A systematic survey of PRMT interactomes reveals key roles of arginine methylation in the global control of RNA splicing and translation [Poly-Seq]
To examine how PRMT inhibitions affect the translation of different mRNAs, we sequenced the mRNA population associated with different ribosomal fractions after treatment of PRMT1 and PRMT4 inhibitors Overall design: DMSO or Inhibitor-treated HEK293T cells were subjected to polysome profiling. Different polysome profiling fractions bound with indicated ribosomes were analyzed with RNA-seq to test translation alteration under PRMT inhibition.