Identification of Human Pluripotent Stem Cell Derived Astrocytic Progenitors that Correlate with Glioblastoma Subtypes
To investigate the heterogeneity of astrocyte progenitor subtypes present during human astrocyte differentiation that share molecular similarities with tumor initiating stem cells in GBM. Overall design: human ESC derived astrocytic progenitor subtypes at 160 and 220 days after sequential treatment of LIF, BMP4 and FGF1 treatment were dissoiated and used for single cell RNA sequencing