Study on the role and mechanism of DAT, a metabolite of intestinal flora, in attenuating fatty liver disease
The treatment of obesity remains one of the major challenges facing the health care system.Dietary and lifestyle changes can be effective in preventing and treating obesity, but these approaches are difficult to maintain in the long term. Deaminotyrosine is one of the products of flavonoid metabolism by intestinal flora.The research group found that the function of gut flora in converting flavonoids to DAT is reduced in high-fat diet hosts, and supplementation of DAT can reduce the risk of high-fat diet.Supplementation of DAT can reduce high-fat diet-induced obesity. However, the role of DAT in fatty liver is still unclear. Therefore, the present work is intended to further explore whether DAT can alleviate fatty liver and explore the molecular mechanism within it to provide theoretical basis for fatty liver treatment.