The role of CMTM3 in a sepsis mouse model
Sepsis is a life-threatening condition characterized by an imbalanced immune response to infection, leading to multiple organ dysfunction. It has a high incidence and mortality rate. CMTM3 is a member of the CKLF-like MARVEL transmembrane domain (CMTM) gene superfamily, and it is widely expressed in the immune system, playing a critical role in immune response. However, the precise role of CMTM3 in sepsis remains yet to be determined. Overall design: To investigate the role of CMTM3 in sepsis, we generated Cmtm3 knock-out mice. Subsequently, we induced sepsis in both Cmtm3 wild-type and knock-out mice by performing cecal ligation and puncture (CLP) surgery. After 24 hours of modeling, we isolated bone marrow cells for transcriptome sequencing.