gut metagenome
The gut microbiota 16S rRNA sequencing results of healthy Lewis rats and experimental autoimmune myasthenia gravis (EAMG) rats were systematically analyzed to characterize the compositional changes and distinctive features. EAMG rats showed distinct gut microbiota profiles versus healthy controls (HC). In order to further explore the relationship between gut microbiota and EAMG, we employed fecal microbiota transplantation (FMT) to transfer microbiota from healthy rats and EAMG rats into antibiotic-treated, microbiota-depleted animals. By comparing 16S rRNA sequencing results from rats receiving healthy versus EAMG microbiota, we established a causal relationship between gut microbiota and EAMG.