Single-cell transcriptomic profiling of mouse kidneys with cisplatin-induced acute kidney injury
This dataset contains single cell RNA sequencing data of immune cells isolated from whole blood collected via cardiac puncture in a mouse model of cisplatin-induced acute kidney injury (AKI). Following cisplatin administration, mice were intravenously treated with either phosphate-buffered saline (PBS), extracellular vesicles derived from unmodified mesenchymal stem cells (naive EVs), or extracellular vesicles expressing the SIRP alpha protein (SIRP-EV). This dataset was generated to analyze the immunomodulatory effects of extracellular vesicles expressing the SIRP alpha protein on circulating immune cells, particularly the myeloid cell population, under AKI conditions at the single-cell transcriptomic level.