6-letter genome for ES-E14
duet multiomics solution is a new technology which sequences at single base resolution the complete genetic sequence integrated with modified cytosine, providing separate measurement of 5-mC and 5-hmC. We use the mouse embryonic stem cell-line, ES-E14TG2A, to map for the first time a simultaneous reading of the genome and epigenome at high depth. In this data, we show how these epigenetic modifications are segregated across the genome and how a 6-letter (epi-)genome can be used to predict gene expression and chromatin accessibility.