Heterogeneity and Homogeneity in Treg responses to Interleukin-2 [RNAseq1: IL2/JES6-1 timecourse]
IL2 is an immune-regulatory cytokine that is crucial for the development and maintenance of Tregs. Here we investigate how temporal IL2 stimulation affects Treg gene expression and chromatin landscape via RNASeq and ATACSeq Overall design: We tested IL2/JES6 and IL2 immunocytokines F10 and F511 compared to PBS in Foxp3IRES-GFP mice, harvesting cells at 1 to 128 hours post-injection for bulk RNA-seq.