Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_01070101
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2012
completeness score
94.19
completeness software
checkm2 0.1.3
contamination score
0.59
environmental medium
stool
geographic location (country and/or sea)
China
geographic location (latitude)
55.67609700
geographic location (longitude)
12.56833700
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
The gut microbiota has been linked to cardiovascular diseases, most notably through the production of trimethylamine and its hepatic conversion to the proatherogenic metabolite, trimethylamine-N-oxide. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health. We further identify common themes by comparison with gut microbiome data associated with other cardiometabolic diseases (obesity and type 2 diabetes), liver cirrhosis, and an autoimmune disease, rheumatoid arthritis. Our data represent a comprehensive resource for further investigations on the role of the gut microbiome in promoting or preventing ACVD as well as other related diseases.
sample derived from
SAMEA104142117
sample name
spire_mag_01070101
scientific_name
Bacteroides uniformis
sequencing method
Illumina HiSeq 2000
taxonomic identity marker
multi-marker approach