggers the pathogenesis of hypertension through altering the metabolic effects. Notably, we demonstrate similar discrepancy of microbial compositional and functional features in pre-hypertension and hypertension when compared with the controls, highlighting varied intestinal microbiota in prehypertensive populations. The impairment of host metabolism in pre-hypertension and hypertension was identified to be closely linked with dysbiotic gut microbiome. The hypertensive phenotype was transferrable from hypertension patients to germ-free mice by faecal transplant. Overall, our results explicate a novel role for aberrant gut microbiota as key contributor to the pathogenesis of hypertension, and emphasize the significance of early intervention for pre-hypertension.
sample derived from
SAMEA3951693
sample name
spire_mag_01386601
scientific_name
Bacteroides uniformis
sequencing method
Illumina HiSeq 2500
taxonomic identity marker
multi-marker approach