Genome-wide analysis of H3K27ac and RBPJ distribution in a human chronic B cell leukemia cell line.
The Notch signaling pathway regulates several processes including development and differentiation and its aberrant regulation leads to several diseases such as leukemia. Here, we investigated the genome-wide distribution of the transcription factor RBPJ and of the active histone mark H3K27ac in a human chronic B cell leukemia cell line called HG3. Overall design: Human HG3 cells were analyzed by ChIP-Seq using an RBPJ-specific antibody or by CUT&TAG  using an antibody directed against H3K27ac.