Genome-Wide Analysis of HIF-1a in LPS-Activated Macrophages in mice
To investigate HIF-1a role in macrophage under LPS stimulation, we performed chromatin immunoprecipitation sequencing (ChIP-seq) and RNA-seq to identify genome-wide HIF-1a binding sites and their transcriptional activity in mouse macrophages treated with LPS and compared them with those in hypoxia.