Effet of pioglitazone and darglitazone on AML cell lines
As PPAR-gamma is a nuclear receptor acting as a transcription factor regulating the expression of multiple genes and to better understand the signaling pathways involved, we performed RNAseq analysis on AML cell lines cultured in the absence or presence of pioglitazone or darglitazone. Overall design: KG-1a, MV4-11, MOLM-14 and OCI-AML3 were treated either by pioglitazone 10µM, darglitazone 10µM or DMSO as control during 12H.