Effect of Chenpi on Liver Lipid Metabolism in a High-Fat Diet
Hepatic transcriptomics is a specialized area of research dedicated to mapping and analyzing the dynamic landscape of gene expression in liver tissues, aiming to elucidate how transcriptional programs regulate hepatic functions and contribute to disease pathogenesis. This field leverages advanced technologies such as RNA sequencing (RNA-seq) and microarray platforms to capture comprehensive transcriptomic profiles, enabling the identification of differentially expressed genes under varying physiological, pathological, or environmental conditions. Through computational approaches like weighted gene co-expression network analysis (WGCNA) and machine learning algorithms, researchers uncover functional modules, key regulatory hubs, and potential biomarkers associated with liver disorders. Integrative studies often combine transcriptomic data with epigenomic, proteomic, or metabolomic datasets to reconstruct multi-layered regulatory networks, offering insights into gene-environment interactions and drug response mechanisms. By validating candidate genes through loss/gain-of-function experiments and patient-derived models, hepatic transcriptomics not only advances understanding of liver biology but also accelerates the development of precision therapies for conditions such as non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. This systems-level approach bridges basic science and clinical translation, paving the way for personalized diagnostic and therapeutic strategies.