The gut metagenome of mice with DSS-induced colitis
This study aims to explore the impact of Pdcd1lg1 knockout on gut microbiota composition in C57BL/6J mice under inflammatory bowel disease conditions. DSS-induced colitis was established in both PD-L1 knockout (Pdcd1lg1-/-) mice and wild-type (wt) control mice. To characterize gut microbiota alterations, we performed metagenomic sequencing of fecal samples with comprehensive bioinformatic analyses.