Transcriptome analysis of the dorsal root ganglion of SOD1 mice.
Our study aims to understand the earliest pathological changes that occur in the central and peripheral nervous systems in mouse models of amyotrophic lateral sclerosis (ALS). To achieve this aim, we analyze the ALS mouse model, SOD1G93A mice, and wild-type mice at postnatal day 30 and 120. Transcriptome analysis is performed using next-generation sequencing technology about each organ to examine alteration of gene expression in SOD1G93A mice. Characterization of early events associated with ALS pathology will provide insight into disease mechanisms.