Comparison of pathogenicity and host responses of emerging porcine reproductive and respiratory syndrome virus variants in piglets
In this study, we investigated the pathogenicity of two emerging PRRSV variants, NADC30-like PRRSV strain SD53 (SD53-1603) and high-pathogenic PRRSV strain HuN4. Transcriptome analysis of differently expressed genes from lungs and lymph nodes provide a comprehensive basis of the molecular networks involved in the different pathogenic mechanism between these two variants.