Pathogenic mtDNA mutations inhibit melanoma metastasis
We report the transcriptome profiles of A375 melanoma tumors containing distinct mtDNA mutations. This study was performed using subcutaneous tumors implanted into NSG mice, and identifies transcriptomice changes in response to pathogenic mtDNA mutations. Overall design: A375 cells containing various mtDNA mutations were implanted into NSG mice to create subcutaneous tumors. Subcutaneous tumors were harvested at 20-25mm in diameter for RNAseq analysis.