Effect of GNAS mutation on the gene expression of HCT116 colon cancer cell line
To investigate the effect of activating GNAS mutation on gene expression of colorectal cancer cells, we utilized the GNAS R201C knockin cell line produced by Horizon Discovery Ltd. We compared the gene expression of parental and GNAS R201C/+ HCT116 cells with RNA-Seq, using four biological replicates. Overall design: Comparative gene expression profiling analysis of RNA-seq data for parental HCT116 cell line and its GNAS mutant derivative.