B-cell receptor repertoire sequencing in metastatic renal cell carcinoma patients with immune checkpoint inhibitors
This study characterizes the B-cell receptor (BCR) repertoire in patients with renal cell carcinoma undergoing immune checkpoint inhibitor therapy, with a focus on immune-related adverse events (irAEs). Peripheral blood mononuclear cells (PBMCs) were collected before treatment and one month after therapy initiation, and immunoglobulin heavy chain (IgH) sequencing was performed. The dataset enables longitudinal assessment of clonotype diversity and shared immunoglobulin sequences associated with irAEs.