HIF-2a in the development of NASH
We studied the effect of myeloid HIF-2a on the development of NASH and the underlying mechanisms. Overall design: WT and myeloid-specific HIF-2a KO mice were fed NASH-inducing high fat high cholesterol diet. Non-paranchymal liver cells were isolated using a collagen fusion method and CD45+ live cells were sorted for scRNA-seq analysis.