Gene regulation profiling by KMT2D under different glucose conditions in HNSCC (RNAseq)
Histone H3 lysine (H3K4) methyltransferase KMT2D is a key regulator of gene expression, mainly through promoting H3K4 methylation and activating enhancers, and plays critical roles in development, differentiation, metabolism, and tumor suppression. To investigate the mechanisms by which KMT2D loss promotes HNSCC and to identify potential therapeutic targets, we generated KMT2D wild-type (KMT2D-WT) and KMT2D knock-out (KMT2D-KO) SCC23 HNSCC cells and performed RNA-seq under different glucose conditions. Overall design: Comparative gene expression profiling analysis of RNA-seq data for KMT2D-WT and KMT2D-KO SCC23 HNSCC cells under high glucose conditions (+Glc) or with glucose deprivation treatment for 6 hours (-Glc).