Baseline and Follow-up Methylation Profiling of Whole Blood DNA in Normoglycemia, Prediabetes, and Type 2 Diabetes
This study explores genome-wide DNA methylation patterns in adults across three glycemic states: normoglycemia, prediabetes, and type 2 diabetes mellitus (T2DM). Whole-blood DNA samples were sequenced using Oxford Nanopore long-read technology at baseline and after six years of follow-up. The resulting dataset allows a detailed comparison of epigenetic changes during glycemic progression and provides a valuable resource for identifying early methylation markers that may predict the onset of diabetes.