Metagenome-assembled genome: MGYG000054053
uncultured Methanobrevibacter sp.
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic assembly ERZ1303493 of study PRJEB37358.
ENA first public
2026-06-09
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000054053
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
2014
completeness score
92.46
completeness software
CheckM2_v1.1.1
contamination score
0.14
environmental medium
faeces
geographic location (country and/or sea)
China
geographic location (latitude)
55.67609700
geographic location (longitude)
12.56833700
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Metabolic diseases such as type 2 diabetes (T2D) and T2D-related comorbidities (eg. obesity, metabolic syndrome, pre-diabetes and impaired glucose tolerance) are major public health issues worldwide. Recent experiments in animal and human studies have generated growing evidence for the association of gut microbiome and development of these diseases. Using next generation sequencing, large amounts of metagenomic data have been generated from T2D and control subjects. However, the disease-associated prokaryotic repertoire of the human gut microbiota is still undefined. Here we identified 389 uncultured novel prokaryotic species, including 388 bacteria and 1 archaea, by reconstructing 95871 metagenome-assembled genomes (MAGs) from 5814 disease-associated human gut microbiomes and de-replicating the MAGs against a comprehensive human gut library (ERP108418). Amongst these uncultured genomes, 302 are novel species and 87 are related to known species but have never been found in the human gut before. Our work expands the knowledge of the diversity of uncultured human gut bacteria associated with metabolic diseases, and can be used as a valuable reference library to help improve the species detection in future disease-associated metagenomics studies.
sample derived from
SAMEA3708587
sample name
MGYG000054053
scientific_name
uncultured Methanobrevibacter sp.
sequencing method
Illumina HiSeq 2500
taxonomic identity marker
multi-marker approach