Evaluating the effects of polyoma small T antigen on gene expression
We developed an inducible degradation system for murine polyoma small T antigen (PyST) to study the effects of PyST on gene expression. We examined changes in expression following ectopic expression of tagged antigen and following their degradation in the MCF10A human mammary epithelial cell line. Overall design: Examination of the effects of murine polyoma small T expression and degradation in mammary epithelial cells