Transcriptomic Analysis of Midn Deficiency in Zebrafish at Whole-Body (48 hpf) and Head Tissue (9 mpf) Stages
Midnolin (Midn) is a nucleolar protein implicated in neurodevelopment and cellular homeostasis, but its role in vertebrate neural system development remains poorly understood. In this study, we generated Midn-deficient zebrafish to investigate its biological function.RNA sequencing was performed on two distinct sample types: whole-body samples at 48 hours post-fertilization (48 hpf) and head tissues at 9 months post-fertilization (9 mpf), collected from both wild-type and Midn knockout zebrafish.The dataset aims to identify differentially expressed genes and pathways associated with Midn deficiency across developmental stages and tissue contexts. Particular attention is given to neural-enriched regions, cell adhesion molecules, and extracellular components.These data provide a resource for understanding the molecular mechanisms underlying Midn function in neurodevelopment and tissue-specific regulation in zebrafish.