Dietary restriction mitigates 5-fluorouracil-induced thrombocytopenia in aged mice via mitochondrial potentiation in hematopoietic stem cell and megakaryocyte progenitor (PRJCA047733)
Short-term dietary restriction before chemotherapy enhances mitochondrial function in hematopoietic stem and progenitor cells, mitigating thrombocytopenia and promoting platelet recovery in aged mice. Clinically, lower BMI correlates with reduced CIT risk, suggesting mitochondrial targeting as a potential strategy for elderly cancer patients.