Crosstalk between CD8+ T cells and systemic bile acid metabolism shapes antiviral immunity and immunopathology during chronic LCMV infection
his study contains 16S rRNA gene sequencing data generated from a mouse model of chronic viral hepatitis. Lymphocytic choriomeningitis virus (LCMV) infection was used to induce immune-mediated liver injury and associated alterations in bile acid metabolism. The study assesses changes in BA metabolism and its possible connection to BSH-expressing gut microbial species. Moreover, using either pharmacological or genetic disruptions of bile acid transporters, LCMV induced a differential antiviral immune response based on the deficient hepatic bile acid transporter, resulting in altered immune responses and immunopathologies. Collectively, this study highlights how immuno-metabolic changes in viral hepatitis may affect the body's ability to fight the underlying viral infection. Sequencing was performed at the Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna under the project ID JMF-2202-03.