EYA1 Tyrosine Phosphatase Inhibition using a Repurposed Drug as an Effective Treatment for MLL-Rearranged Leukemia
MLL-rearranged acute leukemia is aggressive with poor prognosis, highlighting the need for new therapeutic approaches. This study investigates the effects of benzbromarone (BBR) on gene expression in MLL-rearranged leukemia cell lines using RNA sequencing (RNA-seq). MOLM-13, SEM, and KOPN-8 cells were treated with 18 - 20 uM BBR for 24 hours, and transcriptional changes were analyzed to identify differentially expressed genes. This dataset provides insight into the mechanism of BBR in leukemia cells, contributing to the understanding of novel therapeutic strategies for MLL-rearranged leukemia.