Mutation panel in precancerous stages of CRC
Colorectal adenomas (CRA) are recognized as precancerous lesions with the potential to progress to colorectal carcinoma (CRC). This study investigates the mutational landscape of CRA to identify candidate biomarkers for early CRC detection, which may contribute to improved treatment outcomes and patient survival. A total of 67 CRA samples, along with matched adjacent unaffected mucosa, were analyzed using next-generation sequencing. The analysis targeted a panel of 176 genes, including those involved in DNA repair pathways, cell cycle regulation, and genes known to be associated with CRC development.