Identification of a possibbly null novel HLA-B*15 allele
HLA typing was performed using NGS on a patient on the kidney transplant waiting list who had been initially studied by serological methods in 2011. While the first typing assigned to the B locus was B65,-, after performing high-resolution genomic analysis, the result was B*14:02P, *15 (mismatch E2-255 G>T, codon 19 exon 2). This point mutation involves the change of the amino acid Glu to a STOP codon. Since this is a premature stop in protein translation, we believe it may be a previously undescribed null allele.