Loss of synovial tissue macrophage homeostasis precedes Rheumatoid Arthritis clinical onset
To investigate the transcriptional profiles of distinct macrophage subsets residing within the inflammed RA synovium. RNA sequencing was perfomed on FACS sorted CD206+CD163+ and CD206-CD163- synovial tissue macrophages from RA synovial tissue and fluid samples. Overall design: Comparative gene expression profiling analysis of RNA-seq data for CD206+CD163+ and CD206-CD163- synovial tissue macrophages from RA synovial tissue and fluid.