Effect of Fibrosis in FMO3 Knockout Mice in a bleomycin-induced fibrosis Model
FMO3 knockout attenuates bleomycin-induced lung fibrosis Overall design: Female C57BL/6J mice (8–12 weeks old) and FMO3 knockout mice (C57BL/6J-Fmo3^em1Bdgr/J; strain #037364) were obtained from The Jackson Laboratory.  Mice received daily subcutaneous (s.c.) injections of bleomycin (10 mg/kg/day) or phosphate-buffered saline (PBS) for 10 days (5 days per week). Animals were euthanized on day 22, and lung were used for RNA isolation.