Transcriptomic profiling of peripheral blood mononuclear cells reveals differential expression of genes associated with inflammation in pediatric dengue infection
This study investigates the host immune response in pediatric patients during the acute phase of dengue virus (DENV) infection. Using RNA-Seq, we performed global transcriptomic profiling of peripheral blood mononuclear cells (PBMCs) collected from a cohort of children diagnosed with varying clinical severities of dengue (e.g., Dengue Fever vs. Severe Dengue) and healthy controls. Our primary objective was to identify differentially expressed genes (DEGs) and molecular pathways associated with systemic inflammation and disease progression. These data provide insights into the innate and adaptive immune signatures that characterize pediatric dengue and highlight potential biomarkers for inflammatory complications.