Transcriptome profiling of urothelial cells after exposure to low-grade oxidative stress
In this study, we aimed to determine the overall effect of glucose oxidase (GO) on transcriptomic profile of urothelial cells using RNA sequencing. Our study represents a reference database that could lead to a better understanding of the link between oxidative stress and innate immune response of urothelial cells leading to continuous cycle of inflammation in IC/BPS pathology. Furthermore, the study sets grounds for future studies exploring potential biomarkers and therapeutic targets for IC/PBS diagnosis and treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for SV-HUC1 normal urothelial cell line (untreated vs glucose oxidase-treated, four independent experiments).