Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model
Retinal neovascularization poses heightened risks of vision loss and blindness. Despite its clinical significance, the molecular mechanisms underlying the pathogenesis of retinal neovascularization remain elusive. This study utilized single-cell multiomics profiling in an oxygen-induced retinopathy (OIR) model to comprehensively investigate the intricate molecular landscape of retinal neovascularization. Overall design: Multiome-seq: Single nuclei were extracted from retinas from postnatal day 17 (P17) mice under the OIR model.Joint snRNA- and scATAC libraries were prepared using the 10x Genomics platform.