Effect of monosodium urate (MSU) on gene expression of mouse bone marrow-derived dendritic cells (BMDCs) and splenic B cells
DCs and B cells are main target cells activated by uric acid (MSU, one of DAMP molecules). Ultimately, we would like to figure out signaling pathways significantly affected, and narrow down potential receptor candidates for uric acid (MSU). Overall design: Comparison of each immune cell depending on stimulation (mainly [control vs MSU] or [LPS vs LPS+MSU]. If necessary, [control vs LPS+MSU])