Spatial transcriptomic analysis of brain in a mouse model of chronic kidney disease
This project aims to elucidate the mechanisms of central nervous system damage in chronic kidney disease (CKD). Spatial transcriptomics with Visium was performed on FFPE sections (5 Âµm) of brain tissue from a mouse model of CKD (12 weeks on adenine diet), a CKD model with vascular calcification (6 weeks on adenine diet + 6 weeks on adenine diet with high phosphate diet) and control C57BL/6J mice (12 weeks on normal diet).