Decreased SRSF7 expression induces cellular senescence via generating MDM2 variants
To evaluate the role of alternative splicing in cellular senescence, we analyzed transcriptomics by RNAseq in SRSF3 and SRSF7 suppressed human diploid fibroblasts. Overall design: A transcriptomic analysis by suppression of SRSF3 and SRSF7 with siRNA transfection in human diploid fibroblasts.