Effects of microcystins on the liver of Pelodiscus sinensis
Microcystins, produced by cyanobacteria, are crucial toxins for aquatic livestock. As an important species in aquaculture, Pelodiscus sinensis is susceptible to microcystins. However, knowledge regarding the impacts and mechanisms of microcystins on P. sinensis, remains unclear. Comparative transcriptome analysis indicated that MC-LR significantly affected pathways such as the p53 signaling pathway, ferroptosis, apoptosis, autophagy, and lipid metabolism. Key regulatory genes identified include BAX, BID, GPx4, and P53. These findings indicated that MC-LR causes significant physiological interference in P. sinensis, potentially adversely affecting its long-term health and survival. These findings provide valuable data for understanding the toxicity of microcystins in P. sinensis and offer insights into the healthy aquaculture of this species.