Genomic profiling of biocontrol Streptomyces UC1A-3 with activity against bacterial wilt in tomato and eggplant
Whole genome sequencing and analysis revealed the genetic basis for its plant growth-promoting and biocontrol capabilities, identifying 27 biosynthetic gene clusters (BGCs) including non-ribosomal peptide synthetases (NRPS), polyketide synthases (PKS), and terpene clusters, several of which represent potentially novel metabolic pathways. Metabolomic profiling through GNPS-based molecular networking identified diverse bioactive metabolites including siderophores (ferrioxamine B, dehydroxynocardamine), peptides, oxylipins, and terpene glycosides with ß-carboline-like features, alongside numerous unannotated compounds suggesting new congeners.