RNA-seq of Candida albicans cells of the wildtype strain SC5314 and a sky2 deletion mutant grown on different carbon sources (glucose, malic acid, succinic acid)
RNA-sequencing was performed to investigate the role of the Candida albicans protein kinase Sky2 in metabolic adaptation to alternative carbon sources. The Candida albicans wildtype strain SC5314 and a sky2 deletion mutant were grown in medium with either glucose (3h), malic acid (6h) or succinic acid (6h) as the sole carbon source. Because the sky2 deletion mutant showed decreased growth in media that contain either malic acid or succinic acid as the sole carbon source, we wanted to investigate the transcriptional changes in the sky2 mutant grown on these carbon sources.