Canine hemangiosarcoma and nodular hyperplasia primary cell RNA sequencing
Canine hemangiosarcoma is considered a close preclinical model for human angiosarcoma for their high metastasis rate feature, similar pathology and molecular signatures. The goal of this project is to analyze and compare the transcription profile of canine hemangiosarcoma and a fast-proliferating benign tumor, nodular hyperplasia, to explore pathway changing of hemangiosarcoma related to malignant metastasis, explore new treatment target and diagnosis marker, which could also provide information for human angiosarcoma research. Total RNA of each sequencing sample was extracted from primary cultured cell of each clinical sample.