Transcriptome analysis of human clear cell renal cell carcinoma cells, 786-O and Caki-1,  transducted empty or DDX41-expressing lentiviral vector.
The present study shows novel findings that STING-independent tumor-promoting activity through DDX41 expression and the suppression of normal STING response owing to VHL loss lead to poor prognosis in clear cell renal cell carcinoma with tumor necrosis.