Systems biology profiling reveal changes following short-term exposure of an epithelial-endothelial coculture to secondary organic aerosols
To investigate the toxicological mechanisms induced by an antrhopogenic SOAs (SOANAP-SP) and a biogenic SOAs (SOAßPIN-SP), as well as, fresh soot particles (SPs) in either the directly exposed A549 cells cultured at the air-liquid interphase or in the indirectly exposed EA.hy926 cells. Overall design: Comparative gene expression profiling analysis of RNA-seq data of a coculture cell model system (A549 and EA.hy926 cells) that have ben exposed to different aerosols (SOANAP-SP, SOAßPIN-SP, SPs) and clean air (CA) as control.