Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling pathway
Dextran sulfate sodium (DSS) was added to the drinking water of C57BL/6 mice for 5 days to induce colitis. Afterward, S1P were injected intravenously on 1, 3, and 5 days. Colons were collected of normal, DSS and S1P group. We explored the underlying mechanisms of S1P by RNA sequencing.