Single-Cell analysis Reveals the Therapeutic Effects of Upadacitinib on Experimental Autoimmune Uveitis (PRJCA016731)
our study firstly present novel findings regarding the therapeutic effects of UPA on EAU. Our findings reveal the upregulation of the JAK1 pathway in both VKH patients and EAU models, providing a comprehensive map of the immune cells impacted by UPA treatment. Our investigation identifies ISG15+ CD4TC, CD8TC and BC, as potentially pathogenic factors involved in the development of uveitis, and demonstrates that UPA administration can reduce the frequency of these cells and related gene transcription