gut metagenome
A rabbit model of diarrhea induced by Folium sennae, a widely used botanical medicine to resolve constipation in humans and animals, has been used in research to explore new treatments for diarrheal disease; however, the validity of the model and the mechanisms of Folium Sennae aqueous extract (FSAE) leading to diarrhea in rabbits remain unclear. Metabolomics and gut microbiota in colonic content were analyzed to explore the possible action mechanisms of FSAE in rabbits.