medial prefrontal cortex microglial rna-Seq
Experimental purpose: To detect the changes in RNA expression of microglia in the medial prefrontal cortex (mPFC) of animals with chronic pain comorbid with emotional disorders, and to explore the potential molecular mechanism of microglia in the interaction between chronic pain and emotional disorders.Groups: Chronic constriction injury of the infraorbital nerve (CION) mice 2 weeks after surgery VS Sham mice (Con)Sample: Microglia obtained by anti-CD11b magnetic bead sorting