Medieval social landscape through the genetic history of Cambridgeshire before and after the Black Death
The extent of devastation of the Black Death pandemic (1346-53) on European populations is known from documentary sources and its bacterial source illuminated by studies of ancient pathogen DNA.  What has remained less understood is the effect of the pandemic on human mobility and genetic diversity at local scale in the context of the social stratification of medieval communities. Here we study 275 newly reported ancient genomes from later medieval  and post-medieval Cambridgeshire, from individuals buried before, during, and after the Black Death. The majority of the individuals examined had local genetic ancestries. Consistent with the function of the institutions, we found a lack of close relatives  among the friars and the inmates of the hospital in contrast to their abundance in general urban and rural parish communities. Accounting for the genetic component for height accentuates the disparities between social groups in stature estimated from long  bones, as a proxy for health and the quality of life. While we detect long-term shifts in local genetic ancestry in Cambridgeshire that either pre- or postdate the Black Death, we find no evidence of major changes in genetic ancestry nor, in contrast to recent  claims, higher differentiation of immune loci between cohorts living before and after the Black Death.