Whole-genome CRISPR/Cas9 screening of key host factors for rotavirus infection
Rotaviruses pose a significant and constant threat to the health of children under 5 years of age and newborn animals. To identify host factors that play an important role in rotavirus infection, we performed two genome-wide loss-of-function CRISPR/Cas9 screens using rhesus rotavirus RRV strain and a matched African green monkey library.