RNAseq anaylsis of three Islet-1+ Cardiac Stem Cell Clones derived from Neonatal Cardiac Tissue
Islet-1+ Cardiac Stem Cells (CSCs) derived from neonatal cardiac tissue are promising candidates for cardiac repair due to their ability to differentiate into all cells of the cardiovascular lineage and the innate ability of the neonatal heart to regenerate after injury. In this study we analyzed the transcriptome and differentiation capability of Islet-1+ cardiac progenitor cell clones isolated from neonatal human patient-derived tissue and demonstrated that matched ovine CSCs restore function when administered for cell-based repair in an allogeneic ovine model of myocardial infarction. Overall design: Neonatal Islet-1+ CSCs were derived from discarded patient cardiovascular tissue. This tissue was used to generate uniform clonal populations for transcriptomic anaylsis.