Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Cardiometabolic heart failure with preserved ejection fraction (cHFpEF) is highly prevalent and associated with a poor outcome. Pathological gene expressions in heart failure are accompanied by changes in active histone marks without major alterations in DNA methylation.  Whether chromatin modifications participate to obesity-induced HFpEF is largely unknown. We will investigate whether chromatin marks participate to obesity-induced HFpEF in vivo. Overall design: RNA-seq in cardiomyocytes obtained from Control and HFpEF with and without SET7 knockout hearts were analyzed