Whole Genome Sequence Analysis of Mycobacterium tuberculosis Strains from Patients in Campania Region
Tuberculosis (TB) is one of the deadlier infectious disorders in the world. For an adept TB management, it is necessary the insight into the lineage Mycobacterium tuberculosis (MTB) and drug resistance distributions. Although the Campania region is declared a cluster area of the infection, TB evolution and transmission remain poorly known. In this study, 109 genomes of MTB strains from Campania region were analysed. The most frequently encountered MTB lineage is lineage 4 (n=91,  83.49%). Regarding drug resistance, 94 strains (86.3%) were classified as multi susceptible, while the other 15 (13.7%) strains showed drug resistance. Among resistance strains, 7 were isoniazid-resistant MTB (HR-MTB), 2 were multidrug resistant MTB (MDR-MTB), while only one was classified as extensively drug-resistant MTB (Pre-XDR-MTB). The presented data will broaden the existing available knowledge on drug resistance and evolution of M. tuberculosis, contributing to further TB-related genomics studies to improve the management of TB infection.