The Role of the Non-Coding RNA Uhg5 Involved in Ribosomal RNA Modification in Drosophila Sleep
This study explores the role of non-coding RNA Uhg5 in sleep regulation in Drosophila. Findings indicate that Uhg5 is essential for sleep, as the Uhg5B507 mutant shows significant differences in sleep patterns compared to the control group. Uhg5 influences sleep by modulating mitochondrial function, as evidenced by changes in the NADP/NADPH ratio after sleep deprivation. The study also highlights Uhg5's role in rRNA modification and its genetic interactions with the stx gene, confirming its importance in development. Additionally, GoldCLIP analysis reveals that Uhg5 regulates snoRNA expression through specific protein interactions. Overall, this research emphasizes Uhg5's critical role in sleep regulation and its connections to mitochondrial function and genetic interactions.