Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [scRNAseq]
Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development Overall design: We used scRNAseq to compare gene transcriptome profiles of sgNTC or sgFlcn-transduced OT-1 cells purified from the siIEL on days 4.5 and 7.5 post-LM-OVA infection