Expression profiling of STAT3-regulated genes in U937-derived macrophages
We used RNA-Seq assay to characterize STAT3-regulated gene expression patterns in U937-derived macrophages. We wanted to determine how STAT3 activation involves in function, differentiation, cytokine secretion of macrophages. Overall design: Vehicle control and STAT3 knockdown U937-derived macrophages were used for RNA-Seq assays in order to compare the transcriptional profiles that are regulated by STAT3.