9-methoxystrobilurin-G induced resistance
The natural product 9-methoxystrobilurin-G (9MG) from Favolaschia spp basidiomycetes is a potent and selective antimalarial. The mechanism of action of 9MG is unknown, but structurally related strobilurins from other fungal species are known to inhibit mitochondrial cytochrome b (CYTB) complex III. We induced 9MG resistance in Plasmodium falciparum laboratory strains 3D7 and Dd2 and identified mutated genes associated with resistance by genome sequencing.