Chronic hypoxia favours adoption to a castration-resistant cell state in prostate cancer
Hypoxia is associated with poor prognosis in solid tumours and hypoxia has been associated with prostate cancer progression. The investigation of how chronic (CH) hypoxia affected prostate cancer show a loss in sensitivity to androgen deprivation and increased dependancy on glucose uptake in cells. Overall design: Comparative gene expression profiling of LNCaPs to LNCaP-CH and LNCaP to LNCaP-V16A cell lines