KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma
The goal of this study was to define functional and gene regulatory effects of KDM3A and Ets1, and their relationship to the PAX3/FOXO1 driver oncofusion, in fusion-positive Rhabdomyosarcoma. Overall design: RNA-seq was used to define the effects of KDM3A and Ets1 shRNA-mediated depletion on gene expression in the patient-derived fusion-positive Rhabdomyosarcoma cell lines Rh41 and Rh30.