IKZF1 gene deletions in BCP-ALL promote resistance to cytarabine treatment
To obtain further insight into the pathways or specific genes that drive resistance to AraC upon loss of IKZF1, we performed RNAsequencing on samples from wildtype and IKZF1 knockout Sem cells treated with and without AraC Overall design: SEM IKZF1 wildtype and SEM IKZF1 knockout cells were were either treated or untreated with 1uM AraC  for 16 hours, after which mRNA is isolated and transcriptome analyzed