RNA-seq of adrenal cortical cells of Cacna1h-deficient mice against wild-type controls
CaV3.2 (encoded by Cacna1h gene) is necessary for the generation of calcium oscillations by maintaining voltage oscillations in zona glomerulosa cells of mice. However, Cacna1h knockout mice have normal plasma aldosterone levels, suggesting additional calcium entry pathways. We used RNA-seq to investigate such pathways in the murine zona glomerulosa. We want to investigate whether other calcium channels or transporters were upregulated to compensate for the loss of CaV3.2.