ALFIN-like proteins link histone H3K4me3 with H2A ubiquitination and coordinate diverse chromatin modifications in Arabidopsis [RNA-seq]
The Arabidopsis H3K4me3-binding ALFIN-like proteins are components of the PRC1 complex and promote H2A ubiquitination, thereby establishing a connection between H3K4me3 and H2A ubiquitination across the genome. Additionally, the ALFIN-like proteins interact with various chromatin-related proteins involved in H2A.Z deposition, H3K27me3 demethylation, histone deacetylation, and chromatin accessibility. The ALFIN-like proteins play a crucial role in coordinating H3K4me3 with diverse other chromatin modifications. Overall design: Examination of the mRNA expression of 11-day-old wild type and two mutants in Arabidopsis