Dapagliflozin protects against chronic heart failure in mice via inhibiting macrophage-mediated inflammation, independent of SGLT2 [scRNA-Seq]
The specific mechanism of sodium-glucose cotransporter 2 (SGLT2) inhibitor in heart failure (HF) needs to be elucidated.Based on single-cell RNA sequencing dapagliflozin causes significant differences in the gene expression profile of macrophages and fibroblasts. Overall design: Single cell RNA-sequence experiments: Heart tissues were harvested from mice 2 weeks post myocardial infarction (MI) surgery. sham surgery + NS (Sham-NS), MI + NS (MI-NS) , and MI + dapagliflozin (MI-DAPA).