Transcriptome Profiling of Cell Line Responses to Small Molecule Treatments
RNA sequencing was conducted 24 hours after compound treatment. For old fibroblast samples (Coriell GM4204), treatments included Mocetinostat, Resveratrol, Radicicol, DMSO, and EtOH. Young fibroblast samples (HDF-f) were treated with 5-Iodotubercin, Alvocidib, and Mitoxantrone, with DMSO as a control. PSC-derived neurons were subjected to Fludarabine, Vinorelbine, and AGK-2, with DMSO as a control.