The Notch1/Delta-like-4 axis is crucial for the initiation and progression of oral squamous cell carcinoma
The Notch signaling pathway is frequently altered in oral squamous cell carcinoma (OSCC), the most common malignant neoplasm of the oral mucosa. Transcriptomic analyses confirmed the dysregulation of the Notch pathway circuitry and identified a genetic signature for undifferentiation in OSCC cells.