Analysis of bacterial factors contributing to quinolone resistance in Neisseria gonorrhoeae.
To search for determinants involved in quinolone resistance of Neisseria gonorrhoeae, comparative genomic analysis of wild type strain MS11 (Kupsch et al. 1993. EMBO J. 12:641-650) and its spontaneous mutants MS11-R1 and MS11-R2 was performed. For this purpose, we determined the draft genome sequences of these three strains and compared them with regard to genome content and occurring mutations that could possibly be involved in the quinolone resistance of the isolates.