CRISPR/Cas9 screening in proneural-like GBM samples
Glioblastoma (GBM) is a fatal disease with a poor prognosis, whose aetiology involves profound molecular alterations. Given the limited progress made in recent years, research into new therapeutic avenues may improve the treatment of GBM patients. In this work, we have identify regulatory factors involved in the ascorbic acid mediated response in proneural-like patient derived stem cells by means of a high-throughput CRISPR/Cas9 library screen.