A Titin Missense Variant Causes Atrial Fibrillation
A single TTN point mutation- a missense variant ( TTN-T32756I) can impair sarcomere integrity and lead to atrial electrical remodeling, increasing AF- A link that needs investigation Overall design: We performed an unbiased global transcriptomic analysis by RNA sequencing (RNA-Seq) separately on TTN WT and TTN-T32756I- hiPSC-aCMs.