Modeling of Aberrant Epithelial Reprogramming in Idiopathic Pulmonary Fibrosis using Human Induced Pluripotent Stem Cell-derived Alveolar Organoids
Alveolar type 2 (AT2) organoids, derived from induced pluripotent stem cells, were stimulated with a fibrosis cocktail containing the pro-fibrotic and inflammatory cytokines TGF-ß (5 ng/ml), TNF-a (10 ng/ml), PDGF-AB (10 ng/ml) and LPA (5 µM) or control cocktail containing diluents for 72 h.