BET Bromodomain Proteins Regulate Transcriptional Reprogramming in Genetic Dilated Cardiomyopathy
In a model of chronic heart failure, BET bromodomain inhibition delayed cardiac remodeling and fibrosis by halting pathologic inflammatory gene networks in an NFkB-dependent manner. Overall design: RNA-seq of mice treated with either JQ1 or vehicle; n=3 individual biologic replicates sequenced in each experiment