A Cellular Atlas of the Down Syndrome Brain Identifies Accelerated Oligodendrocyte Precursor Cell Senescence
We performed single nucleus RNA-seq and single nucleus ATAC-seq on the cortex of Ts65Dn mouse model of Down Syndrome and euploid controls (wild types). Overall design: Single nucleus RNA-seq and ATAC seq from 6 month old mouse cortex under two conditions: 1)Control (wild type), 2)Ts65Dn mouse model for Down Syndrome.