Analysis of rectal transcriptome in ulcerative colitis (UC) patients who received tofacitinib
The gold of this study is to identify genes that differentially expressed in rectum of ulcerative colitis patients who are responisve to tofacitinib compared with the patients who are refractory to the drug. This study may help to identify preditive markers to determine tofacitinib responders prior to the treatment. Overall design: We enrolled 48 UC patients for this project and collected rectum pinch biospies during colonoscopy at the baseline (week 0, before tofacitinib treatment) and end of study (week 24, after tofacitinib treatment). RNA-seq was performed using RNA isolated from the biopsies .