RNA-seq of ChI-D2RKO mouse nucleus accumbens following a progressive ratio schedule of reinforcement of intravenous cocaine or saline
ChI-D2RKO mice showed an altered transcriptomic profile in the dorsomedial striatum in response to contingent cocaine administration. In particular, the expression of critical cocaine-induced transcription factors was not activated in the mutants. This evidence suggests that the altered transcription profile of ChI-D2RKO mice after acute cocaine might lead to long-term changes underlying the reduced PR breakpoint of ChI-D2RKO mice. Thus, RNA-seq was performed on the nucleus accumbens of these mice and their controls.