RNA-seq of ATF-3 overexpressing and Neomycin control melanoma cell lines
The present study demonstrates that ATF-3 plays a tumor suppressing function in melanoma. Overexpression of ATF-3 in metastatic melanoma cell lines significantly inhibited their growth, migration and invasion in vitro as well as inhibited tumor growth in human melanoma xenograft mouse model in vivo. Overall design: We performed RNA-seq of the melanoma cell lines A2058 and C8161 overexpressing ATF-3 by retroviral transduction and their corresponding neomycin controls.