cdc42 and racA regulate the mechanism of Aspergillus flavus
Aspergillus flavus is an opportunistic pathogen with a wide host range that produces highly carcinogenic aflatoxins. These harmful secondary metabolites have a significant impact on the environment, the global economy, agriculture, and the health of humans and animals. Therefore, there is an urgent need to identify target genes in A. flavus to effectively inhibit its reproduction and reduce aflatoxin contamination. cdc42 and RacA are highly conserved in eukaryotes and are Rho GTPases that can act as molecular switches to regulate multiple signal transduction pathways. . Transcriptome analysis showed that cdc42 and racA affect many metabolic processes and co-regulate a large number of genes. The functions of cdc42 and racA clearly overlap, and both are potential targets to mitigate the negative effects of A. flavus and A.