Liver transcriptomics
To understand how dietary trans-fatty acids worsen Metabolic Dysfunction-Associated steatotic Liver Disease (MASLD) at a molecular level, we analyzed gene activity in the livers of mice. We compared mice fed a diet high in trans-fatty acids to those fed a control diet or a diet high in other fats. Our liver transcriptomics analysis revealed that trans-fatty acids profoundly disrupted the expression of hundreds of genes. These findings offer new mechanistic insights and highlight potential gene targets for future therapeutic strategies against diet-induced MASLD progression.