A Comparative Analysis of HMGB1 and pCTS-L Immunomodulatory Properties in Human Peripheral Blood Mononuclear Cells
High Mobility Group Box 1 (HMGB1) and Procathepsin L (pCTS-L) are crucial inflammatory mediators, but their immunomodulating properties in human immune cells have not been systematically compared. This study employed RNA-sequencing to comparatively analyze their transcriptional effects on primary human peripheral blood mononuclear cells (PBMCs).