To Decipher the Functional Interaction of Reproductive Longevity Targets Induced by Insulin Signalling in Gonads
Our research focuses on understanding how the insulin signaling pathway affects reproductive aging. This pathway is known to play a crucial role in maintaining the quality of germ cells and oocytes, which are essential for fertility and healthy embryos. However, it is less clear how IIS impacts the somatic gonads-the cells that support and maintain these germ cells. To explore this, we studied worms with normal and low levels of IIS at different stages of their life. We examined the RNA from their gonads and whole bodies to identify which genes are active and how these change with age. This study provides new insights into the mechanisms of reproductive aging and suggests that targeting the IIS pathway could be a potential strategy for improving reproductive health and combating age-related fertility decline.