CDK10 suppresses nucleic acid sensors-mediated antitumor immunity [RNA-Seq]
Cdk10 knockout significantly reduced CT26 tumor growth in immunocompetent BALB/c WT mice.To elucidate the molecular mechanisms by which Cdk10 suppresses anti-tumor immunity, we conducted transcriptomic analyses on WT and Cdk10 KO CT26 cells Overall design: Total RNA was isolated from sgControl and sgCdk10 CT26 cells using TRIzol Reagent, following the manufacturer's instructions.