Osteopontin promoted cardiac inflammation through increased interleukin-12 in acute myocarditis (PRJCA047488)
Osteopontin (OPN) is a multifunctional glycoprotein known to play critical roles in autoimmunity and tissue repair, yet its function in acute viral myocarditis remains poorly understood. To systematically investigate the pathogenesis of viral myocarditis, this study integrated clinical observations from human myocarditis patients and four genetically distinct myocarditis mouse strains.