PAX3-dependent nonsense-mediated RNA decay in melanoma
Public description: While PAX3 is mainly known to function as a transcription factor, this factor also regulates nonsense mediated decay (NMD). To identify PAX3 NMD targets, RNAseq from PAX3 depleted, PAX3 overexpressing, and parental cells was generated, with or without cycloheximide treatment, to differentiate PAX3 transcriptional versus NMD downstream genes.