The single-nucleus RNA-seq of AAV-Abeta42 injected hippocampus of crab-eating macaque
The difference in Abeta42 influence between young and aged monkeys prompted us to explore the underlying mechanism of Abeta42 neural toxicity with aging at single-cell resolution. We performed unilateral injections of AAV-Control and AAV-Abeta42 virus into the left and right hippocampi, respectively, of young and aged monkeys. After three months post-injection, the hippocampal tissues of the injected sites were collected and mixed for single-nucleus RNA sequencing.