Rare resistome enrichment in fish guts and elevated transmission risk relative to the core resistome
Metagenomic sequencing was used to characterize core and rare antibiotic resistance genes (ARGs) in water, sediment, and fish gut samples collected from the Qiantang River basin, China. This project aims to compare the composition, genomic localization, transmission potential, and health risk profiles of core and rare ARGs across environmental and host-associated compartments, with a particular focus on the enrichment of rare ARGs in fish guts and their potential involvement in horizontal gene transfer.