GBA Mutations and Their Interaction with the Gut Microbiota Brain Axis in Parkinson Disease
Evaluate whether pathogenic GBA variants are associated with gut microbiota brain axis (GBMA) changes in PD. Pathogenic GBA variants were not associated with intestinal inflammation or permeability. Although no significant differences in fecal microbiomes were observed between groups, a slight trend towards greater dysbiosis was observed in GBA-positive subjects. These data suggest that PD GMBA disruption is independent of GBA mutation status.