Gene expression profile at single cell level of T cells from the brain of running wheel tranied or untrained mice after phototrombotic stroke
We used single cell sequencing to analyze the impact of running wheel training on CD3+ T cells in the brain of mice suffering from stroke. Overall design: Stroke was induced in C57BL/6 mice by photothrombosis. At day two mice started training on running wheels. Controls did not undergo training. At day 14 mice were sacrificed and CD3+ T cells were isolated from brains by single cell sorting and analyzed by using scRNA-Seq