whole-exome seq_Brca1(L63X/+) rat
We previously reported that the Brca1(L63X/+) rat, a model of Brca1 haploinsufficiency carcinogenesis, exhibits a significantly higher incidence of mammary carcinomas than wild-type rats exposed to ionizing radiation; notably, the carcinomas retained a wild-type Brca1 allele. To explore the mutation spectrum underlying Brca1 haploinsufficiency, we performed whole-exome sequencing of spontaneous and radiation-induced mammary carcinomas from wild-type and Brca1(L63X/+) rats. Contains Fastq data of microdissected cancer cells and corresponding normal mammary tissue.