16S rDNA sequencing of mouse fecal samples in a Salmonella infection model
To investigate the modulatory effect of Lactobacillus plantarum RT1 on gut microbiota in Salmonella induced colitis, mice were randomly divided into four groups: a PBS control group, a DSS model group, a Carb positive control group, and a RT1 intervention group. The study aimed to evaluate whether RT1 could restore gut microbial diversity, reverse inflammation associated dysbiosis, enrich beneficial bacteria, suppress pathogenic taxa, and recover short chain fatty acid production, thereby exploring the microbiota dependent mechanism by which RT1 protects against Salmonella induced colonic injury.