Expression data of primary liver sinusoidal endothelial cells from wild type and LSECs-specific TGF-beta R2 knock out mice
Liver sinusoidal endothelial cells (LSECs) form discontinuous, permeable microvessels, and their characteristic gene expression profile is significantly different from that of continuous microvascular endothelial cells. LSECs play a significant role in maintaining liver homeostasis. The TGF-beta signaling pathway plays a pivotal role in regulating the proliferation and differentiation of LSECs during liver homeostasis. Therefore, we utilized LSEC-specific TGF-beta signaling blockade mice and wild type mice, isolating their primary LSECs to obtain their gene expression profiles.