Hematopoietic stem cell membrane-coated vesicles for targeted drug delivery to the bone marrow and elimination of leukemia cells
In order to study the mechanism of apoptosis of leukemia cells induced by HSC-lipo, we conducted transcriptome sequencing of leukemia cells treated with HSC-lipo. Overall design: Leukemia cells were incubated with free chemotherapeutic drugs, Ara-C@Lipo and Ara-C@HSPC-Lipo, respectively. After 24h, cells were collected and RNA was extracted for transcriptome sequencing.