Distal Electrical Stimulation Enhances Neuromuscular Reinnervation and Satellite Cell Differentiation for Functional Recovery
Peripheral nerve injuries cause significant motor deficits, with limited treatment options for full recovery. Distal electrical stimulation (E-stim) shows potential in promoting neuromuscular reinnervation, although its mechanisms remain unclear. This study examines how distal E-stim influences neuromuscular junction reinnervation and Satellite cell activity in denervated muscles. Overall design: The satellite cell cluster was identified using the Seurat package in R and subsequently subjected to gene set enrichment analysis for further insights.