Dietary inulin ameliorates obesity-related male reproductive dysfunction via Ileibacterium valens and its metabolite 12-keto-lithocholic acid through the VDR-Sirt3-ferropotsis signaling pathway
Gut dysbiosis has been implicated in the development of obesity-related male reproductive dysfunction. As a typical prebiotic, inulin exhibits a robust capacity to modulate the gut microbiota. Nevertheless, its potential effects on male reproductive health remain largely unexplored. This study is aimed to investigate the effect and underlying molecular mechanism of inulin on obesity-related male reproductive dysfunction.