The Cleavage Under Targets and Tagmentation sequencing of CCI-ION Mice Y-box binding protein 3  in Trigeminal ganglion
In the CCI-ION (chronic constriction injury of the infraorbital nerve) mouse model, the application of CUT&amp;Tag sequencing technology to study Y-box binding protein 3 (YBX3) in the trigeminal ganglion (TG) has revealed its potential regulatory mechanisms in trigeminal neuropathic pain. The CCI-ION model mimics chronic pain induced by trigeminal nerve injury, leading to aberrant expression of molecular markers in the TG. As a transcriptional regulator, YBX3 may bind to specific DNA loci to modulate pain-related genes , thereby influencing neuronal excitability and inflammatory responses.