Metagenome-assembled genome: MGYG000239222
Prevotella sp. 885
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample SRS883035 of study SRP056480.
ENA first public
2026-07-16
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000239222
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human gut
broker name
EBI-EMG
collection date
2013-01
completeness score
91.01
completeness software
CheckM2_v1.1.0
contamination score
4.12
environmental medium
feces
geographic location (country and/or sea)
Tanzania
geographic location (latitude)
-3.63475880
geographic location (longitude)
35.08285880
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
organic feature
metagenomic source
human gut metagenome
project name
By human microbiome sequencing we can better understand how host evolutionary and ontogenetic history is reflected in the microbial function. However, there has been no information on the gut metagenome configuration in hunter-gatherer populations, posing a gap in our knowledge of gut microbiota (GM)-host mutualism arising from a lifestyle that describes over 90% of human evolutionary history. Here, we present the first metagenomic analysis of GM from Hadza hunter-gatherers of Tanzania, showing a unique enrichment in metabolic pathways that align with the dietary and environmental factors characteristic of their foraging lifestyle. We found that the Hadza GM is adapted for broad spectrum carbohydrate metabolism, reflecting the complex polysaccharides in their diet. Furthermore, the Hadza GM is equipped for branched-chain amino acid degradation and aromatic amino acid biosynthesis. Resistome functionality demonstrates the existence of antibiotic resistance genes in a population with little to no antibiotic exposure, indicating the ubiquitous presence of environmentally derived resistances. Our results demonstrate how the functional specificity of the GM correlates with environment and lifestyle, and how complexity from the exogenous environment is matched by endogenous homeostasis. The Hadza gut metagenome structure allows to appreciate the co-adaptive functional role of the GM in complementing the human physiology, providing a better understanding of the versatility of human life and subsistence.
sample derived from
SRS883035
sample name
MGYG000239222
scientific_name
Prevotella sp. 885
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach