Spermidine Metabolism Regulates Leukemia Stem and Progenitor Cell Function through KAT7 Expression
To invesetigate the transcriptional changes as a result of polyamine depletion in AML leukemic stem cells and normal hematopoietic stem cells Overall design: Leukemic stem cells enriched from patient samples and hematopoietic sten cells enriched from normal bone marrow samples were treated with polyamine analog DENSpm or control and collected for RNA sequencing.