RNA-seq of mouse primary neurons and treatment with resveratrol/SRT1720/SRT2104
This RNA-sequencing (RNA-seq) dataset was generated from mouse primary neurons, including three experimental groups: control group, mitochondrial-related gene knockdown group, and mitochondrial-related gene knockdown group treated with resveratrol, SRT1720, or SRT2104 (indicated concentrations). The aim of this study is to identify the transcriptional profiles and differentially expressed genes (DEGs) associated with mitochondrial-related gene deficiency and the potential rescue effects of resveratrol, SRT1720, and SRT2104 in primary neurons. The dataset provides insights into the molecular mechanisms underlying mitochondrial-related gene-mediated neuronal function and the therapeutic potential of sirtuin-activating compounds (STACs) and resveratrol.