Cohesin mutations in CBFB-MYH11 murine leukemia
The goal is to assess the impact of cohesin haploinsuffiiciency on transcriptional output and chromatin accessibility in the setting of CBFB-MYH11 expressing leukemia. CBFB-MYH11-expressing leukemia with or without heterozygous deletion of cohesin genes Smc3 or Rad21 were used for these experiments