Discerning the roles of key cytokine signaling pathways in DS HN878 Mtb infection [dataset2]
We have found that drug-resistant (DR) Mtb infection alters the host pathogen interactions thought to occur during drug-sensitive (DS) Mtb infection. Recent data suggests that lack of IL-1, but not Type I IFN, signaling pathways leads to susceptibility to infection to DR Mtb infection. To understand the pathways involved in maintaining control of DS Mtb infection, we are sequencing the bulk lung cells early in infection. Overall design: Lung mRNA profiles of DS Mtb infected wt, Ifnar-/-, Il1r1-/-, and Ifnar-/- Il1r1-/- mice at 14 dpi