Analysis of Peripheral Blood T Cell CDR3 Repertoire Characteristics in Multidrug-Resistant Tuberculosis Patients
This study aims to investigate the impact of prolonged persistent infection on cellular immunity and T-cell exhaustion in patients with multidrug-resistant tuberculosis (MDR-TB). Using Adaptive immune receptor repertoire sequencing (AIRR-seq), we analyzed the diversity and characteristics of T-cell receptor (TCR)beta CDR3 repertoires in MDR-TB patients compared to drug-sensitive tuberculosis (DS-TB) patients. The research identifies selective expansion of specific (TCR)beta CDR3 sequences and potential MDR-TB-specific clones, providing a new experimental foundation for understanding the adaptive immune response and developing diagnostic tools for drug-resistant tuberculosis