cRel Expression Regulates Distinct Transcriptional and Functional Profiles Driving Fibroblast Matrix Production in Systemic Sclerosis
The scope of this project is to investigate transcriptional differences bewteen wild type and Rel-/-  fibroblasts under basal conditions. Mouse fibroblasts were isolated via explant culture from  skin and  lungs of un-challenged mice. Overall design: Male C57BL/6J and Rel -/- mice (housed in IVC cages) aged 8-10 weeks, mice were euthanized by cervical dislocation and skin (dorsal area) and lung tissues were extracted