Investigation of the impact of B cell senescence on oral microbiota
Rag1KO mice were transferred with T and B cells isolated from young or aged WT mice (each n=7), or T cells isolated from young WT mice and B cells isolated from middle-aged WT or p16/p21-DKO mice (n=7 or 13). Saliva samples were collected from these transferred mice before and after transplantation and 16S rRNA gene sequencing analysis was performed.