Effects of Wumei Wan (WMW) on the Gut Microbiota in APCmin/+ Mice (PRJCA040820)
Eight-week-old C57BL/6 or APCmin/+ mice were fed a high-fat diet ad libitum and randomly divided into four groups:(1)Control group (wild-type C57BL/6 mice), (2)Model group (APCmin/+ mice), (3)WMW-treated group (APCmin/+ mice receiving Wumei Pill at 17 g/kg/day via oral gavage), and (4)BBR group (APCmin/+ mice administered berberine at 100 mg/kg/day via oral gavage).All treatments were continued for 10 consecutive weeks. Fecal samples collected post-intervention underwent shotgun metagenomic sequencing to analyze the effects of WMW and BBR on gut microbiota composition in APCmin/+ mice.