RNA-Seq of Shank3-/- and Shank3+/+ mice
To investigate the impact of the loss of the major SHANK3 isoforms on the transcriptome, we performed RNA-seq on up to four brain structures (whole cortex, striatum, hippocampus, and cerebellum) of seven Shank3+/+ and eight Shank3 mutant mice deleted for exon 11 after their behavioral characterization at twelve months of age.