Next generation mRNA and miRNA sequencing data sets from young and adult female and male healthy cats, and female and male adult cats with hypertrophic cardiomyopathy (HCM).
Next generation sequencing for the feline transcriptome (mRNA and microRNA profiles) was carried out using myocardial samples from female and male young healthy cats, adult healthy cats, and cats with hypertrophic cardiomyopathy. Overall design: The study comprises of myocardial samples from young healthy male cats, adult healthy male cats, young healthy female cats, adult healthy female cats, and female and male cats with hypertrophic cardiomyopathy (HCM). The young healthy cats were control cats from a research cat colony, their hearts were donated for the current study. The healthy adult cats were pet cats that were euthanised for reasons not related to the study. Cats with HCM were pet cats with progressed disease that were euthanased on owners request because of poor prognosis. All cats underwent postmortem examination carried out by a specialist in veterinary pathology to confirm HCM and exclude systemic diseases in cats with HCM, and to exclude cardiac and systemic diseases in cats categorized as healthy. The young healthy cats were 1.5 years old, the adult healthy cats ranged in age between 2 and 12 years, and the cats with HCM range in age between 2 and 15 years. The objective of the study was to investigate the influence of age, sex and HCM on the feline myocardial transcriptome and miRNA profiles. The tissue samples were sequenced using RNA seq technology for mRNA and small RNA seq for miRNA profiling.