Identification of the target genes of androgen in skeletal muscle using myofiber specific ARKO female mice
Androgens have a strong effect against skeletal muscles to increase muscle mass and strength. However, a molecular mechanism of AR action on muscle strength is not clear. To identify the target genes of AR in skeletal muscle, we generated myofiber specific ARKO using HSA-Cre and AR flox mice (cARKO). Nine-week-old female control and cARKO mice were treated with or without DHT for 4 weeks. After euthenization, gastrocunemius muscle were collected and total RNA were extracted. Overall design: mRNA profiles of gastrocunemius muscle obtained from control and cARKO mice treated with or without DHT for 4 weeks were generated by sequencing, in triplicates, using Illumina Myseq.