Mannosylated CTLA-4-displaying small EVs regulate CD8+ T lymphocytes (PRJCA033208)
This study aimed to elucidate the in vivo effects of CTLA-4-displaying small EVs on CD8+ T lymphocytes. C57BL/6 mice received intravenous administration of mannosylated CTLA-4-expressing small EVs on Days 1, 2, and 3 post-MI. Following this, splenic CD8+ T lymphocytes were isolated and subjected to RNA sequencing to evaluate their cellular responses.