DYRK1B Overexpression Promotes  Senescence-Like Transcriptional and Secretory Programs in A549 Lung Cancer Cells
We investigated the transcriptional changes in A549 lung cancer cells to characterize the effects of DYRK1B kinase overexpression on the phenotype of human A549 lung cancer cells. Overall design: Comparative gene expression profiling analysis of RNA-seq data from A549 cells with tet-inducible expression of wild type or mutant (Y273F) DYRK1B. Each cell type (WT and Y273F) was treated or untreated with doxycyclin for 7 days.  Data were obtained for three independent cell populations that were cultivated and lysed in parallel.