Fludioxonil-induced differential gene expression in Aspergillus fumigatus and its DtcsC and  Dskn7 mutants
The antifungal compound fludioxonil targets the fungal specific group III hybrid histidin kinaseTcsC of A. fumigatus, which in turn activate the High Osmolarity Glycerol (HOG) pathway and  leads to drastic swelling of the fungal cells. We investigated the different responses of the AfS35 (wild type), the completely resistant mutant strain DtcsC and the partial resistant mutant strain Dskn7 to fludioxonil. Overall design: Comparative gene expression profiling of the A. fumigatus parental wild-type strain and the mutant strains DtcsC as well as Dskn7 after treatment with fludioxonil for 1 and 3 hours versus untreated controls