Cell Therapy for Hirschsprung Disease-Associated Enterocolitis: Evaluation of the Effects and Safety of Mesenchymal Stem Cells on Intestinal Macrophages
MSCs were transplanted into HAEC mice for therapeutic purposes. Our data showed that MSCs could ameliorate HAEC symptoms by promoting M1-to-M2 phenotype polarization via COX-2 mediated MAPK/ERK signaling pathway, thus providing novel insights and potentially promising strategy for the treatment or prevention of HAEC.