RNA sequencing reveals a natural product derivative regulates gene expression in 5xFAD mice
The project aimed to find novel compounds for AD. We discovered that P, a natural product derived analog, improved learning, memory, anxiety, and social deficits in 5xFAD mice. It reduced Abeta accumulation, cellular senescence, neuroinflammation, and neuronal loss. RNA seq suggested P regulated the nervous and immune systems. In conclusion, the project highlight the potential clinical application of P as an innovative and multi-target drug for AD treatment.