AHR protects against lung vascular leakage in viral infection
We have identified the apelin-APJ axis as a mechanism of protection mediated by AHR signalling in lund=g endothelial cells. This RNAseq experiment will compare the effects of apelin receptor blockade on endothelial and epithelial responses in the lung during influenza infection. Overall design: Endothelial cells and epithelial cells isolated from influenza infected (d6) mice treated with the apelin receptor antagonist (MM54) or PBS controls will be compared by RNAseq analysis.