Oscillospiraceae bacterium
This sample represents a Third Party Annotation (TPA) Metagenome-assembled genome generated from the metagenomic sample ERS1138928 of study ERP015450.
assembly software
missing: third party data
broad-scale environmental context
human-associated habitat
collection date
2015-01-05
sample derived from
ERS1138928
geographic location (longitude)
116.05000000
binning parameters
missing: third party data
contamination score
1.0
completeness software
CheckM2_v1.1.0
geographic location (country and/or sea)
China
binning software
missing: third party data
organism
Oscillospiraceae bacterium
assembly quality
Many fragments with little to no review of assembly other than reporting of standard assembly statistics
taxonomic identity marker
multi-marker approach
completeness score
75.08
environmental medium
feces
geographic location (latitude)
39.90000000
scientific_name
Oscillospiraceae bacterium
investigation type
metagenome-assembled genome
local environmental context
human gut
metagenomic source
human gut metagenome
project name
Hypertension is one of the most prevalent cardiovascular diseases worldwide. Recent findings have identified a link between gut microbiota and blood pressure, yet the contributions of gut microbes and bacterial metabolites towards hypertension remain largely uncharacterized. We carried out metagenomic and metabonomics analyses, in combination with faecal microbiota transplantation, and elucidate that dysbiosis of gut microbiome triggers the pathogenesis of hypertension through altering the metabolic effects. Notably, we demonstrate similar discrepancy of microbial compositional and functional features in pre-hypertension and hypertension when compared with the controls, highlighting varied intestinal microbiota in prehypertensive populations. The impairment of host metabolism in pre-hypertension and hypertension was identified to be closely linked with dysbiotic gut microbiome. The hypertensive phenotype was transferrable from hypertension patients to germ-free mice by faecal transplant. Overall, our results explicate a novel role for aberrant gut microbiota as key contributor to the pathogenesis of hypertension, and emphasize the significance of early intervention for pre-hypertension.
sequencing method
missing: third party data
isolation_source
human gut metagenome