Transcriptomic profiling of mouse brain tissue under acute high-altitude exposure and hyperbaric/normobaric oxygen therapy
RNA-seq was performed on mouse brain tissue to analyze transcriptomic alterations under acute hypobaric hypoxia (HH, simulating high-altitude exposure) and the therapeutic effects of normobaric oxygen (NBO) and hyperbaric oxygen (HBO). Four groups were included: Control (Con), acute HH, HH+NBO, and HH+HBO. This dataset aims to reveal the molecular mechanisms of high-altitude cerebral injury and oxygen-mediated neuroprotection.