Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance. [Ribo-seq]
Here we identify a novel RAS-responsive element binding protein 1 short isoform, RREB1a, as a key in governing mitochondrial complex II translation to promote stemness and drug resistance of cancer stem cells of acute myeloid leukemia Overall design: This dataset contains Ribo-seq experiments of leukemia stem cells isolated fromWT or Rreb1-KO mice.leukemia stem cells were isolated from the bone marrow for Ribo-seq analysis with two biological replicates.