Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_02677741
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2015-02
completeness score
87.66
completeness software
checkm2 0.1.3
contamination score
8.97
environmental medium
stool
geographic location (country and/or sea)
Germany
geographic location (latitude)
52.41958000
geographic location (longitude)
13.16418000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Periods of fasting and refeeding may reduce cardiometabolic risk elevated by Western diet. We show that in hypertensive metabolic syndrome patients, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension diet reduced systolic blood pressure, need for antihypertensive medications, body-mass index at three months post intervention compared to a modified Dietary Approach to Stop Hypertension diet alone. Fasting altered the gut microbiome, impacting bacterial taxa and gene modules associated with short-chain fatty acid production. Cross-system analyses revealed a positive correlation of circulating mucosa-associated invariant T cells, non-classical monocytes and CD4+ effector T cells with SBP. Furthermore, regulatory T cells positively correlated with body mass index and weight. Machine learning analysis of baseline immunome or microbiome data could predict sustained systolic blood pressure response within the fasting group, identifying CD8+ effector T cells, Th17 cells and Tregs or Desulfovibrionaceae, Hydrogenoanaerobacterium, Akkermansia, and Ruminococcaceae as important contributors to the model.
sample derived from
SAMN17719302
sample name
spire_mag_02677741
scientific_name
Bacteroides uniformis
sequencing method
Illumina MiSeq
taxonomic identity marker
multi-marker approach