Genetic variation of Aspergillus fumigatus in patients with cystic fibrosis during chronic infections
Cystic fibrosis is a genetic disorder leading to thick, sticky mucus production that affects the lungs. It results in chronic respiratory infections including infection by the fungal pathogen Aspergillus fumigatus. In this study chronic and transient Aspergillus fumigatus infection isolates from cystic fibrosis patients were isolated. Their phenotypes and genotypes were studied to uncover the adaptation of Aspergillus fumigatus to the human host during infection and to better understand the characteristics that make Aspergillus fumigatus a successful pathogen.