Harnessing T-cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR
Exhausted Tumor-specific T cells circulate in patients and their specificity can be typed by trogocytosis and Peptidome on chip screening. Overall design: T cells specific for  tumor antigens were expanded from HSCT-transplanted patients by means of Leukemic Dendridic Cells sequential stimulation or via Dextramer sorting and anti-CD3/anti-CD28 stimulation.