PI3Kß controls immune evasion in PTEN-deficient breast tumors
We used scRNA-seq to characterize the anti-tumorigenic or pro-tumorigenic immune infiltrate into the tumor microenvironment of TNBC genetically engineered mouse models with PI3Ka versus PI3Kb isoform knockouts. Overall design: Mouse tumors were dissociated, and live immune cells and live T cells were sorted to load onto Seq-Well arrays for scRNA-seq library generation.