The direct and indirect inhibition of pro-inflammatory adipose tissue macrophages by acarbose in diet-induced obesity
Li et al. identify that acarbose enhances the abundance of propionic acid-producing Parasutterella, therefore indirectly inhibiting M1-like adipose tissue macrophages (ATMs) via GPR43 in diet induced obese mice. Meanwhile, acarbose directly inhibits M1-like ATM proinflammation through GPR120, thus leading to a reduction in adipose tissue inflammation overall.