Influence of the anti-MUC16 humanized monoclonal antibody AR9.6 on gene expression in MUC16 expressing cancer cells in patient-derived organoids
To investigate the differentially expressed genes and the pathways they might alter upon humanized AR9.6 mediated blockade of MUC16 and subsequent perturbation of its downstream signaling We then performed gene expression profiling analysis using data obtained from RNA-seq of the two different conditions (organoids treated with huAR9.6 versus huIgG) (three replicates each). Overall design: Comparative gene expression profiling analysis of RNA-seq data from patient-derived organoids treated with huAR9.6 and isotype control huIgG for 24 hours at a dose of 40 µg/mL