Chronic Cold Stress-induced Transcriptomic Alterations in Multi-metabolically Active Tissues of Pigs (PRJCA041344)
Cold stress poses significant challenges to livestock production; however, the regulatory mechanisms underlying pig responses to chronic cold stress remain inadequately understood. To address this gap, we characterized the transcriptional responses of metabolism-related tissues to chronic cold stress via bulk RNA sequencing. Our findings revealed tissue-specific transcriptional responses to cold stress. Furthermore, single-nucleus RNA sequencing analysis revealed cellular heterogeneity and metabolic remodeling in the metabolism-related tissues, which were induced by chronic cold stress.