Microglial Ccl4-Ccr5 Signaling Links Systemic Inflammation to Synaptic Loss and Memory Deficits in Chronic Kidney Disease
Chronic kidney disease (CKD) is increasingly associated with cognitive impairment, yet the molecular pathways connecting systemic inflammation to synaptic dysfunction remain unclear. This study investigates the role of the Ccl4-Ccr5 axis in microglia-mediated synaptic phagocytosis during CKD-associated cognitive decline