bulkRNA seq of spleens from humanized mice comparing NRG to NSG-DKO strains and additionally vaccination using lentiviral constructs
Decifering why NSG-DKO mice have better humanization upon CD34+ stem cell injection than NRG mice. Additionally, checking effects of lentivirus administration that delivers human HLAs, human cytokines and a viral antigen, which, as a consequence, should improve human adaptive immunity in our huNSG-DKO mouse model.