Precision Mitochondrial Delivery for Tissue Repair in Intervertebral Disc Degeneration
This study aims to develop a pathological microenvironment-responsive hydrogel system leveraging AMP-activated protein kinase (AMPK) activation and mitochondrial delivery to regulate mitochondrial function, mitigate oxidative stress, and inhibit ferroptosis in nucleus pulposus cells (NPCs) for microenvironmental remodeling and tissue repair in intervertebral disc degeneration (IVDD).