Solithromycin mitigates Prevotella intermedia–induced exacerbation of MRSA ventilator-associated pneumonia by modulating hyperinflammatory responses and enhancing alveolar macrophage function
Solithromycin protects by activating alveolar macrophages and promoting TNF-related responses, suggesting a novel immunomodulatory role for solithromycin in host defense against exacerbation of MRSA-VAP by P. int. sup. Overall design: In vitro, total RNA was extracted from the lungs infected with MRSA in the presence of P. int. sup. or P. int. sup. (SOL) at 12 h post-infection in mice