Effects and mechanisms of Faecalibacterium prausnitzii and its metabolite indole-3-carboxaldehyde on atherosclerosis by regulating CXCL10/CXCR3 signaling pathway
Faecalibacterium prausnitzii is enriched in the gut of healthy individuals but significantly reduced in atherosclerosis patients; Faecalibacterium prausnitzii and its metabolite indole-3-carboxaldehyde (ICA) markedly inhibit the development of atherosclerosis; further studies revealed that they suppress PI3K/AKT activation via the CXCL10/CXCR3 pathway, thereby alleviating atherosclerosis progression.