RNA-Seq of A549 cells treated with chemical modification patterns for microRNA therapeutic mimics, a case-study on miR-200c
We examined the influence of chemical modifications patterns in a set of miR-200c mimics, assessing the regulation of the whole transcriptome in A549 cells. We examined 37 mimics and provided an initial set of rules for designing miRNA mimics with potency and selectivity similar to an unmodified miRNA duplex.