Inulin supplementation alters the gut microbiome and improves dysglycaemia following kidney transplantation: Results from the DIGEST pilot trial
Dysglycaemia is common following kidney transplantation and contributes to significant morbidity and mortality. Dietary fibre supplementation has been shown to alter the composition of the gut microbiome, favouring generation of short-chain fatty acids (SCFAs) which may improve glycaemic control. We performed a single-centre, randomised, controlled trial of 40 kidney transplant recipients that either received 4 weeks of oral inulin or continued standard care. Change to the gut microbiome were characterised by 16S rRNA sequencing from stool samples collected prior to, and at the end of the intervention period.