CD146 as a potent target for anti-vascular therapies in lung cancer brain metastasis
To investigate the function of CD146 in the lung cancer brain metastasis cells, we established PC9-BrM3 cells in which CD146 has been knocked down by shRNA. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of  PC9-BrM3 cells with or without AKR1B10 knockdown.