Cell type and age-dependent effects of Brap loss of function on cerebral cortical gene expression
To determine the impact of Brap loss of function on cellular senescence in cerebral cortex, we performed gene expression profiling analysis of mice with Brap conditional deletions in neural progenitors, postnatal neurons, and vascular endothelium cells, respectively. To understand the premature death caused by Brap conditional deletions in neural progenitors or neurons, we also analyzed mice at two different ages. Overall design: Comparative gene expression profiling analysis of cerebral cortical RNA-seq data of mice with Brap conditional deletions in neural progenitors, postnatal neurons, or vascular endothelium cells and their wild type-like control littermates at 3 months of age.  Comparative gene expression profiling analysis of cerebral cortical RNA-seq data of mice with Brap conditional deletions in neural progenitors and their wild type-like control littermates at 10 months of age.