RNA sequencing for wild type and shENO1 Daudi cells.
We systematically evaluated the expression pattern and function of ENO1 in BL and clarified that ENO1, regulated by cMyc, can promote BL cell proliferation and metastasis by activating TGFß1 signaling pathways in a plasmin-mediated manner. Through structure-based virtual screening, we successfully discovered Ciwujianoside E (L-06) as a novel ENO1 inhibitor which can limit BL cell proliferation and dissemination in vitro and in vivo. Overall design: Examination of drug sensitivity for ENO1 knockdown in Burkitt's lymphoma cell line Daudi