Complementary HLH Susceptibility Factors Converge on CD8 T-cell Hyperactivation [TCR-seq]
To determine the effects of excess IL-18 and perforin deficiency on CD8 T cell clonality toegther and separately under homeostatic conditions. These data support that together perforin deficiency and excess IL-18 promote hyperexpansion of CD8 T cell clones. Overall design: FACS sorted CD8 T lymphocytes from Prfko, Il18tg, PrfHET18tg, and Prfko18tg mice under homeostatic conditions