Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models [organoid]
Performed transcriptomic analysis of BRAF K499E homozygous and wildtype organoid to investigate the molecular basis of BRAF K499E-induced learning and memory deficits. Overall design: 3 BRAF K499E homozygous organoid were compared to 3 wildtype organoid.