ChIPseq of RNA Exosome components in BMEL cell lines invalidated or not for the expression of the three HP1 isoforms (CBX1, CBX3, CBX5)
Chromatin association of several nuclear RNA exosome components and cofactors in BMEL cells is dependent on the presence of HP1 proteins. TKO2 cells invalidated for the expression of the three HP1 isoforms (Cbx1-/-; Cbx3-/-; Cbx5-/-) are compared to Het32 cells (Cbx1+/+; Cbx3+/+; Cbx5+/-) expressing HP1 as controls.