Transcriptomic Analysis of WT and IGF2BP2 KO Macrophages Reveals Metabolic Alterations
This dataset contains RNA-Seq data from wild-type (WT) and IGF2BP2 knockout (KO) bone marrow-derived macrophages (BMMs) under basal and IL 4-stimulated conditions. Loss of IGF2BP2 led to significant transcriptional changes, particularly in genes regulating metabolism, mitochondrial function, and cell migration. Pathway analysis (GO, KEGG) revealed a metabolic shift toward glycolysis and reduced migratory capacity. These data provide insights into the role of IGF2BP2 in macrophage function and adaptation.