Lysosomes signal through the epigenome to regulate longevity across generations [II]
Profiling of H3K79me2 occupancy in F3 wild-type progeny, designated as second transgenerational (T2) descendants, derived from N2, lipl-4 Tg, or dot-1.3 Tg parents. Overall design: Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for H3K79me2 in F3 wild-type progeny, designated as second transgenerational (T2) descendants, derived from N2, lipl-4 Tg, or dot-1.3 Tg parents at day-1 adulthood.