Transcriptome sequencing of Lycoris species at 5 growing stages
Galantamine, a clinically valuable Amaryllidaceae alkaloid used to treat Alzheimer disease, exhibits striking variations in accumulation among Lycoris species, yet the underlying biosynthetic mechanisms remain obscure. Here, we integrate metabolomics, transcriptomics, and functional assays, and reveal that Lycoris longituba, rich in galantamine, shows coordinated enrichment of isoquinoline alkaloid biosynthesis genes.