Mus musculus gut microbiome changes associated with nicotinamide-supplemented high-fat diet
Dietary nicotinamide (NAM) is neuroprotective in rodent models of glaucoma. With dietary delivery, additional systemic influences of NAM are possible, prompting us to test for influences on non-neuronal phenotypes relevant to glaucoma. Test cohorts of mice on high-fat diets differed by NAM content (control, "CON-diet"; 2,000 mg/kg/day supplementation, "NAM-diet") and ocular treatments inducing various levels of ocular hypertension (Naive; Ad5-Empty; Ad5-ATF4). Naive and Ad5-Empty cohorts were analyzed for gut microbiome composition using the Transnetyx Microbiome Service.