Genomic Epidemiology of a Candida auris Outbreak in a Tertiary Care Hospital in Beijing
This genomic epidemiology study investigated a Candida auris outbreak in Beijing at a tertiary care hospital between 2023 and 2025. Whole-genome sequencing of clinical isolates showed that Clade I was the predominant lineage in the local outbreak. Phylogenetic analyses supported the presence of multiple closely related transmission groups and suggested that patient movement between wards may have facilitated nosocomial spread. Antifungal susceptibility testing revealed a high burden of multidrug resistance, highlighting the challenge of infection control and clinical management. Overall, the findings support enhanced surveillance, early screening of high-risk patients, and the use of molecular diagnostics to interrupt transmission and improve infection prevention and control.