Different gene expression between normal and cancer-associated fibroblasts from diffuse-type gastric cancer
To identify a cancer-associated fibroblast (CAF)-specific molecule that contributes to tumor-promoting effect, we utilized trnascriptome analysis. We performed RNA-sequencing with three normal fibroblast (NF)-CAF pairs derived from diffuse-type gastric cancer patients' tissues. RNA-sequencing revealed several commonly increased CAF-specific genes among each pair. Overall design: RNA-sequencing of paired normal fibroblast and cancer associated-fibroblast cells from three diffusse-type gastric cancer patients.