An integrated model of PEL lymphomagenesis
Primary B lymphocytes were dually-infected in vitro with Epstein-Barr virus (EBV) andKaposi sarcoma-associated herpesvirus (KSHV) to generate PEL-like cells (PEL-LCs). RNA-Seq was performed on PEL-LCs and established PEL cell lines passaged in vitro and as in vivo xenografts in NSG mice and revealed contributions of the body cavity microenvironment on viral and host cell gene expression.