Smad4 restricts injury-provoked biliary proliferation and carcinogenesis (AKPS_EV_vs_Smad4_MethylSeq)
Reduced representation bisulfite sequencing (RRBS) on the same TGFß-treated AKPS lines (with EV or Smad4) revealed that Smad4 impacts DNA methylation (DNAme), with decreases in intergenic DNAme as the most impacted in our CCA models. Overall design: Comparative methylation profiling analysis of bisulfite-seq data for TGFß treated empty vector (EV) or Smad4-expressing AKPS lines