H3K4me3 and H3K27ac CUT&RUN in GD86 porcine placenta from control and MMI-induced hypothyroid fetuses
The placenta is critical for fetal development, supporting nutrient transport, while at the same time isolating the developing conceptus from adverse maternal signals and gas exchange. The porcine placenta creates an enzymatic barrier for thyroid hormones following activation of the fetal endocrine system in early gestation. Perturbation of the fetal thyroid system can have significant developmental consequences. However, research examining the relationship between fetal thyroid hormone availability, the placental epigenome, and global effects on placental gene expression is limited, particularly in swine. To address this, we analyzed placental tissues from gestation day 86 fetuses exposed to 21-day maternal methimazole (MMI) treatment and matched controls using RNA-seq and CUT&amp;RUN.