Differential regulation of miRNA profiles of human cells experimentally infected by Leishmania donovani isolated from Indian Visceral Leishmaniasis and Post Kala-azar Dermal Leishmaniasis
The study involves the comparative analysis of changes in miRNA expression in Human cell line infected with visceral Leishmaniasis and Post-kala azar dermal leishmaniasis. The result suggested that the involvement of differentiallyexpressed miRNAs in various biological processes like PI3K pathway activation, cell cycleregulation, immunomodulation, apoptosis inhibition, different cytokine production, and T-cell phenotypic transitions calcium regulation.