Dietary fiber restores skin barrier function exacerbated by fiber free diet and particular matter via regulation of gut-skin axis
As societies change, alternation in eating behavior and environmental pollution have emerged. Dietary fiber deprivation is a characteristic of westernized diet and has become a threat to human health, including skin, gut, and immune response. It also disrupts epithelial barrier function both skin and gut. Increased concentration of air pollutants is a representative phenomenon of environmental pollution, which causes severe human disease mainly caused by penetrating into human body. Therefore, we investigated widespread health concerns in the condition of daily lives. People with lack of dietary fiber affected air pollutant more? And, how it can overcome?We demonstrated the effect of particulate matter both skin and gut health in the condition of lack of dietary fiber consumption. Also, we investigated dietary fiber consumption restores deteriorated skin and gut health caused by dietary and environmental stress. And then, we studied how dietary fiber connects gut and skin health. Gut microbiome analysis was performed, and selected major microorganism also be studied it is a real major microbiota that contribute to gut-skin axis regulation. Furthermore, we proved our hypotheses have heterogeneous effect both mice and human by using human epithelial keratinocytes. These processes led us to know the exact mechanism of their action.