Differential microRNA profiles associated with the hydroxyurea-inducible SAR1A gene
We used small-RNA sequencing to carry out the first comprehensive survey of miRNAs expressed in SAR1A-knockout K562 cells without or with HU treatment and assessed their potential functions related to HbF induction. our findings suggest a profile of dysregulated miRNAs associated with SAR1A downregulation which may influence HbF expression directly or indirectly targeting the transcription factors linked to gamma-globin gene regulation. Overall design: small RNA-Seq profiling of wildtype K562 cells and SAR1A-knockout K562 cells without or with HU treatment