Senolytics reduce senescent characteristics and enhance activation of tumor-infiltrating CD4+ Naive T cells (PRJCA028161)
To investigate the unique functionality of significantly increased CD4+CD62L+ Naive T cells in tumors after combined anti-PD-1+DQ therapy in anti-tumor immunity, we isolated CD62L+CD44-CD4+ cells from tumors of mice treated with Isotype, anti-PD-1, or anti-PD-1+DQ, and performed RNA-Seq and ATAC-Seq.