Identifying new Alzheimers genes based on LTP induced expression change differences
Synaptic dysfunction is an important pathological hallmark and causing factor of Alzheimers disease . High frequency stimulation induced long term potentiation LTP has been widely used to study synaptic plasticity; and impaired LTP has been found in AD. However, the exact molecular mechanism underlying synaptic plasticity and LTP has yet to be completely elucidated. Whether genes and proteins regulating synaptic plasticity LTP are altered in AD and contribute to disease progression also remains to be deciphered. Herein, we propose that by comparing the difference between LTP induced gene and protein expression changes in AD and control mice, we may identify new genes and proteins that not only regulate synaptic plasticity LTP, but also lead to AD progression when their expression response to LTP is altered.