Epithelial NAD+ Depletion Drives Mitochondrial Dysfunction and Contributes to Intestinal Inflammation
NAD+ metabolism and PGC1a expression with the intestinal epithelium play a significant role in the development and progression of intestinal inflammation. Modulating cellular NAD+ levels with NAD+ precursors enhances mitochondrial function through the PGC1a axis in murine models of experimental colitis.