A three-dimensional ex vivo model recapitulates in vivo features and unravels increased drug resistance in childhood acute lymphoblastic leukemia
Single cell RNA sequencing of ex vivo 3D cocultures with MSCs, ECs and ALL PDXs to evaluate their interdependance Overall design: 3D ex vivo vascular-like structures(MSC-HUVEC) were co-cultured with acute lymphoblastic leukemic pateint-derived xenograft cells for 72hours