Differences of genomic profiles between NSCLC patients with and without osseous metastasis
In this study, we carried out targeted next-generation sequencing (NGS) of tumor tissues from NSCLC patients by a hybridization capture-based panel. The differences in somatic mutations, somatic interactions, key signaling pathways, functional biological information, and clinical actionability for the therapy of targeted agents were explored between advanced patients with and without osseous metastasis.