Lysosomes signal through the epigenome to regulate longevity across generations [I]
Profiling of H3K79me2/3 occupany between wild-type N2 worms and lipl-4 transgenic (lipl-4 Tg) worms. Overall design: Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) was performed for histone modifications H3K79me2, H3K79me3, as well as histone H3, in wild-type N2 worms and lipl-4 transgenic (lipl-4 Tg) worms at day 1 of adulthood.