Transcriptional analysis of CD8+ T lymphocytes isolated from syngeneic MC38 tumors implanted in young adult or aged mice
Evaluation of transcriptional changes associated with advanced age in tumor-infiltrating CD8+ T lymphocytes from within MC38 colorectal tumors. Overall design: Single-cell transcriptional analysis of CD8+ T lymphocytes isolated 12 days post-implantation from subcutaneous MC38 tumors in young adult (~3 months) or aged (~21-22 months) C57BL6 mice. Each sample contains tumor-infiltrating CD8+ cells combined from 3-4 mice, individually barcoded using hashing antibodies.