bulk RNA-seq of lichen planus
An early and sustained clinical response was seen, with 83.3% of patients responsive at week 16. Our molecular data identified a unique, oligoclonal IFN-?, CD8+, CXCL13+ cytotoxic T-cell population in LP skin and demonstrated a rapid decrease in IFN signature within 2 weeks of treatment, most prominently in the basal layer of the epidermis. Overall design: Whole transcriptomic analysis using bulk RNA-seq was performed on lesional and non-lesional skin prior to therapy (n=11, 12, respectively).