Children microbiome
Probiotics, known for their potential health benefits, notably regarding gut health and immune enhancement, have garnered limited attention concerning individual variability in the responses to these microorganisms. This study, encompassing children aged 0-12 years, was conducted to explore the influence of oral and gut microbiome types on the responsiveness to probiotics. The findings unveiled distinct ecosystems within the oral and gut microbiomes, showcasing varied reactions to probiotics among diverse microbiome communities. The oral microbiome type 1 (OT1) group, characterized by a predominance of Streptococcus, exhibited an amplified a-diversity following probiotic intake. Conversely, the oral microbiome type 2 (OT2) group, marked by Prevotella dominance, displayed notable alterations in ß-diversity values, coinciding with a reduction in the relative abundance of Prevotella. These shifts also extended to influence the metabolic potential of the oral microbiome after probiotic supplementation. The gut microbiome type 1 (GT1) group, primarily dominated by Bacteroides, demonstrated substantial alterations in ß-diversity values alongside heightened a-diversity subsequent to probiotic consumption. In contrast, the gut microbiome type 2 (GT2) group, characterized by Faecalibacterium dominance, exhibited less pronounced disparities before and after probiotic intervention, diverging notably from the GT1 group. Furthermore, differences in gut microbial types showed a distinct response in the metabolic prediction of the gut microbiome after probiotic administration. In conclusion, this study illuminates the diverse responses of oral and gut microbiomes to probiotics, providing valuable insights into their intricate relationships and potential health implications, which may aid in tailoring probiotic interventions for specific microbiome profiles.