Implicating type 2 diabetes effector genes in relevant metabolic cellular models using promoter-focused Capture-C [Capture-C]
We used ATAC-seq, RNA-seq, and promoter to create atlases of the regulatory elements to provide context to type 2 diabetes associated variants from publically available genome-wide association studies Overall design: We performed ATAC-seq, RNA-seq, and Promoter Capture C/HiC on EndoC-BH1, HepG2, and SGBS cells