RNA-seq of human airway epithelial cells infected with SARS-CoV-2
The aim of this study was to compare the transcriptomic response of airway cells from donors with different chronic respiratory diseases following SARS-CoV-2 infection. We used four reconstituted samples of airway epithelium from either healthy donors, donors with cystic fibrosis or donors with chronic obstructive pulmonary disease (COPD). These samples were uninfected or infected with SARS-CoV-2 at a multiplicity of infection (MOI) of 0.1 for 24, 48 and 72 hours.