Integrated Analysis of DNA Methylome and Renal Pathology in a Diabetic Nephropathy Rat Model Treated with Enalapril-Folic Acid (PRJCA045868)
This project investigates the epigenetic mechanisms of Enalapril-Folic Acid combination therapy for diabetic nephropathy (DN) using a rat model. STZ-induced diabetic male Wistar rats were divided into normal controls, high-methionine diet models (HM+STZ), and treatment group (EM+FA) receiving both high-methionine diet and Enalapril-Folic Acid. After 12 weeks, renal tissues underwent RRBS analysis on Illumina HiSeq 4000.The dataset includes raw RRBS sequencing data (FASTQ) and analyzed methylation profiles, revealing differential methylation patterns among groups. These findings provide insights into DN's epigenetic regulation and the therapy's mechanism, aiding identification of novel epigenetic biomarkers and therapeutic targets for diabetic kidney disease.