Sex-biased transcriptome profiling in embryonic mouse cortex under Pax6 haploinsufficiency
This study aims to characterize sex-biased transcriptomic profiles in the embryonic cortex of Pax6 mutant mice. Total RNA was extracted from the telencephalon of wild-type (WT), heterozygous (Sey/+), and homozygous (Sey/Sey) embryos from both males and females at embryonic day 14.5 (E14.5). Bulk RNA sequencing was performed to compare gene expression patterns between sexes and genotypes. The dataset provides a resource for investigating sex-dependent transcriptional regulation during cortical development under Pax6 haploinsufficiency. Data were generated at the Department of Developmental Neuroscience, Graduate School of Medicine, Tohoku University, Japan.