Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen).
Gene expression profile at single cell level of whole lung cells from C57BL/6J mice or global STING knock-out mice (STING-/-), exposed to either room air or chronic hypoxia (4-week 10% oxygen). Study described in manuscript "A non-inteferon role of STING in pulmonary hypertension". We used scRNAseq to analyze the difference in pulmonary cells and different gene expression across populations between wild type and STING-/- underwent pulmonary hypertension induction with chronic hypoxia. Overall design: Lung left lobes from 8-week-old male C57BL/6J and STING-/- mice exposed to chronic hypoxia or room air (normoxia) were collected. Lung tissues were digested and suspended into single cell suspension for scRNAseq.