Gene expression and V(D)J profiles of B-lineage cells from bone marrow samples of healthy adults (HA) and patients with multiple myeloma (MM)  and light-chain amyloidosis (AL).
We employed single-cell RNA sequencing combined with BCR sequencing (scRNA/BCR-seq) to identify transcriptional differences between clonal B cells and non-clonal B cells from MM and AL patients versus their healthy counterparts. Overall design: Freshly collected bone marrow aspirate samples and extracted B-lineage cell by fluorescent-activated cell sorting (FACS)