Enteric neuronal GPR41-DHX9 signaling senses microbial metabolites to mediate the crosstalk between serotonergic neurons and intestinal stem cells [Ribo-seq]
We show that Dhx9 deficiency restricts the development and homeostasis of enteric neuron, and specifically suppresses the early development of serotonergic neurons. Overall design: To investigate potential mechanisms whereby Dhx9 regulates the development and maturation of serotonin neuron,we performed Ribo-IP-seq analysis.