Cattle and Sheep Pan-Epigenome
This project is designed to establish a cattle and sheep pan-epigenome. To accomplish this goal, we comprehensively characterize epigenomic conservation and diversity through examination of 5-methylcytosine, 5-hydroxymethylcytosine, histone marks H3K4me3, H3K27ac, H3K4me1 and H3K27me3, open chromatin, and n6-methyladenosine in the liver, muscle and prefrontal cortex of multiple breeds of cattle and sheep.