Transcriptional profiling of striatum from a mouse model of Huntington's disease (Q140) crossed with Ccdc82 heterozygous and homozygous mice [Ccdc82]
Striatum was isolated from 6-month-old Ccdc82+/- and Ccdc82-/- mice crossed with the Q140 knock-in (KI) HD mice and their respective controls. Transcriptomic analysis (RNASeq) was performed on 6 genotypes: WT, Q140, Ccdc82+/-, Q140 X Ccdc82+/-, Ccdc82-/-, and Q140 X Ccdc82-/-, 7-8 replicates per genotype. Overall design: RNASeq analysis was performed on samples from the striatum tissues of 6-month-old wild type, Q140, Ccdc82+/-, Q140 X Ccdc82+/-, Ccdc82-/-, and Q140 X Ccdc82-/- mice. N = 7-8 per group.