THERMAL MODULATION OF GENETIC RESISTANCE TO INFECTIOUS SALMON ANEMIA VIRUS: TRANSCRIPTOME ANALYSES OF ATLANTIC SALMON FAMILIES (SALMO SALAR) AT 10 C AND 20 C
Experimental infection was carried out using cohabitation of study fish with Atlantic salmon IP-injected donors with a highly virulent ISAv isolate (HPR4, TCID50 of 1x10^5 mL). There was a significant relationship between the fish's family and environmental temperature, revealing that both factors notably influenced the viral load, timing of mortality, and overall mortality rates.Transcriptomic responses related to ISA resistance were examined by conducting RNA sequencing analysis of head kidneys at peak mortality for each temperature and using individuals representing two families with the highest and the two families with the lowest survival observed at 10 C and 20 C.