PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology
Phospholipase C gamma 2 (PLCG2) is an intracellular effector of microglial cell surface receptors, including TREM2. Variants which alter PLCG2 activity impact Alzheimer's disease (AD) risk, but the effects of PLCG2 deficiency in AD remain unclear. Overall design: 5xFAD mice were crossed with PLCG2 and TREM2 deficient mice to assess the role of PLCG2 in response to amyloid pathology. Bulk RNA-Seq of cortices from 7.5-month-old mice was conducted for murine transcriptomic analyses.