Leishmania transcriptome under heme limitation reveals LHR2, a protein required for leishmaniasis development
Leishmania parasites cause leishmaniasis, a neglected disease without adequate treatments. Its heme-auxotrophy is one of its Achilles heel. A transcriptomic study of heme-regulated genes identifies LHR2, an essential gene for Leishmania intracellular replication and development of pathology proposed as a novel drug target.