Transcriptomes of polarized naked mole-rat bone marrow-derived macrophages
The study focused on phenotypical and functional characterization of primary naked mole-rat macrophages under polarizing stimuli (LPS/IFN-gamma or IL-4) in comparison with pro- and anti-inflammatory populations of mouse bone marrow-derived macrophages. RNA-sequencing of M0 (control), M1 (LPS/IFN-gamma), and M2 (IL-4) cells from 21-day differentiated naked mole-rat bone marrow-derived macrophage cultures was performed.