Histone modification changes during RASMCs' transformation into macrophage-like cells
We report histone modification status of H3K4me1, H3K4me2, H3K4me3 and H3K27ac within rat vascular smooth muscle cell at de-differentiated state (induced by DAPT treatment), inflammatory state (induced by cholesterol treatment) and macrophage-like state (induced by combined treatment of DAPT and cholesterol) Overall design: Primary rat aortic smooth muscle cells were treated by NOTCH inhibitor DAPT, soluble cholesterol or both of them for 48 hrs to achieve cell state transformations