Expression changes after Inhibition of AHD in Molm-13 cells
Formation of AF9/ENL/AF4/AFF4-containing super elongation complexes (SEC) and catalytic activity of DOT1L are required for MLL-rearranged leukemia. We evaluated gene expression changes after inhibition of AHD in leukemia cells. Overall design: Molm-13 cells containing MLL-AF9 gene were treated by AHD inhibitor for 4 days, and gene expression changes were monitored.