Bronchoalveolar Lavage Fluid Microbiota of Lung Cancer
Distinct differences in the microbial profiles were evident in the lower airway of patients with LC and N-LC, which was also found between non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). A combined random forest model was built to distinguish NSCLC from SCLC could reach 0.919 (95%CI: 87.5–97.69%) and 0.893 (95%CI: 79.39–99.29%) AUC in the training and test group respectively. The lower alpha diversity of BALF microbiota in the NSCLC patients was associated with reduced PFS significantly, although this link was not seen in SCLC. Specifically, NSCLC with higher abundance of Lachnospiraceae, Enterococcus and Prevotella_nigrescens achieved longer PFS. The enrichment of Streptophyta, Capnocytophaga and Aggregatibacter_segnis was observed in SCLC with worse PFS.