Characterising_the_molecular_basis_of_treatment_failure_in_Neisseria_gonorrhoeae_infection_
Neisseria gonorrhoea represents an important cause of vaginal bacteriosis. As part of a recent clinical trial evaluating different treatment regimens, a small number of patients appeared to fail treatment, and remained gonorrhoea positive post-treatment. This project will use direct sequencing approaches from residual NAAT samples to study the genotype of reoccurring strains to discriminate between relapse and reinfection, as well as investigating the microevolutionary changes associated with ongoing vaginal colonisation under selective drug pressure.  This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/