RNAseq of liver of CD and HFD fed mice in fed or fasted conditions
The liver is key for maintaining metabolic homeostasis between feeding and fasting in healthy conditions. However, this is dysregulated during high fat diet feeding. What are the transcriptomic changes required for rapid adaptation of the liver to respond to feeding and fasting and how is this altered in the development of metabolic disease? Overall design: RNAseq of liver tissue from control diet and high fat diet (60% cal. from fat) mice harvested under fed (ad libitum) or fasted (16h) status