EZH2 knockout and rescue in WCM154 NEPC organoid model. [RNA-Seq]
EZH2 silencing led to further maturation of neuroendocrine terminal differentiation in NEPC. Overall design: EZH2 was silenced in WCM154 NEPC organoids using 2 independent single-guide RNAs. EZH2 expression was rescued using a recombinant dTAG-EZH2.