PD-1-PD-L1 Axis Activation Suppresses CD8+ T Cells and Improves Nephritis [scRNA-seq, scTCR-seq]
To dissect whether PD-1+CD8+ T cells are exhausted in lupus nephritis, scRNA-seq were performed to define the heterogeneous and pathologic subset. Overall design: Splenic and kidney-infiltrating PD-1+CD8+ T cells were sorted for scRNA and scTCR sequencing.