Comparative Transcriptomic Study of Infections by Nocardia asteroides and Providencia vermicola in Nile Tilapia
This work aimed to analyze the transcriptome of Nile tilapia infected with emerging bacterial pathogens: Nocardia asteroides or Providencia vermicola. Results showed that both N. asteroides and P. vermicola modulated pathways related to amino acid metabolism, cell adhesion molecule expression, innate immune response, antigen processing and presentation, and neuropeptide signaling. Comparative analysis revealed that N. asteroides downregulates cell-mediated adaptive immunity and upregulates cytokines associated with the anti-inflammatory response, as well as cell proliferation and differentiation. Meanwhile, P. vermicola induced hormonal and neurotransmitter signaling pathways, including genes related to antimicrobial peptides and tumor necrosis factor receptors, while energy production-related metabolic pathways were downregulated.