Inhibitiing the SELP/PSGL-1 axis might reduces M2 macrophage polarization and improves the efficacy of antiPD1 therapy in Gastric Cancer
SELP expression in GC tissues was assessed by immunohistochemistry, correlated with clinicopathological features, and analyzed for immune infiltration using public datasets. TAM polarization was evaluated in co-culture systems, with molecular mechanisms investigated via multi-omics, signaling, metabolic, and reporter assays. Syngeneic GC mouse models were treated with SELP knockdown, blockade, or inhibition (KF38789) alone or with antiPD1 therapy