Moraxella catarrhalis O35E Transcriptome or Gene expression
RNA-seq-based analysis of the physiologic cold shock-induced changes in Moraxella catarrhalis gene expression. Moraxella catarrhalis, a major nasopharyngeal pathogen of the human respiratory tract, is exposed to rapid downshifts of environmental temperature when humans breathe cold air. The prevalence of pharyngeal colonization and respiratory tract infections caused by M. catarrhalis is greatest in winter. We investigated how M. catarrhalis uses the physiologic exposure to cold air to regulate pivotal survival systems that may contribute to M. catarrhalis virulence.