RNA sequencing-Usnic acid target CRYAB phosphorylation to induce ferroptosis
Differences in gene expression in COAD-derived organoid samples under hypoxic and normoxic microenvironments; differences with and without the use of usnic acid/CRYAB recombinant protein; intrinsic differences between COAD and CCLM organoids under normoxic conditions; differences in COAD organoids co-cultured with liver fibroblasts under normoxic and hypoxic conditions; differences with and without the use of usnic acid/CRYAB recombinant protein; differences in liver fibroblasts themselves under normoxic and hypoxic conditions.