Proteasome isoform expression in HEK293 cells
Proteasome is an enzymatic complex that degrades cellular proteins into short peptides. Different cell types express different combinations of proteasome catalytic subunits. In this study, we use HEK293 cell line expressing standard, immuno, thymo and mixed proteasomes in order to characterize the influence of proteasome expression on transcriptome, proteome and MHC-I immunopeptidome of the cells.