Phosphorylation of Runx protein controls thymocyte fate.
To understand the impact of Runx3 WRPW variant on the histone marks, we performed ChIP-seq of H3K4me3 and H3K27me3 using Runx3 +/+ and Runx3 +/WRPW mature CD8 SP thymocytes. Overall design: Investigation of alteration of H3K27me3 marks between Runx3 +/+ and Runx3 +/WRPW mature CD8 SP thymocytes.