Profiling the response of trophoblast organoids to diverse viruses and DUX4
This project includes single cell RNA sequencing experiments and bulk RNA sequencing experiments of varying conditions in placenta-derived trophoblast and decidua organoids. This includes: bulk RNA sequencing of trophoblasts infected with seven different teratogenic viruses, bulk and single cell RNA sequencing of trophoblast organoids engineered to express DUX4 under a doxycycline inducible promoter, bulk RNA sequencing of trophoblast and decidua organoids infected with HSV-1, and single cell RNA sequencing of trophoblast organoids infected with HSV-1.