Bacteroides uniformis
ENA first public
2024-09-21
INSDC center name
EMBL Heidelberg
INSDC status
public
Submitter Id
spire_mag_00069129
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
megahit 1.2.9
binning parameters
default
binning software
metabat 2.12.1
broad-scale environmental context
human digestive system
broker name
EBI-EMG
collection date
2016
completeness score
91.71
completeness software
checkm2 0.1.3
contamination score
1.33
environmental medium
stool
geographic location (country and/or sea)
not provided
geographic location (latitude)
34.37000000
geographic location (longitude)
109.22000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
The gut-brain axis has been enthusiastically discussed in recent years. Gut bacteria are known to promote serotonin biosynthesis from colonic enterochromaffin cells1. Germ-free mice are also known to have impaired blood-brain barrier, which could be rescued by short-chain fatty acids2. However, there has been little evidence from human studies, not to mention a study that combined human cohorts with animal models. Here we provide metagenomic shotgun sequencing data for a typical psychiatric disease, schizophrenia, for which tens of thousands of samples have been characterized in genome-association studies (GWAS). Metagenome-wide association studies (MWAS) identified bacteria that differ between patients and controls, which was partially recapitulated in mice transplanted with the human faeces. We show that the schizophrenic gut microbiome was causally responsible for core symptoms such as psychomotor hyperactivity and impaired learning and memory, whereas non-specific symptoms such as anxiety were lost in the mice model. Our findings pave the road for better diagnosis as well as mechanistic understandings of this devastating disease.
sample derived from
SAMEA4968206
sample name
spire_mag_00069129
scientific_name
Bacteroides uniformis
sequencing method
HiSeq X Ten
taxonomic identity marker
multi-marker approach