CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas
Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intra-tumor heterogeneity characteristic of gliomas, we hypothesized that CD8+ T-cells mediate immunoediting in these tumors. We developed retrovirus-induced PDGF+Pten-/- murine gliomas and evaluated glioma progression and tumor immunogenicity in the absence of CD8+ T-cells by depleting this immune cell population. Furthermore, we characterized the genomic alterations present in gliomas that developed in the presence and absence of CD8+ T-cells.