The m1A methyltransferase TRMT61A regulates the pathogenicity of CD4+ T cells and promotes the development of autoimmune diseases.
To investigate how TRMT61A regulates CD4+ T cell function in autoimmune diseases, we performed single-cell RNA sequencing (scRNA-seq) of TCR-b+ T cells isolated from the CNS of Trmt61a-cKO and WT mice at the peak of inflammation in the EAE model