Potential Mechanism of Chinese herbal formula Sijunzi Decoction in Treating Gastric Cancer
Establishment 615 mouse subcutaneous tumor model using mouse derived gastric cancer cell lines (MFC),and intervention with traditional Chinese medicine(Sijunzi Decoction). The mice model were indived into Model group(model), early Sijunzi Decoction (E-SJZD), synchronization Sijunzi Decoction (S-SJZD).The size of GC tumor changes and body weight in these groups of 615 mice were observed. The mRNA-seq analysis of mouse models and the network pharmacology technology based on TCM Systems Pharmacology database and Swiss target prediction were used to predict corresponding potential target genes of SJZD.