Whole exome sequencing of mouse endometrial cancer cell lines and matched primary tumors (PRJCA020376)
we established endometrial cancer genetically engineered mice PTEN flox/+; STK11 flox/flox; LTF-Cre (PSC) and constructed corresponding epithelial cell lines using their uterine tumor tissues isolated using conditional reprogramming techniques, which were successfully passaged, frozen, and preserved in a biobank, Further whole exome sequencing assays were performed on mouse endometrial cancer cell lines and matched primary tumors to observe gene profile characteristics.