Multi-omics analysis of human dermal fibroblast
Protection against skin aging is important for not only facial appearance but also in the terms of biological defence. In this study, the mechanism of human skin aging was identified by in vitro  multi-omics analysis. Replicative stress was introduced into human dermal fibroblasts, HFF-1, as a senescent cell model. RNA-seq, ATAC-seq, and ChIP-seq (histone H3 lysine 27 (H3K27Ac)) were performed on different passages of HFF-1.