Steamed root of Rehmannia glutinosa Libosch alleviates methotrexate chemotherapy induced intestinal mucositis by modulating gut microflora
Chemotherapy induced intestinal mucositis is a serious clinical problem in cancer patients for whom there are presently no viable treatments. Chemotherapeutic toxicity is diagnosed as Qi and Yin deficit in traditional Chinese medicine, and steamed root of Rehmannia glutinosa Libosch. Steamed root of Rehmannia glutinosa Liboschis widely recommended to these patients, and good curative effects have been obtained in TCM clinics. Since the relationship between gut microbiota dysbiosis and mucositis has received much attention recently, the current work aimed to investigate whether SRR may alleviate the mucositis caused by MTX chemotherapy by modulating intestinal microbiota.