A novel human heart-derived natural adeno-associated virus capsid combines cardiospecificity with cardiotropism in vivo
Adeno-associated virus serotype 9 (AAV9) is currently considered the benchmark vector for clinical cardiac gene transfer applications but can entail severe hepatotoxicity due to its strong hepatotropism. Against this background, we report the discovery of a novel AAV capsid (cap) isolated from human myocardium that uniquely combines cardiospecificity with cardiotropism in vivo and bears potential to impact future cardiac gene therapy developments. Overall design: snRNA-Seq profile of left venctricle from a male C57BL/6N mouse 2 weeks after transduction with AAVC7.