Effects of NR1H4/FXR on Gene Expression Profiling of mice BMSC-derived adipocyte
Bone fractures occurring in patients with osteoporosis can substantially affect their quality of life and are a steadily increasing problem due to the ageing of the population.Bone marrow mesenchymal stem cells (BMSCs) are common precursors of osteoblasts and adipocytes, and the regulation of their differentiation direction plays a critical role in maintaining skeletal metabolic homeostasis.Therefore, it is crucial to understand the underlying mechanisms that regulate the switch between bone and fat in the bone marrow. Modulating the lineage commitment of BMSCs could offer an effective therapeutic strategy for related bone disorders.The aim of this study is to evaluate the effects of NR1H4 on adipocyte differentiation.Using mice bone marrow stromal cell line (BMSCs) obtained from FXR fl/fl and FXR fl/fl ;prx1-cre mice, our microarray-based transcription profiling showed that FXR inhibits adipocyte differentiation.