The role of TRAF1 in Helicobacter pylori infection
Our previous study has found the VacA virulence of Helicobacter pylori could induce the apoptosis of gastric epithelial cells and TRAF1 plays a crucial role in this process. In order to further investigate the detailed mechanism of TRAF1-related apoptosis, we constructed a TRAF1 knockdown model in MKN74 cells and TRAF1 overexpressing model in HGC27 cells. Overall design: RNA-seq profiling of TRAF1-knockdown MKN74 cells and TRAF1-overexpressing HGC27 cells as well as corresponding controls.