Chronic endoplasmatic reticulum stress in myotonic dystrophy type 2 promotes autoimmunity via mitochondrial DNA release
In this study, next generation sequencing of fibroblasts from healthy controls and patients with myotonic dystrophy type 1 or 2 was performed. The aim is to compare the obtained profiles (RNA-seq) and to find differences between controls and patients or between the two types of the disease. These results may help to further clarify the origin of the autoimmune disease that some patients develop. Overall design: RNA sequencing of transcripts isolated out of native cell (fibroblast) samples