Directional oxygen-generating microneedles for the healing of diabetic wounds
This study aimed to investigate the transcriptional responses of mouse macrophages under hypoxic conditions following treatment with oxygen-generating microneedles (V-MN). The murine macrophage cell line RAW264.7 was cultured under hypoxia to mimic the diabetic wound microenvironment. RNA sequencing was conducted to identify differentially expressed genes associated with oxygen metabolism, inflammation, and immune regulation during microneedle-mediated stimulation.