Epigenetic sequencing of the ovary in PCOS model rats (PRJCA040822)
This project aims to explore the epigenetic mechanisms of polycystic ovary syndrome (PCOS) by conducting epigenetic sequencing of ovarian tissue in PCOS model rats. PCOS is a common endocrine disorder with complex causes. This study will establish a reliable PCOS rat model and use advanced sequencing technologies to analyze DNA methylation, histone modifications, and non - coding RNA expression in ovarian tissue. The findings will help identify epigenetic changes associated with PCOS - related ovarian dysfunction, discover potential biomarkers for diagnosis, and explore new therapeutic targets. This research is expected to enhance our understanding of PCOS pathogenesis and contribute to the development of more effective diagnostic and treatment strategies for this condition.