Global transcriptional reprogramming by cytomegalovirus infection in murine dendritic cells.
In this study, we analyzed the global transcriptional changes induced in dendritic cells by Murine Cytomegalovirus infection. Considering the in vivo dynamics of DC activation/differentiation, the relative paucity of MCMV+ DC in vivo and the epigenetic changes likely conferred by tissue environments, we used controlled, synchronized in vitro MCMV infection of DC as a starting point for analysis.