Salmonella enterica serovar Typhimurium
This current strain of Salmonella enterica serovar Typhimurium was isolated from Indian poultry breed and was used to create six mutant strains of msr genes. Salmonella encounters but survives host inflammatory response. To defend host-generated oxidants, Salmonella encodes primary antioxidants and protein repair enzymes. Methionine (Met) residues are highly prone to oxidation and convert into methionine sulfoxide (Met-SO) which compromises protein functions and subsequently cellular survival. However, by reducing Met-SO to Met, methionine sulfoxide reductases (Msrs) enhance cellular survival under stress conditions.