Cyfip2 drives renal Tubular senescence and fibrosis in hypertensive .
RNA sequencing was performed in TGF-B1-stimulated human renal tubular epithelial (HK-2) cells under CYFIP2 knockdown and control conditions. Our analysis revealed significant transcriptomic alterations in response to silencing of CYFIP2. Pathway enrichment analysis further indicated that CYFIP2 deficiency significantly impacted the p53 signaling pathway, highlighting its pivotal role in the regulation of cellular processes under fibrotic stress.