Multiomics Analyses Reveal The Intervene of Codonopsis pilosula Extract Modulate the Gut Microbiota And Metabolism in Aging Mice
In this study, D-galactose was used to establish an aging mouse model, and Codonopsis pilosula extract was used as the intervention treatment for the aging model mice. Pathological, immunohistochemical, and electron microscopic methods were used to demonstrate the protective effects of Codonopsis pilosula on intestinal tissue and mucosal barrier in aging mice. And then, a combination of metabolomics and microbiomic analyses was performed to explore the molecular mechanisms involved in the anti-aging effect of Codonopsis pilosula on the gut microbiota.