Tet2 deficiency alters CD4+ T-cell function and promotes T-cell lymphoma with a TFH-cell immunophenotype
We generated Cd4cre;Tet2FL/FL mice, which developed aggressive T-cell lymphoma (m-TCL) with a TFH cell-like-immunophenotype and used multi-omics analysis, including RNA-seq, 5-hydroxymethylcytosine (5-hmC), and 5-methylcytosine (5-mC) profiling of Tet2-/- CD4+ T cells before lymphoma development (12, 48, 60 weeks) and at the lymphoma stage (>1.2 years).