FAM135B deficiency inhibits cytotoxic T cell activity in triple-negative breast cancer by blocking the IFI16-dependent STING pathway.
Despite advances in immune checkpoint blockade (ICB) for cancer treatment, only a minority of triple-negative breast cancer (TNBC) patients derive benefits, and the underlying mechanisms remain largely unknown. Sequence similarity 135 family member B (FAM135B) is identified as a tumor suppressor in TNBC. Here, we used RNA-sequencing to determine the potential biological function of FAM135B in TNBC cells.