Transcriptome of RAW264.7 cells
Bacterial invasion of eukaryotic cells and establishment of intracellular infections have been shown to be effective means of resist the action of antibiotics because anti-infective agents generally exhibit poor permeability to host cell membranes. Anti-infective drug encapsulation to nanoscale delivery system, such as liposomes, is proved to enhance intracellular delivery, therefore, this study focuses on the natural products epigallocatechin and liposome application in the field against intracellular parasitic bacteria, aims to reveal its inhibitory effect and potential mechanism, to provide theoretical support for the development of new antibacterial strategy, with Salmonella as the research object, through the in vitro experiment poor permeability anti-infection drug catechin into liposome), analyze the antibacterial activity of catechins on intracellular Salmonella.