ChIP-seq for beta-catenin, EZH2, EED, KMT2B, H3K4me3, H3K27me3 and sequential chipseq
Genome-wide measurements of histone modifications and transcripton factors binding in different prostate cancer clinical tumors tissue, PDX tumor, and cell models to study the tumor lineage plasticity and chromatin bivalency. Overall design: ChIP-seq for different histone marks and transcriptional factors in LNCaP_42D, LuCaP_77_ENZR, LuCaP_35CR, MyC-CaPCR, C4-2B, LNCaP and clinical tumor tissue samples.