Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [EPIC]
To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation. Overall design: We performed EPIC (methyl-capture) in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas.