PD-L1/CD80 regulates pulmonary endothelial barrier functions through mtROS/NLRP3/caspase-1 mediated pyroptotic pathway
In this study, we sought to explore the potential ligand-receptor crosstalk andintracellular mechanisms underlying PD-L1-mediated ECs hyperpermeability inhuman lung microvascular endothelial cells (HMVECs).