Changes of gene expression in DRG tissue after pathologic pain
To identify common mechanisms and targets regulating different types of pathological pain, we established models for neuropathic pain induced by spinal nerve ligation (SNL), inflammatory pain induced by complete Freund's adjuvant (CFA), chemotherapy pain induced by paclitaxel (PTX), and bone cancer pain induced by Lewis lung carcinoma (LLC) cells. We then collected dorsal root ganglion (DRG) tissues from mice for RNA-seq analysis. Overall design: Dorsal root ganglion mRNA profiles of CFA, SNL, PTX, LLC mice were generated by deep sequencing, in triplicate, using Illumina GAIIx.