Comprehensive ceRNA Network Analysis Reveals Regulatory Mechanisms of mRNA, miRNA, circRNA, and lncRNA in Methcathinone-Induced Neurotoxicity_circRNA
Whole-transcriptome sequencing was then used to characterize the expression of mRNAs, miRNAs, circRNAs, and lncRNAs. Differentially expressed mRNAs(DEmRNAs), miRNAs(DEmiRNAs), circRNAs (DEcircRNAs), and lncRNAs (DElncRNAs) were identified, and circRNA-miRNA-mRNA and lncRNA-miRNA-mRNA networks were constructed. Compared with the control group, 784 DEmRNAs, 32 DEmiRNAs, 391 DElncRNAs and 749 DEcircRNAs were identified in the low-concentration group, 607 DEmRNAs, 28 DEmiRNAs, 369 DElncRNAs and 728 DEcircRNAs were identified in the medium-concentration group, and 501 DEmRNAs, 23 DEmiRNAs, 371 DElncRNAs and 753 DEcircRNAs were identified in the high-concentration group.