CRISPR screen of La2O3 Nanoparticles
Functional genomics assessment of La2O3 nanoparticles, including La2O3 spheres and rods, reveals the molecular mechanisms of rare earth oxides-induced immune cells toxicity. We utilized a CRISPR-based genome-scale knockout approach to identify genes involved in the biotransformation of rare earth oxide nanoparticles. Biotransformation of REOs in lysosomes could be genetically controlled via SMPD1.