Comparative Analysis of Gut Microbiome and Bone Microarchitecture and bone turnover in Hip Fracture and Osteoarthritis patients and undergoing arthroplasty
Boopalan Ramasamy Discipline of Orthopaedics and Trauma Adelaide University Adelaide Australia.Balamurugan Ramadass Additional Professor Department of Biochemistry Head Center for Excellence of Clinical Microbiome Research (CCMR) All India Institute ofMedical Sciences Bhubaneswar Odisha India.This study investigates the relationship between gut microbiome composition and bone health in patients undergoing hip arthroplasty for hip fracture or osteoarthritis. Gut microbial profiles were generated using 16S rRNA gene sequencing and associations with bone microarchitecture geometry and biochemical markers of bone turnover were explored. Comparative analyses were performed to identify differences in microbial diversity and community structure between clinical groups.The study further examines how variations in the gut microbiome relate to measures of bone strength and structural integrity highlighting potential disease specific microbiome bone interactions. These findings contribute to a broader understanding of the gut bone axis and its relevance in musculoskeletal disorders.