Cooperativity between H3-K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatars (RNA-Seq)
PDGFRA and H3.3 mutations cooperate in an iPSC-based model of diffuse midline glioma to alter tumor biology. Overall design: Cleavage Under Targets & Release Using Nuclease of iDMG tumor cells