Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and lncRNA-DRR-/- Heart Transcriptomes
To understand the mechanism of lncRNA-DRR induced effect on cardiomyocyte proliferation, high-throughput transcriptome sequencing was performed on hearts of WT and lncRNA-DRR-/- mice 2w  after myocardial infarction, and gene enrichment analysis revealed that cell cycle process and cellular response to DNA damage were up-regulated in hearts of lncRNA-DRR-/- mice Overall design: Heart mRNA profiles of  wild type (WT) and lncRNA-DRR-/- mice 2w after myocardial infarction