RNA-seq data from ARPE-19 cellular senescence models.
This study investigates the role of STAT1 as a central transcriptional regulator of cellular senescence in retinal pigment epithelial cells. Using RNA sequencing, we profiled transcriptomic changes induced by STAT1 overexpression in ARPE-19 cells and compared them with those observed in oxidative stress induced senescence models. Differential expression and pathway enrichment analyses were performed to evaluate the extent to which STAT1 activation recapitulates senescence associated transcriptional programs. The dataset reveals strong concordance between STAT1 driven gene expression changes and canonical senescence signatures, particularly involving interferon signaling, immune activation, and inflammatory pathways. These data provide a resource for investigating STAT1 mediated regulatory networks in retinal aging and cellular senescence and may support future studies of inflammation related degenerative processes in the retina.