RNA-binding protein IGF2BP1 is required for spermatogenesis in an age-dependent manner
This study characterizes the in vivo function of RNA-binding protein IGF2BP1 during spermatogenesis, and further identifies ELAVL1 as a novel binding partner, and Lin28a mRNA as a downstream target. Overall design: RNA immunoprecipitation-sequencing (RIP-Seq) of IGF2BP1 in mouse cultured germ stem cells