Sequencing of Clostridium difficile in Chinese Hospitals
This BioProject encompasses a longitudinal genomic surveillance study of Clostridioides difficile isolates collected over a four-year period from a tertiary hospital in Hangzhou, China. The research focuses on the evolutionary dynamics of antibiotic resistance and virulence factors. Using whole-genome sequencing (WGS), we aim to monitor shifting minimum inhibitory concentration (MIC) trends for vancomycin and metronidazole, and to characterize the genomic landscape of clinical strains to improve infection control and treatment strategies in the region.