Genome-wide map of RECQ1 binding in breast cancer cells.
RECQ1 is a DNA helicase that is important for DNA replication and repair. Recent evidences indicate a role for RECQ1 in regulation of gene expression. However, the mechanisms by which RECQ1 regulates gene expression are unknown.  We find that RECQ1 plays an direct role in gene regulation in breast cancer cells in collaboration with master transcription factors ER alpha and FOXA1. Overall design: Genome-wide profiles for RECQ1 and ER alpha in breast cancer cells.