Reduction of neuronal activity mediated by blood-vessel regression in the adult brain
To explore the role of brain vascular TAK1 and its functional mechanism , we performed RNA-seq between Cdh5-CreER::Tak1fl/fl mice and their littermate control mice at the age of 12–14 weeks to identify the expression of some unique genes and possible pathway related to the function of brain vascular TAK1. We confirmed the role of brain vascular TAK1 contributed to Glutamate neuronal survival and activity. Overall design: Differential expression analysis and Gene Set Enrichment Analysis of RNA seq data. We performed differential expression analysis of RNA seq data obtained from Cdh5-CreER::Tak1fl/fl mice and their littermate control mice at the age of 12–14 weeks and Gene Set Enrichment Analysis