Astrocyte morphology driven improvements to OCD phenotypes
We investigated the consequences of striatal astrocyte Gi-GPCR activation in the SAPAP3 KO mouse model of OCD Overall design: 16 whole striatum tissue samples for whole tissue bulk transcriptomics. 4 mice per experimental group, 4 experimental groups: wild-type + tdT, wild-type + hM4Di, KO + tdTomato, KO + hM4Di all treated with DCZ, the agonist of hM4Di.