Proteomics Reveals the Regulatory Mechanism of the PI3K/AKT Signaling Pathway in the Development of Hepatic Fibrosis
Quantitative proteomic analysis combined with bioinformatics enrichment identified significant activation of the PI3K/AKT signaling pathway in hepatic fibrosis models. This pathway activation was confirmed to drive hepatic stellate cell activation and extracellular matrix deposition, highlighting its critical regulatory role in hepatic fibrosis progression.