The I7L Protein of African Swine Fever Virus Is Associated with Viral Pathogenicity by Antagonizing the IFN-gamma-Triggered JAK-STAT Signaling Pathway through Inhibiting the Phosphorylation of STAT1
To investigate the functions of pI7L and pI8L in ASFV life cycle, we thus systemically analyzed the DEGs of the PAMs infected with ASFV-DeltaI7L, ASFV-DeltaI8L, or ASFV-WT (ASFV HLJ/18) (MOI = 1) at 4, 12, and 20 hpi by RNA sequencing (RNA-seq) analysis.