HNF1amaintains pancreatica and ß cell functionsin primary human islets [RNA-seq]
Transcriptomic profiling by high-throughput sequencing of primary human alpha and beta cells following HNF1A loss of function. Overall design: Profiling of FACS-purified human pancreatic HNF1A shRNA-mediated knockdown GFP+ alpha or beta cells by RNA-Seq, compared to a non-targeting shRNA control for each donor.