Transcriptomic, epigenetic and chromatin changes of the embryonic and neocortical neural precursor cells in the stage dependent manner
Neurons and glial cells that consist central nervous system are differentiated from neural precursor cells (NPCs). During the early stage of cortical development, NPCs proliferate symmetrically to increase NPC pool (expansion phase), and then they switch to an asymmetric mode of division to generate neurons and glial cells (neurogenic/gliogenic phase). The timing of the expansion-to-neurogenic or neurogenic-to-gliogenic phase transition is important for the proper brain construction. Here, we are examining the mechanisms of fate transition focusing on the transcriptomic, epingenetic and chromatin changes of embryonic NPCs.