Homo sapiens Genome sequencing and assembly
In this study, we performed ITS1 gene sequencing on tumor tissue from patients with EBOT and EOC and identified M. restricta as a predominant fungal genus in EOC tumor tissues. In a subcutaneous EOC mouse model, intratumoral injection of either mixed intratumoral microbiota from EOC patients or M. restricta significantly accelerated tumor growth and increased M2 macrophage infiltration. Mechanistically, EVs derived from M. restricta promoted tumor progression by facilitating M2 macrophage polarization via the JAK2/STAT3 signaling pathway.