Multi-omics analysis reveals the effects of brown seaweed residue hydrolysate on intestinal lipid metabolism in large yellow croaker (Larimichthys crocea)
This study aims to systematically investigate the effects of dietary supplementation with brown seaweed residue hydrolysate (BSRH) on intestinal lipid metabolism in large yellow croaker (*Larimichthys crocea*), a species of significant economic importance in Chinese aquaculture. The research is motivated by the challenges of visceral fat accumulation and disease outbreaks in intensified farming, which lead to substantial economic losses. Using a multi-omics approach integrating transcriptomics, metabolomics, and metagenomics, the study seeks to elucidate the underlying regulatory mechanisms by which BSRH modulates host gene expression, metabolite profiles, and gut microbiota composition. The findings are highly relevant as they provide a scientific foundation for developing BSRH as an eco-friendly feed additive to improve lipid metabolism and overall health in farmed fish, while also promoting the high-value utilization of seaweed processing by-products.