O-GlcNAcylation regulates c-Myc/PDK2 axis to rewire TCA cycle and promote colorectal tumor growth
To investigate the function OGT in the regulation of colorectal tumor growth, we established HT-29 cell lines in which OGT has been knocked down by shRNA. Overall design: Comparative gene expression profiling analysis of RNA-seq data for HT-29 cells and its knock down OGT (shOGT).