Overexpression of FOXO1 enhances CAR T cell polyfunctionality, metabolic fitness and efficacy against solid tumors [Human RNAseq CD4]
Investigating the effect on CAR T cell phenotype by overexpressing FOXO1 Overall design: Human PBMCs were transduced to express a human Lewis-Y directed CAR and FOXO1 or mCherry. Following transduction, CAR T cells were sorted on CD4+ CAR T cells and analyzed by 3' RNA-seq