Opposite strategies targeting Tmem176b from cancer cells or in T cells to improve the efficacy of cancer immunotherapies
expression profiling by high throughput sequencing,mouse CAR-T cells with retrovirus transduction with (CART-TOE) or without (CART-Vect) Tmem176b over-expressing were harvest, and 14 days after adoptive transfer to B16F10-bearing Rag1-/- mice, intratumoural CAR-T cells were isolated for RNA bulk sequencing.