title: CUBIST-18
organism: Staphylococcus aureus
description: Clinical bloodstream isolate CUBIST-18 is part of the Cubist Pharmaceuticals Isolate Collection. CUBIST-18 is the daptomycin-resistant isolate of the CUBIST-17/CUBIST-18 sequential isolate paired strains obtained from a patient with endovascular staphylococcal infection following daptomycin treatment failure. It is multilocus sequence type 5, clonal complex 5, SCCmec-II (+), spa type t002 / T1-J1-M1-B1-M1-D1-M1-G1-M1-K1. Compared to CUBIST-17, CUBIST-18 has sequence variations in mprF (L341S) and in cls2 (R295C). It was previously described in a 2015 report as strain "C18".