Mutant p53 dysregulates gene transcription in hematopoietic stem and progenitor cells [RNA-seq 2]
We found that mutant p53 dysregulates gene transcription in hematopoietic stem and progenitor cells duirng aging. Overall design: Aged mice to 13to 15 months. Sorted LSKs from the bone marrow of wild type and p53 mutant mice. We then performed paired-RNA sequencing.