Localized condensation of the cBAF remodeler is governed by ARID1A/B and is required for transcriptional activation [CUT&RUN]
Specifically, we find that the N-terminal disordered region of ARID1A/B and the DNA binding ARID domain are required for condensate formation and chromatin targeting. Overall design: Cleavage Under Targets and Release (CUT&RUN) for BAF subunits ARID1A (HA-tagged), SMARCA4, SMARCC1, ARID1B (HA-tagged) as well as the histone modification H3K27ac in AN3CA cells.