Effects of cannabidiol on the inflammation-stimulated keratinocytes
Cannabidiol (CBD) oral spray on murine oral ulcer significantly inhibited inflammation, relieved pain and accelerated healing process. To gain insight into transcriptional regulation of CBD on cells related to healing progress of oral ulcer, we performed RNA-Seq on the immortalized human oral keratinocyte HOK-16B cell lines stimulated with LPS and ATP, after 10µM CBD or vehicle excipient pretreatment. Overall design: Comparison of gene expression between inflammation-stimulated HOK-16B cell lines pretreated with CBD or vehicle