lncRNA TUG1 resolves R-loop and prevents DNA damage in cancer cells
We investigated the role of taurine upregulated gene 1 (TUG1) long noncoding RNA and its ability to cope with intrinsic replication stress in cancer cells. Genome-wide R-loop mapping using DNA/RNA immunoprecipitation and high-throughput sequencing (DRIP-seq) was performed in HeLa cells after knock down of TUG1.