mNGS Diagnosis of Disseminated Cutaneous Mycobacterium Avium Complex (MAC) Infection in an Immunocompetent Patient
Background: Mycobacterium avium complex (MAC) infection primarily affects immunocompromised individuals, and disseminated cutaneous MAC infection in immunocompetent patients is rarely reported.Methods: We collected skin tissue samples from an immunocompetent patient with disseminated cutaneous lesions, and performed Q-mNGS™ 3.0 (a metagenomic next-generation sequencing assay) to identify the pathogen.Results: MAC was detected as the dominant pathogen (175,555 specific sequences, relative abundance 55.36%) via mNGS, and the patient achieved clinical cure after triple antibiotic therapy (clarithromycin + doxycycline + levofloxacin).Conclusion: mNGS is a valuable tool for the diagnosis of rare cutaneous MAC infection in immunocompetent patients, supporting targeted clinical treatment.