Zeb2 regulates differentiation of long-lived effector of invariant NKT cells
Some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells after ligand stimulation. However, the regulation from the effector phase to the memory phase has not been elucidated. We here report the crucial transcriptional regulation by Zeb2 in establishment of the memory iNKT phase through driving differentiation of Klrg1+ Cx3cr1+GzmA+ iNKT population.