Salivary EVs from cognitively normal older adults
We characterized the RNA cargo of extracellular vesicles (EVs) isolated from saliva (salEVs) from individuals over the age of 65 with normal cognition. Human saliva contains numerous factors, including DNA, RNA, and protein, that may reflect the health status of the individual. Many of these factors are contained within EVs. The contents of EVs are thought to mirror the cytoplasm of the cell of origin, providing insight into the health of the cell. The goal is to identify salEV transcripts that are associated with brain health