RNA-seq of human influenza- and cytomegalovirus-specific CTLs for identification of BATF3-associated memory differentiation factors
This project contains RNA-seq data generated from human influenza virus-specific and cytomegalovirus-specific cytotoxic T lymphocytes derived from healthy donors. Cells were analyzed after repetitive antigen stimulation at days 20 and 30 to identify transcription factors and gene expression programs associated with sustained IL-2 production and less differentiated memory-related phenotypes. The dataset was generated to discover candidate regulators, including BATF3, involved in human CD8+ T-cell memory differentiation.