Transcriptomic profiling of midbrain in MPTP-treated mice under chronic intermittent hypoxia
Chronic intermittent (CIH), a hallmark of sleep-disordered breathing, may accelerate neurodegeneration in Parkinsons disease (PD). This study combines MPTP-induced PD modeling with CIH exposure to map midbrain transcriptomic changes, seeking mechanisms of PD synergy. Results could guide personalized interventions for PD patients with respiratory comorbidities, addressing an urgent unmet clinical need.