Graves' disease peripheral blood
Graves' diseaseis a classical autoimmune disorder resulting from interactions between genetic susceptibility and immune dysregulation. However, the transcriptomic mechanisms underlying disease relapse and remission, particularly those involving alternative splicing, remain poorly understood. Here, we performed an integrative RNA-seq analysis of 33 GD patients in remission, 31 in relapse, and 30 healthy controls, interrogating gene expression, transcript usage, AS events, RNA-binding protein regulation, and splicing quantitative trait loci