16S rRNA gene sequencing of gut microbiota in HFD-induced obese mice treated with Danlou tablet
This dataset presents the V3-V4 region 16S rRNA gene sequencing data of fecal gut microbiota from C57BL/6N mice under three intervention conditions: normal chow diet (Control), high-fat diet (HFD, 60% fat), and HFD combined with high-dose Danlou Tablet (DLT-H, 1360 mg/kg/day) for 22 weeks. Each group included 10 male 6-week-old mice, with fecal samples collected at week 20. Sequencing was performed on an Illumina paired-end platform, and the data include raw sequencing reads, ASV tables, and taxonomic annotation results. The dataset characterizes the effects of DLT on gut microbial diversity, community structure, and differential taxa in HFD-induced obese mice, and provides a resource for studying the modulation of traditional Chinese medicine on the gut microbiota in metabolic syndrome. All animal experiments were approved by the Experimental Animal Ethics Committee of Henan University of Chinese Medicine (IACUC-202403008).