A comparative evaluation of the tumor microenvironment of dog hepatocellular carcinoma
Liver cancer remains a leading cause of death in humans. Its primary form hepatocellular carcinoma (HCC) is frequently resistant to chemotherapy and radiation, and often shows insufficient responses to immunotherapy. Dogs often develop HCC spontaneously, without the environmental or viral exposures typically associated with human cases, providing a unique perspective on the intrinsic genetic and molecular drivers of the disease. Using whole exome sequencing (WES) and single nucleus RNA sequencing (snRNA-seq) in tandem we offer a powerful multi-omic approach to understanding dog HCC.