Effect of TAOK1 knockout on doxorubicin induced cardiomyocyte dysfunction
We investigated the role of thousand and one amino acid protein kinase 1 (TAOK1) in doxorubicin(DOX)-induced cardiomyocyte dysfunction. To gain insight into the mechanism underlying the protective effect of the TAOK1 knockout on DOX-induced cardiomyocyte death and dysfunction, we performed global gene expression analysis using RNA-seq in TAOK1- and Ctrl-KO hPSC-CMs treated with DOX