Procyanidin B2 alleviates triphenyl phosphate-induced colon injury through TMIGD1/NF-kB/NLRP3 signal axis
This study aimed to investigate the mechanism of triphenyl phosphate (TPHP)-induced colon injury and the protective role of PCB2. In a mouse model, TPHP exposure caused colon shortening, barrier damage, inflammation, and oxidative stress, all of which were dose-dependently reversed by PCB2. RNA-seq analysis identified the NF-kB signaling pathway as a key pathway and highlighted Tmigd1 as a core differential gene.