MODELLING GENETIC POLYCYSTIC KIDNEY DISEASE USING HUMAN PLURIPOTENT STEM CELL- DERIVED KIDNEY ORGANOIDS
To investigate the transcriptional features during cystogenesis, we performed bulk-RNA sequencing on ARPKD organoids. We then performed gene expression profiling and Gene Set Enrichment Analysis using data obtained from bulk RNA-seq. Overall design: Comparative gene expression profiling analysis of RNA-seq data for ARPKD DMSO and ARPKD FSK groups.