Activation and functions of Col6a1+ fibroblasts in colitis-associated canceer
This study shows that Col6a1cre+ cells constitute a subpopulation of cancer-associated fibroblasts in colitis-associated cancer that partly maintains its homeostatic features, while its activation is characterized by the acquisition of a distinct proangiogenic signature, which could be associated with their initial perivascular location. Overall design: 3' RNA-Seq (QuantSeq) profiling of 2 sorted mesenchymal cell subpopulations (Col6a1Cre-GFP+, Col6a1Cre-Tomato+) from AOM/DSS-induced colitis-associated tumors. 3 replicates per group.