IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer
To investigate the effect of transcriptomic changes in colorectal cancer, we performed 3' bulk mRNA sequencing of naive and AOM/DSS treated mice. Mice were subjected to the AOM/DSS mouse model for colorectal cancer or kept under naive conditions. Samples of the most distal 0.5 cm of the colon were taken on day 70 of the model and processed for 3' bulk mRNA sequencing. Overall design: Comparative gene expression analysis of naive and AOM/DSS-treated mice.