USP2 inhibition prevents infection with ACE2- dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice
In this study, we identified USP2 as a physiological deubiquitinase of ACE2 and USP2 inhibition led to ACE2 protein destruction, thereby preventing infections of coronaviruses that reliant on ACE2 Overall design: RNA-seq study of lung samples derived from K18-hACE2 mice infected with SARS-CoV-2 (Wuhan strain) and subjected to the treatment of vehicle control or USP2 inhibitor ML364