Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
RNA-seq analysis were applied to elucidate the transcriptional differences between PC-3 cell lines transfected with control-sgRNA (Control) and PHF8-shRNA (PHF8-KD). a total of 1122 DEGs were identified with 775 upregulated and 347 downregulated genes (FDR<0.05, |log2FoldChanges|>1) Overall design: Comparative gene expression profiling analysis of RNA-seq data for PC-3 cells and its KD derivatives (shPHF8).