AICAR regulate IEGs expression in ALL cells
To identify genes transcriptionally regulated by AICAR under cellular stress, We treated NALM6 cells for 45 min with vehicle (DMSO) or AICAR (15 mM), and examined their RNA profile using RNA-Seq. The immediate early genes (IEGs) were identified as a subset of genes downregulated by AICAR. Overall design: RNA-seq in NALM6 cells treated with vehicle or AICAR