RARg bookmarking functions in prostate cancer (IMPACT-Seq)
To define the RARg complex in PCa cell models, including isogenic variants of 22Rv1, how this is targeted by miR-96, and regulates the AR cistrome, and how this is specifically enriched in G2/M cells and how these actions collectively shape the transcriptional programs associated with PCa outcomes. Overall design: IMPACT-Seq was undertaken on HPr1AR or LNCaP cells transfected with 3' biotinylated miRIDIAN miR-96 mimic and scramble controls