NANOG governs cell metabolism and redox homeostasis to secure human naive pluripotency(NANOG ChIP-seq ATAC-seq RNA-seq)
Naive human embryonic stem cells (hESCs) possess some advantages over their primed counterparts, displaying distinctive metabolic and epigenetic properties. However, the master regulator governing these features remains unrecognized. Here, we systemically investigate unique functions of core transcriptional factor NANOG in naive hESCs.