Global gene expression profiles in HIF3A gene-disrupted neonatal mice in lungs.
The mice carrying HIF3A gene disruption were generated by genome editing technology; a C insertion (HIF3A_ins) and a G deletion (HIF3A_del) in exon2. To assess the impact of HIF3A gene disruption on global gene expression in the lung, RNA-seq was performed employing the whole lungs of HIF3A_ins, HIF3A_del and wildtype mice at postnatal day 0.