Transcriptome of the hippocampus and sorted astrocytic nuclei in a mouse model of astrocyte specific ATRX deletion
Study to characterize the regulatory role of ATRX in the transcriptome of astrocytes and in turn, in brain function. RNA-seq analysis of 1-month-old hippocampus and RNA and ATAC-seq analysis of cortical astrocytic nuclei enriched through sorting were used in a mouse model for targeted deletion of ATRX in astrocytes. Control and ATRX floxed GlastCreER mice were treated with tamoxifen from 10 to 12 days of age. PolyA enriched RNA a was obtained from hole hippocampal tissue. RNA and chromatin were obtained from florescent-labelled cortical astrocytic nuclei.