Metformin reverses PhIP-induced ovarian toxicity by alleviating Ca2+ Overload-mediated TCA Cycle suppression
2-Amino-1-methyl-6-phenylimidazo pyridine (PhIP) is linked to hormone-related cancers, potentially mediated through estrogen receptor alpha (ERa). However, there is no direct evidence linking PhIP to hormonal imbalances and ovary toxicity.