Genome-wide CRISPR screen of HoxA9 immortalised R26-CreERT2 Adar1fl/+ and R26-CreERT2 Adar1fl/E861A cells
ADAR1 E861A CRISPR knockout pooled library screen Overall design: Genome-wide CRISPR knockout screen, Cas9 HoxA9 immortalised R26-CreERT2 Adar1fl/+ and R26-CreERT2 Adar1fl/E861A cells with a genome-wide Brie sgRNA library. 2 independent replicates of each genotype, sampled at 0, 7 and 14 days post tamoxifen .