scRNA-sequencing of gastric tissues derived from three inflamed-type and three desert-type tumors
Transforming gastric tumors from immunosuppressive to immunostimulatory is a potential approach to enhance immune checkpoint blockade  response. Here, we developed a chromosomal instability subtype gastric cancer mouse model with an immunoactive tumor microenvironment (TME) and a stem cell-originated mouse-derived allograft model with an immunosuppressed TME to investigate mechanisms regulating the tumor immunophenotype and uncover therapeutic strategies to remodel the TME. Overall design: We collected gastric tissues derived from three inflamed-type and three desert-type tumors and then applied for scRNA-sequencing.