Transcriptome analyses in brain metastases from breast cancer
An integrated analysis of breast cancer BM by using different methods including immunohistochemistry, in-situ hybridization (ISH), quantification of tumor-infiltrating lymphocytes (TILs), and bulk RNA-sequencing analysis to capture comprehensively their biology and differences to the corresponding primary tumor. A special focus was set on the characterization of the immune infiltration in the two different compartments