SMAD4 lossdifferentlyshapespancreatictumorswithdistinct KRASmutations
We compared KPC Smad4 WT and Smad4 KO tumours from orthotopically-grafted organoid-derived mouse models Overall design: 8 samples in total - 3 KPC Smad4 WT (ROSA) and 5 KPC Smad4 KO murine PDAC tumours