ApoE4 prime editing
The alolipoprotein E4 (ApoE4) allele is one of the strongest genetic risk factors for Alzheimer's disease. ApoE4 modification represents a therapeutic strategy to mitigate disease progression. In this study, we applied the prime editor 7 (PE7) system to enable precise and efficient conversion of the ApoE4 allele to the neuroprotective ApoE3 variant.