CTCF mutation at R567 causes developmental disorders by 3D genome rearrangement, premature exhaustion of stem cells and abnormal neurodevelopment [scRNA-seq]
In this study, we performed single RNA sequencing in 1-month and 2-month cortical organoids derived from wild-type and Ctcf heterozygous hESCs. Overall design: ScRNA-seq was performed using cortical organoids derived from wild-type and Ctcf heterozygous hESCs.