Lin28 is essential for the maintenance of chicken primordial germ cells
To investigate the function of Lin28A and B in primordial germ cell (PGC) , we generated chicken PGCs in which Lin28A or B has been knocked out by CRISPR/Cas9. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different cell types. Overall design: Comparative gene expression profiling analysis of RNA-seq data for (1) control, (2) Lin28A knockout, (3) Lin28B knockout chicken PGCs.