The Genetic and Epigenetic Features of Bilateral Wilms Tumor Predisposition
This study comprehensively evaluated the landscape of genetic and epigenetic events that predispose to synchronous bilateral Wilms tumor. We performed whole exome or whole genome sequencing, total-strand RNAseq, and DNA methylation analysis using germline and/or tumor samples from 68 patients with BWT from St. Jude Children's Research Hospital and the Children's Oncology Group.