Mus musculus Genome sequencing and assembly
The study goals focus on investigating the therapeutic effects of probiotic interventions on rheumatoid arthritis (RA) in a mouse model, while concurrently examining the differences in gut microbiota composition among treatment groups. The relevance of this research lies in the potential for probiotics to modulate gut microbiota, which have been implicated in the pathogenesis of RA. By comparing the gut microbial profiles of mice treated with probiotics versus controls, the study aims to identify specific microbial changes that correlate with disease improvement. This understanding may reveal novel mechanisms underlying the immunomodulatory effects of probiotics in RA and facilitate the development of targeted microbial-based therapies. Additionally, the study contributes to the growing body of evidence on the gut-joint axis, emphasizing the interconnectedness of gut health and inflammatory diseases beyond the gastrointestinal tract. Ultimately, the findings of this research could lead to improved treatment strategies for RA patients, leveraging the power of the gut microbiome to promote disease remission and overall health.