Peripheral nerve injury induces dystonia-like movements and dysregulation in the energy metabolism: A multi-omics descriptive study in Thap1+/- mice
To elicit a dystonia-like phenotype in a genetically predisposed DYT-THAP1 mouse model (Thap1+/-) by performing a right sciatic nerve crush injury. Overall design: To identify novel pathophysiological pathways and possible biomarkers, we performed a multi-omic analysis of three dystonia-relevant brain regions Comparative gene expression profiling analysis of miRNA-seq data for the cortex, striatum, and cerebellum of naive and nerve-injured wildtype and Thap1+/- mice