GPX4 overexpression attenuates the development of experimental abdominal aortic aneurysm.
GPX4-KI and WT mice were treated with elastase and BAPN for 4 weeks to induce AAA, and then key pathophysiological events were assessed. According to the RNA-seq analysis, we found that WT mice and GPX4-KI mice showed extensive changes, which protected against the development of AAA.