BE-based Functional Screen Reveals METTL3 S2 Dephosphorylation Sensitizes Gastric Cancer Cells to Oxaliplatin by Interfering METTL3-eIF3H Interaction
This study employs adenine base editors combined with CRISPR screening to pinpoint critical phosphorylation sites associated with OXA resistance, uncover underlying mechanisms, and identify potential therapeutic targets to enhance treatment outcomes for gastric cancer patients.