Metagenome-assembled genome: MGYG000034074
Ruminococcus sp.
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample ERS436750 of study ERP005534.
ENA first public
2026-06-12
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000034074
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
2004/2006
completeness score
99.74
completeness software
CheckM2_v1.1.0
contamination score
0.62
environmental medium
faeces
geographic location (country and/or sea)
France
geographic location (latitude)
0.00000000
geographic location (longitude)
0.00000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC-associated changes of fecal microbiota and their potential for cancer screening remain to be explored. Here we used metagenomic sequencing of fecal samples to identify taxonomic markers that distinguished CRC patients from tumor-free controls in a study population of 156 participants. Accuracy of metagenomic CRC detection was similar to the standard fecal occult blood test (FOBT) and when both approaches were combined, sensitivity improved >45% relative to the FOBT while maintaining its specificity. Accuracy of metagenomic CRC detection did not differ significantly between early and late-stage cancer and could be validated in independent patient and control populations (N=335) from different countries. CRC-associated changes in the fecal microbiome at least partially reflected microbial community composition at the tumor itself, indicating that observed gene pool differences may reveal tumor-related host-microbe interactions. Indeed, we deduced a metabolic shift from fiber degradation in controls to utilization of host carbohydrates and amino acids in CRC patients accompanied by an increase of lipopolysaccharide metabolism.
sample derived from
ERS436750
sample name
MGYG000034074
scientific_name
Ruminococcus sp.
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach