Associations Between Exposure to Endocrine Disruptors and Gut Microbiota in children population
The main objective of this project is to investigate the association between chronic exposure to bisphenols (BPs) and parabens (PBs), and the composition of the gut microbiota in the pediatric population. To this end, a cross-sectional study is being conducted in a cohort of 154 children aged 3 to 12 years, residing in the province of Granada, Spain. Chronic exposure to BPs and PBs is assessed through the analysis of hair samples using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS), a non-invasive method that enables the estimation of long-term accumulation of environmental contaminants. In parallel, stool samples are collected to analyze gut microbiota composition through 16S rRNA gene sequencing.