RNA Seq of GBM cell lines overexpressing or knocking out SRF
U87MG and G10 cells (constructed by our lab) were selected to construct stable overexpression and knockout cell lines. RNA-Seq identified 1480 DEGs (812 upregulated, 668 downregulated) in U87MF-SRF.OE and 851 DEGs (305 upregulated, 546 downregulated) in G10-sgSRF groups. GO and KEGG analyses revealed DEGs enriched in cytokine/chemokine activities, ECM, cell adhesion, angiogenesis, and immune response pathways.