Stress-induced Red Nucleus Attenuation induces Anxiety-like Behavior and Lymph Node CCL5 Secretion (PRJCA019740)
Using stressed human participants and rat models, we show that CCL5 levels are increased in stressed individuals compared to controls. Stress-inducible CCL5 is mainly produced from cervical lymph nodes (CLN). Given the observed difference in RS-induced changes in cervical lymph nodes, the molecular mechanisms were assessed. To address transcriptome-wide alterations in CLNs in stressed rats, we performed RNA sequencing (RNA-seq) analysis.