Role of small non-coding RNAs in chondrosarcoma
Chondrosarcoma (CS) is the second most common primary bone tumour of the skeletal system characterised by abnormal cartilage production. Chemo- and radiotherapy are not sufficient treatment options as CS tumours have proven resistant. Moreover, there is a lack of data regarding the genetic and molecular mechanisms underlying CS pathogenesis. Non-coding RNAs (ncRNAs) are RNA species that are not translated into proteins and are considered promising candidates for future cancer therapeutics, both as molecular targets and disease biomarkers. However, research regarding the role and function of ncRNAs in CS is scant. In the current study, we identified differentially expressed small ncRNAs in patients with CS of the distal femur and the knee by using a small RNA sequencing approach. This study has contributed to the discovery of novel molecular players of CS pathogenesis and investigated potential disease mechanisms. This will nurture further research in the field and facilitate the discovery of more effective biomarkers and anti-cancer treatments for patients, through substantive additional research.