Transcriptomic profiling of liver tissue in Tibetan sheep following rumen fluid transplantation
This project presents liver transcriptome data from Tibetan sheep treated with rumen fluid transplantation (RFT) to investigate its effects on host metabolism and immune regulation. RNA sequencing was used to analyze gene expression changes in liver tissue. Differential expression analysis identified genes involved in metabolic processes, oxidative stress, and immune related pathways, including TLR4, NOD2, PPARA, and ABCG2. Functional enrichment analysis indicated that RFT affected pathways related to metabolic homeostasis and immune regulation, without strong activation of pro inflammatory signaling. These data provide insight into the molecular mechanisms of gut liver axis regulation and support the use of microbiota based strategies in ruminant health management.