Transcriptional analysis of ZX-7101 treatment.
The potential mechanism of ZX-7101 against influenza viruses is unknown. In this study,  Transcriptome analysis demonstrated that ZX-7101 could directly inhibit viral replication and therefore affected the expression of genes involved in inflammation and the cell cycle. Overall design: A549 cells were infected with pH1N1 for 1 hour. The cells were then treated with ZX-7101 (10 nM) for 48 hours. Total RNA was extracted at 48 hpi for RNA-seq