Disruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome [ATAC]
This work attempt at characterizing the chromatin accessibility of control and HVDAS lines. We profiled 5 control and 5 HVDAS lines with bulk ATAC-seq, to reconstruct the molecular basis of HVDAS at early stages of development. This data was then integrated with HPTMs and TF ChIP-seq generated from the same lines to identify chromatin accessibility changes connected with ADNP binding changes in HVDAS.