Comparison of transcriptional changes in regenerating mice livers at baseline and 3-12 hours post 70% partial hepatectomy
To refine the timeframe of liver regeneration initiation and investigate the temporal characteristics of metabolic reprogramming in the preparatory stage, we here established partial hepatectomy model and performed gene expression profiling analysis using data obtained from RNA-seq of regenerating livers at different time points. Overall design: To investigate the changes of gene expression in the preparatory phase of liver regeneration. Wild-type C57/BL6J mice were performed sham operation or 70% hepatectomy. Liver tissue was analyzed at 3, 6, 12 hours post resection by RNA-seq, respectively.