Candida albicans resistance to hypochlorous acid
Hypochlorous acid (HOCl), commonly known as bleach, is generated during the respiratory burst by phagocytes and is a key weapon used to attack C. albicans and other microbial pathogens. To better understand how C. albicans respond to HOCl, we carried out RNA-seq analysis to identify the genes that are regulated by this oxidant. For comparison, we also analyzed the effects on transcription when cells were treated with H2O2 or with benzoquinone, which are chemically very different from HOCl.