Single-cell transcriptome sequencing of the skin of cGVHD mice
Cutaneous chronic graft-versus-host disease (cGVHD) is a severe complication of allogeneic stem cell transplantation(allo-HSCT), characterized by fibrosis and immune dysregulation. The dysregulated activation and proliferation of donor T, B cells, and macrophages, leading to the development of autoantibodies and fibrosis, is central to the pathogenesis of cGVHD. Phosphoinositide-3 kinase (PI3K), a key lipid kinase, plays a critical role in the activation and function of multiple immune cells, making it a potential target for therapeutic intervention in cGVHD. As a result, this study aimed to evaluate the efficacy of PI3K inhibitors in the treatment of cGVHD.