Fecal microbiota transplantation for intractable diarrhea due to severe dysbiosis and cytomegalovirus enteritis: a case report
This case report describes a 40-year-old woman with traumatic brain injury who developed intractable bloody diarrhea (up to 40 episodes daily) after prolonged antibiotic use. Colonoscopy confirmed CMV enteritis, and 16S rRNA sequencing revealed severe gut dysbiosis. Treatment with intravenous ganciclovir combined with fecal microbiota transplantation via jejunal tube led to resolution of diarrhea, mucosal healing, and restoration of gut microbiota diversity. The 16S rRNA sequencing data presented here support the efficacy of combined antiviral and FMT therapy for refractory diarrhea associated with dysbiosis and CMV infection.