RNA-seq analysis of cardiac fibrosis in mouse hearts 28 days post-myocardial infarction with (MIEru) or without (CONMI) dietary erucic acid supplementation
This dataset contains RNA sequencing data from mouse cardiac tissue collected 28 days after myocardial infarction (MI). The study investigates the effect of dietary erucic acid supplementation on post-MI cardiac fibrosis. All animals underwent MI surgery. The experimental group (MIEru, n=4) received a diet containing 20% erucic acid for the entire 28-day post-operative period. The control group (CON, n=4) received a standard diet without erucic acid supplementation following MI. RNA was extracted from whole heart tissue (with a focus on the fibrotic region/infarct border zone) and subjected to standard Illumina library preparation and paired-end sequencing. The data can be used to explore the transcriptional profile associated with post-MI remodeling and the impact of erucic acid on pathways related to fibrosis, inflammation, and metabolism.