Effect of LRP1 deletion in vascular mural cells and APOE gentotype on gene expression in mouse brains
To investigate the apoE isoform-dependent role of vascular mural cell (VMC)-LRP1, we generated VMC-specific LRP1 knockout mice (smLrp1-/-), followed by breeding these mice with either APOE3-targeted replacement (TR) or APOE4-TR mice We then performed gene expression profiling analysis using data obtained from RNA-seq of cortical samples from 4 different mouse models Overall design: Comparative gene expression profiling analysis of RNA-seq data for VMC-LRP1 deificency in the presenc eof apoE3 or apoE4