Genome sequencing and assembly of imipenem and imipenem-relebactam resistant clinical isolates of Pseudomonas aeruginosa
This project aims to elucidate the resistance mechanisms to the Imipenem-Relebactam formulation in multidrug-resistant hospital strains of Pseudomonas aeruginosa in Brazil through genomic analysis. Comprehensive understanding of antibiotic-resistance genes and genetic variations within these strains can inform the selection of appropriate antibiotic therapies for similar pathogens in the future. This knowledge represents a pivotal initial step toward the development of novel antibacterial formulations targeting imipenem-relebactam resistant P. aeruginosa.