Role of DYRK1A in MPN
We aim to investigate the role of DYRK1A gene in MPN pathogenesis by DYRK inhibitor and genetic knockout Overall design: RNA-sequencing was performed in SET2 DYRK1A KO clone 11H1 and 14B5 generated by CRISPR/Cas9. Wild-type SET2 cells was included as a control. DYRK1A KO clones 11H1 and 14B5 were compared to wild-type SET2 cells repsectively (3x3 analysis).