Transcriptomic Analysis Reveals the Molecular Mechanisms of Methylene Blue-Mediated Photodynamic Therapy Against Microsporum canis
Background: Microsporum canis, a primary cause of dermatophytosis, presents a growing therapeutic challenge... This study employed RNA-sequencing (RNA-Seq) to investigate the global transcriptomic response of M. canis to a sub-inhibitory concentration of MB-PDT... Conclusion: MB-PDT exerts its potent antifungal effect against M. canis through a multi-targeted mechanism that overwhelms cellular repair systems and induces PCD