Evaluation of HIV-1C diversity at different stages of HIV-TB coinfection
Next generation sequencing was performed on HIV amplicons obtained from PBMCs and plasma viral RNA in HIV+ individuals coinfected with latent or Active TB. Phylogenetic characterization and drug resistance mutation analysis is being carried out for the above sequences. By comparing the sequences between viral RNA and DNA from PBMCs we would be able to compare the diversity between provirus and circulating virus in our cohort of PLHIV coinfected with and without active TB.