Gene expression and mutation profiling of sarcoma cell lines
Sarcomas are rare malignant tumors arising from mesenchymal cells of connective tissues, but because of its poor prognosis, the development of novel therapeutic agents is desirable. To find novel, highly effective therapeutic agents for sarcoma, we previously established a sarcoma panel consisting of cell lines from various sarcoma origins and investigated their sensitivity to a number of drugs. In this study, we profiled the baseline gene expression and mutation status of 23 sarcoma cell lines in the sarcoma panel by RNA-seq and WXS to compare with their drug sensitivity data.