Transcriptomic analysis of fetal epaxial muscle fibers from wildtype and dyW/dyW mice at embryonic day 17.5
LAMA2-congenital muscular dystrophy (LAMA2-CMD) is the most common congenital muscular dystrophy and is triggered by mutations in LAMA2, coding for laminin a2 chain. Several phenotypes have been associated with LAMA2-CMD, including inflammation, fibrosis and increased oxidative stress. However, it is not yet known what mechanisms are faulty, right at disease onset, which in the mouse model of LAMA2-CMD dyW/dyW has been previously established to occur between embryonic days (E) 17.5 and E18.5. This transcriptomic analysis of fetal muscle fibers perfomed at E17.5 provides critical information regarding the genes and pathways that are altered in LAMA2-CMD right at the onset of the disease. Overall design: This analysis was performed via the comparison of 4 samples each obtained from a different wildtype mouse and 3 samples each obtained from a different dyW/dyW mouse