Disruption of the nucleocapsid-RNA condensation by Tannic acid is a broad-spectrum antiviral approach
SARS-CoV-2 infection triggers immune responses that can lead to severe disease. Identifying compounds that modulate these responses is critical for developing effective treatments. This study investigates the antiviral and immunomodulatory effects of Tannic acid in human A549 cells infected with SARS-CoV-2.In the in vitro experiments, A549 cells were treated with Tannic acid for 1 hour, followed by exposure to either viral RNA for 6 hours or SARS-CoV-2 nCoV-SH01 (MOI = 1) for 1 hour. Control groups consisted of cells exposed to viral RNA or SARS-CoV-2 without Tannic acid treatment. RNA sequencing was performed on total RNA extracted from treated and control cells to analyze gene expression changes associated with immune responses, inflammation, and viral replication.This study highlights the potential of Tannic acid to modulate immune responses, reduce inflammation, and inhibit viral replication during SARS-CoV-2 infection. These findings offer valuable insights for the development of antiviral therapies against COVID-19.