Design and Submission of Synthetic CDS Sequences for HA6 and fPE Antigens Targeting H9N2 Avian Influenza
This study involves the design and submission of synthetic coding sequences (CDS) for two recombinant antigens: HA6 and fPE. HA6 is a truncated and structure-optimized stem domain derived from H9N2 hemagglutinin (HA), designed to maintain the prefusion conformation of HA2. fPE is a synthetic fusion construct composed of screened B-cell and T-cell epitopes from HA1, linked by flexible linkers. These sequences were optimized for expression and submitted to support the development of a broad-spectrum subunit vaccine against H9N2 avian influenza.