Mus musculus strain:not applicable Raw sequence reads
This study aims to investigate the immunomodulatory effects of stem cell secretions on inflammation. We profiled the transcriptome of mouse macrophage cell line RAW264.7 under two conditions: one treated only with lipopolysaccharide (LPS) to induce inflammation, and another treated with LPS followed by concentrated secretions (SS-E) from stem cell sheets of human exfoliated deciduous tooth pulp. Comparative analysis reveals the global gene expression changes and key pathways through which SS-E may ameliorate the inflammatory response in macrophages. This work provides insights into the therapeutic potential of dental stem cell secretions.