Whole-exome sequencing identifies HLA-B associated with sulfasalazine-induced severe hypersensitivity
Sulfasalazine is a disease-modifying antirheumatic drug used to treat arthritis and ankylosing spondylitis. However, sulfasalazine may cause life-threatening severe hypersensitivity reactions (SHRs), including Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS).