C57 mice spleen Transcriptome or Gene expression
Immune senescence is usually caused by age-related structural damage and functional changes in the body's immune system. Spleen, as the largest secondary lymphoid organ in human body, plays an important role in the immune system. This study aims to investigated the molecular changes of age-related splenic tissues by gene expression set (GEO) dataset and transcriptomics. In this study, we investigated the molecular changes of age-related splenic tissues, including 6 weeks and 20 months old, by RNA-seq and bioinformatics methods. Meanwhile, a transcriptomic dataset GSE73450 was downloaded from GEO database to explore the differentially expressed genes (DEGs) in aging.