Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying the neurogliomal synaptic communication [OPC2 ATAC-seq]
Glioblastoma (GBM) is the most aggressive of all primary brain tumours. Here, we perform a multi-omics approach to map the promoter-enhancer interactome and the regulatory landscape of glioblastoma, including RNA-seq, ChIP-seq of histone marks, HiChIP and ATAC-seq. Overall design: Comparative gene expression profiling analysis of RNA-seq data for 15 GBM celllines (representative of 4 molecular subtypes) vs normal human Astrocytes