Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_02337433
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
not provided
completeness score
65.83
completeness software
checkm2 0.1.3
contamination score
0.58
environmental medium
stool
geographic location (country and/or sea)
Tanzania
geographic location (latitude)
missing: third party data
geographic location (longitude)
missing: third party data
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
The human gut microbiota is increasingly recognized as an important factor in modulating innate and adaptive immunity through release of ligands and metabolites that translocate into circulation. Urbanizing African populations harbor large intestinal diversity due to a range of lifestyles, providing the necessary variation to gauge immunomodulatory factors. Stool metagenomics uncovers a gradient of intestinal microbial compositions from rural through urban Tanzania, towards European samples, manifested both in relative abundance and genomic variation. The rural population shows increase Bacteroidetes, led by Prevotella copri, but also presence of fungi. Measured ex vivo cytokine responses were significantly associated with 34 significant microbes. Pathway effects on cytokines, notably TNF-alpha and IFN-gamma, differential metabolome analysis and enzyme copy number enrichment converge on histidine and arginine metabolism as potential immunomodulatory pathways mediated by Bifidobacterium longum and Akkermansia muciniphila.
sample derived from
SAMN17126951
sample name
spire_mag_02337433
scientific_name
Bacteroides uniformis
sequencing method
Illumina NovaSeq 6000
taxonomic identity marker
multi-marker approach