Genome-wide profiling of transcription factor binding and epigenetic mark for expression and function of GREB1 in hepatocellular carcinoma
The aim of this project was to reveal the regulatory mechanism of GREB1 transcription in hepatocellular carcinoma (HCC). ChIP-seq using HCC cell lines was performed to clarify the association of HNF4a, FOXA2, b-catenin and TCF4 with regulatory region for GREB1 expression. Also, GREB1 ChIP-seq was performed for investigation of GREB1 function in transcriptional regulation.