Balb/c mouse lung tissue RNA-Seq in mouse OVA asthma model with and without anti-mouse-IL-4Ra antibody treatment.
Purpose: Identify genes disregulated in Balb mouse lung tissue in the Ovalbumin (OVA) asthma disease model and genes disregulated by OVA challenged mice treated with with an Anti-mouse-IL-4Ra mAb Overall design: Balb mice were sensitized to ovalbumin systemically (i.p.) and challenged with nebulized ovalbumin.  The OVA challenged mouse lung RNA-Seq was compared to RNA-Seq from lungs of mice sham (Saline) sensitized or treated with 30 mg/kg of an anti-mouse-IL-4Ra mAb