Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition [bulkRNA-seq]
Comparative gene expression profiling analysis of bulk RNA-seq data for control 501mel cells compared to transient knockdown with two different TBX3 siRNAs Overall design: 501mel human melanoma cells were transfected with either siCtrl or siTBX3 for 24h to contrast global gene expression differences in control versus knockdown. Three biological replicates of each condition were harvested for RNA extraction and bulk RNA sequencing