16S Sequencing Orthotopic Colorectal Cancer Model
Variants of the MC38 mouse colorectal cancer cell line that were engineered to possess either chromosomal instability (CIN) or microsatellite instability (MSI) were injected orthotopically into the colons of immunocompetent C57BL/6 mice. Feces was collected from the mice at the time of tumor harvest and submitted for 16S sequencing.