RNA-seq of MDA-MB-231 cells with various levels of FANCA expression
FANCA, one of the 23 fanconi anemia genes, is elevated in breast cancer. High-FANCA expression promotes cell proliferation in breast cancer. In order to determine the mechanisms how FANCA plays a role in breast cancer development, we manipulated FANCA expression in human breast cancer cell line MDA-MB-231 by overexpression and knockout and performed RNA-seq.