microbiota profile of 16p11.2 microduplication (dp) mouse
Chromosomal 16p11.2 microduplication (dp) is among the most prevalent genetic copy number variations (CNV) linked with ASD.However, the implications of gut microbiota status underlying the development of ASD-like impairments induced by 16p11.2dp remains unclear.To address this,we conducted a comparative analysis of the gut microbial community and metabolomic profiles between 16p11.2 dp/+ and their wild-type counterparts using 16S rRNA sequencing.