Role of osteopontin in the progression of malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive cancer of the mesothelial lining. It is characterized by chronic non-resolving inflammation. In order to study the role of the osteopontin protein, we used a murine mesothelioma cell line called AB22 (epitheliod histology) by comparing control samples and cells in which osteopontin was silenced.