Transcriptomic Analysis of ACACA Knockdown in MC38 Colon Cancer Model
This study investigates the transcriptional changes induced by ACACA (Acetyl-CoA Carboxylase Alpha) knockdown in a murine colon cancer model. MC38 cells, with or without ACACA knockdown, were implanted into mice, and the resulting tumors were analyzed using RNA-sequencing. By comparing gene expression profiles between ACACA-depleted and control tumors, we aimed to analyze ACACA's role in cancer metabolism and its potential impacts on the tumor microenvironment in vivo. This study provides insights into the molecular mechanisms underlying ACACA's function in tumor progression within a physiological context.