ADSC-Exos can improve acute lung injury by regulating alveolar macrophage polarization through IRF7/NLRP3
Alveolar macrophages (AMs) are crucial for pulmonary defense and immune regulation. Exosomes from adipose-derived mesenchymal stem cells (ADSC-Exos) have emerged as a promising therapy for inflammatory lung diseases by modulating immune responses. This study investigates the ability of ADSC-Exos to alleviate inflammation in acute lunag injury (ALI), a condition often triggered by sepsis and characterized by lung permeability and respiratory failure. Overall design: After treatment with ADSC-Exos, macrophages were subjected to RNA sequencing to identify differentially expressed genes (DEGs) that could reveal the molecular mechanisms underlying the immunomodulatory effects of ADSC-Exos on macrophage polarization.