Gene expression profile of hypoxia-treated IOMM-Lee cells (malignant grade 3 meningioma cells)
Tumor development relies on numerous factors, including the capacity to adapt to hypoxic conditions. Hypoxic microenvironment is a critical driver of the malignant phenotype, which is often correlated with meningioma grade, aggressive behavior, therapeutic resistance, and higher recurrence rates, leading to poor prognosis. Hence, the exploration of genes involved in tumor adaptation to hypoxia can reveal novel molecular targets for the development of hypoxia-targeted therapeutics for meningioma. Overall design: We generated transcriptomic profiles of IOMM-Lee cells (representative of Grade 3 meningioma) exposed to chronic hypoxic conditions (~ 0.2% O2 for 48 hours) using data obtained from RNA-seq. Three biological replicates of each hypoxia-treated and hypoxia-untreated (Normoxic) sample.