ZNF217 promotes ovarian cancer progression
Ovarian cancer is characterized by aggressive metastasis, chemoresistance, and poor survival outcomes. Gaps in understanding of factors that drive these phenotypes have hindered the development of actionable therapeutic targets. We demonstrate that Zinc Finger Protein 217 (ZNF217) is a key pro-metastatic factor in ovarian cancer cells. ZNF217 overexpression dramatically increases proliferation, metastasis, and chemoresistance while its depletion severely impairs these phenotypes. Consistently, ZNF217 overexpression in ovarian tumors is associated with poor prognosis in multiple mouse models and ovarian cancer patients. Interestingly, ZNF217 also induces metastatic phenotypes in immortalized fallopian tube epithelial cells, suggesting a potential role in the transition of early-stage tumors to aggressive carcinoma. ZNF217's oncogenic activity is dependent on its ability to bind DNA and alter multiple processes, including EMT, that are critical in driving different aspects of cancer progression. Thus, our data establishes ZNF217 as a potent oncogene in ovarian cancer cells that impacts multiple steps in the metastatic process and a potential therapeutic target.