Annexin-A1-mediated regulation of the efferocytosis in tumor-associated macrophage promotes anti-tumor immune response by activating the cGAS/STING pathway in pancreatic cancer
To explore the mechanism of macrophage Anxa1 deficiency to induce anti-tumor responses, we  preformed RNA sequencing of pancreatic tumors from Anxa1?M? and Anxa1WT mice. Overall design: Panc02 cells were subcutaneously implanted into Anxa1flox/flox and Anxa1?M? mice. After 4 weeks, the mice were sacrificed and the tumors were obtained for RNA sequence.