Endothelial cell-derived lactate triggers mesenchymal stem cell histone lactylation to attenuate osteoporosis
To better understand molecular mechanisms of bone mesenchymal stem cells (BMSCs) osteogenic differentiation in endothelial Pkm2-deleted mice, RNA sequencing was applied to BMSCs from Wt and endothelial Pkm2-deleted mice after osteogenic differentiation.