Effects of Probiotic Supplementation and Physical Exercise on Gut Microbiota in Pediatric Acute Lymphoblastic Leukemia Patients in Remission
This study investigates the independent effects of an 8-week physical exercise program and subsequent 8-week probiotic supplementation (Lacticaseibacillus paracasei) on gut microbiota composition in pediatric acute lymphoblastic leukemia (ALL) patients in remission. Stool samples were collected for 16S rRNA gene sequencing to assess changes in microbial community structure, alongside measurements of physical performance, anthropometry, and stool metabolites. The results highlight differential impacts of exercise and probiotic intervention on gut microbiota in a clinically vulnerable population