Inferring time-course chromatin states for promoter-enhancer pairs based on Hi-C data
Co-localized combinations of histone modifications ("chromatin states") have been shown to correlate with promoter and enhancer activity. Changes in chromatin states over multiple time points ("chromatin state trajectories") have previously been analyzed at promoter and enhancers separately. With the advent of time-course Hi-C data it is now possible to connect promoters and enhancers and to analyze chromatin state trajectories at promoter-enhancer pairs. We present TimelessFlex, a framework for investigating chromatin state trajectories at promoter-enhancer pairs based on Hi-C information. Overall design: Investigation of chromatin state trajectories at promoter-enhancer pairs based on Hi-C information