Comprehensive analysis of fecal metagenomic and serum metabolism revealed the role of gut microbes and related metabolites in detecting colorectal lateral spreading tumors
Colorectal lateral spreading tumors (LST) are early-stage colorectal cancer (CRC) lesions linked to gut microbiota dysbiosis. However, the functional changes in gut microbiota and their metabolic pathways remain poorly understood. A comprehensive metagenomic and metabolomic analysis was conducted on 35 LST patients and 35 healthy controls to explore the interactions between gut microbiota and intestinal as well as serum metabolites in LST.