Dengue virus 4/2 Envelope domain chimeric virus panel maps type-specific responses against Dengue serotype 2
To identify and quantify E-domain, TS antibody responses in polyclonal sera, we developed a panel of chimeric DENV4/2 viruses that incorporate DENV2 envelope domain 1, 2, and 3 (DENV4/2-EDI, EDII, EDIII, respectively) into the DENV4 E glycoprotein.