Transcriptome analysis of DCK-deficient CFPAC-1 pancreatic cancer cell line
We lentivirally transduced a gemcitabine-sensitive pancreatic cancer cell line CFPAC-1 with Cas9 and DCK sgRNA. The resulting DCK-deficient cells (DCK#10) displayed a significant resistance to gemcitabine. RNA-seq was performed for CFPAC-1 cell line and DCK#10, respectively.