JunB-HBZ nuclear translocation by TGF-beta is a key driver in HTLV-1-mediated leukemogenesis
RNA-Seq and ChIP-Seq analysis revealed that TGF-beta promotes HBZ and JunB expression, which is associated with ATL oncogenesis. However, HTLV-1-infected non-leukemic clone cell lines show no response to TGF-beta stimulation.