Alterations in lysosomal gene expression and lipid homeostasis in patient-derived liver organoids with acid sphingomyelinase deficiency
We generated hepatic organoids from Nieman Pick Type B patients with the aim to investigate their lipid status.  To discover genes related to lipid metabolism likely involved in lipid deposits. Overall design: Comparative gene expression analysis of RNA-seq data of hepatic organoids derived from Niemann Pick Type B (ASMD-B)