Confirming genotype specific effects for a Parkinsons disease associated variant in induced pluripotent stem cells
We characterised the effects of the rs11610045 genotype in KOLF2.1J iPSCs by integrating CRISPR-Cas9 SNP introduction and reversal, transcriptomics, spatial genomics (Micro-C), long-read whole-genome sequencing for mutational load, and proteomics (AP-MS).