Characterizing gene expression after expressing  genetically encoded tools to change cellular NADH/NAD+ ratio in living cells
To study the  overabundance of reducing equivalents, termed reductive stress, specifically for NADH reductive stress, we introduce a soluble transhydrogenase from E. coli (EcSTH) as a novel genetically encoded tool to promote NADH overproduction Overall design: Comparative gene expression profiling analysis of RNA-seq data for Hela cells expressing LUC, LbNOX, EcSTH, mitoEcSTH