Single-cell sequencing of carfilzomib-associated HSV-1 encephalitis mouse model
A murine model of central nervous HSV-1 infection was established by corneal scarification with HSV-1 to investigate the dynamic cellular composition and transcriptional landscape following administration of carfilzomib(CFZ). Brain tissues were collected 5 days post-HSV-1 inoculation at the onset of encephalitis symptoms. Mice were intraperitoneally administered CFZ or saline every other day from inoculation until euthanasia.