Whole Exome Sequencing of AMG510-Resistant and Parental KRAS mutant NSCLC Cell Lines
We conducted whole exome sequencing on two pairs of parental and drug resistant (to AMG510) non small cell lung cancer cell lines (H358, H1373 and their derivatives) to identify genomic alterations associated with acquired chemotherapy resistance. Sequencing data were analyzed to detect somatic single nucleotide variants (SNVs), small insertions and deletions (indels), and copy number alterations. This study aims to uncover novel resistance mechanisms and potential biomarkers for non small cell lung cancer treatment.