Multi-omic analysis of neuroinflammation and occult infection in sudden infant death syndrome
In this case series, postmortem brain and liver tissue and CSF from 6 sudden unexpected infantile death (SUID) inflammatory cases, as well as 3 non-inflammatory SUID cases were subjected to metagenomic next generation sequencing (mNGS). Human parechovirus 3 (HPeV3) was detected in all tissues profiled of a single case (HPeV3+ SUID), but no pathogens were detected in the other cases or controls.