Copy_number_variation_in_mouse_oesophagus__others
We wish to determine how the mutational burden in mouse oesophagus changes in transgenic mice induced to carry mutations known to cover significant areas of human oesophagus.  In some cases the mice will be further treated with DEN a carcinogen present in cigarette smoke.  Ultilising a combination of targetted high-depth sequencing and low depth WGS we will attempt to understand how the mutational landscape of the oesophagus changes with different background mutations.