KPT-330-modulated cold adaptation in various thermogenic organs of prediabetic mice
Transcriptomic analysis on white adipose tissues (WAT), brown adipose tissues (BAT), skeletal muscles and liver from cold-exposed obese mice treated with KPT-330 or DMSO, and those from obese mice housed at ambient temperature indicated that KPT-330 profoundly modulates immune responses in these thermogenic tissues and organs. Overall design: To understand how KPT-330 elicits protective effects against acute cold exposure, Epididymal WAT, BAT, thigh skeletal muscle, and liver samples were collected and snap frozen in liquid nitrogen