Functional Variant at 19q13.3 Confers Nonsyndromic Cleft Palate Susceptibility by Regulating HIF3A
To explore the potential mechanisms in hif3a function in palatal tissues, we performed RNA-Seq of mouse embryonic palatal tissues overexpressing Hif3a and the control groups. Fetal mouse plate shelves were transfected with Hif3a overexpressing lentivirus and a non-targeting sequence to observe biological effects in vivo.