Crosstalk of astrocyte, microglia, and neuronal subtypes correlates to Alzheimer's disease pathology
To identify cell-cell interactions between the subtypes of astrocytes, microglia and neuronal subtypes that were profiled profiled using sn/scRNA-sequencing. Overall design: snRNA-seq was performed for NeuN-/Olig2- nuclei from frontal cortex of 9 Alzheimer's disease and 9 control brains.Nuclei isolation was performed from fresh frozen tissue of postmortem brains.