Single cell RNA analysis of lung endothelial cells in mouse model of Hereditary Hemorrhagic Telangiectasia 2
Arteriovenous malformations (AVMs) are characteristic of hereditary  hemorrhagic telangiectasia (HHT). We used single cell RNA sequencing (scRNA-seq) to analyzed the pulmonary ECs in mice with endothelial-specific deletion of Alk1 gene. Overall design: Lung VE-cadherin+ and CD45- cells were isolated by fluorescence-activated cell sorting (FACS), and analyzed using scRNA-seq.