HVEM in Acute Lymphocytic Leukemia Facilitates Tumor Immune Escape by Inhibiting CD8+ T Cell Function
Our research uncovered that the genetic deletion of HVEM in EL4 can markedly inhibit tumor progress thus prolong survival prognosis of tumor-bearing mouse. Additional experiments also verified that HVEM exerted its oncogenous-effect by constraining the anti-tumor function of T cells in vivo and in vitro. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Vec-EL4 and HVEM-KO EL4 tumors.