Genome-winding binding profile of KDM5 in Drosophila larval prothoracic gland cells via Targeted DamID analysis
kdm5 is an essential gene in Drosophila that has critical developmental roles in the prothoracic gland cells of the larval ring gland.  To profile KDM5 binding within these cells and this developmental stage, we performed Targeted DamID (TaDa). By profiling the nearest genes to significant TaDa peaks (FDR < 0.01), we identified 5815 candidate KDM5 target genes.  Interestingly, 42% of these candidate KDM5 target genes appear to be conserved across multiple cellular contexts in Drosophila and span many cellular processes for future investigation. Overall design: Targeted DamID (TaDa) for profiling KDM5 binding in Drosophila prothoracic gland cells