PTEN regulates chromatin accessibility and hematopoietic lineage plasticity via the transcription factor PU.1
We elucidate the molecular and cellular mechanism underlying PTEN-regulated hematopoietic lineage choice and suggest a critical role of PU.1 in modulating the epigenetic state of prepro-B progenitors. Overall design: Examination of chromatin accessibility in stem and progenitor cells from WT and PTEN loss mouse bone marrow. Examination of chromatin accessibility and expression level in prepro-B cells from WT and PTEN loss mouse bone marrow.