RNA-seq of sipinal cord of AR-97Q and WT mice at P7 and 13 weeks of age
Antisense oligonuleotides targeting human AR (AR-ASO) or Rest4 (Rest4-ASO) are intracerebroventriculary injected to AR-97Q mice at postnatal day 1 (P1). Gene expression profiles were analysed in the spinal cord of WT and AR-97Q mice at P7 and 13 weeks of age. Overall design: RNA-seq analysis was performed in the mouse spinal cord at P7 (WT vs. AR-97Q vs. AR-ASO treated AR-97Q, Scramble-ASO vs. Rest4-ASO treated AR-97Q) and 13 weeks of age (WT vs. AR-97Q).