Effect of D419N mutation on STAT6 transcription factor activity, in EuMyc murine lymphoma cells
To investigate how mutation of STAT6 at residue D419 impacts gene expression in EuMyc lymphoma tumour cells Overall design: EuMyc cells which are STAT6 WT or D419N mutant, were transplanted into C57BL6 mice. After 11 days, once tumours have formed in the cervical and inguinal lymph nodes, tumour cells were isolated with CD19 microbeads, and subject to bulk RNAseq