Crnic Institute Human Trisome Project - Trisomy 21 Model Atlas: PolyA RNA-seq from 6-month old mouse brain hippocampus tissue ± JAK1/3 inhibition with tofacitinib
Analysis of steady-state mRNA levels in mouse brain hippocampus tissue at 5 months from wild-type C57BL/6J, Dp16, 5xFAD, and 5xFAD-Dp16 mice. Overall design: Comparison of sham-treated wild-type (n=5), Dp16 (n=3), 5xFAD (n=4), and 5xFAD-Dp16 (n=4) versus tofacitinib-treated wild-type (n=5), Dp16 (n=5), 5xFAD (n=6), and 5xFAD-Dp16 (n=4) mice.