Ovarian Cancer Network Analysis
This project investigates regulatory relationships between microRNA (miRNA) and messenger RNA (mRNA) expression in ovarian cancer using an integrated multi omic analysis framework. Matched bulk RNA-seq and NanoString miRNA expression data were generated from ovarian cancer cell lines and non malignant ovarian epithelial control cell lines. The study combined differential expression analysis, miRNA mRNA network inference, community detection, functional enrichment, biomarker-oriented prioritization, and external validation in TCGA OV to identify coordinated regulatory modules associated with ovarian cancer biology. Key outputs include processed expression matrices, differential expression results, integrated network edge and node tables, module assignments, enrichment analyses, and biomarker-prioritization summaries. The project is intended to support reproducible investigation of miRNA associated regulatory programs in ovarian cancer and to provide a resource for downstream mechanistic and translational follow up.