Berberine utilizing bacteria
Plants produce a wide range of specific secondary metabolites in response to various environmental stresses, particularly biological stresses. These compounds show strong biological activities and high stability against degradation by microbes and animals. Berberine, a benzylisoquinoline alkaloid, is found in many plant species and exhibits potent antimicrobial activity, often being included in traditional herbal medicines. We investigate how berberine is degraded in nature and isolate bacteria that utilize it. We are searching for bacteria responsible for the degradation of naturally occurring alkaloids.