Endothelial Map2k1 mutation affects vasculogenesis: RNA sequencing analysis in a conditional murine model
To determine RNA expression changes caused by AVM MAP2K1 K57N mutation Overall design: Conditional mouse model expressing MAP2K1 K57N in endothelial cells after recombination at day 1 of life produced mice with brain AVM lesions. Endothelial cells from mutant and wild type mice were compared at day 9 to determine changes in RNA expression