ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress [ATAC-Seq]
We analyze the contribution of ATRX, DAXX and HIRA to the chromatin accessibility at G-quadruplex in mESC We analyze the contribution of ATRX and ESET to the chromatin accessibility at G-quadruplex in mESC Overall design: ATAC-seq analysis in mouse embryonic stem cell lines (WT, ATRX KO, DAXX KO, HIRA KO). ATAC-seq analysis in mouse embryonic stem cell lines (ATRX addback into ATRX KO, and ESET KO).