Blood transcriptional response to treatment-resistant depression during electroconvulsive therapy
This study aimed to elucidate the transcriptional differences in peripheral blood mononuclear cells (PBMC) between individuals with treatment-resistant depression (TRD) and a control group without a psychiatric illness; and between patients with TRD, treated with either standard antidepressant drugs alone, or in combination with electroconvulsive therapy (ECT) or ketamine. Additionally, PBMC transcriptomics were compared between treatment responders, following completion of their treatment protocols. PBMC transcriptomics were compared between treatment responders, following completion of their treatment protocols. Overall design: Comparative gene expression profiling analysis of RNA-seq data for PBMC under 3 different treatments (Serotonin, electroconvulsive therapy, ketamine)