Polymorphisms profiling of selected neurotransmitter receptors genes implicated in Chemotherapy-induced nausea and vomiting(CINV) in Nigerian cancer patients
The survival and quality of life of many patients with cancer are negatively affected by treatment-induced side effects, two of which are chemotherapy-induced nausea and vomiting (CINV). Recent evidence suggests that polymorphisms in genes involved in the nausea and vomiting pathways may influence oncology patients risks for CINV. Hence, this study was aimed at profiling polymorphisms in the neurotransmitter receptors encoding genes, with major interest in the three most clinically significant receptors implicated in CINV, namely HTR3A, DRD2, TACR 1 as well as COMT enzyme