Genomic Characterization of the Lytic Edwardsiella Phage vB_EiA_CT68P1 with Potential for Biocontrol of Multidrug-Resistant Edwardsiella ictaluri in Striped Catfish (Pangasianodon hypophthalmus)
Edwardsiella ictaluri is a major pathogenic bacterium responsible for enteric septicemia in striped catfish (Pangasianodon hypophthalmus), causing substantial economic losses in aquaculture. In this study, the multidrug-resistant strain E. ictaluri E1 was analyzed to obtain its complete genome sequence. Additionally, a novel lytic bacteriophage, Edwardsiella phage vB_EiA_CT68P1, was isolated and characterized as a potential biocontrol agent against E. ictaluri. Whole-genome sequencing of phage vB_EiA_CT68P1 revealed the absence of genes associated with lysogeny, virulence, or antimicrobial resistance, indicating a strictly lytic lifestyle.