HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation
RNA-seq experiments were performed to assess effects of degradation of HDAC3 and HDAC8 on transcriptome Overall design: Cells were treated with control (DMSO), an HDACi (UF010), PROTACs (YX968, YX26862) that degrade HDAC3/HDAC8, or a negative control (YX968-NC) for various lengths of time