Oleanolic acid inhibits the development of breast cancer by regulating lactic acid bacteria and the Cytokinecytokine receptor interaction pathway
It was found that after OA treatment, compared with the CK group, the abundance of lactic acid bacteria in the intestinal flora of mice in the OA group increased, and the increase in the abundance of lactic acid bacteria made the gene Il10 upregulated, Il10 had a significant effect on tumor volume reduction and prolongation of mouse survival, and played a role through cytokine receptor interaction pathway. Overall design: In this study, a mouse breast cancer model was constructed, and the phenotypic effect of oleanolic acid on mice was analyzed after the end of the administration cycle, and the cecum tissues of the model group (CK) and oleanolic acid group (OA) were sequenced by 16SrRNA to analyze the differential flora of each group, and the tumor tissues of the model group (CK) and oleanolic acid group (OA) were analyzed with reference transcriptome.