RNA sequencing of dorsal root ganglia tissues from mice with metabolic neuropathy
The reactive metabolite methylgloxal sensitizes nociceptive neurons through activation of the integrated stress response. To define how it alters the landscape of nascent protein synthesis, we applied riobosome profiling to the DRG in parallel with RNA-seq. Overall design: Comparative gene expression analysis of RNA-seq and ribosome profiling data on mouse DRG tissues.