Exploration of genomic variant for canine malignant hyperthermia using whole-genome sequencing
Malignant hyperthermia (MH) is a life-threatening perioperative complication triggered by inhalant anesthetics or depolarizing muscle relaxants. Genetic variants affecting skeletal muscle are believed to underlie susceptibility to MH. However, its specific genetic background in dogs remains unclear. The aim of this study is to explore and identify causative genomic variants in dogs affected with MH using whole-genome sequencing.