Pan KRAS inhibitor selectively inactivates oncogenic signaling and tumor growth
To investigate the effect of KRASi treatment on transcriptional output, we sequenced RNAs from 22 cell lines with different KRAS genotypes. We then performed gene expression profiling analysis using data obtained from RNA-seq comparing untreated and 2hr treated samples. Overall design: Comparative gene expression profiling analysis of RNA-seq data for cells with different KRAS genotypes (WT, UAWT,G12C,G12D,G12V,G13D).