IDR-Targeting Compounds Suppress HPV Genome Replication via Disruption of Phospho-BRD4 Association with DNA Damage Response Factors
Perturbation of genome-wide expression profiles and BRD4 isoform (BRD4-L and BRD4-S) binding by phospho-BRD4-targeting compounds (pNPS14, pNPS90, or pNPS145) or BET bromodomain inhibitor JQ1 in proliferating and differentiated W12E human cervical keratinocytes Overall design: RNA-seq, PRO-seq, and CUT&RUN-seq were performed in extrachromosomal HPV16 (ecHPV16)-containing W12E cells with or without phospho-BRD4 inhibitor (pNPS14/90/145) or BET bromodomain inhibitor JQ1 treatment.