Evaluation of a non-animal toolbox informed by adverse outcome pathways (AOPs) for human inhalation safety
Concentration- and time- response and human lower EpiAveolar™ respiratory tract tissues comparison  of transcriptional responses following 12-day exposure with different test materials.  Differential expression and pathway analyses were performed to estimate the lowest transcriptional point of departure (PoD) - minimum effect concentration when a  biological perturbation as estimated by gene expression changes could be identified.