Ultraviolet B downregulates adipocyte-derived exosome miR-466c-5p to promote breast cancer progression
Breast cancer remains one of the leading global malignancies, with its progression regulated by complex interactions between genetic alterations, environmental factors, and the tumor microenvironment. The impact of UVB exposure, a ubiquitous environmental factor, on breast cancer remains unclear due to potential confounding factors in clinical studies. To date, miRNA sequencing reveals that UVB downregulates miR-466c-5p in Exo-UVB, activating the PI3K-Akt signaling pathway, which promotes tumor growth and inhibits apoptosis.