Pig model of Angelman syndrome DNA and RNA sequencing
A de novo genome of a pig model of Angelman syndrome to resolve the Angelman syndrome (AS)/ Prader-Willi syndrome (PWS) locus, including small nuclear host gene 14 (SNHG14).SNHG14 is of clinical interest as the critical region for PWS and a therapeutic target for AS, but is frequently misassembled in genome assemblies due to its size and repetitive complexity. This is the case in the current pig reference genome, Sscrofa11.1, which fragments and collapses much of the region.