Type I Interferon Induced Apoptosis Drives Chronic Wounds in ISG15 deficiency
Chronic exposure to IFN-I in ISG15 deficiency drives impaired wound healing, improper macrophage activation and enhanced Epithelial-to-Mesenchymal transition, likely causing fibrosis in multiple organ systems. Overall design: This is a cross-sectional study involving the accrual of 3-4-mm skin punch biopsy samples from one healthy control and biologic naïve ISG15 deficient patients with skin lesions. The samples were then subjected to the protocols entailed by spatial transcriptomics platform.