Transcriptional and Epigenetic Control of Human Naive CD8 T Cell Activation
The differentiation of CD8 naive T cells into effector cells upon activation is essential for eliminating intracellular pathogens and cancerous cells, although the underlying epigenetic mechanisms remain incompletely characterized. By integrating multi-omics approaches, we systematically mapped chromatin remodeling dynamics and transcriptional networks during human CD8 naive T cell activation.