PRMT5 maintains homeostasis of the intestinal epithelium (PRJCA020196)
We investigated the role of Protein arginine methyltransferases 5 (Prmt5) in regulating homeostasis of mouse intestinal epithelium. Here, the in vitro cultured small intestinal organoids (Villin-CreERT2; Prmt5 fl/fl) was treated with EtOH (Control group) or 4-hydroxytamoxifen (4-OHT) (Prmt5 KO group) for 24h. Then the bulk RNA-sequencing was performed at 4 days post treatment. Two biological replicates/ group. Control group: EtOH_1, EtOH_2; Prmt5 KO group: 4-OHT_1, 4-OHT_2.