Atherosclerotic process regulates arterial damage, abdominal aortic aneurysm (AAA) formation and rupture
By modeling interaction of cigarette smoke and hypercholesterolemia, we provide experimental evidence that atherosclerotic disease directly contributes to AAA formation and rupture; AAA progression is mediated by inflammatory Mf residing within associated atherosclerotic plaque. Overall design: Single cell transcreptome of human AAA