ATF4 regulates MYB to increase g-globin in response to loss of ß-globin [RNA-seq]
Boontanrart et al model the cellular stress that occurs upon reduction in ß-globin in human erythroid cells. Decrease in ß-globin attenuates the eIF2aP-ATF4 pathway and results in upregulating fetal g-globin. Down-regulation of ATF4 leads to decreased levels of the g-globin repressor MYB through direct binding at the HBS1L-MYB intergenic region. Overall design: RNA-seq of WT and HBBko HUDEP-2 cells