Temperature and developmental stage govern intestinal susceptibility to human coronavirus 229E.
Transcriptional profiling of fetal, pediatric, and adult human intestinal enteroids following Human Coronavirus 229E infection at 32C and 37C. Overall design: 6 different human intestinal enteroids (2 fetal donors, 2 pediatric donors, and 2 adult donors) were generated, differentiated, and subsequently infected for 48h with clinical strain of  human coronavirus 229E at either 32C or 37C. Controls included mock-infected enteroids.