SARS-CoV-2 Spike Protein Induces Salivary Gland Pathology in C57BL/6 Mice
This study examined the effects of SARS-CoV-2 spike protein on salivary gland function and local immune responses in healthy C57BL/6 mice, aiming to gain new mechanistic insights into SARS-CoV-2-induced salivary gland pathology with autoimmune features in human patients. Recombinant spike protein were injected directly into the submandibular glands of healthy C57BL/6 mice. Salivary secretion, histology, immune cell profiles, and transcriptomic changes were analyzed. This dataset contains bulk RNA-seq data from submandibular gland cells collected after spike protein or vehicle treatment.