An allelic series of spontaneous Rorb mutant mice exhibit a gait phenotype, changes in retina morphology and behavior, and gene expression signatures associated with the unfolded protein response
We have identified and characterized an allelic series of spontaneous Rorb mutations in mice We perform RNASeq to identify gene expression changes associated with Rorb mutations in brain and spinal cord from all five mutant strains.  We also perform CNS region-specific RNASeq in the Rorbh5/h5 mutant. Overall design: Comparative gene expression analysis of RNA-seq data for five strains of mice with spontaneous Rorb mutations and C57BL/6J and DBA/1J control mice.