Exploring the Molecular Mechanisms of Cisplatin-Induced AKI via smgGDS Knockdown
The smgGDS-knockdown cell line was established to explore the underlying mechanism of CDDP-AKI, and shRNA targeting smgGDS produced a robust knockdown of smgGDS protein expression compared with control shRNA. For further mechanistic studies, the RNA-seq and related bioinformatics analysis were performed.