miRNA-seq analysis of differentiated HL-60 cells treated with fMLF or untreated
secretion of cytokines in a model of human neutrophils. For that, we differentiated the human promyelocytic leukemia HL-60 cell line and treated or not (control) with 100 nM fMLF in a physiological salt solution. Experiments of miRNA sequencing were conducted in three different batches. Results showed that dysregulation of miRNA-132-5p expression can modulate the intensity of inflammation and prevent its persistence by decreasing S100A8/A9-mediated IL-8 secretion.