Danio rerio Raw sequence reads
In teleost, type I IFNs are categorized into 2 subgroups containing one or two pairs of disulphide bond. However, their functional differences have not been fully unveiled. It has been shown that IFN1 can be induced by viruses and trigger strong antiviral response in inducing hundreds of IFN stimulated genes , conferring cell resistance to viruses. However, the antiviral functions of IFN4 have been debated. To investigate the genes modulated by IFN1 and IFN4, ZF4 cells were stimulated with recombinant IFN1 and IFN4, and were performed transcriptome analysis of the small RNA.