3D Bioprinted Liver Cancer Models Derived from Primary Hepatocytes for Simulating Cancer Initiation and Drug Screening (PRJCA046703)
In this study, we developed early-stage liver cancer cell lines by introducing distinct combinations of oncogenes into primary mouse hepatocytes (mHeps). Using 3D bioprinting technology, combined with bioinks composed of gelatin and alginate, we constructed a more precise representation of liver cancer tissue to better simulate key tumor characteristics.