Faces in a rat model of MASH treated with Sacubitril/Valsartan
This study aimed to evaluate the effects of Sacubitril/Valsartan on gut microbial composition in a rat model of metabolic dysfunction-associated steatohepatitis (MASH). Male rats were fed a high-fat diet and administered dimethylnitrosamine (DMN) to induce MASH. Fecal samples were collected at the end of the treatment period from three groups: control (no treatment), Valsartan-treated, and Sacubitril/Valsartan-treated. 16S rRNA gene sequencing was performed to analyze differences in microbial diversity and taxonomic profiles among the groups.