Myocardial Rev-erb regulates metabolic diurnal rhythm in heart failure
Rev-erba/ß are druggable components of the molecular circadian clock. Rev-erb agonists can mitigate pressure overload-induced cardiac hypertrophy and myocardial infarction in mice, while Rev-erb antagonist increases myocardial ischemia-reperfusion tolerance ex vivo at the sleep-to-wake transitionHow cardiac Rev-erb regulates heart function has not been studied in vivo. ChIP-seq of Rev-erba in the heart confirmed the robust diurnal rhythmicity of Rev-erba genome binding with about 5 times more binding at ZT9 than at ZT21. Overall design: Examination of Rev-erb binding