An integrative single-cell multiomics profiling of human pancreatic islets identifies T1D associated genes, regulatory regions, and single nucleotide polymorphism [bulk RNA-seq]
To investigate the mechanism of DLK1 and RASGRP1 knockout in inducing beta cell apoptosis, we performed gene expression profiling analysis using data obtained from RNA-seq of DLK1 WT vs DLK1-/- and RASGRP1 WT VS RASGRP1-/- hPSCs differentiated beta cells. Overall design: Comparative gene expression profiling analysis of RNA-seq data for DLK1 WT vs DLK1-/- and RASGRP1 WT VS RASGRP1-/- hPSCs differentiated beta cells.