Spatial immune landscape of large artery atherosclerotic and cardioembolic thrombus retrieved from mechanical thrombectomy
Cardioembolic (CE) and large artery atherosclerosis (LAA) strokes are two main causes of acute ischemic stroke (AIS), carrying a high risk of recurrence. This study investigated the immune cell-specific role in thrombosis between CE and LAA stroke using NanoString GeoMX Digital Spatial Profiler. Overall design: Thrombi from AIS patients who underwent mechanical thrombectomy were fixed in 4% paraformaldehyde, embedded in paraffin. The Formalin-fixed paraffin-embedded tissue sections were used for Nanostring's GeoMX Whole Transcriptome Atlas Digital Spatial Profiling.