Gene expression profile of Fcrls+/CD11b+/Ly6C- microglia from the brain I
We used bulk RNA sequencing to investigate the molecular signature of microglia affected by PU.1 inhibitor in APP/PS1:APOE4-KI mice. Overall design: Fcrls+/CD11b+/Ly6C- microglia were isolated by Fluorescence-activated cell sorting (FACS) and analyzed using Smartseq2 RNAseq.