Effects of a fibrate drug, bezafibrate on ascites-mediated transcriptional changes in epithelial cancer cells
Ascites is an abnormal fluid that accumulates in the peritoneal cavity of more than 90% of patients with metastatic ovarian cancer. Despite its common occurance, little is known about its effects on detached and metastasizing ovarian cancer cells, which frequently metastasize to the peritoneum. This experiment aims to identify any transcriptional changes that occur in ovarian cancer cell lines as a result of exposure to ovarian cancer ascites and whether the fibrate drug, bezafibrate had any reversing effect on the ascites-mediated changes Overall design: To investigate any transcriptional changes that occur in ovarian cancer cell lines as a result of exposure to ovarian cancer ascites and the fibrate drug, bezafibrate