Diversity of Oxidative Stress and Senescence Phenotypes Induced by Chemotherapeutic Agents in HUVECs
Chemotherapeutic agents triggered endothelial senescence via DNA damage and ROS accumulation, with heterogeneity in potency and mechanisms. ROS scavengers may mitigate methotrexate-associated vascular toxicity, and targeting ROS could enhance chemotherapy safety by preserving endothelial function.