Impaired Branched-Chain Amino Acid Catabolism is Associated with Chemotherapy-Induced Heart Failure and Rescued by Metformin
To investigate the cooperative function KDM4D/NFIB/MLL1 complex in the regulation of adipogenic differentiation, we established 10T1/2 cell lines in which each target gene has been knocked down by shRNA. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different drug treatments. Overall design: Comparative gene expression profiling analysis of RNA-seq data for hiPSC-cardiomyocyte cells treated with doxorubicin versus DMSO, and doxorubicin and metformin co-treatment versus DMSO