Oxygen-Sensing KDM6A Regulates Chondrocyte-to-Osteoblast Transdifferentiation and Accelerates Fracture Healing
Recent evidence suggests that a subset of hypertrophic chondrocytes can transdifferentiate into osteoblasts, contributing to bone regeneration. The local oxygen microenvironment and the oxygen-sensing histone demethylase KDM6A are hypothesized to play pivotal roles in regulating this process, yet the underlying mechanisms remain unclear.