Effect of medermycin on TNF-alpha mediated inflammatory cytokine expression in synovial cells
Synovial inflammation contribute to osteoarthritis pathology. Medermycin was isolated from Streptomyces sp. K73 and have antibiotic active against Gram-positive bacteria. Additionally, medermycin exhibits anticancer activity. It has been found that medermycin inhibits the serine/threonine kinase AKT/PKB activity. Akt singnaling modulates NF-kB activation involved in stimulating transcriptional activity of inflammatory processes. We hypothesized that MED may have anti-inflammatory effect via to Akt inhibition in synovial cells. Here, we investigated the effect of medermycin on inflammatory reaction and its mechanism on human synovial fibroblasts.