The effect of myeloid STING knockout after tumor formation on gene expression in AOM/DSS-induced CAC mice
Myeloid-derived STING has been recognized to play a vital role in mediating the development of colitis-associated carcinoma (CAC). We here report that myeloid-specific knockout of STING after tumor formation enhanced tumor growth by modifying the tumor microenvironment to a more immunologically inactive state. Pathways related to antigen presentation, macrophage and DC activation, T cell chemotaxis and activation, T cell-mediated cytotoxicity and other immune responses to tumor cells were all inhibited by lateral myeloid STING kncckout after tumor formation. Overall design: Tmem173fl/fl mice and Tmem173fl/flLzym-Creert2 mice were performed tamoxifen administration after three circles of AOM/DSS induction. Total tumor RNA was extracted and RNA-sequecing was performed.