Molecular effects of cardiac contractility modulation in patients with heart failure of ischemic aetiology uncovered by transcriptome analysis
In this study we investigated the fundamental aspects of rhythm disturbance in patients with chronic heart failure who underwent the implantation of support device Optimizer (OPT). We evaluated the changes in molecular pathways as well as in clinical indicators after the devise implantation Overall design: Libraries were prepared with TruSeq Stranded mRNA kit, samples were RNA-sequenced on Illumina NextSeq 2000, read length 51 bp.