Genomic Investigation of a Chikungunya Outbreak in Cambodia, 2020 to 2022
Analysis of 48 chikungunya virus genomes from Cambodia (2020 to 2022) revealed exclusive circulation of ECSA-IOL lineage with E1:K211E and E2:V264A mutations but absence of E1:A226V. Phylogenetic dating estimated origin around June 2017, indicating approximately 3 years of cryptic circulation before outbreak recognition. Findings underscore need for genomic surveillance.