Targeted NGS of pediatric and adult T-cell lymphoblastic neoplasia
T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL) share an origin in thymic T-cell precursors but are differentiated by infiltrated blasts into the bone marrow.Targeted next-generation sequencing was performed for a cohort of 211 patients with T-LBL and T-ALL. These included pediatric as well as adult cases. In addition to primary tumor material, germline and - if available - relapse samples were additionally sequenced.