Small RNA sequencing of Bovine leukemia virus and Bovine foamy virus naturally infected cattle
We identified the expression of BFV- and BLV-derived miRNAs in naturally BLV-infected cattle. Also, bovine miRNAs were differentially expressed between BLV/BFV-infected cattle and BLV-uninfected animals. Functional analysis of the protein-protein interaction network of genes potentially targeted by both viral- and host-derived miRNAs revealed key metabolic pathways involved in tumorigenesis and immune response regulation in cattle.