Effects of Cannabidiol and Tetrahydrocannabinol on Gut Microbiota in Mice Infected with Trichinella spiralis
This study investigated how the cannabinoids cannabidiol and tetrahydrocannabinol influence gut microbiota in mice infected with Trichinella spiralis. Because both helminth infections and cannabinoids can modulate immune responses and microbial communities, understanding their combined effects is important for clarifying host parasite microbiota interactions. Using a murine model with infected and uninfected groups treated with CBD or THC, we analyzed microbiota profiles over time through 16S rRNA sequencing. The study provides insight into how CBD helps maintain microbial stability while THC induces dynamic compositional changes, highlighting the broader relevance of cannabinoid exposure for microbiome regulation during helminth infection.