Single cell-RNA-sequencing to study the mechanism of meiosis initiation
To make haploid gametes, mitotically proliferating cells enter meiosis. The mechanism of transition from mitosis to meiosis is still unclear. To analyze the cell property during this transition, transcriptomic analyses were conducted in single cell resolution for murine embryonic ovarian germ cells from control, STRA8-null and STRA8 mutant which fail to interact with mitosis regulator RB.