Radon Exposure Delays the Development of Skin Lesions in a Mouse Model of Psoriasis
We used transgenic mice that spontaneously develop chronic psoriatic skin lesions inflicted (CD11c-IL-17Aind/ind mice) to investigate effects induced by multiple radon exposures. Comprehensive transcriptome profiling of non-lesional skin showed downregulation of genes associated with psoriasis initiation, while anti-inflammatory genes were upregulated. Pathway enrichment analysis revealed immunosuppressive effects related to T cell regulation, similar to UV radiation-induced response. Overall design: Investigation of plaque formation (skin) throughout the observation period; cytokine release (serum), immune status and proliferation marker after sacrification. Transcriptome profiling (skin) was performed.