Metagenome-assembled genome: MGYG000027858
Collinsella sp.
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample SRS2267599 of study SRP108915.
ENA first public
2026-06-12
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000027858
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
missing: third party data
completeness score
98.92
completeness software
CheckM2_v1.1.0
contamination score
0.53
environmental medium
feces
geographic location (country and/or sea)
Canada
geographic location (latitude)
43.65000000
geographic location (longitude)
-79.38000000
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Colorectal cancer is the second leading cause of cancer-related death in the United States and is a primary cause of morbidity and mortality throughout the world. Its risk has been linked to changes in colonic bacterial community composition. Viruses are another important component of the colonic microbial community, however they have yet to be studied in colorectal cancer despite their oncogenic potential. We evaluated the colorectal cancer virome (virus community) in stool using a cohort of 90 human subjects with either healthy, adenomatous (precancerous), or cancerous colons. We utilized 16S rRNA gene, whole shotgun metagenomic, and purified virus metagenomic sequencing methods to compare the colorectal cancer virome to the bacterial community. We identified no detectable difference in diversity (alpha or beta) between healthy, adenomatous, or cancerous colonic samples, but more sophisticated random forest models identified striking changes in the virus community. The majority of the cancer-associated virome consisted of temperate bacteriophages, suggesting that the community was indirectly linked to colorectal cancer by modulating bacterial community structure and function. Our data suggested that the influential phages did not exclusively infect influential bacteria, but rather acted through the community as a whole. These results provide foundational evidence that bacteriophage communities are associated with colorectal cancer and likely impact cancer progression by altering the bacterial host communities.
sample derived from
SRS2267599
sample name
MGYG000027858
scientific_name
Collinsella sp.
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach