RNA sequencing data from wild type and Mst1/2 knockout esophageal epithelium
Hippo signaling regulates the homeostasis of multiple organs. Mst1 and Mst2 (Mst1/2) are critical components of the Hippo signaling pathway. Here, we utilized RNA sequencing to determine the transcriptional change in the esophageal epithelium upon Mst1/2 deletion. The analysis of gene expression profiles allows us to understand the role of Mst1/2 in the regulation of various biological processes in the esophageal epithelium. Overall design: Wild type (WT) and p63CreERT2;Mst1loxp/loxp;Mst2-/- (KO) mice were administered 3 doses of tamoxifen every 2 weeks. RNA was extracted from the esophageal epithelium after around 8 weeks and sequenced.