miR184 and miR499 in HSPC proliferation and differentiation
We observed that platelet-derived extracellular vesicles (pEV) are enriched in miR184 and miR499. These pEVs are taken up by hematopoietic stem and progentior cells (HSPC). We wanted to know the effects of miR184 and miR499 on HSPC proliferation and differentiation. Overall design: We transfected mouse hematopoietic stem and progenitor cells with control miR, miR184, or miR499. Two days after the transfection, mRNA was extracted and RNAseq was performed.