snATAC data analysis for Hidradentis Suppurativa patients' epidermis
In this study, we used single-nucleus ATAC-sequencing (snATAC-seq) to reveal how cellular heterogeneity of Hidradenitis Suppurativa (HS) lesional epidermis was reshaped at the genomic level. Overall design: The Institutional Review Board of the University of Alabama at Birmingham approved the protocol (IRB-300005214) for obtaining surgically discarded skin tissues from heathy and HS (Hurley II/III stage) subjects. Surgical excisions from 2 patients with HS (axillary and groin lesions) and 2 healthy controls (discarded tissue from breast or abdominoplasty reduction surgery) were collected.