Characterization and high-throughput screening of bacterial communities in the soil: mechanisms of antibiotic resistance
soil metagenome
Soil is a formidable reservoir of microbial biodiversity and existing antibiotics are principally secondary metabolites produced by soil microorganisms, or semisynthetic derivatives thereof. In nature, these compounds serve as weapons in the competition between genotypes, and their evolution and dissemination are intimately coupled with the evolution and dissemination of antibiotic resistance. This project aims i) to investigate the functional diversity (genes and metabolic pathways) of soil microbial communities involved in resistomes, ii) to develop a better understanding of ecological and evolutionary processes in the soil communities involved in resistomes, iii) to develop a better understanding of the role and mechanisms of horizontal and vertical gene transfer in the evolution and dissemination of antibiotics and antibiotic resistance, and iv) to discover new natural classes of antibiotics, in particular more pathogen-specific antibiotics that reduce the risk of emergence of adapted resistomes.
ENA first public
2026-07-06
INSDC center name
INRA-CMSE
INSDC status
public
Submitter Id
1888
broad-scale environmental context
terrestrial biome
collection date
2017
depth
0-200
elevation
496
environmental medium
bulk soil
geographic location (country and/or sea)
France
geographic location (latitude)
44.234
geographic location (longitude)
3.925
local environmental context
anthropogenic terrestrial biome
project name
PRJEB113680
sample name
1888
scientific_name
soil metagenome