Up-regulation of Ifi27l2a expression in bone marrow monocytes contributes to glucocorticoid induced bone loss (PRJCA045782)
Glucocorticoid-induced osteoporosis (GIO) is the most common complication of prolonged, high-dose glucocorticoid therapy and is also one of the most common types of secondary osteoporosis. The enhancement of osteoclast differentiation is a key factor in the pathogenesis of osteoporosis. Osteoclasts originate from the hematopoietic lineage. There is a strong association between the bone marrow microenvironment and osteoporosis. This study performed scRNA-seq of bone marrow cells of GIO mice model, furnishing insights into bone marrow cellular heterogeneity.