ChIP-seq following CRISPRi perturbations to MYC enhancers in K562 cells
We previous identified enhancers that regulate MYC expression in K562 cells (Fulco et al. Science 2016). Here, we perturbed MYC enhancers with individual CRISPRi gRNAs and performed ChIP-seq to study the effects on chromatin state. Overall design: ChIP-seq following CRISPRi perturbations to MYC enhancers in K562 cells