Effect of polyIC administration on gene expression in decidual tissues of E13.5 mice
Previous research indicate that maternal immune activation (MIA) correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Our data sugests that aberrant decidual NK cells are required for MIA-induced neurodevelopment and behavioral disorders. To determine what triggers dNK cells to react to MIA at the maternal-fetal interface, we evaluated the DEGs of decidua tissue samples from dams triggered with polyIC or saline control. Overall design: Decidual tissues were isolated from saline- or polyIC-treated dams at E13.5 for whole-genome transcriptome analyses by RNA-seq.