Single-Cell Profiling of the Inflammatory Microenvironment in the Aged Rats Hippocampus and the Contributions of Cerebrovascular Endothelial Cells
To map the cell type-specific transcriptome landscape of the inflammatory microenvironment induced by systemic injection of lipopolysaccharide (LPS), we analyzed the hippocampus of aged rats on day 3 following a single injection to identify key molecules within specific cell subsets by single-cell RNA sequencing (scRNA-seq).