Genome-wide analysis of differentially expressed mRNAs and lncRNAs during pseudorabies virus-induced encephalitis in a mouse model
This study provides a genome-wide transcriptomic analysis of brain tissues from a mouse model of pseudorabies virus (PRV)-induced encephalitis. Using high-throughput RNA sequencing, we examined the expression profiles of both messenger RNAs (mRNAs) and long non-coding RNAs (lncRNAs) to explore host responses to PRV infection. Mice were intranasally infected with PRV, and total RNA was isolated from the brains of infected and control groups. The results revealed significant changes in both coding and non-coding transcripts, offering insights into the molecular mechanisms of PRV neuropathogenesis and host immune regulation. This dataset serves as a valuable resource for understanding viral encephalitis and the functional roles of lncRNAs in neuroinflammation.