RNA-seq of HTR-8/SVneo cells with MELTF-AS1 knockdown
The study includes two experimental conditions: 1. **MELTF-AS1 knockdown group:** HTR-8/SVneo cells transfected with specific siRNAs targeting the MELTF-AS1 gene.2. **Control group:** HTR-8/SVneo cells treated with non-targeting scramble siRNA. The goal of this project is to identify differentially expressed genes (DEGs) and dysregulated signaling pathways resulting from MELTF-AS1 loss-of-function. As HTR-8/SVneo cells are a well-established model for studying trophoblast invasion and placentation, this data provides a valuable resource for understanding the potential role of MELTF-AS1 in the molecular etiology of pregnancy-related disorders, such as pre-eclampsia, where inadequate trophoblast invasion is a key pathological feature. Researchers can use this dataset to explore lncRNA-mediated regulatory networks in placental development and disease.