Total RNAseq of human healthy control inferior turbinate and glucocorticoid-treated, aspirin-exacerbated respiratory disease (AERD) nasal polyp nasal brushings
Aspirin-exacerbated respiratory disease (AERD) represents a particularly severe endotype of chronic rhinosinusitis with nasal polyps (CRSwNP), which affects around 10-16% of CRSwNP patients. AERD is characterized by severe and refractory nasal polyposis, bronchial asthma and intolerance to non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin. Today, the pathogenesis of AERD remains incompletely understood and curative treatments are lacking.  Using a global transcriptomic approach, we identified local changes between the mucosa of AERD nasal polyps and healthy control inferior turbinates. Nasal brushing samples were collected from inferior turbinates of healthy controls and nasal polyps of AERD patients under anterior rhinoscopy and stored at -80°C in RNAprotect until RNA isolation and RNAseq.