Host transcriptome upon SARS-CoV-2 expressing wild-type and mutant Nsp15 infection
Human lung A549-ACE2 cells infected with SARS-CoV-2 expressing wild-type and mutant (H234A and N277A) Nsp15 for 8 and 24 h. Poly(A) enriched RNA-seq performed to evaluate the host gene profiles among the viruses. Four groups (mock, WT, H234A, N277A) with biological triplicates.