Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality
Combined single cell RNA transcriptomic and TCRa/b sequencing analysis on renal transplant biopsies (rBx) from patients with acute cellular rejection (ACR) under differing immunosuppression (IS) modalities: tacrolimus, iscalimab, and belatacept. Results define the clonal CD8+ T cell response to ACR, paving the next steps to improve detection, assessment, and treatment of rejection.