MeRIP-seq profiling in Ti-Treg cell with Glud1 depletion or not
This research interrogates the landscape of mRNA m6A methylation governed by Glud1 and its metabolic product alpha-ketoglutarate (alpha-KG) within tumor-associated Tregs. This work systematically delineates the broad mechanistic link between cellular metabolism and epitranscriptomic regulation, unveiling a novel metabo-epigenetic layer of control in TI-Treg function.