Characterization of N-acetamide indoles as antimalarials that target PfATP4
To discover new antimalarial chemotypes a phenotypic screen of the Janssen Jumpstarter library against the P. falciparum asexual stage was undertaken and uncovered the N-acetamide indoles structural hit class. Forward genetics uncovered that N-acetamide indoles resistant parasites have mutations in PfATP4.