Gut microbiome profiles following vancomycin pretreatment in an experimental human C. difficile colonisation model
Stool metagenomic sequencing from healthy participants collected after short- or extended-course vancomycin pretreatment in a randomized, placebo-controlled human colonisation trial with non-toxigenic C. difficile (NTCD). These samples represent the microbiome state after antibiotic exposure and prior to administration of NTCD spores or placebo, and were used to assess antibiotic-induced microbiota disruption and susceptibility to colonisation.