Role of LINC01235 on transcriptional output in HCC1954 HER2 positive breast cancer cells
LINC01235 plays a crucial role in HER2-positive breast cancer by regulating global histone modifications (H3K27ac, H3K9ac, H3K36me3) and promoting H2A.Z expression in its regulatory regions. It enhances the accessibility of DNA licensing factors at their promoter regions, leading to increased DNA replication and chromosomal instability. These mechanisms contribute to clonal expansion and resistance to anti-HER2 therapies, highlighting LINC01235 as a potential therapeutic target. Overall design: RNA-Seq was performed inASO-NC and ASO-1235 HCC1954 cells .