Detection of APOBEC3B-mediated RNA editing sites in SK-OV-3 cells
RNA editing is a key post-transcriptional modification that enhances proteomic diversity and regulates gene expression.APOBEC3 family has emerged as a significant player in this mechanism, with APOBEC3A (A3A) showing notable roles in immune response and stress conditions. APOBEC3B (A3B), another family member, has garnered attention for its potential role in breast cancer genomic mutations. The SK-OV-3 cell line, known for its application in ovarian cancer research, provides a robust model for studying gene expression alterations. In this study, we employ an inducible expression cell model and a novel methodology for identifying differential variants in RNA (DVRs) to map A3B-mediated RNA editing sites.