Association between genomic single nucleotide polymorphisms and susceptibility of Talaromyces marneffei
Talaromyces marneffei is a pathogenic fungus that can cause talaromycosis. Although many antifungal drugs have been used for the treatment of talaromycosis, the effects of genomic mutations of different T. marneffei strains on the susceptibilities of these antifungal drugs have not been fully studied. To reveal the association between genomic single nucleotide polymorphisms (SNPs) and susceptibility of T. marneffei, we sequenced the genomes of 15 clinical isolates of T. marneffei, and analyzed the association between their SNPs and susceptibilities to 5-fluorouracil, anidulafungin, posaconazole, voriconazole, fluconazole, caspofungin, amphotericin B, micafungin, and itraconazole.