The identification of Ogfrl1 expressing cells in jawbone tissue
Human data demonstrates loss of function mutations of OGFRL1 are a cause of autosomal recessive forms of cherubism. However, the gene function of OGFRL1 is unknown. We performed scRNAseq to investigate the cell types expressing Ogfrl1 in jawbone tissue. Overall design: Jawbone cells isolated from mouse maxilar and madibular with collagenase/EDTA digestion and analyzed using scRNAseq