Selective translation of nuclear mitochondrial respiratory proteins reprograms succinate metabolism in AML development and chemoresistance. [RNA-seq]
Here we identify a novel RAS-responsive element binding protein 1 short isoform, RREB1a, as a key in governing mitochondrial complex II translation to promote stemness and drug resistance of cancer stem cells of acute myeloid leukemia Overall design: [RNA-seq] This dataset contains RNA-seq experiments of leukemia stem cells isolated fromWT or Rreb1-KO mice.leukemia stem cells were isolated from the bone marrow for RNAseq analysis with two biological replicates.