The role of PTENa in brain
In contrast to the ubiquitous expression profile of PTEN, PTENa is predominantly expressed in brain. To study the biological function of PTENa in brain, we employed LCMV to induce murine viral encephalitis model. Through single cell RNA sequencing, we revealed the immunological function of PTENa during viral infection in the brain. Overall design: The cortex from infected wild-type and Ptena-specific deficient mice on day 7 after intracranial injection of LCMV-Cl13 were isolated and dissociated. Cells were pooled by 10x Genomics platform.