Lifetime ovulatory years and ovarian cancer gene expression profiles
Greater ovulatory years is associated with increased ovarian cancer risk. Although ovulation leads to an acute pro-inflammatory local environment, how long-term exposure to ovulation impacts ovarian carcinogenesis is not fully understood. Thus, we examined the association between gene expression profiles of ovarian tumors and lifetime ovulatory years to enhance understanding of associated biological pathways. Overall design: Ovarian cancer case-only analysis, association between gene expression profiles of ovarian tumors and lifetime ovulatory years