Multimodal single-cell profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities
The redirection of T-cells has emerged as an attractive therapeutic principle in B-cell non-Hodgkin lymphoma (B-NHL). However, a detailed characterization of lymphoma-infiltrating T-cells across B-NHL entities is missing. Here, we present cellular indexing of transcriptomes and epitopes of lymph-node derived T-cells from patients with diffuse large B-cell, mantle cell, follicular, or marginal zone lymphoma, and from healthy controls. These data revealed quantitative aberrations of the T-cell microenvironment across and within B-NHL entities. Overall design: Lymph node-derived cells were isolated from patients with nodal B-cell lymphoma entities. Lymphocytes were forwarded to cellular indexing of transcriptomes and epitopes (CITEseq). An panel of 70 different antibodies was used. [UPDATE] 05-09-2024: The raw data and processed data were removed from this dataset due to patient privacy concerns. All single-cell sequencing data have been deposited at the European Genome-phenome Archive (EGA) under accession number EGAS50000000342: https://ega-archive.org/studies/EGAS50000000342