The effect of Lactobacillus on intestinal microbiota in ALD mice
Excessive alcohol intake disrupts gut microbiota homeostasis, facilitating lipopolysaccharide (LPS) translocation into circulation, which drives hepatic inflammation. Concurrently, chronic alcohol consumption impairs lipid metabolism, exacerbating the progression of alcoholic fatty liver disease. Notably, ethanol metabolism generates acetaldehyde and reactive oxygen species (ROS) via redox imbalances, further promoting oxidative stress and pro-inflammatory cascades. In this study, we investigated the therapeutic potential of Lactobacillus acidophilus (Lac) in mitigating ALD.Our results demonstrate that Lac administration restores gut microbial composition, enhances intestinal barrier integrity, reduces LPS leakage, and ultimately alleviates ALD injury.