Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate
Uterine epithelial transformation/metaplasia occurs in Rar tKO mice at a young age. We performed single cell RNA sequencing (scRNA-seq) of isolated uterine cells at two time points during development in order to investigate the origin and charactoristics of these transformed cells. Overall design: Uterine cells were isolated from postnatal day 21 (PD21) and PD54 Rar tKO and control (CTRL) mice and analyzed using scRNAseq