Succinate preserves CD8+ T cell fitness to augment anti-tumor immunity
The tricarboxylic acid cycle intermediate succinate accumulates in tumors harboring succinate dehydrogenase (SDH) mutations. Despite evidence that succinate modulates CD8+ T cell cytotoxicity, its influence on T cell differentiation trajectories remains poorly understood. Here we reveal that SDHB-deficient tumors exhibit enriched tumor-specific CD8+ T cell infiltration and enhanced responsiveness to PD-L1 blockade. Overall design: Detect the primary mouse cells cultured in vitro, the CD8+ T cells sorted from tumor-bearing mice, and the CD8+ T cells sorted from bacteria-loaded mice