Bulk RNA Sequencing of Mouse Models for TLS Formation in KxPxCx Pancreatic Cancer
The formation of tertiary lymphoid structures (TLSs) in human cancer patients is significantly correlated with prolonged survival, better prognosis, and improved responses to immune checkpoint therapy. We generated mouse models to investigate TLS formation using the KxPxCx pancreatic cancer model Overall design: Tumor-inoculated mice were treated with an agonistic antibody of LTßR, a STING agonist (ADU-S100), or a combination of these agents. Following treatment, tumor tissues were collected and used for bulk RNA sequencing