Implementation of a 1021-Gene Liquid Biopsy Assay for Real-World Tumor Genomic Profiling in Oncology Practice
In this study, we investigated the performance and clinical utility of liquid biopsy in metastatic cancer patients, focusing on biomarker detection efficiency and the concordance between cfDNA and tissue biopsy results. In addition, we evaluated the utility of ctDNA fraction monitoring and explored the feasibility of performing concurrent germline analysis through parallel sequencing of genomic and tumor-derived DNA