Netrin-1 facilitates pancreatic cancer liver metastasis
When pancreatic cancer cells metastasize to the liver, resident hepatic stellate cells release retinoic acid. Attached is an analysis of retinoic acid-induced genes in the highly metastatic murine pancreatic cancer cell line Ink4a Overall design: The mouse pancreatic cell line Ink4a was treated for 16 hours with DMSO or with 5 nM all-trans-retinoic acid in vitro