Pseudomonas aeruginosa transcriptomes during biofilm dispersal in mouse chronic wounds
The opportunistic human pathogen Pseudomonas aeruginosa can cause both acute and chronic infections. To investigate P. aeruginosa gene expression during the chronic-to-acute transition, we obtained its transcriptomes before and after the addition of glycoside hydrolases (GH) or cis-2-decenoic acid (cis-DA) in mouse chronic wounds. Both GH and cis-DA can induce systemic dissemination, mimicking chronic-to-acute transition.