Single-nucleus Multi-Omics profiling of the ventral spinal cord in an 7-month-old Cabin1 mutant mouse model of ALS
This project aims to elucidate the transcriptomic and epigenetic mechanisms mechanisms underlying Amyotrophic Lateral Sclerosis (ALS) pathogenesis associated with Cabin1 mutations. We performed single-nucleus multi-omics sequencing on the ventral gray matter of the spinal cord from 7-month-old wild-type (WT) and heterozygous (Cabin1 HET) mice. The dataset consists two samples (WT and HET), both snRNA-seq and snATAC-seq data are included. These data provide a high-resolution map of transcriptional and chromatin accessibility changes in the spinal cord during late-stage disease progression, facilitating the identification of gene expression levels in different cell types disrupted by Cabin1 deficiency.