Whole genome sequencing was performed on Indian desi cattle to identify genetic variations associated with susceptibility and resistance to paratuberculosis, a chronic infectious disease caused by the bacterium Mycobacterium avium subspecies paratuberculosis . By comparing the genomes of cattle with differing disease outcomes, we aim to uncover genetic markers that can predict an individuals risk of infection and inform breeding strategies for disease resistance.
This research delves into the genetic basis of paratuberculosis susceptibility within Indian desi cattle. By conducting whole genome sequencing on cattle exhibiting varying levels of resistance to the disease-causing bacterium, Mycobacterium avium subspecies paratuberculosis , the study aims to identify specific genetic markers associated with disease outcome. This comprehensive genetic analysis seeks to uncover the underlying mechanisms of infection vulnerability. Ultimately, the identified genetic predictors will be instrumental in developing predictive tools and informed breeding strategies to cultivate cattle populations with enhanced resistance to paratuberculosis. By pinpointing genetic factors that influence susceptibility, this research holds the potential to significantly impact disease prevention and control efforts in the Indian cattle.