Genome-wide chromatin profile of Lamin bound region (LADs) in skeletal muscle in PIGB mutant of Drosophila.
It is known that lamin binds to chromatin to form Lamin-associated Domains (LADs) to control the three-dimensional structure of chromatin. We found that loss of PIGB which is one of lamin binding protein in Drosophila, leads to heterogeneous distribution of B-type lamin which normally localizes uniformly under the nuclear envelope. The purpose of this study is to clarify whether the LADs in PIGB mutant are changed or not.