Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry
Simple derivatives of the well-known antifungal drug, fluconazole, were highly effective in vivo against fungal infections and were also potent against the parasitic worms Brugia, which causes lymphatic filariasis and Trichuris, one of the soil-transmitted helminths that infects millions of people globally.