Bulk RNA sequencing of human ALS spinal cords
There remains a poor understanding of cell-specific responses in the human ALS spinal cord, including differences in cell type composition, changes in cell state, and contribution of various cell types to neuroinflammation. Overall design: Transcriptomic analysis of postmortem cervical spinal cord samples from 8 people with ALS (6 sporadic and 2 familial cases) and 4 age-matched non-neurological controls