RNA-seq of mouse distal colon treated with prednisolone, rapamycin or both in dextran sodium sulphate (DSS)-induced colitis
Glucocorticoids are antiinflammatory and immunosuppresive drugs employed in the treatment of inflammatory bowel disease and many other conditions. However, their clinical efficacy is limited due to deleterious effects on the intestinal barrier function. In this experiment, we evaluate rapamycin as a potential candidate to mitigate these deleterious effects on the intestinal barrier while maintaining the antiinflammatory effect of prednisolone, the glucocorticoid used in this experiment.