Manipulation of Mitochondrial Metabolism Sensitizes Acute Myeloid Leukemia to MCL-1 Inhibition
Metabolic CRISPR KO Screen Identifies OXPHOS as a Sensitizer to MCL-1 Inhibition in AML. MV4-11 cells containing the Metabolic CRISPR KO library were treated with either DMSO or low dose MCL-1i inhibitor for 24h and then cultured for up to 14 population doublings in drug free media. Illumina sequencing was performed on DNA extracted from the surviving population to determine genes that could be targeted to sensitize AML to MCL-1 inhibition.