Transient E-cadherin knockdown promotes epithelial regeneration in murine colonoids
This project investigates how transient downregulation of E-cadherin (Cdh1) influences intestinal epithelial regeneration. RNA sequencing was performed on murine colonoids with IPTG-inducible E-cadherin knockdown and matched controls to identify transcriptional programs associated with stemness, regeneration, and mucosal healing.