Oral microbiota 16S sequencing of probiotic effects on vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication
This 16S rRNA sequencing dataset includes tongue coating microbiota samples from 84 participants (64 H. pylori-infected patients and 20 healthy controls) enrolled in a randomized controlled trial of probiotic supplementation during 14-day vonoprazan-amoxicillin H. pylori eradication therapy. Samples were collected longitudinally at baseline, post-treatment, and 6-week follow-up. Sequencing was performed on the Illumina NovaSeq 6000 platform targeting the V3-V4 region of 16S rRNA gene. These data enable analysis of oral microbiota dynamics during H. pylori eradication and probiotic-mediated microbial stability maintenance.