Characterization of intestine specific TRPM6 knockout C57BL/6J mice: effects of short-term omeprazole treatment
The transient receptor potential melastatin type 6 (TRPM6) is a divalent cation channel pivotal for gatekeeping Mg2+ balance. To study the role of TRPM6 in the intestine, we generated mice lacking intestinal TRPM6 (Vill1-TRPM6-/-). In this study, the distal colon of Vill1-TRPM6-/- mice and of the control mice (TRPM6fl/fl) was subjected to RNA sequencing. Overall design: Total RNA from the distal colon of Vill1-TRPM6-/- and TRPM6fl/fl control mice following 1 day of low Mg2+ diet (0.02% w/w) was extracted. Furthermore, these RNA samples were subjected to RNA-sequencing.