Utility of shotgun metagenomics analyses in prenatal diagnosis a proof-of-concept pilot study
Shotgun metagenomics is increasingly used for diagnosis (pathogen detection or specific transcriptomic profile) and for pathophysiological analyses. Its exponential gain in processing speed and sample capacity and its reduced cost now make it attractive for prenatal diagnosis and pathogen identification when standard investigations fail to determine the causes of fetal anomalies consistent with infection, such as growth restriction (FGR) or cerebral abnormalities.