Insulin Receptor Loss Impairs Mammary Tumorigenesis in Mice
To investigate the role of Insr in processes affecting tumor initiation, we generated Comma1D luminal cells with a CRISPR Insr knockout. We then performed RNA-seq followed by differential gene expression analysis and pathway enrichment analysis. Overall design: Differential gene expression analysis of RNA-seq data for wild-type Comma1D cells and Comma1D cells with CRISPR Insr knockout.