A Self-curling Si3N4-biofunctionalized Nerve Wrap for Suture-free Peripheral Nerve Repair with Multimodal Regenerative Bioregulation
An integrated therapeutic system featuring a Si3N4 (SN)-reinforced bioactive collagen nerve wrap (SNC) combined with a nerve adhesive tape (NA) composed of polyethylene glycol diacrylate/dopamine-grafted gelatin dual-network hydrogel was developed. Through hydration-activated shape memory and a staged adhesion mechanism, the SNC-NA wrap system achieves instantaneous conduit formation, intraoperative repositioning, and stable nerve-end approximation upon application to transected nerves. The sustained hydrolysis of SN generates bioactive ions (NH4+ and SiO44-) that orchestrate multi-targeted regulation, including immunomodulation, angiogenesis promotion, and Schwann cells (SCs) reprogramming.