PdgfrB signaling alters the beige adipogenic niche
Ageing beige adipose progenitor cells overexpress platelet derived growth factor receptor beta (PdgfrB) to prevent beige adipogenesis. Genetically deleting PdgfrB in restores beige adipocyte generation whereas activating PdgfrB in juvenile mice blocks beige fat formation. Overall design: Comparative gene expression profile analysis of RNA-Seq data between 2 and 12 month old control mice, as well as 12 month old control and SMA-PdgfrB knock out mice