Early life MES exposure inhibits testosterone production by upregulating TGF-ß1 expression in mesenchymal cells by direct binding to GATA2
In this study, we investigated the effects of early life exposure to C18-MES on the reproductive system of mice, and by measuring semen quality, testicular structure, blood-testicular barrier integrity, and sex hormone levels, we clarified the reproductive toxicity of C18-MES and revealed its specific molecular regulatory mechanism. Overall design: RNA-seq analysis was performed on testicular tissues of mice in the control group and MES-exposed group