Dynamics of UV-induced changes and regulations in 3D genome organization
The goal is to understand the effects of UV-exposure on the 3D genome architecture and transcriptional regulation. Accordingly, HeLa-S3 cells were cultured and exposed to 254-nm UV (1 J/m2/s) for 20 seconds. At the recovery time points of 12, 30 and 60 minutes post-UV, cells were harvested. A non-UV control group has been processed as well. Hi-C, and RNA-Seq techniques have been applied.