Integrated transcriptomic and proteomic analysis of CD4+ T cells from DSS-induced colitis mice treated with Akkermansia muciniphila
This project investigates the immunoregulatory effects of Akkermansia muciniphila on host CD4+ T cells in a murine model of DSS-induced colitis. Wild-type C57BL/6J mice were orally administered A. muciniphila or PBS, followed by DSS treatment to induce colitis. Spleen-derived CD4+ T cells were isolated for both transcriptomic (RNA-seq) and proteomic profiling to explore how A. muciniphila modulates immune metabolism and inflammatory responses.