Microbial and Metabolomics Profiles of Ulcerative Colitis Patients in Clinical Remission
16S rRNA gene sequencing was performed of fecal samples collected from 106 ulcerative colitis patients in clinical remission (SCCAI <5), of which 89 also had fecal calprotectin < 150 ug/g. Longitudinal fecal sampling and 16S rRNA gene sequencing was performed for 40 subjects who experienced clinical flare (SCCAI equal or greater than 5) during a follow-up period which could extend up to 2 years. Samples were collected every 3 months and at the time of flare. Global untargeted fecal metabolomics was also performed at baseline and time of flare for this cohort.