Exploring the molecular mechanism of cafestol regulating the OLR1/NLRP3 'lipid-inflammatory' pathway to alleviate ulcerative colitis
Cafestol is a natural diterpene compound extracted from coffee beans with various pharmacological activities such as anti-inflammatory, anti-cancer and antioxidant. However, its therapeutic role and underlying mechanisms for ulcerative colitis (UC) still need to be elucidated.In order to explore the alleviation effect of cafestol on UC and its mechanism.We had built a model of UC mice by using DSS. Then, to investigate the effect of cafestol intervention on DSS-induced ecological changes in the flora of UC mice, we subjected faecal samples from six groups of mice to high-throughput 16s rRNA sequencing to determine the structure and composition of their gut flora.