ATF4-Histone 2-Hydroxyisobutyrylation Feedback Loop Drives Sepsis-Induced Inflammation
The roles and mechanism of lysine histone 2-hydroxyisobutyrylation (khib) in the acute inflammation phase of sepsis remain unknown. We aimed to investigate the roles and underlying mechanisms of histone H4K5-khib (H4K5-hib) in sepsis-induced inflammation models in vivo and in vitro.