RNA-seq of human type 2 innate lymphoid cells (ILC2) stimulated with PGD2 or PGD2 metabolites (?12PGJ2, ?12PGD2, 15-deoxy?12,14PGD2, 9a,11ß-PGF2) with or without the selective DP2 antagonist fevipiprant
ILC2s were isolated from peripheral blood of four patients with atopic asthma. ILC2s were stimulated with PGD2 and four PGD2 metabolites (?12PGJ2, ?12PGD2, 15-deoxy?12,14PGD2, 9a,11ß-PGF2) with or without the selective DP2 antagonist fevipiprant. Total RNA was sequenced, and differentially expressed genes (DEG) were identified by DeSeq2.