Preclinical Evidence for the Glucocorticoid-Sparing Potential of a Dual Toll-Like Receptor 7/8 Inhibitor in Autoimmune Diseases
Single cell RNA-seq analysis of PBMCs testing for a synergistic effect of TLR7/8 inhibition and the glucocorticoid dexamethasone Overall design: Isolated PBMCs of four healthy human blood donor leukopaks, treated with a TLR7 and/or TLR8 inhibitor and/or dexamethasone