New insight into Ginseng root polysaccharide GRP-E1F2 on prodynorphin inhibition to delay senescence-associated neuroaging via modulating cellular senescence
Male KM mice (5- and 18-month-old) were acquired from the Animal Core Facility of Changchun Yisi Experimental Animal Technology Co. Ltd (Changchun, China). For negative and positive control, 5- and 18-month-old mice received oral physiological saline for 4 weeks every 2 days, respectively. The experiment group comprised 18-month-old mice, who were given 200 mg/kg GRP-E1F2 by gavage for 4 weeks every 2 days