Multi-omics maps the epigenetic drivers of metabolic dysfunction-associated steatohepatitis in liver of non-human primate model
Here, we utilize an integrative multi-omics approach (ChIP-seq, and DNA methylation sequencing) to systematically map the epigenetic landscape of MASH using a non-human primate model that closely recapitulates human pathophysiology. We identify widespread alterations in DNA methylation, and histone modifications (H3K4me3, H3K27ac, H3K27me3).