IL-34 actions on FOXP3+ Tregs and CD14+ monocytes control human graft rejection
Overall, we show that IL-34 induced the differentiation of human monocytes with a particular transcriptional profile and these cells favor the development of potent suppressor CD4+ and CD8+ FOXP3+ Tregs. Overall design: mRNA profils of 5 conditions Monocytes, M1 and M2 macrophages, IL34 induced macrophages and M-CSF induced macrophages, from 3 healthy volunteers