Gut derived (S)-Equol mitigates lung inflammation in influenza by inhibiting pro-inflammatory macrophage polarization via Nrf2 mediated AKT/ERK/NF-kappaB pathways (PRJCA040211)
By employing metagenomic and metabolomic, we revealed dynamic alterations of gut microbiota and serum metabolites during influenza infection. We identified an important metabolite Eq produced from dietary soy isoflavones by some species in genera Eggerthella and Bifidobacterium that alleviates lung inflammation through modulating macrophage polarization.