Single-cell landscape reveals heterogeneity and change of NK cell function induced in Schistosoma japonicum infected C57BL/6 mice (PRJCA019709)
Schistosomiasis japonica is a severe zoonotic parasitic disease that seriously threatens human health. Natural killer (NK) cells play an essential role in preventing hepatic fibrosis by killing activated hepatic stellate cells. However, in the schistosomiasis hepatic fibrosis model, NK cell function is inhibited, and the specific mechanism is unclear. It is essential to study the role and regulatory mechanism(s) of NK cells in schistosomiasis-induced liver fibrosis by identifying the phenotypes, clusters, and functional changes of NK cells. Here, single-cell RNA sequencing was performed on liver NK cells in a mouse model of schistosomiasis-induced liver fibrosis to reveal the heterogeneity of NK cells and changes in NK cells following infection with Schistosoma japonicum. These data help to understand the role of NK cells in schistosomiasis liver fibrosis and identification of important regulatory targets.