Metagenome-assembled genome: MGYG000030266
Bacillota bacterium
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample ERS1138780 of study ERP015450.
ENA first public
2026-06-12
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000030266
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
2015-01-05
completeness score
90.89
completeness software
CheckM2_v1.1.0
contamination score
0.26
environmental medium
feces
geographic location (country and/or sea)
China
geographic location (latitude)
39.90000000
geographic location (longitude)
116.05000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Hypertension is one of the most prevalent cardiovascular diseases worldwide. Recent findings have identified a link between gut microbiota and blood pressure, yet the contributions of gut microbes and bacterial metabolites towards hypertension remain largely uncharacterized. We carried out metagenomic and metabonomics analyses, in combination with faecal microbiota transplantation, and elucidate that dysbiosis of gut microbiome triggers the pathogenesis of hypertension through altering the metabolic effects. Notably, we demonstrate similar discrepancy of microbial compositional and functional features in pre-hypertension and hypertension when compared with the controls, highlighting varied intestinal microbiota in prehypertensive populations. The impairment of host metabolism in pre-hypertension and hypertension was identified to be closely linked with dysbiotic gut microbiome. The hypertensive phenotype was transferrable from hypertension patients to germ-free mice by faecal transplant. Overall, our results explicate a novel role for aberrant gut microbiota as key contributor to the pathogenesis of hypertension, and emphasize the significance of early intervention for pre-hypertension.
sample derived from
ERS1138780
sample name
MGYG000030266
scientific_name
Bacillota bacterium
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach