Metagenome-assembled genome: MGYG000038367
uncultured bacterium
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample ERS714116 of study ERP010229.
ENA first public
2026-06-12
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000038367
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
2011
completeness score
88.32
completeness software
CheckM2_v1.1.0
contamination score
0.07
environmental medium
feces
geographic location (country and/or sea)
Bangladesh
geographic location (latitude)
23.70000000
geographic location (longitude)
90.36670000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Disability after childhood diarrhea is an important burden on global productivity. Recent studies suggest that gut bacterial communities influence how humans recover from infectious diarrhea, but we still lack extensive data and mechanistic hypotheses for how these communities respond to diarrheal disease and its treatment. Here, we report that after V. cholerae infection, human gut microbiota undergo an orderly and reproducible succession featuring transient reversals in relative levels of enteric Bacteroides and Prevotella. Elements of this succession may be a common feature in microbiota recovery from acute secretory diarrhea, as we observed similar successional dynamics after enterotoxigenic Escherichia coli (ETEC) infection. Our metagenomic analyses suggest multiple mechanisms driving microbial succession after cholera, including bacterial dispersal properties, changing enteric oxygen and carbohydrate levels, and phage dynamics. Thus, gut microbiota recovery after cholera may be predictable at the level of community structure, but driven by a complex set of temporally varying ecological processes. Our findings suggest opportunities for diagnostics and therapies targeting the gut microbiota in humans recovering from infectious diarrhea.
sample derived from
ERS714116
sample name
MGYG000038367
scientific_name
uncultured bacterium
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach