RNA sequencing of cochlear tissues in a murine endolymphatic hydrops model treated with berberine chloride hydrate-loaded GelMA hydrogel
This study investigates transcriptomic changes in cochlear tissues from a murine endolymphatic hydrops model. Mice were divided into four groups: control, LPS-induced model, LPS treated with berberine chloride hydrate (BCH), and LPS treated with berberine chloride hydrate-loaded GelMA hydrogel (GelMA-BCH). RNA sequencing was performed to analyze differential gene expression and to explore molecular mechanisms associated with inflammation and oxidative stress in the cochlea.