RNA seq data of sorafenib resistant HepG2 cells
To investigate the molecular mechanism of ferroptosis resistance in HCC, we applied sorafenib, one of the class I ferroptosis inducers (FINs), to generate HepG2 sorafenib resistant (SR) cells. Overall design: Sorafenib-resistant cell line were constructed using the hepatocellular carcinoma cell line HepG2. Cells were treated with 2.5 µM sorafenib as the initial concentration, each increase was 0.5µM when the cells tolerated. The final concentration is 7µM and the cells can proliferate normally.