Transcriptomic profiling of hippocampal tissue in LPS-induced sepsis-associated encephalopathy mice treated with Yiqi Huoxue Prescription
Sepsis-associated encephalopathy (SAE) is a frequent and severe complication of sepsis characterized by neuroinflammation, blood-brain barrier dysfunction, and cognitive impairment. In this study, we established an LPS-induced mouse model of SAE and investigated the effects of Yiqi Huoxue Prescription (YQHXP), a traditional Chinese medicine formula, on hippocampal transcriptomic alterations. Hippocampal tissues were collected from control, model, and YQHXP-treated mice for RNA sequencing. These data were generated to identify differentially expressed genes, enriched biological pathways, and potential molecular mechanisms underlying the neuroprotective effects of YQHXP in SAE.