human gut metagenome Raw sequence reads
In this study, we aimed to address such a role of the host gut microbiome during schistosomiasis using:i- experimental chronic infections of mice i.e. with different genetic make-ups and levels of susceptibility to the disease to functionally assess, by fecal microbiota transfer by cohousing, the role of the gut microbiota in the progression of chronic schistosomiasis-associated fibrogranulomatous disease despite different genetic backgrounds andii- shotgun metagenomics screening of stool DNA from school-aged children from S. mansoni endemic areas followed by validation of identified candidate microbial species by qPCR and multi-omics integration to identify consensus microbial and metabolite signatures that might associate, beyond host genetic differences, with S. mansoni-infection and/or associated liver pathology.