mRNA sequence of WT and AIM2-KO mice aged 8 and 30 weeks after APAP trastment
To further investigate the reason for the discrepancy in experimental results between 6-8 and 30-32-week-old mice, we conducted RNA-seq on liver tissues from three WT andAIM2-/- mice at each age stage after 24 hours of APAP stimulation. We detected 18,410genes, and the average mapping ratio with both the reference genome and gene was95.26% and 84.12%, respectively.