Genetic landscape of extramedullary plasmacytoma
Extramedullary (or extraosseous) plasmacytoma (EMP) is a localized plasma cell neoplasm lacking apparent bone marrow involvement and other features of multiple myeloma (MM). The prognosis is usually favorable, and progression to MM is infrequent. The genetic landscape of EMP remains largely unknown. Importantly, EMP must be distinguished from extramedullary manifestations of MM (EMM), which typically exhibit aggressive behavior. Here, we demonstrate that EMP shows a significantly less complex and, in part, distinct genetic profile compared to EMM.