Drosophila melanogaster Genome sequencing
We investigated how host immune pressure shapes virus quasispecies and pathogenicity, using the fruit fly Drosophila melanogaster and one of its natural pathogens, Drosophila C virus (DCV), as a model. We performed an experimental evolution experiment in which three fly genotypes (wild type flies and flies in which the endonuclease Dicer-2 was either overexpressed or inactivated) were infected with DCV over ten fly generations. The parental stock and viral passages 1, 5 and 10 were subjected to sequencing.