Interplay between nutrient stress and lysosomal signaling imprints immune memory in tissues [ATAC-seq]
Uncovered organelle signaling and metabolic processes shaping CD8+ tissue-resident memory (TRM) development Overall design: We used ATAC seq to compare chromatin accessibility profiles of sgNTC or sgFlcn-transduced OT-1 cells purified from the spleen and siIEL from the same host on day 7.5 post-LM-OVA infection