STING1 orchestrates the injurious neuronal stress response
In this study we investigated the neuronal stress response in the experimental autoimmune encephalomyelitis (EAE), the animal model of MS. Overall design: We used Glt25d2 BacTRAP which allowed to analyze the translatome of layer 5 motoneurons from the cortex of EAE animals. We compared healthy mice, acute phase (15 days after immunization), and chronic phase (30 days after immunization). We sequenced the input and the immunoprecipitated RNA.