A shift towards an emergency myelopoiesis in critical COVID-19 patients
Five critical life-endangered COVID-19 patients were enrolled to donate blood. Family signed consent was obtained. The peripheral blood leukocytes were obtained by standard centrifugation methods. Then the leukocytes were single cell RNA sequenced using 10X Genomics Protocol. High presence of myeloid lineage subsets whereas low count of lymphoid lineage populations in COVID-19 patients was readily observed. Interestingly, among the cellular subset present in myeloid lineage there was immature states.