Genetic changes of Hep3B cells after acquired resistance to sorafenib
In order to explore the genetic changes of Hep3B cells after resistance to sorafenib, we used a dose-increasing method to obtain drug-resistant cell lines from parental Hep3B cells by intermittent stimulation with sorafenib. Overall design: Comparative gene expression profile analysis of RNA-seq data from Hep3B parental cells and their sorafenib acquired resistance cells.