Effect of SWI/SNF pertubations on macrophage inflammatory activation [RNA-seq]
To characterize macrophage inflammtory activation and the role of the SWI/SNF complex, we first profiled gene expression for WT BMDMs with 0hr, 1hr, or 4hr LipidA stimulation. In addition, we also profiled gene expression for WT BMDMs treated with ACBI1, BRM014, or BRDK98 treatment and for Arid1A-/- or Pbrm1-/- BMDMs after 1hr or 4hr LipidA or LPS stimulation. Overall design: RNA-seq for WT, drug treated, or SWI/SNF KO BMDMs with 0hr, 1hr, or 4hr LipidA or LPS stimulation.