lung microbiota in coal dust-induced lung injury
The rats were divided into five groups, including the control group, CWP group, silicosis group, CWP+antibiotic group, and CWP+MCC950 group. An animal model of CWP and silicosis was established using a non-exposed tracheal instillation method. The CWP+antibiotic group was treated with drinking and nasal drip broad-spectrum antibiotics in CWP rats, while the CWP+MCC950 group received intraperitoneal injections of NLRP3 inhibitors MCC950 in CWP rats. 16S rRNA sequencing was used to detect the lung microbiota in rats.