Colistin-resistance mediated by PhoQ sensor histidine kinase mutagenesis in a clinical Enterobacter cloacae
A disrupted variant of PhoQ in the colistin-resistant strain was characterized by deleterious mutations within TM1 (A22P, A23P) and HAMP linker domain (S260_E261insER), possibly contributing to a hyperactive “locked-on” state.