Applying cross-scale regulations to Sedum plumbizincicola and revealing by transcription
regulation regimes significantly regulated transcription genes of S. plumbizincicola. In general, function annotation illustrated cross-scale regulations significantly influenced microorganisms and metabolites in the rhizosphere and transcription genes of S. plumbizincicola to improve bioremediation efficiency through the promotion of plant growth and tolerance to environmental stress. Our integration of multi-omics provides comprehensive and deep insights into mechanisms in soil bioremediation, which would favor techniques advances.