Homo sapiens Transcriptome or Gene expression
This study aims to investigate the molecular mechanisms underlying docetaxel (DTX) resistance in gastric cancer. A DTX-resistant gastric cancer cell model (MGC-803R) was established from the parental MGC-803 cell line through stepwise exposure to increasing concentrations of docetaxel. Transcriptome profiling was performed using high-throughput RNA sequencing to identify differentially expressed genes associated with acquired chemoresistance. Bioinformatics analyses were conducted to characterize gene expression changes and related signaling pathways. This project provides a resource for understanding the molecular basis of DTX resistance and may facilitate the identification of potential biomarkers and therapeutic targets in gastric cancer.