Nervous system injury establishes a microenvironment sufficient for brain tumor formation
To investigate the mechanism by which optic nerve crush induces microglia Ccl5 production, we performed bulk RNA sequencing on isolated optic nerves from crush- and sham-treatedNf1flox/flox;hGFAP-Cre miceat 3 months of age. Overall design: Comparative gene expression analysis using buk RNA-seq data from optic nerves of 3 crush-treated mice vs 3 sham-treated (control) mice