Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis
Variants close to the VPS13C/C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies. Here have performed RNAseq on pancreatic islets from C2CD4B-null mice and their littermate controls. Overall design: C2cd4b-null mice (C2cd4bem2Wtsi) were generated at the International Mouse Phenotyping Consortium (IMPC), using CRISPR/Cas9. RNA from pacreatic islets was isolated and