Neuro 2A Transcriptome or Gene expression
5-methylcytosine dioxygenase 3 (TET3) is a member of the Ten-Eleven-Translocation (TET) family of enzymes shown to mediate DNA demethylation by oxidising 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC) and further oxidative intermediates. 5-hmC is a stable DNA modification associated with actively transcribed euchromatin and thus may serve as a mechanism underlying the activation of lineage-specific transcriptional programmes. TET3, specifically, has been proven to be highly expressed in neurons. Nevertheless, the molecular mechanisms which underlie the role(s) it plays in brain function such as its plasticity are yet to be discovered.