Familial history and prevalence of BRCA1, BRCA2 and TP53 pathogenic variants in Brazilian patients with Hereditary Breast/Ovarian Cancer syndrome referred to a public healthcare service
NGS data on Hereditary Breast and Ovarian Cancer patients referred to the National Institute of Cancer from Brazil between 2016-2019. BRCA1, BRCA2 and TP53 sequenced for most samples. The study encompass 257 patients , but not all NSG data is deposited here since some patients were sequenced at private laboratories.  The study provides information on prevalence of pathogenic variants, as well as predictive models for risk assessment.