Pharmacological Inhibition of Frizzled 4 Reveals Its Tumor-Suppressive Role in OSCC
Oral squamous cell carcinoma (OSCC) is an aggressive cancer driven by dysregulated signaling, including Wnt pathways. Transcriptomic analyses revealed that inhibition of Frizzled 4 (FZD4) suppresses proliferation and alters adhesion-related gene expression, partially reversing malignant traits and highlighting FZD4 as a potential therapeutic target.