Effect of Sox7 endothelial conditional knock out on blood vessel differentiation in vivo in a mouse model [scRNA-seq]
To study the effects of the loss of Sox7 function on gene expression of the endothelium in vivo during development. We generated a endothelial specific ko using a Sox7fl/fl Cdh5 creERT2 inducible system. Overall design: Gene expression profiling analysis using single cell (10x) RNA-seq of whole embryonic heart at 12.5 dpc from Sox7 inducible endothelial conditional knock out or sibling control embryos.