Multiple approaches for massively parallel sequencing of SARS-CoV-2 samples
COVID-19 has caused a major epidemic worldwide, however, much is yet to be known about the epidemiology and evolution of the virus. One reason is that the challenges underneath sequencing SARS-CoV-2 directly from clinical samples have not been completely tackled. Here we expound the application of amplicon and hybrid capture (capture)-based sequencing, as well as ultra-high-throughput metatranscriptomic (meta) sequencing in retrieving complete genomes, inter-individual and intra-individual variations of SARS-CoV-2.