MDA5 regulates BCR signaling and B cell function via DNM1 mediated by NF-kappaB (PRJCA043599)
Melanoma Differentiation-Associated gene 5 (MDA5) is an important pattern recognition receptor (PRR). PRRs recognize pathogen-associated molecular patterns (PAMPs) and play an essential role in antiviral immunity. However, the non-canonical role of MDA5 in adaptive immunity, especially in B cell immune functions, is poorly defined. We show that MDA5 contributes to marginal zone (MZ) B cell differentiation, BCR signal transduction and cytoskeleton dynamics.