RNA-Seq analyses of myocardium specific hey2- overexpressing zebrafish hearts and Adv-Hey2 infected NRVMs
To elucidate the molecular underpinning of cardiac dilation and myocardial mitochondrial dysfunction caused by hey2 induction, we conducted RNA-seq analyses in hey2 overexpression zebrafish hearts and control littermate hearts at 1 week or 1 month post 4-HT treatments. To further investigate the impact of Hey2 in mammalian cardiomyocytes and mitochondria, we performed comparative analysis of transcriptome profiles on NRVMs infected with adenovirus containing Hey2 (Adv-Hey2) or vectors (Adv-Ctrl).