Effect of genetic deletion of TREM1 on gene expression of brain primary microglia during aging and in 5XFAD Alzhiemer mice
To investigate the function of TREM1 in the regulation of innate immune cell function, we established mice in which TREM1 target gene has been genetically deleted. We then performed gene expression profiling analysis using data obtained from RNA-seq of microglia from young and old WT and TREM1-/-mice and from 5XFAD and 5XFADxTREM1+/- mice Overall design: Comparative gene expression profiling analysis of RNA-seq data for TREM1+/- microglia