Circulating microRNA Biomarker for Detecting Breast Cancer in High-Risk Benign Breast Tumors
We sought to identify circulating microRNAs (miRNAs) from blood plasma that could be used as biomarkers to detect breast cancer existing in high-risk benign breast tumors. Plasma samples were collected from patients with early-stage breast cancer (CA), high- (HB), moderate- (MB), and no-risk (Be) benign tumors. The miRNAs we have identified have the potential to develop into a crucial blood-based screening tool to help monitor the development of breast cancer in benign breast tumors. Overall design: small RNA-seq was performed on plasma RNA obtained from patients with early-stage breast cancer or high-, moderate-, and no-risk benign breast tumors.