Multi-Omics Reveal the Critical Role of Lactylated MOESIN-Driven TGF-beta Signaling Axis in Gut Microbiota-Mediated Improvement of Diabetic Osteoporosis
Diabetic osteoporosis (DOP), as a typical example of metabolic-immune crosstalk imbalance, remains poorly understood and lacks effective targeted interventions. This study aimed to systematically elucidate, through integrated multi-omics analysis, the molecular mechanism by which fecal microbiota transplantation (FMT) improves the pathological progression of DOP by activating the TGF-beta signaling axis via lactylated MOESIN (L-MOESIN), thereby remodeling the regulatory T cell (Treg)/T helper 17 cell (Th17) immune balance.