Bidirctional regulatory effects of frequency-dependent splenic apex electrical stimulation on peripheral immune suppression and central neural repair after SCI
High level spinal cord injury (SCI) often triggers secondary complications characterized by immune supressions, leading to infections. The spleen, as a densely innervated immune hub, undergoes pathological remodeling of its regulatory network post-SCI. However, whether targeted electrical stimulation of the spleen at specific frequencies can reverse peripheral immune suppression or improve the central immune milieu remains unclear. This study aim to elucidate the differential regulatory mechanisms of trans-splenic apex electrical stimulation (10Hz, 50Hz, 100Hz) on peripheral immune suppression and spinal cord homeostasis after SCI.