Ffar4ko mice gut microbiota
This study suggests that intestinal Ffar4 deficiency leads to increased sugar preference in mice, which may be an important contributor to the development of diabetes. We demonstrated a mechanism affecting sugar preference in mice through gut-liver-brain interactions which B. vulgatus-derived pantothenate mediated GLP-1-FGF21 hormone axis. It provides a preventive strategy for diabetes prevention, while the development of Ffar4 tissue-specific agonists may be a approach for diabetes prevention.