Acute Lung injury (PRJCA047000)
Acute lung injury (ALI) is a life-threatening respiratory disorder characterized by excessive inflammation and oxidative stress, with no specific pharmacological therapy currently available. Cornuside (CNS), a bioactive iridoid glycoside derived from Cornus officinalis (Sieb. et Zucc.), has garnered increasing attention for its bone-protective, neuroprotective, anti-inflammatory, and anti-diabetic properties, yet its effects on ALI remain unclear. Male C57BL/6J mice received intratracheal lipopolysaccharide to induce ALI and intragastric Cornuside (50 mg/kg) 1 h before and 3 h after LPS.  Lung tissues were used for RNA sequencing analysis.