Long QTc in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy (HCM), an autosomal dominant disease characterized by asimmetric left ventricular hypertrophy, is often associated with electrocardiographic abnormalities including QTc prolongation. The main explanation for the prolonged QTc in HCM is myocardial hypertrophy and the related structural changes. However, other mechanisms, including long QT syndrome (LQTS) genes mutations, may be involved.The screening for ion channel genes mutations may be considered in HCM patients with prolonged QTc unexplained by any other cause.