EWSR1::ATF1 Orchestrates the Clear Cell Sarcoma Transcriptome in Human Tumors and A Mouse Genetic Model [RNA-Seq 2]
a particular fusion protein that drives the rare, but deadly pediatric cancer, clear cell sarcoma. The fusion protein was expressed in mice, leading to the formation of similar tumors as those it causes in humans. This permitted the study of fusion protein function in these tumors. Overall design: To investigate the fusion protein EA1' role in CCS formation, we KD EA1 and perform RNASeq for the total RNA.