Spinal cord RNA sequencing was performed in mice
This study aims to evaluate the therapeutic effects of moxibustion in an EAE mouse model and to elucidate whether its protective mechanisms involve suppression of the NLRP3 inflammasome pyroptosis axis. Integrated behavioral, histopathological, transcriptomic, and molecular analyses will be conducted to compare its efficacy with conventional moxibustion and methylprednisolone, providing mechanistic insights into its potential as a sustained therapeutic approach for multiple sclerosis.