Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders.
After placement on a high fat diet (16 weeks), Il22ra1fl/fl;Villin-cre- and cre+ mice displayed an altered gut microbiome composition. The intestinal microbiota was analyzed in 11 mice in total. Fecal samples were collected from the same mice before and after high fat diet