Immunoregulatory Role of IL-1R-NFKBIZ in ALCL
Anaplastic Large Cell Lymphoma (ALCL), a subtype of mature T-cell neoplasms with an aggressive clinical course, is defined by elevated surface expression of CD30. Despite recent advances, including CD30-directed CAR-T cell therapy, further improvements in treatment strategies are needed. To uncover factors influencing immunotherapy efficacy, we performed genome-wide CRISPR library screens in ALCL. These screens revealed an unexpected role for the IL-1R pathway in promoting tumor immune evasion and establishing an immunosuppressive tumor microenvironment. Our findings uncover a novel mechanism of immune resistance and highlight IL-1R signaling as a promising target to enhance the efficacy of immunotherapy in ALCL.