Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage [ATAC-seq]
To investigate the mechanisms of IRF1 in the development of OA, we characterized regulatory elements accessible to IRF1 via DNA footprinting analysis in chondrocytes by employing the assay for transposase-accessible chromatin with sequencing (ATAC-seq). Overall design: ATAC sequencing data using samples from primary mouse articular chondrocytes