Nutrient landscape shapes the genetic diversification of Bacteroides thetaiotaomicron
Bacteroides thetaiotaomicron is a prominent member of the human gut microbiome that has evolveda suite of polysaccharide utilization loci (PUL) to break down a range of diet- and host-derived glycans.To gain insight into the evolution of this bacterium on ecologically meaningful time scales, we carriedout an in vitro evolution study in which B. thetaiotaomicron was cultivated on media of differentcarbohydrate complexity for three months.