Microbiome of SARS-CoV-2 infected Golden Syrian hamsters.
Fecal microbiome analysis through 16S rRNA sequencing in SARS-CoV-2-infected Syrian golden hamsters provides valuable insights into how the virus impacts the gut microbiota. Syrian golden hamsters are a well-established model for studying SARS-CoV-2 pathogenesis, replicating key aspects of human infection, including respiratory and systemic immune responses. By analyzing fecal samples, 16S rRNA sequencing allows us to characterize shifts in gut microbial composition during and after infection. These changes can reflect broader effects of the virus on host metabolism, immune function, and gut-lung axis interactions. Alterations in the microbiome may contribute to inflammation, immune dysregulation, or even long-term complications associated with COVID-19.