Multiomics analyses of somatic cell reprogramming into neural stem cells by PTF1A
How 3D genome organization regulates cell fate transition remains poorly understood at present. By multiomics analyses integrating the Hi-C data, PTF1A and CTCF DNA-binding profiles, H3K27ac modification, and gene expression, we demonstrate that 3D genome reorganization as a driving force instrumental for cellular transcription program changes and cell fate transitions, and highlight an essential role for PTF1A in orchestrating multiscale 3D genome remodeling during cell reprogramming.