Comparative Transcriptomic Analysis of Vibrio parahaemolyticus Vp1018 and Its Phage vB_Vp_ZX1018 Resistant Strain Vp1018-RP1
In this study, a phage vB_Vp_ZX1018 resistant strain of Vibrio parahaemolyticus Vp1018 was established through continuous in vitro selection under phage infection pressure. The resistant strain exhibited a stable phenotype conferring resistance to phage vB_Vp_ZX1018 infection. Transcriptomic sequencing was subsequently performed on both the wild-type Vp1018 strain and the phage-resistant strain to systematically investigate gene expression changes associated with phage resistance and to explore the underlying molecular mechanisms.