Loss of Serpin E2 alters antimicrobial gene expression by microglia but not astrocytes
To investigate the influence of Serpin E2 (aka PN-1) on glia in the brain, we purified microglia and astrocytes and performed RNA sequencing from Serpine2-/- mice Overall design: Microglia or astrocytes were purified from the brain of adult Serpine2-/- mice and littermates with at least one functional Serpine2 allele. Half of the sibling pairs were injected with lipopolysaccharides and others received saline injections.