Evaluation of gene expressions in epididymal white adipose tissue (eWAT) of genetic and diet-induced NASH model.
To investigate the alterlation of eWAT gene expression in diet-induced NASH model with adipose tissue insulin resistance, we evaluated eWAT of control mice and adipocyte-specific PDK1 knockout (PDK1KO) mice  fed either normal chow(NC) or  Gubra amylin NASH (GAN) diet for 16weeks after weaning at 4 weeks old. We then performed gene expression profiling analysis using data obtained from RNA-seq of these 4 groups. Overall design: Comparative gene expression profiling analysis of RNA-seq data for eWAT of 4 groups[Control(NC), Contro(GAN), PDK1KO(NC),PDK1KO(GAN)].