Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_01883578
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2011
completeness score
98.05
completeness software
checkm2 0.1.3
contamination score
3.39
environmental medium
stool
geographic location (country and/or sea)
Sweden
geographic location (latitude)
55.70000000
geographic location (longitude)
11.96666667
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Bariatric surgery is the most effective procedure for the treatment of obesity. Given the role of the gut microbiota in regulating host metabolism and adiposity, we investigated the long-term effects of bariatric surgery on the human gut metagenome in patients randomized to Roux-en-Y gastric bypass and vertical banded gastroplasty. Genera of the Proteobacteria were specifically enriched after bypass, and the abundance of genes for fatty acid metabolism, nitrogen metabolism and two-component systems was increased after both procedures nine years after surgery. Through colonization of germ-free mice with stools from the patients we demonstrated that the altered gut microbiota promoted reduced fat deposition in recipient mice. Recipients of bypass microbiota also had a lower respiratory quotient, indicating decreased utilization of carbohydrates as fuel. Our results suggest that the gut microbiota may play a direct role in the reduction of adiposity observed after bariatric surgery.
sample derived from
SAMEA3212991
sample name
spire_mag_01883578
scientific_name
Bacteroides uniformis
sequencing method
Illumina HiSeq 2000
taxonomic identity marker
multi-marker approach