Deletion of the gene encoding the N-methyl-D Aspartate Receptor GluN1 subunit in Schwann cells causes ultrastructural changes in Remak bundles and hypersensitivity in pain processing
Mouse  DRGs (n=3 per genotype)  were isolated from a novel mouse model with conditional deletion of Glun1 in Schwann cells (GluN1-)  and corresponding  littermate controls (Glun+).  P0Cre recombinase is the driver. Transcriptome profiling of DRGs revealed 138 differenially regulated genes in Glun1- mice.  On third of the regulated genes are known to be involved in pain processing. Overall design: 6 samples total. Examined differential expression between wildtype DRG (n=3) versus NMDA-R knockout DRG (n=3).