Hippocampal epitranscriptomic (m6A) in IA-KA mouse model of Temporal Lobe Epilepsy
RNA is subject to extensive processing and modification. N6-methyladenosine (m6A) is the most abundant internal modification and regulates RNA fate in several ways including stability and translational efficiency. Here, we provide a detailed analysis of the m6A-ome in hippocampus of a mouse model of temporal lobe epilepsy during epileptogenesis and into the epilepsy stage of the disease. Our results suggest that m6A represents a novel layer of complexity in gene regulation in epilepsy. Overall design: m6A-RNA-sequencing of hippocampi of IA-KA mouse model of temporal lobe epilepsy