Regulation of 3 Splice Site Selection by Prp8 in Scerevisiae
Pre-mRNA splicing requires precise recognition of the 3 splice site (3SS) to ensure accurate mRNA processing. Prp8, a central component of the spliceosome, interacts with key splicing factors and may act as a sensor for 3SS selection. This study examines the role of Prp8 Q1594 in regulating splicing efficiency and fidelity.