RNAseq data from mouse skin Treg isolated after imiquimod treatment
Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and  non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin. Overall design: Mice were treated for 5 days with tamoxifen to induce Cre recombinase before the start of the treatment. On the last day of tamoxifen treatment, the back skin of the mice were shaved. Two days later,we started the imiquimod 5% cream (Taro) application for 4 consecutive days and harvest on day 5 for sort and bulk RNAseq