Research on the gut Transcriptome of sea perch  Lateolabrax japonicus
This study investigates the molecular mechanisms underlying the antiviral effects of Lactococcus lactis M48 in sea perch (Lateolabrax japonicus) infected with sea perch iridovirus (SPIV). Transcriptome analysis of gut tissues from SPIV-infected fish fed with or without M48 identified differentially expressed genes (DEGs) associated with immune response, metabolism, and host-pathogen interactions. Integrated multi-omics analysis revealed that M48 modulates host gene expression, particularly in pathways related to pantothenate and CoA biosynthesis, lipid metabolism, and immune signaling. These findings provide insights into how probiotic supplementation enhances antiviral immunity through host transcriptomic reprogramming.