UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma
The goal of this experiment was to characterize the impact of Upf1 knockdown on the transcriptome of a murine pancreatic adenocarcinoma cell line (Kras G12D/+;Tp53 R172H/+;Pdx-1 Cre/+ or KPC cells, derived from pancreatic tumors of GEMM model).