Single-cell RNA-seq of uterine blood across endometrial cancer development
This project generates single-cell RNA sequencing (scRNA-seq) profiles from uterine blood collected at hysterectomy to characterize how the local uterine immune and stromal microenvironment changes during endometrial adenocarcinoma development. Samples span benign controls, endometrial intraepithelial neoplasia (EIN), lesions transitioning from EIN to carcinoma, and endometrial cancer, enabling analysis of microenvironment remodeling across disease states.