Whole genome sequencing of Bifidobacterium pseudolongum isolated from mice fed low fiber diet
Dietary fiber deficiency induces intestinal dysbiosis and increases susceptibility to allergic and other inflammatory diseases. Yet, even under such detrimental dietary conditions, certain beneficial commensal bacteria persist and ameliorate these immune disorders; however, the mechanisms by which they are maintained in a dysbiotic gut and exert their immunoregulatory effects remain poorly understood. Here, we show that Bifidobacterium elicits self-recognizing, T cell-dependent secretory IgA (TD sIgA) and harnesses this sIgA to enhance its mucosal adhesion, thereby securing stable colonization even under diet-induced dysbiotic conditions.