Efficacy and Safety of Total Neoadjuvant Therapy Combined with PD-L1 Blockade in pMMR/MSS Locally Advanced Rectal Cancer (ESTIMATE): A Prospective, Phase II Trial
While total neoadjuvant therapy (TNT) improves outcomes in locally advanced rectal cancer (LARC), patients with proficient mismatch repair (pMMR)/microsatellite stability (MSS) tumors respond poorly to conventional regimens.