Investigation of human sperm epigenomic profile diversity by single cell analysis
Sperm chromatin is highly condensed due to the loss of histones and their replacement by proteins called Protamines. Abnormal sperm chromatin condensation is a cause of male infertility, and recently it has been suggested that sperm epigenome alterations are associated with increased risk of disease in children. Recently, it has been suggested that sperm epigenome alterations are associated with increased risk of disease in children. In this research proposal, we aimed to clarify the inter-individual and inter-sperm diversity of human sperm epigenome profile by quantifying human sperm chromatin using sequencing.