Does the Distribution of Antibiotic Resistance Differ Between Antibiotic-Degrading and Non-Degrading Microbial Communities in Different Soils
This study aims to explore A, the differences in the ARG profiles of ADB across distinct soil types. B, whether variations in MGE abundance and ARG transmission efficiency between ADB and NADB are regulated by soil-specific degradation functions; and C, the correlation between ARGs and human pathogenic bacteria in ADB and their potential biosafety risks. This study will elucidate novel mechanisms by which soil microbes' functional interactions regulate ARG dissemination risks through adaptive strategies such as resistance genotype-degradation phenotype coupling. The findings will provide theoretical insights for developing region-specific strategies for antibiotic pollution control.