Neurons undergo IFN?-driven persistent epigenetic shifts and synaptic remodeling in the inflamed brain [ATAC-Seq]
Our study provides novel evidence that neuronal intrinsic epigenetic changes are established as a consequence of cytotoxic T cell-mediated immune attacks and persist long after the resolution of the inflammatory process and associate to long lasting synaptic loss Overall design: Chromatin accessibility of neurons derived from two neuroanatomical structures, namely hippocampus and brainstem, from control conditions and sequential disease timepoints of CD8 T cell-mediated encephalitis disease in a genetic background of NuTRAP transgenic and NuTRAP transgenic and IFNGR floxed mice