Trypanosoma cruzi Raw sequence reads
We generated avirulent and virulent derivatives of the Trypanosoma cruzi Y strain and investigated the molecular bases underlying their differential infectivity using integrated genomic, transcriptomic, and proteomic approaches. Parasites maintained exclusively in in vitro cell culture (YP0) displayed low virulence in mice, whereas 20 successive passages in the murine model (YP20) resulted in a highly virulent isolate