Transcriptomic profiling of differentially expressed mRNA in liver tissue of Dgaln/LPS induced liver injury mice [mRNA_Dgaln]
Acute liver failure is a serious clinical manifestation resulting from sudden liver injury, which can be triggered by various factors. Early studies have shown that PGE2 significantly alleviated acute liver failure induced by galactosamine/lipopolysaccharide(Dgaln/lps), APAP, and carbon tetrachloride. However, the precise mechanism by which PGE2 alleviates Dgaln/lps-induced acute liver failure remains unclear. The aim of this study is to investigate the mechanisms underlying the protective effects of PGE2 against Dgaln/lps-induced hepatocyte injury. Overall design: RNA-seq was conducted on total RNA isolated from livers of AILI mice treated with D-GalN 500mg/kg, LPS 5µg/kg or dmPGE2 300µg/kg for 6 h; n = 3 per group except dmPGE2+Dgaln/LPS group. The number of samples in dmPGE2+Dgaln/LPS group is 4.