Trimethoprim-resistant Escherichia coli
In this project we selected for trimethoprim-resistant derivatives of clinical isolates of Escherichia coli which were isolated from urinary tract infections in vitro in Mueller Hinton broth. Clinical isolates were sourced from the Nottingham University Hospitals NHS Trust Pathogen Bank. We subsequently assessed collateral effects of these trimethoprim-resistant Escherichia coli to nitrofurantoin and fosfomycin.