Multi-omics analysis of the protective effects of aqueous extract of Artemisia argyi on lipopolysaccharide-induced acute lung injury in mice
This project investigates the protective effects of aqueous extract of Artemisia argyi (AEAA) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. A multi-omics strategy was used, including gut microbiota 16S rRNA sequencing, non-targeted metabolomics of colon contents and serum, and lung transcriptome sequencing, to characterize changes associated with AEAA pretreatment. The study aims to reveal how AEAA modulates the gut-lung axis, metabolic reprogramming, and inflammatory signaling during ALI.