Expression profile of 22Rv1 cells with GFP or HNF4G exogenous expression when treated with BETi ABBV-075
To study the consequence of HNF4G target genes expression with ABBV-075 treatment in cells that have BETi-independent HNF4G expression, we performed RNA-Seq on 22Rv1 cells that exogenously express HNF4G using GFP expression as control. Overall design: GFP or HNF4G transgenes were expressed in 22Rv1 cells in BET independent manner and cells were treated with ABBV-075 (25 nM for 24 hrs) or DMSO and global transcriptome was evaluated using RNA-Seq.