Transcriptome profiling of RB1 wild-type and heterozygous mutant mesenchymal stem cells during adipogenic differentiation
This study investigates the role of RB1 gene status in the differentiation of mesenchymal stem cells (MSCs) derived from orbital adipose tissue of retinoblastoma patients. RNA sequencing was performed on wild-type and heterozygous mutant RB1 MSCs at multiple stages of adipogenic differentiation (day 7, day 14, and day 21). The dataset provides insights into gene expression dynamics associated with adipocyte lineage commitment and highlights potential transcriptional differences linked to RB1 dosage.