Commensal bacteria from Oryctolagus cuniculus harbour novel, uncharacterised biosynthetic gene clusters exhibiting antimicrobial activity against selective multi-drug-resistant clinical pathogens
Anti-Microbial Resistance (AMR) poses a significant threat, resulting in millions of deaths annually. Commensal bacteria often produce antimicrobial compounds to survive in competitive environments, and theidentification of these novel compounds will be beneficial. In this study, the commensal bacteria isolated from Oryctolagus cuniculus were evaluated for their antibacterial properties against clinically important drug-resistant pathogens. The commensals exhibited inhibitory activity against drug resistant pathogens such as MRSA, and carbapenem resistant E.coli, colistin-resistant E. coli. This submission includes the raw sequence of one of the representative commensals that exhibited biosynthetic gene clusters that included lanthipeptide class I showing a similarity to nukacin.