Epigenetic Profiling Reveals Key Super-Enhancer Networks Driving Oncogenesis in HPV-Positive HNSCC
The objective was to investigate the impact of JQ1, a bromodomain inhibitor, on two cell lines of HPV+ HNSCC by comparing it to a control group that did not receive any treatment (DMSO). Overall design: For every experiment conducted on the UM-SCC-47 or UPCI-SCC-090 cell line treated with JQ1 or DMSO, we sequenced three repeats, and each of these was performed twice (2 different lanes).