scRNA-seq of 4T1 tumors inhibited for Hedgehog signaling
We performed scRNA-seq analysis of tumors from Balb/c mice bearing mammary tumors (4T1 tumors), that were treated with Vismodegib or DMSO as vehicle control. The goal of the experiment was to determine the impact of Hh blockade on individual immune cell populations of the complex tumor microenvironment of mammary tumors.