RNA sequencing of multi-tissue samples from obese and lean Ossabaw pigs
The experiment was designed to investigate the effects of a medium-cholesterol, high-fat, high-fructose diet over a relatively short period in the Ossabaw pig, a well-established model for studying obesity and metabolic syndrome. Whole transcriptomic changes were investigated in visceral and subcutaneous adipose tissue, liver and heart, from control and obese pigs, using RNA sequencing.