ALKBH5-Mediated m6A Demethylation Stabilizes HMGB1 to Drive Hepatocyte Pyroptosis and Liver Injury in Heat Stroke: Targeting via Biomimetic Nanodelivery
Heat stroke (HS) causes life-threatening liver injury, yet the molecular drivers remain poorly defined. We investigated whether ALKBH5-mediated m6A demethylation stabilizes HMGB1 transcripts to promote hepatocyte pyroptosis via the NLRP3 inflammasome. We further developed mesenchymal stem cell membrane-coated glycyrrhizic acid liposomes (MMGLs) as a targeted nanotherapeutic strategy.