Ubiquitination of RIPK1 regulates its kinase independent function in development and inflammation
To investigate the role of of Ripk1K376R,D138N mutant in skin inflammation, we performed RNA-seq analysis of skin tissues from 2 weeks mice(Ripk1+/+, Ripk1+/-, Ripk1K376R,D138N/+, Ripk1K376R,D138N/ K376R,D138N, Ripk1K376R,D138N/- and Ripk1K376R /- mice). RNA-seq analysis revealed significant upregulation of cell death-related genes and inflammation-related genes in Ripk1K376R,D138N/K376R,D138N skin tissue compared to control mice.