Genome-wide maps of chromatin state changes upon NFATc3 overexpression in mouse bone marrow-derived macrophages
To explore the role of macrophage NFATc3 on steatohepatitis, macrophage-specific Nfatc3 knockin mice (Nfatc3-MKI) were generated. Lyz2-Cre mice were used as control. Mouse bone marrow-derived macrophages (BMDMs) were isolated from Lyz2-Cre and Nfatc3-MKI mice and then were subjected to ChIP sequencing analysis. Overall design: ChIP-seq was performed to analysis the chromatin state changes and NFATc3 enrichment in BMDMs from Lyz2-Cre and Nfatc3-MKI mice.