Profiling and Rewiring Dysfunctional NK cells to Restore Anti-Tumor Activity
Unraveling the molecular mechanisms of NK cell dysfunction and implications for anti-tumor immunotherapy. Overall design: CD56+CD3neg cells were isolated from the PBMCs of 4 control healthy donors and sorted for Anergic (NKG2A-panKIR-) and Responsive (NKG2A+ panKIR+)