Metagenome-assembled genome: MGYG000038041
Alistipes sp.
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample SRS294958 of study SRP008047.
ENA first public
2026-07-15
INSDC center name
EMG
INSDC status
public
Submitter Id
MGYG000038041
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
assembly software
missing: third party data
binning parameters
missing: third party data
binning software
missing: third party data
broad-scale environmental context
human-associated habitat
broker name
EBI-EMG
collection date
missing: third party data
completeness score
91.8
completeness software
CheckM2_v1.1.0
contamination score
0.35
environmental medium
missing: third party data
geographic location (country and/or sea)
missing: third party data
geographic location (latitude)
missing: third party data
geographic location (longitude)
missing: third party data
investigation type
metagenome-assembled genome
isolation_source
human gut metagenome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.
sample derived from
SRS294958
sample name
MGYG000038041
scientific_name
Alistipes sp.
sequencing method
missing: third party data
taxonomic identity marker
multi-marker approach