Detection of PBMC methylation biomarkers in pulmonary nodules through TBS
We established two well characterized cohorts to validate PBMC DNA methylation biomarkers for the non-invasive classification of indeterminate pulmonary nodules. 100 samples (30 BPN, 37 MIA, 33 eIAC) were used as a Train cohort for TBS detection. Moreover, 93 samples (24 BPN, 34 MIA, 35 eIAC) was Test cohort for evaluating the performance of models.