Bifidobacterium- and Escherichia-dominated gut microbiome metabolic shifts in tuberculosis patients
This study characterizes the baseline gut microbiome composition and functional potential in treatment-naive tuberculosis patients prior to chemotherapy initiation. Using deep metagenomic sequencing of fecal samples from drug-naive TB patients, we reconstructed the metabolic capacity and strain-level diversity of the intestinal microbial community. These findings establish a fundamental baseline of the gut microbiome in tuberculosis patients and provide data for understanding how subsequent anti-TB chemotherapy alters the gut ecosystem, potentially informing personalized treatment approaches.