Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide [RNA-Seq]
To investigate the effect of SIRT2 inhibition on global transcriptomics  profile, we inhibited Sirt2 using small molecules (AGK2) Our analysis reports phenotype-reversal of gliomas as well as induction of terminal differentiation program. Overall design: Comparative gene expression profiling analysis of RNA-seqdata for murine neuroprogenitor cells (Tp53-/- and Atrx-/- ) and HDAC inhibitiors (AGK2)