Transcriptomic profiling of SD rat cornea in dry eye disease: Comparative analysis between disease model and therapeutic intervention
This study investigates the molecular mechanisms of dry eye disease (DED) induced by 0.2% benzalkonium chloride (BAC) and evaluates the therapeutic efficacy of a novel synthetic compound, DFIL, in SD rats. Corneal transcriptomes were analyzed using de novo RNA sequencing to compare gene expression patterns between BAC-induced DED models and DFIL-treated animals. The results will identify key differentially expressed genes (DEGs) and pathways involved in corneal damage and repair, providing insights into potential therapeutic targets for DED. This research contributes to the understanding of ocular surface disorders and supports the development of novel treatment strategies.