Mechanisms of PDCD4 Regulation in MASLD
This study investigates how the gene PDCD4 influences the development of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), a common liver condition linked to obesity and metabolic syndrome. Using mouse models with and without PDCD4, fed either normal or high-fat/high-cholesterol diets, we performed RNA sequencing to uncover the molecular mechanisms by which PDCD4 regulates liver metabolism and inflammation. Our findings may help identify new therapeutic targets for treating fatty liver disease.