Comparison of the RB loss-induced E2F1 cistrome in hormone-therapy sensitive and castration-resistant prostate cancer [ChIP-seq]
These studies examine the consequence of RB loss on E2F1 function across prostate cancer progression. Overall design: E2F1 cistrome alterations in resposne to RB loss after AR stimulation were assessed in early (LNCaP-shCon and LNCaP-shRB) and late (C42-shCon and C42-shRB) stage disease models