Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses
scRNA-seq analysis of patient-derived xenografts (PDX) in immunocompromised mice transfected by an intratumorally injected lipid nanoparticle carrying the reporter mRNA encoding for aVHH revealed that an optimized lipid nanoparticle, LNP-IT, transfected malignant cell types of HNSCC tumors and upregulated RNA and protein metabolic pathways.