Metastatic potential in clonal melanomal cells is driven by a rare, early-invading subpopulation [RNA-Seq]
To investigate the molecular basis driving a highly invasive phenotype of a rare subpopulation of melanoma cells; The highly invasive phenotype was regulated by the NKX2.2 transcription factor and it was marked by transiently high levels of SEMA3C. Overall design: We performed gene expression profiling analysis using data obtained from RNA-seq of parental and NKX2.2 knockout FS4 and 1205Lu melanoma cell lines.