Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development [RNA-Seq]
Our study suggested a direct link between maternal high-fat diet exposure and TET-mediated epigenetic regulation during heart development. Furthermore, we also uncovered beneficial effects of maternal vitamin C intake to protect heart development under maternal obesity conditions Overall design: We collected E15.5 embyronic hearts from C57/BL6 WT dams fed with either normal diet(injected with vitamin C or PBS) or high-fat diet (injected with vitamin C or PBS) for RNA-Seq and ATAC-Seq