Gene expression of Parkin-overexpressing cells after mitophagy induction.
"Mitochondria are highly dynamic cellular organelles that repeatedly divide and fuse, and dysfunctional mitochondria are degraded by mitophagy. At the same time, mitochondrial biosynthesis takes place in a regulatory system centered on PGC-1a, and homeostasis is maintained by maintaining a balance with degradation. The crosstalk between mitophagy and mitochondrial biogenesis is vital for cellular and organismal physiology.Our objective is to identify molecular network between mitochondria and nucleus underlying mitochondrial biogenesis after mitophagy."