B CELL RECEPTOR IMMUNOGLOBULIN GENE REPERTOIRE PROFILES POST-INFECTION VERSUS POST-VACCINATION AGAINST SARS-CoV-2
Published evidence supports significant heterogeneity of immune responses among individuals infected with or vaccinated against SARS-CoV-2. This highlights the need for in-depth investigation of the implicated processes towards refined understanding and improved management of COVID-19. The main objective of the present study was to investigate the dynamics of B-cell responses to SARS-CoV-2, focusing on how initial infection and subsequent vaccination influence the immunoglobulin gene repertoire, with special emphasis on the impact of somatic hypermutation (SHM) on antibody maturation.