RNA-Seq analysis of the effect of regorafenib on melanoma cells
Melanoma is a malignant tumor with a terrible prognosis. In this study, we showed regorafenib has the ability to limit the growth, invasion and metastasis of melanoma cells but to upregulate apoptosis-prompting markers (cleaved-PARP and Bax). Moreover, ERK/E2F3 signaling influences regorafenib's ability to suppress melanoma cell growth. Ultimately, regorafenib significantly inhibits tumor growth in a dose-dependent manner in vivo. Overall design: To investigate the influence of regorafenib for melanoma cell, melanoma cell SK-MEL-2 was treated regorafenib and followed performed RNA-Seq.