epigenome and transcriptome in AML cells
we performed ATAC-seq, CUT&amp;Tag and RNA-seq to reveal the role of ESCO2 deficiency and NPM1c on genome-wide H3K27ac, H3K9me3, chromatin accecibility and transcription changes in NPM1-wild-type cells (OCI-AML2) and NPM1-mutated cells (OCI-AML3).