A role of Hdac1 in fate decision to exhausted CD8+ T cells in response to chronic viral infection
The goal of this study is to determine how an epigenetic regulator, Hdac1, mediates control of exhausted CD8 T cell fate decision and differentiation at the early stage of responses to chronic viral infection. Overall design: Cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) was performed on sort-purified GP33-tetramer+ CD8+ T cells on day 8 post-infection with LCMV clone 13.