Whole Exome Sequencing Analysis of a Rare Biphasic Sinonasal Sarcoma
This study aims to conduct whole - exome sequencing analysis of a rare Biphasic Sinonasal Sarcoma (BSNS) case to explore its molecular mechanisms. The patient presented with chronic nasal congestion and rhinorrhea, and imaging showed a low - density nasal mass. Pathology confirmed BSNS characterized by spindle cells infiltrating the respiratory epithelium. By performing whole - exome sequencing, we seek to identify significant genetic alterations in this rare tumor, which may provide valuable insights into the diagnosis and treatment of BSNS. This study is relevant as it combines imaging, pathology, and molecular genetics to enhance our understanding of BSNS. The findings can guide treatment strategies and highlight the importance of a multidisciplinary approach in managing rare tumors. Moreover, the molecular genetic data obtained can contribute to the emerging role of molecular genetics in shaping therapeutic decisions for BSNS, potentially improving patient outcomes.