Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_01892118
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2009/2013
completeness score
86.94
completeness software
checkm2 0.1.3
contamination score
0.15
environmental medium
not provided
geographic location (country and/or sea)
Canada
geographic location (latitude)
49.28270000
geographic location (longitude)
-123.12070000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Allergic disease is the most frequent chronic health issue in children and has been linked to early life gut microbiome dysbiosis. Many lines of evidence suggest that microbially derived short-chain fatty acids, and particularly butyrate, can promote immune tolerance. We used shotgun metagenomic analysis to determine whether dysbiosis in butyrate fermentation could be identified in human infants, prior to their developing allergic disease. We found that the microbiome of infants that went on to develop allergic sensitization later in childhood lacked genes encoding key enzymes for carbohydrate breakdown and butyrate production. Our findings support the importance of microbial carbohydrate metabolism during early infancy in protecting against development of allergies and suggest metabolite therapy as a potential prevention strategy.
sample derived from
SAMEA5564405
sample name
spire_mag_01892118
scientific_name
Bacteroides uniformis
sequencing method
NextSeq 500
taxonomic identity marker
multi-marker approach