Super-enhancer based development of an endothelial specific lentiviral vector
Hypoxia-regulated endothelial-specific lentiviral vector that can be used for endothelial-targeted gene therapy. Overall design: Construction of Lentiviral vectors containing endothelial-specific enhancer driving expression of reporter gene, vectors evaluation in vitro and Knock out validation studies with CRISPR/Cas9, followed by RNA-Seq in EA.hy926.