RNA sequence analysis of HBV genome inserted iPS cells derived hepatocyte
To investigate the mechanism how hepatitis B virus (HBV) genome integration into hepatocyte contribute HCC development, we developed HBV integration model where partial HBV genome including HBx region were inserted into TERT promoter region of hiPScells by gene editting. We differenciated the HBV integration model iPS cells into hepatocyte and RNA sequence analysis were performed.