Transcriptomic prolife of HEK293T cells upon knockdown of AFF1, p300, HDAC5
In this study, we unraveled the mechanism behind human HDAC1 and HDAC5 mediated regulation of p300 acetylation and its effect on global transcription regulation via AFF1, in normal condition as well as genotoxic stress condition. For that matter, we have identified common target genes working in p300/HDAC1/HDAC5/AFF1 axis.