Comparison of transcriptional changes in regenerating mice livers at baseline and 24-48 hours post 70% partial hepatectomy with or without etomoxir treatment
To investigate liver transcriptomes in the proliferative stage of early liver regeneration, we here established 70% partial hepatectomy model and performed gene expression profiling analysis using data obtained from RNA-seq of regenerating livers at different time points. Overall design: To investigate the changes of gene expression in the proliferative stage of early liver regeneration. Wild-type C57/BL6J mice were performed sham operation or 70% hepatectomy. Liver tissue was analyzed at 0, 24 and 48 hours post resection by RNA-seq, respectively. Etomoxir (12.5 mg/kg) was treated intraperitoneally 4 hours before partial hepatectomy (PHx), and an extra dose was administrated 24 hours post-PHx for mice in the 48 hours group.