SOX2 is required independently in both stem and differentiated cells for pituitary tumor genesis in p27 null mice III
Exploration of the molecular mechanisms underlying melanotroph tumourigenesis and the role of SOX2 in both SCs and melanotrophs Overall design: Single cell RNA sequencing analysis on pituitary intermediate lobe dissected from three-month old tamoxifen treated Sox9iresCreERT2/+;p27-/- , Sox9iresCreERT2/+;Sox2fl/+;p27-/- animals and control Sox9iresCreERT2/+ animals.