POSTN secreted from glioblastoma stem cells can recruit microglia and upregulate CD70 expression in microglia through the aVß3/PI3K/AKT/NF?B pathway
Our findings revealed that POSTN secreted from GSCs can recruit microglia and upregulate CD70 expression in microglia through the aVß3/PI3K/AKT/NF?B pathway, which in turn promotes Treg development and functionality and supports the formation of an immunosuppressive tumor microenvironment. Overall design: Comparative gene expression profiling analysis of RNA-seg data of HMC3 cells treated with PBS or human recombinant POSTN.