Tumor-infiltrating gamma delta T-cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer
Here, we sought to investigate the expression pattern of inhibitory receptors and functional state of TI-?d T-cells, and reveal the features of exhausted TI ?d T-cells in the TME of CRC. In this study, the ?d T-cell subpopulations and gene expression profiles of TI-?d T-cells and colonic intraepithelial lymphocytes (IELs) were analyzed by single-cell RNA sequencing (scRNA-seq). Overall design: Comparative gene expression profiling analysis of RNA-seq data for IEL-?dT cells and TIL-?dT cells.