Anti-tumor necrosis factor-alpha monoclonal antibody suppresses colorectal cancer growth in an orthotopic transplant mouse model
In order to investigate the effect of anti-TNFa mAb  on colorectal cancer, we generated a orthotopic transplantation model of colorecatal cancer. We performed a comprehensive gene expression profiling analysis by extracting total RNA from cecal tumor of mice treated with and without anti-TNFa mAb (MP6-XT22) Overall design: Comparative gene expression profiling analysis of RNA-seq data for cecal tumor of mice that received no treatment and anti-TNFa mAb treatment