Methionine metabolism regulates T cell fate by KCa3.1 activity (RNA-Seq)
We found that methionine availibility during T cell activation regulates rapid NFAT1 activation, thereby governing T cell fate. Further, acute methionine limitation didn't affect global histone methylation status stating the crucial role of methioinine during early TCR activation. Overall design: RNA-Seq analysis of 8 samples. CD8+ Tumor infiltrating T cells were isolated at day 9 post T-cell transfer. Two groups 0.1mM Methionine and 0.03mM Methionine (n=4/group).