RNA-seq profiling of mouse testicular tissue in control and high-dose lithium exposure groups
This BioProject includes RNA-seq data from mouse testicular tissue collected after subchronic lithium exposure. Male mice were acclimatized for 7 days and then treated by daily oral gavage for 35 days. The submitted transcriptomic dataset comprises samples from the control group (CON) and the high-dose lithium group (Li-H). Mice in the Li-H group were exposed to lithium at 25 mg Li/kg/day (equivalent to 155 mg LiCl/kg/day), representing 500-fold the real environmental exposure dose (REED, 0.05 mg Li/kg/day). The aim of this project is to identify differentially expressed genes and transcriptional pathways associated with lithium-induced testicular toxicity.