Dr. Taj Ali Khan and Dr. Taane G. Clark Salmonella typhi WGS Project
This BioProject encompasses the whole genome sequencing (WGS) and comparative genomic analysis of Salmonella enterica subsp. enterica serovar Typhi isolates collected in Peshawar, Khyber Pakhtunkhwa, Pakistan, between December 2020 and July 2021. The project is conducted under the supervision of Dr. Taj Ali Khan and Dr. Taane G. Clark, in collaboration with Dr. Asghar, Dr. Noor Rehman, and Ms. Aiman. A total of sixteen S. Typhi isolates were sequenced, representing multidrug-resistant (MDR), extensively drug-resistant (XDR), and non-resistant strains recovered from human blood samples.The primary objectives are to characterize the genomic diversity, antimicrobial resistance (AMR) determinants, virulence genes and phylogenetic relationships among circulating S. Typhi isolates in the region. This study contributes to national and global efforts to monitor the emergence and spread of XDR typhoid fever. The data will serve as a valuable resource for public health genomics, antimicrobial surveillance, and vaccine impact evaluation. The project provides important insights into the molecular epidemiology of typhoid in Pakistan and supports comparative studies with global S. Typhi lineages to track transmission dynamics and resistance evolution.