Transplanted Human Neural Stem Cells Rescue Phenotypes in zQ175 Huntington's Disease Mice and Innervate the Striatum
Long-term implantation of human NSCs in Huntington's disease (HD) mice ameliorates behavioral deficits and reduces mutant Huntingtin accumulation. The human NSCs survive and differentiate into diverse neuronal populations, form connections, improve synaptic properties and show restoration of several transcriptional changes in HD mouse cells. Overall design: Single nuclei RNAseq (snRNAseq) was performed on striatal tissue from female zQ175 mice implanted with hNSCs for 6 months to observe gene expression changes at a similar time frame as behavioral changes.