The construction and application of synthetic gut microbiota for the treatment of inflammatory bowel disease (IBD) (PRJCA032486)
Inflammatory bowel disease (IBD) is a major digestive system disorder posing a global threat to human health. It is characterized by high incidence rates, low cure rates, and early onset, posing a severe challenge for prevention and treatment. Dysbiosis of the gut microbiota is a prominent clinical feature and an important pathogenic factor in IBD. Although the use of natural probiotics or fecal microbiota transplantation (FMT) has shown some improvement in intestinal diseases for some patients, the mechanisms are unclear and the methods are uncontrollable. With the rise of synthetic biology, it has become feasible to scientifically design and construct synthetic gut microbiota for precision treatment of IBD.The key scientific issue to be addressed in this project is the design and construction of synthetic gut microbiota for the treatment of IBD. Specifically, how can we identify beneficial strains and functional genes related to the improvement of intestinal inflammation? How can we achieve precise genome editing of chassis gut bacteria and high-yield synthesis of functional products? How can we construct synthetic gut microbiota based on microbial ecological networks? Addressing these questions will reveal the design principles of synthetic gut microbiota and further promote their application in the treatment of chronic diseases.