Retinal transcriptome of neonatal mice after optic nerve injury
We performed RNA-seq analysis on the normal and 6-hour post-ONC retinas from the embryonic day (E) 20, postnatal day (P) 1 and P3 mice to determine the retinal transcriptome profiles. The identified differentially expressed genes (DEGs) could be associated with the degeneration of axonal growth capacity after birth, and axonal regeneration. Subsequent K-means, GO, KEGG, PPI, and GSEA analysis revealed the biological processes and regulatory pathways involved in the DEGs. Overall design: Gene expression profiling analysis was performed using data obtained from RNA-seq of whole retinal cells.