The transcriptome profiles of full-thickness cutaneous wound tissues from a diabetic rat model infected with carbapenem-resistant Pseudomonas aeruginosa
The study aims to investigate the molecular mechanisms underlying the synergistic healing effects of combined ceftazidime (CAZ) and 5-aminolevulinic acid photodynamic therapy (ALA-PDT). Tissue samples were collected at a critical early healing time point (day 3 post-treatment) from two experimental groups: 1) Untreated control wounds, 2) Wounds treated with CAZ+ALA-PDT combination therapy. RNA sequencing (RNA-seq) was performed to identify differentially expressed genes and enriched signaling pathways associated with the enhanced wound healing observed in the combination treatment group.