Effects of Light Fermented Tea on Age-Related Obesity
This study aims to systematically evaluate the metabolic intervention effects of light-fermented tea (ST) in an aged obese humanized mouse model, focusing on its comprehensive regulatory effects on the gut microbiome (including bacterial and phage communities), metabolite profiles, and host lipid metabolism and muscle function. Using fecal microbiota samples from aged individuals, the study will establish humanized male mouse models via FMT colonization. Combined with a high-fat diet to induce an aged obese phenotype, this approach will reveal the multidimensional mechanisms underlying ST's effects.