Hepatic GPNMB aggravates NASH through binding to RYK [RNA-Seq]
The goals of this study are to define the moelcular events in NASH and to determine the role of GPNMB and RYK in NASH development Overall design: RNA-seq analysis on mouse livers treated with HFHC, AMLN or ND and on Huh7 cells stably transfected with RYK and treated with GPNMB ECD for 8 h