Gene expression data from zebrafish SHH medulloblastoma brains and normal brains.
Zebrafish SHH MB tumors were generated by CRISPR-Cas9-mediated mutation of ptch1 in the context of tp53 heterozygous and tp53 mutant animals. Gene expression of the entire brain for ptch1 crispant animals and tp53 mutant control animals was analyzed by RNA-seq. Overall design: Whole brains were collected from 3 individual tp53 mutant control animals, 3 individual tp53 mutant and ptch1 crispant animals, and 3 individual tp53 heterozygous and ptch1 crispant animals.