Metagenome-assembled genome: MGYG000153620
Candidatus Methanomassiliicoccus intestinalis
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic assembly ERZ1309539 of study PRJEB37358.
ENA first public
2026-06-09
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000153620
assembly quality
Multiple fragments where gaps span repetitive regions. Presence of the 23S, 16S, and 5S rRNA genes and at least 18 tRNAs
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
2010
completeness score
95.59
completeness software
CheckM2_v1.1.5
contamination score
0.88
environmental medium
faeces
geographic location (country and/or sea)
Denmark
geographic location (latitude)
55.65000000
geographic location (longitude)
12.47000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Metabolic diseases such as type 2 diabetes (T2D) and T2D-related comorbidities (eg. obesity, metabolic syndrome, pre-diabetes and impaired glucose tolerance) are major public health issues worldwide. Recent experiments in animal and human studies have generated growing evidence for the association of gut microbiome and development of these diseases. Using next generation sequencing, large amounts of metagenomic data have been generated from T2D and control subjects. However, the disease-associated prokaryotic repertoire of the human gut microbiota is still undefined. Here we identified 389 uncultured novel prokaryotic species, including 388 bacteria and 1 archaea, by reconstructing 95871 metagenome-assembled genomes (MAGs) from 5814 disease-associated human gut microbiomes and de-replicating the MAGs against a comprehensive human gut library (ERP108418). Amongst these uncultured genomes, 302 are novel species and 87 are related to known species but have never been found in the human gut before. Our work expands the knowledge of the diversity of uncultured human gut bacteria associated with metabolic diseases, and can be used as a valuable reference library to help improve the species detection in future disease-associated metagenomics studies.
sample derived from
SAMEA3888925
sample name
MGYG000153620
scientific_name
Candidatus Methanomassiliicoccus intestinalis
sequencing method
Illumina HiSeq 2000
taxonomic identity marker
multi-marker approach