Myeloid cells single-cell RNA sequencing of distinct Multipe Sclerosis subtypes
This study investigates monocyte alterations in Multiple Sclerosis (MS) progression using single-cell RNA sequencing of myeloid cells from Relapsing-Remitting MS, progressive MS, and healthy controls. We have been able to subdivide patients classified as progressive MS into two distinct groups: clinical progressor and non-progressors, based on having or not sustained disability worsening over the last 6 months.