Whole genome sequencing and analysis of common marmosets (Callithrix jacchus)
In this project, the Baylor College of Medicine HumanGenome Sequencing Center is performing whole genome sequencing and analysisof common marmosets (Callithrix jacchus). Marmosets are used for a variety ofbiomedical research studies, including but not limited to neuroscience,cognition and behavior, reproductive biology, parental behavior and infantdevelopment, endocrinology and other fields. The Baylor genome center isgenerating 30x whole genome sequence coverage using Illumina Nova-Seqsequencing methods, and using standard software tools to map reads, identifysingle nucleotide variants and annotate variants where possible. DNA samplesfor sequencing are currently provided by Dr. Jon Levine (Wisconsin NationalPrimate Research Center), Dr. Corrine Ross (Southwest National PrimateResearch Center). We intend to include other marmoset colonies as samplesbecome available. These data will be used to assist in the genetic managementof marmoset breeding colonies, identify potentially functional geneticvariants, attempt to identify new spontaneous genetic mutations that lead tonew models of genetic disease and evaluate genetic differences among captiveresearch colonies of marmosets, as well as differences between captive andwild marmoset populations.