Differential cell cycle control by oscillatory versus sustained Hes1 expression
To understand the mechanism by which Hes1 differentially regulates NSC proliferation depending on its expression patterns, we performed RNA-seq analyses comparing between wild-type eNSCs and Hes1;Hes3;Hes5;Hey1 knockout (KO) eNSCs, and between wild-type and Hes1-overexpressing NS5 cells.