Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKa2 to inhibit AMPK activity and induce mitochondrial dysfunction
To analyze the mRNA profile of DUBs in diabetic heart, we performed a scRNA-seq of  heart cells from the wild type (WT) mice and db/db mice, a typical T2DM model mouse. Overall design: wild type (WT) mouse (n=1) and  typical T2DM model mouse (n=1)