Paired_guide__combinatorial__uveal_melanoma_screen_data
Metastatic uveal melanoma is an aggressive disease with limited effective therapeutic options and poor survival outcomes. To comprehensively map monogenic and digenic dependencies, we performed CRISPR-Cas9 screening in ten extensively profiled human uveal melanoma cell line models using genome-wide single gene/gRNA and bespoke paired gene/gRNA combinatorial CRISPR libraries.