Global DNA methylome analyses uncover cancer-associated 5hmC signatures preferentially detected in patients cell-free DNA
In this present study, we analyzed genome-wide 5hmC and 5mC DNA methylation patterns and transcriptomics data in paired tumor and matched normal tissues collected from bladder cancer patients as well as healthy and malignant B-cells from germinal tonsils and DLBCL patients. We then investigated whether cfDNA is a faithful surrogate for tumor biopsy when accessing tumor specific methylation patterns in limited numbers of cfDNA samples.