The effect of bcCML leukemia progression on the bone marrow microenvironment
Single Cell RNA-Sequencing was performed on CD45-Ter119- cells from leukemic mice at different stages of leukemic progression. Overall design: Bone and bone marrow from mice transplanted with bcCML leukemia (BCR-ABL and NUP98-HOXA9) were extracted at timepoints 0, 2, 4, 7, 8, 11, and 14 days post transplant. CD45- Ter119- cells were sorted and processed for scRNA-Seq.