ERK5 sustains autocrine mitogenic balance for cell fate specification in human pluripotent stem cells [XMD RNA-seq]
To investigate the function ERK5 in the regulation of hPSC pluripotency, we processed ERK5 inhibition (XMD892) treamtent in E8 medium for 12/24/48hr in H1 ESCs. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of H1 ESCs at 4 time points.