Oral Microbiota Dysbiosis in Pediatric Type 1 Diabetes Stratified by C-Reactive Protein Levels
This study investigates the oral microbiome composition in children with Type 1 Diabetes (T1D) stratified by systemic inflammatory status. Participants were categorized into two groups based on C-reactive protein (CRP) levels: a Normal CRP group (N-CRP; CRP < 10 mg/L) and a High CRP group (H-CRP; CRP >= 10 mg/L). Using 16S rRNA gene sequencing, we profile oral microbial communities to identify microbial signatures and dysbiotic patterns associated with systemic inflammation. The primary objective is to elucidate the relationship between oral dysbiosis and inflammatory biomarkers in pediatric Type 1 Diabetes. This dataset provides a valuable resource for understanding the microbiome-immunity axis in autoimmune disease and supports the discovery of microbiota-based biomarkers for disease monitoring and therapeutic development.