Effects of fluoxetine and venlafaxine in the mouse neural embryonic stem cell test
The neural embryonic stem cell test (ESTn) is in vitro test that mimics early neural differentiation. The aim of this study was to define the biological domain of ESTn based on gene expression of selective markers for certain cell types, and to investigate the effects of two antidepressants, fluoxetine (FLX) and venlafaxine (VNX), on neural differentiation. Overall design: 49 samples, covering seven time+treatment groups