RNA-seq analysis of CAFs and epithelial cells flow-sorted from PDAC tumors derived from the orthotopic transplantation of PDAC T-LOH KPC organoids in C57BL/6J mice following 2-week treatment with Neratinib or vehicle
We investigated changes in CAFs and epithelial cells flow-sorted from PDAC tumors derived from the orthotopic transplantation of PDAC T-LOH KPC organoids in C57BL/6J mice following 2-week treatment with Neratinib compared to vehicle Overall design: We compared CAFs flow-sorted from PDAC tumors following 2-week treatment with Neratinib compared to CAFs flow-sorted from PDAC tumors following 2-week treatment with vehicle. We also compared epithelial cells flow-sorted from PDAC tumors following 2-week treatment with Neratinib compared to epithelial cells flow-sorted from PDAC tumors following 2-week treatment with vehicle