Crosstalk of astrocyte, microglia, and neuronal subtypes correlates to Alzheimer's disease pathology
To identify cell-cell interactions between the subtypes of astrocytes, microglia and neuronal subtypes that were profiled profiled using sn/scRNA-sequencing. Overall design: scRNA-seq was performed for all live cells from forebrains of 15 APP/PS1 and 14 WT mice from ages 3mo, 7mo, 9mo and 12mo