PDOs genetic signature recapitulates mutational profile of the native tissue
This study includes raw and processed next-generation sequencing data derived from patient-derived organoids generated from histologically normal human colon mucosa. Organoids were sequenced using a targeted gene panel covering pathways involved in epithelial homeostasis, stress response, and intestinal regeneration. The dataset contains FASTQ files and processed variant calls (VCF) used to assess genomic fidelity between organoids and matched native tissue. All samples were de-identified prior to sequencing.