Hepatic Glucocorticoid Receptor (GR) drives the diurnal adaptation to Caloric Restriction
We examined the gene expression profiles of liver samples throughout the day/night cycle (ZT0-ZT4-ZT8-ZT12-ZT16-ZT20) from control mice (night-restricted fed) and mice under short-term caloric restriction. Overall design: Bulk RNA sequencing (RNA-seq) from livers of WT and hepatocyte-deleted for Glucocorticoid Receptor mice (GR liver KO ) upon night restricted feeding (NR) and caloric restriction (CR) with sampling every 4hours at 6 different timepoints (ZT0, ZT4, ZT8, ZT12, ZT16, and ZT20), ZT corresponds to Zeitgeber Time, 6 a.m :ZT0 & ZT12: 6 p.m. Additionally, bulk RNA sequencing (RNA-seq) from livers of night-restricted fed (NR) and caloric restricted (CR) WT mice at Zeitgeber 12 (ZT12; 6 p.m).