Multi-omics analysis on overweight subjects under a caloric restriction intervention with fibre supplementation and placebo-controlled.
The objective of this study was to investigate the additive effects of combining energy restriction with dietary fibres on body weight control, lipid metabolism and gut microbiota composition. The study was a 12-week randomised, placebo-controlled, double-blinded, parallel intervention trial. A total of 80 overweight or obese participants were assigned randomly either to 10 g inulin plus 10 g resistant maltodextrin or to 20 g of placebo supplementation through 400 mL of milk a day, while on a - 500 kcal/day energy restricted diet.