MCPIP1 functions as a safeguard of early embryonic development
Expression of zc3h12a encoding Mcpip1 is tightly controlled within first cell divisions of zebrafish. Overexpression of Mcpip1 leads to the profound transcriptomic changes in the developing embryos and impairs early embryonic development of zebrafish. Overall design: RNA-seq was performed to analyse transcriptome of zebrafish embryos overexpressing Mcpip1 (wild type and catalytically inactive mutant).