DNA binding regions of HES4 transcription factor in human T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by an expansion of T-cell progenitors and DNA mutations that lead to an overactive NOTCH1 signaling in over 50% of T-ALL cases. Even though intracellular Notch1(ICN1) can modulate the target gene expression as a monomer, homodimerization of ICN1 is indispensable for the leukemogenesis of mouse T-cells. Hes4 is a direct target of Notch1 dimerization in human T-ALL. To identify the DNA binding regions of HES4 transcription factor in T-ALL, we generated ChIP-seq data with HES4 in CUTLL-1 cell line.