Transcriptomic response of human umbilical vein endothelial cells (HUVEC) to sTREM2 treatment
The soluble triggering receptor expressed on myeloid cells 2 (sTREM2) is a critical signaling molecule in neuroinflammation and has emerging roles in vascular biology. However, its direct effects on human endothelial cells remain poorly characterized. This study employed RNA sequencing (RNA-seq) to profile the global transcriptomic changes in human umbilical vein endothelial cells (HUVEC) in response to sTREM2 treatment. The goal of this project is to identify differentially expressed genes, key signaling pathways, and biological processes modulated by sTREM2 in endothelial cells. This dataset provides a valuable resource for understanding the mechanisms by which sTREM2 influences endothelial function and may shed light on its role in diseases related to vascular hyperpermeability.