HDAC6 deacetylates IDH1 to regulate the homeostasis of hematopoietic stem/progenitor cells [WGBS-seq]
In order to further explore the mechanism by which increased 5hmC inhibits expansion of LSK cells from Hdac6-/- murine primary BM cells, we performed WGBS-seq and oxWGBS-seq analysis using LSK cells isolated from Hdac6-/- and WT mice. Overall design: Comparative differentially methylated regions and differentially hydroxymethylated regions analysis in bone marrow hematopoietic stem/progenitor cells (LSK) of wild-type and HDAC6-deficient mice