Shanxi Provincial Department of Science and Technology (PRJCA045145)
Traumatic brain injury (TBI) is a major global health issue that leads to persistent neurological dysfunction and systemic complications. Although animal studies have suggested an association between TBI and the gut microbiota, human evidence, particularly during the early phase after injury, remains limited. In this study, we analyzed the gut microbiota profiles of 12 TBI patients and 13 healthy controls, all of whom had not received antibiotic treatment within one month prior to sample collection, by integrating high-resolution 16S rRNA sequencing with clinical metadata. This project compared the gut microbial diversity and community composition between TBI patients and healthy individuals, and further predicted potential microbial metabolic pathways.