Mutational_signatures_in_carcinogen_induced_mouse_lung_tumours
Human cancers arise through the combined effect of environmental exposures and endogenous mutagenesis resulting from factors such as replication stress and metabolism. Mouse and human tumour genome analyses have identified the mutational signatures of several known carcinogens, but many human cancers, including lung, carry specific signatures of exposure to agents that are as yet unknown. Here, we will address the question of how exposure to a wide variety of exogenous agents can shape genomic architecture. Specifically, we will characterize the mutational signatures of dozens of suspected/known human carcinogens used to induce hundreds of mouse tumours and then look for these signatures in human tumours. Other aspects of tumour biology will also be explored, such as the profile of the epigenome following carcinogen exposure, driver genes, and the effect that carcinogens have on the copy number landscape and profile of structural variants found in tumours.