Cellular dynamics of transgenic porcine endothelial cells to inflammatory stimuli in xenotransplantation settings
In this study, we investigated the molecular and functional properties of genetically modified porcine aortic endothelial cells (PAECs) that carry a knockout of a1,3-galactosyltransferase and express human CD46 and thrombomodulin (3GM) in xenogeneic (Normal Human Serum alone) and inflammatory environments (TNF + Normal Human Serum), with Wild Type pig aortic endothelial cells as comparison.