Effect of Pdk4 smooth muscle cell-specific knockout on atherosclerosis analyzed by scRNAseq
Knockout of Pdk4 in smooth muscle cells dramatically decreased inflammation, and increased gene expressions in TGFb signaling and glycolysis in the aorta. Overall design: Pdk4 was knocked out at age of 4-6 wk, followed high fat diet feeding for 4 months. Fresh whole aorta were digested for scRNAseq.