Metagenomic profiles of the antimicrobial resistance in traditional Chinese fermented meat products: Core resistome and co-occurrence patterns
In this study, we collected 27 samples of fermented pork products from 11 major production areas in China, spanning diverse anthropogenic environments and fermentation processes. Using a metagenomics-based approach, we identified the diversity and composition of ARG, BMRG and MGE in these samples. We then conducted core resistome analysis (identification of high-abundance genes detected in most samples of fermented meat products) and random forest modelling to identify indicator genes associated with resistance contamination of these fermented meat products. Finally, we analysed the host bacteria of the core resistome of fermented meat products to restore the original pattern of resistance groups in the samples. Our study provides important targets for the detection and control of resistance genes and antimicrobial resistance in fermented meat products.