Macrophage extracellular traps induced by the pyroptotic microenvironment enhance inflammation during HAEC
Pyroptotic microenvironment triggers the formation of METs in colon tissues of HAEC, which further induce the damage of CECs. Targeting METs via HMGB1TLR4p38 MAPK p65 NFkB pathways is a potential therapeutic strategy to inhibit HAEC progression.