Effect of Tet2 deletion on gene expression in mice
To investigate the effect of Tet2 on gene expression, we established Nestin Cre+ Tet2lox/lox (Tet2 cKO) mice and Nestin Cre- Tet2lox/lox (WT) mice , collected their habenular tissue, and compared the differential gene expressions at mRNA levels. We then performed gene expression profiling analysis using data obtained from RNA-seq in the habenular of 2-month mice. Overall design: Comparative gene expression profiling analysis of RNA-seq data in the habenular of Tet2 cKO mice and WT mice, n=3.