mRNA sequencing of mutant Huntingtin expressing Drosophila
To study changes in mRNA levels in response to mutant Huntingtin in a Drosophila melanogaster model of Huntington's disease RNA sequencing was done on Drosophila head samples expressing HTTex1.Q120 (mutant) or HTTex1.Q25 (control) transgenes under the influence of the pan-neuronal elav-GAL4 driver.