Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models [mouse]
Performed transcriptomic analysis of Nestin;BrafKE/+ and Braf+/+ mice to investigate the molecular basis of BRAF K499E-induced learning and memory deficits. Overall design: 4 Nestin;BrafKE/+ mice were compared to 5 Braf+/+ control mice.