CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer's disease pathology [scRNA-seq4]
Our study reveals a previously unappreciated role for microenvironment-specific, inter-cellular crosstalk between CD8+ T cells and microglia in delaying neurodegenerative disease development Overall design: We used scRNA-seq to profile CD45+ cells from the brain parenchyma of 5xFAD and 5xFAD;B2m-/- mice