Increased LEF1 protein levels and isoform switching drive cell proliferation in chronic lymphocytic leukemia [CUT&Tag]
The main goal of this study was to assess the role of LEF1 in patient-derived CLL cells. Overall design: Comprehensive functional analyses to define the role of LEF1 (LEF1 CRISPR in primary CLL cells and LEF1 isoforms overexpression in CLL cell lines).