Inhibition of sphingosine metabolism suppresses ferroptosis and rejuvenates aged hematopoietic stem cells to promote cognition and longevity [Low input RNA-seq]
Deletion of sphingosine kinase 2 (Sphk2) suppresses ferroptosis and restores functional capacities in old HSCs Overall design: Low input RNA-seq on HSCs ABC294640 is the specific SphK2 inhibitor used in this study.