Multiomics study of colistin-resistant Pseudomonas aeruginosa independent of plasmids. Authors: Telma de Sousa, Hsin-Yao Wang, Ting-Wei Lin, MJN Ramos, Manuela Canica, Racha Beyrouthy, Richard Bonnet, Gilberto Igrejas, Patricia Poeta
Microbial resistance to the antibiotic colistin is predominantly mediated by the plasmid, which harbors various variants of the mcr gene. In this study, we are examining colistin-resistant Pseudomonas aeruginosa strains devoid of plasmids against varying colistin concentrations to investigate this resistance.