Human liver derived differentiated HepaRG cells
Homo sapiens
HepaRG cells are a human liver-derived bipotent progenitor cell line capable of differentiating into hepatocyte-like cells and cholangiocyte-like cells, mimicking key structural and functional features of the human liver. Originating from a hepatocellular carcinoma, these cells reproducibly model critical hepatic processes such as xenobiotic metabolism (via phase I/II enzymes), detoxification (e.g., bile acid transport), stress response pathways, and nutrient storage (e.g., glycogen and lipid homeostasis). Their robust differentiation protocol and genetic stability make them a standardized *in vitro* system for high-throughput screening of drug bioactivity, metabolic profiling, and toxicity assessments, bridging preclinical research and human-relevant outcomes in pharmacology, toxicology, and liver disease studies (e.g., steatosis, fibrosis). HepaRG cells are particularly valued for their human-specific responses, offering a reliable alternative to primary hepatocytes for mechanistic and translational applications.
isolate
HepaRG
age
53
biomaterial_provider
Biopredic international
collection_date
2002
geo_loc_name
France
sex
female
tissue
Liver
cell_line
HepaRG
race
Caucasian
BioSampleModel
Human