Effect of ASPA C152W expression on the transcriptome in HEK293T cells
Deep mutational scanning has revealed that some destabilized ASPA variants are toxic, including the C152W variant. To analyze this effect RNA seq was employed to identify genes that are differentially expressed upon ASPA C152W expression. Overall design: Comparative gene expression profiling analysis of RNA-seq data for HEK293T cells expressing wild-type ASPA and the ASPA variant C152W.