RNA-sequencing of exhausted T cells
The transcription factors Blimp1 and TCF-1 exhibit antagonistic effects on the progenitor exhausted and terminally exhausted T cell populations. While Blimp1 drives terminal differentiation, TCF-1 is critical for the maintenance of progenitor exhausted T cells. Here, we generated CD8 T cell conditional KO mice in which both of these factors are ablated and determined differential gene expression by RNA-sequencing.