RNA-seq of mouse incisors from wild-type and Osr2-Cre;pMes-Fgf18 mice.
This RNA-seq study investigates the molecular mechanisms by which Fgf18 regulates mouse incisor development, focusing on its role in the dental mesenchyme. Although Fgf signaling is known to be essential for tooth development, the specific function of Fgf18 in incisor formation remains poorly understood. We performed transcriptome analysis of incisors from postnatal day 3 mice, comparing wild-type (WT) controls with Osr2-Cre;pMes-Fgf18 mutants that overexpress Fgf18 specifically in the mesenchyme.