HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis
Triple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. The metastatic potential in TNBC patients serves as a critical determinant of clinical outcomes. The high mobility group AT-hook 2 (HMGA2) has emerged as a novel chromatin architectural regulator, its specific role in TNBC metastasis requires further investigation.To investigate the mechanism of HMGA2 regulation of TNBC metastasis,we performed RNA-sequencing using shNC or shHMGA2 from MDA-MB-231 cells. Overall design: Total RNA was extracted from MDA-MB-231 cells expressing a control vector (shNC) or HMGA2 had been knocked down (shHMGA2).