Bulk RNA-sequencing of articular cartilage from DMM-treated mice
Identify the therapeutic targets/pathways of Osteoarthritis (OA),  the most frequent joint disease. Surgery-induced cartilage degeneration is used as an experimental model for OA in mice. An inducible cartilage-specific c-Fos loss-of-function model is generated by combining c-fos floxed and Col2a1-CreERT mice. Since c-Fos mutant mice have more severe phenotype than c-Fos wild type mice, we focused on c-Fos-related signaling pathway in the articular cartilage. Overall design: Contralateral side from c-FosWT mice: n = 4, DMM-treated side from c-FosWT  mice: n = 3 and DMMptreated isde from  c-FosDCh mice: n = 4