Effects of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomucetemcomitans on modeling subgingival microbiome.
Periodontitis is currently thought as a dysbiotic disease involving multiple-species microbiota. To be specific, bacteria colonized and assembled into physiologically compatible community through sophisticated signaling mechanisms. There was a dynamic balance exists between the host and the microbiota, internal microorganism community and external environmental changes can drive the shifts of eubiosis to dysbiosis within communities and finally predispose a site to diseaseCertain periodontal bacteria, such as Porphyromonas gingivalis, have been reported to shift the composition and phenotype of microbiota from a healthy/commensal microcosm to a dysbiotic one. The advent of novel molecular techniques to characterize the microbiome has dramatically changed our knowledge of microbial diversity, however, we are beyond the reach of the complex host-microbial and inter-microbial interactions that lead to disease and the experimental evidence in vitro was sparse. Thus, this study is aimed at figuring out the effects of of periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomucetemcomitans on modeling subgingival microbiome through 16S rRNA sequencing technology.