Microbial diversity in adenine-induced renal failure mice with SGLT1 inhibitor treatments.
The composition of gut microbiota is changed with the progression of chronic kidney disease (CKD).  Inhibition of intestinal sodium/glucose co-transporter (SGLT) SGLT altered gut microbiota.  The aim of this study was to examine the effect of a SGLT1 inhibitor on the microbial diversity in an adenine-induced renal failure mice.  To analyze the effect of the SGLT1 inhibitor on the intestinal microbiome, we performed the fecal 16S rRNA gene sequencing using V1-V2 variable region with Next Generation Sequencer. As a result, the principal coordinates analysis of the microbiome and whole gut microbial composition analysis were performed between control and the treated group with renal failure.  In addition, at the genus level, some major taxa reduced in the renal failure mice were altered by SGLT1 inhibitor.  These data suggested that SGLT1 inhibition modified of the gut microbiota, providing a novel and potential therapeutic tool for CKD patients.