mRNAs and lncRNAs profiling of human visceral adipocytes from healthy lean individuals, obese and colorectal cancer patients treated with Omega-3/Omega-6 polyunsaturated fatty acids.
Colorectal cancer (CRC) is a major threatening disease, being the third most common cancer and a leading cause of death worldwide. Enhanced adiposity, particularly visceral fat, is a major risk factor for CRC, and obesity-associated alterations of metabolic, inflammatory and immune profiles in visceral adipose tissue (VAT) strongly contribute to promote or sustain intestinal carcinogenesis. The role of diet/nutrition in obesity and CRC has been extensively demonstrated and AT/adipocytes represent the main place where diet-induced signals are integrated. Among the factors introduced with diet and processed/enriched in AT, Omega-3/Omega-6 polyunsaturated fatty acids (PUFA) are endowed with pro- or anti-inflammatory properties and have been shown to exert either promoting or protective roles in CRC. In this study, we investigated the impact of ex-vivo exposure to the Omega-3 and Omega-6 PUFA docosahexaenoic and arachidonic acids on VAT adipocyte whole transcription in healthy lean, obese and CRC-affected individuals.