Omics analysis of Memory Regulatory T cells in a Recurrent Malaria Model
We investigate the molecular signatures of murine memory T regulatory cells in recurrent malaria episodes. We use a multi-omic approach, namely, single-cell RNA profiling and DNA methylation profiling, to gain deeper insights into the molecular factors associated with the transition of memory T regulatory cells to Tfh-like effectors cells after infection with Plasmodium chaubaudi chaubaudi, an etiological agent of rodent malaria.