Microbiota Transplant Therapy (MTT) Improves Gastrointestinal Symptoms by Modulating Gut Microbiota in Children with Pitt-Hopkins Syndrome, A Rare Neurodevelopmental Disorder
This study investigates Microbiota Transplant Therapy (MTT) as a treatment for children with Pitt-Hopkins Syndrome who suffer from gastrointestinal (GI) problems. It uses a combination of antibiotics, bowel cleansing, and transplant of healthy donor microbiota to restore gut balance. The trial is designed as a randomized, placebo-controlled study to assess safety, tolerability, and effectiveness. Results suggest that MTT can improve GI symptoms by reshaping the gut microbiome. The research also explores how changes in gut bacteria may influence broader neurological and behavioral symptoms in this rare disorder.