The Role of PAR2 in Regulating MIF Release in House Dust Mite-Induced Atopic Dermatitis
Atopic dermatitis (AD) is a chronic disease characterized by relapsed eczema and intractable itch, and is often triggered by dust mites (HDM). PAR2 is a G-protein coupled receptor on keratinocytes and may be activated by HDM to affect AD processes. We first established a HDM-derived AD mouse model in wild-type (WT) and Par2-/-mice. Single cell RNA sequencing of the diseased skins was used to find cellular communication between epidermal and dermal cells.