Cellular Responses of Human Muller Glia to Urban Air Pollution Exposure
Air pollution is a global environmental issue that was demonstrated in recent epidemiological studies to be associated with increased age-related macular degeneration, glaucoma, and other retinal diseases. The response of retinal cells to air pollution has not previously been characterized. Muller glia cells play important roles in maintaining retinal homeostasis, regulating oxidative stress, and modulating inflammation. In this study, we investigated the effect of standardized real-world air pollution (Arizona Road Test Dust, ARD) on a human Muller glial cell line using bulk RNA-seq analysis and other methods.