Association of resistome abundance with hyperuricaemia in elderly individuals: A metagenomics study
The study aimed to explore the gut resistome in elderly individuals with hyperuricemia (HUA) and its correlations with demographics, gut microbiota, and mobile genetic elements (MGEs). By enrolling 504 participants from a large community in Shenzhen, China, it was discovered that there was a heightened presence of antimicrobial resistance genes (ARGs) in the gut of those with HUA than in those without. The study highlighted associations between specific bacterial genera, ARGs, and uric acid levels, offering new insights into the intricate interplay between gut microbiota and antimicrobial resistance in the context of chronic conditions like HUA. These findings underscore the importance of considering the gut resistome in the elderly, especially those with HUA, and suggest potential avenues for interventions to mitigate antimicrobial resistance risks.