HGT in LifelineDeep cohort
Horizontal gene transfer (HGT) is a major driver of bacterial evolution, but its role in shaping the human gut microbiome over time remains poorly understood. Here, we present a longitudinal metagenomic analysis of 676 fecal samples from 338 individuals collected ~4 years apart, using a newly developed workflow to detect recent HGT events from metagenome-assembled genomes.