RNA-seq of C9-ALS human spinal cord organoids treated with several compounds and ATF4 Cut&Tag profiling in PGAM5 overexpressed or thapsigargin treated SH-SY5Y cells
RNA-seq of C9-ALS human spinal cord organoids (35 days post induction) treated with eIF2B agonists, DNL343 or fosigotifator (FOS), or PGAM5-targeting compounds, TAT-PO1 or telmisartan (TEL). In parallel, ATF4 CUT&amp;Tag profiling in PGAM5 overexpressed or thapsigargin (TG) treated SH-SY5Y cells was performed.