CRISPR/Cas9-mediated SPP1 knockout deregulate extracellular matrix organization
High level of SPP1 in tumor tissue was found to be associated with poor prognosis which could upregulate p-glycoprotein expression to induce multidrug resistance in patients in many kinds of cancer. This study is to analyze the change of overal transcriptome after SPP1 konckout in PC3 cell line.