p75ECD-Fc protects the brain against acute ischemic stroke by upregulating Dlg4 in rats
The incidence of acute ischemic stroke (AIS) is increased in recent years worldwide but there is no drug approved by the FDA to protect the brain from ischemic damage. In this study, we investigated the role of the p75 neurotrophin receptor (p75NTR) and its extracellular domain (ECD) in the neuroprotection in the rat stroke model.