Transcriptional profiling of striatum from the Q140 mouse model of Huntington's disease, from A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy
Striatum isolated from 6 m/o wildtype, Q140 knock-in mice in the presence or absence of Alfy overexpression. Alfy overexpression achieved by knockin of human WDFY3 cDNA into Rosa26 locus. Total RNA seq analysis. Overall design: Striata from 6 m/o Q140 and WT in the presence or absence of Alfy overexpression. Total RNA. 4 males and 4 females per genotype. N=8 per group. Littermates used