Improved Efficacy of Fecal Microbiota Transplantation for Ulcerative Colitis with Non-urbanized Donors
This BioProject encompasses a comprehensive multi-omic study of a fecal microbiota transplantation (FMT) treatment cohort comprising Bai ethnic group participants. The study integrates three complementary sequencing datasets to investigate the dynamics of gut microbiota and host mucosal responses during FMT therapy: 1) Fecal whole-metagenome shotgun sequencing, to profile the composition, functional potential, and temporal changes of the luminal gut microbiome; 2) Intestinal mucosal 16S rRNA gene amplicon sequencing, to characterize the mucosa-associated microbial community and its response to FMT; 3) Intestinal mucosal RNA sequencing (transcriptomics), to assess host gene expression changes in the intestinal epithelium and elucidate host-microbiota interactions underlying FMT efficacy. This multi-omic resource aims to advance our understanding of FMT-mediated gut microbiome modulation and host-microbe crosstalk in a distinct ethnic population, providing a foundational dataset for future translational research on FMT therapies.