Analysis and Development of Application Platform of Valuable Marine Microbial Genome (KAP220272)
Conservation of Marine Fisheries Biological Resources and Establishment of Industrial Utilization Foundation through Genetic Research on Marine Fisheries Living Resources. Establishment of standard genomes of 70 species of marine marine life. Establishment of useful genes based on genomic information of marine aquatic organisms. Management and operation of genomic information of marine aquatic organisms. Production, analysis, management, utilization, and training of professional human resources of marine aquatic organisms. Establishment of a standardized system for utilizing genomic information of marine aquatic organisms. Securing genomic structures/information on 17 marine animals and 10 strategic species. A Study on the Key Principles of Evolution through Comparative Genetic Analysis of Marine Animals. Functional analysis of marine animal gene groups in response to changes in the marine environment (salinity, water temperature, pH). Establishment of marine life sovereignty through the detoxification of marine animal genomes on Dokdo. Biological Characteristics of Marine Animal Origin Proteins. Establishment of standard genomes through genomic detoxification of 20 marine plants. Genome study of economical brown algae (komba and motherland), red algae, green algae, live silicon synthetic species, and large-scale marine algae. Research on gene search and application related to bioactive substances in marine plants. Exploring useful genes and studying the usefulness of marine plants. Establishment of standard genomes for aquatic organisms and investigation of genomic characteristics. Development of useful genes and genetic markers related to major economic traits (disease, growth, etc.). Exploring useful gene functions. Establishment of a data platform specializing in marine life. Discover functional biomaterials based on genomic big data. Comparative genomic analysis based on marine organisms. Integrated management of genetic data and analysis results of marine aquatic organisms. Securing genomic information of various marine and fishery organisms at home and abroad. Establishment of research results database and big data analysis-based service for utilizing genomic information. Development of specialized education programs and conducting education and training. Establish the basis for genome-related analysis by processing genetic information of 40 major marine aquatic organisms through assembly work. 40 species of marine marine life, assembly notification. Visualizing genomic information to visually grasp genetic information of marine aquatic life (40 types of Genome Browser construction). Genetic analysis of two species of silver flagellates and five new types of phytochrome candidate genes are discovered. Development of a photogenetic system based on algae (Nannochloropsis sp.) plant (baby pole, tobacco) and animal cell lines (derived from spinal cord, bone, kidney, and brain tissue). Development of a photogenetic system based on plant (baby intestines, tobacco) and animal cell lines (derived from spinal cord, bone, kidney, and brain tissue). Establishment of the standard genomic information of Amur starfish. Development of healthcare and regenerative medical materials based on genomic information (Octopus, Dolgi sea cucumber, Amur starfish). Development of customized material screening system based on genomic information (Octopus, Dolgi sea cucumber, Amur starfish). Select useful marine microbial strains through high-speed dielectric scanning of the new marine microbial strain library obtained. Decryption of electric field genomes of selected useful marine microorganisms (40 types). Obtain a library of biologically active substances such as large-capacity dielectric/transcriptional/metabolism and bioinformatics. Development of the efficient expression activation system and heterogeneous expression cell plant of giant BGC derived from marine microorganisms. Development of a new biological active substance production system based on synthetic biology and investigation of the production and structure of new biological active substances (over 28 types). Discovery of high functional physiologically active substances through activity evaluation (7 or more types). Establishment of source technology for structural deformation of synthetic biological active substances and derivation of leading substances for follow-up research and development through derivative synthesis/active optimization/volume production (at least one type). Detoxification of pathogenic (4) and standard (20) marine microorganism electric field genomes other than useful microorganisms (40 types). Discovery of more than 7 cases of protein that can be used industrially based on marine microorganism and identification of functions. Construction of a database of antibiotic resistance genes in the marine fisheries sector. Identification of resistance mechanisms through the use of antibiotic resistance information in marine fisheries. A Study on the possibility of transmission through comparative analysis of resistance genes between marine marine life and humans. The genetic information infrastructure performance developed in this project will be used as a source technology in industries and research fields such as new materials, useful ingredients, new drugs, bioenergy, environmental purification, fisheries, and new variety development.. It will be used to establish genetic-level sovereignty data for marine aquatic species cultivated, farmed, inhabited and utilized in Korea.. The useful genes developed through this project act as intellectual property rights. In particular, the genetic information infrastructure of strategic species will have the effect of building infrastructure for the development of new high-performance marine varieties.. Research on the use of useful genes and genetic information will have the effect of improving the value of marine fisheries resources and creating high value-added. In conclusion, the development results of this project will have the effect of establishing international sovereignty of marine marine life resources and converting marine marine life genome information resources for academic and industrial use.