Chromatin accessibility of hematopoietic stem/progenitor cells (HSPCs) derived from MDS patients before and after disease progression
Myelodisplastic syndromes are a oligoclonal disease starting at the level of the stem/progenitor compartment. We used ATACseq to determine  changes in chromating landscape between MDS low and high risk samples. Overall design: ATAC-seq of CD34+ HSCPs from MDS patients before and after disease progression