Distinct fecal metagenomic signatures associated with pre-malignant colorectal adenomas
Colorectal cancers arise from pre-malignant lesions, which are either tubular adenomas (TAs) or sessile serrated adenomas (SSAs). Although the molecular genetics underlying these lesions are distinct, it is unknown whether they are also associated with distinct gut microbiomes. To study the microbiome associated with pre-malignant colon lesions, we profiled stool samples from 708 participants undergoing routine colonoscopy using shotgun sequencing and paired these data with curated dietary and medication history.