Comprehensive aß T cell repertoire analysis reveals a unique CD8+ TCR landscape in DOCK8-deficient patients
Dedicator of cytokinesis protein 8 (DOCK8) is a guanine nucleotide exchange factor highly expressed in and critical for the function of various innate and adaptive immune cells. DOCK8 deficiency leads to combined immunodeficiency and a severe Th2-type immune response. We compared immune repertoire profiles determined by high-throughput TCR sequencing of circulating CD4+ and CD8+ T cells from patients with DOCK8 deficiency.Different diversity analyses revealed a restricted TRA and TRB repertoire in both CD4+ and CD8+ T cells from DOCK8-deficient patients.