Identification of the role of TNFR1 on hematopoietic cells in pancreatic tumor growth.
Genetic abrogation of TNFR1 inhibits pancreatic cancer growth by increasing dendritic cell number and function, and enhanced anti-tumor immunity. Overall design: KPC mice were lethally irradiated (9 Gy) at the age of 7 weeks. Irradiated mice were reconstituted with 10^7 bone marrow cells from either WT or TNFR1 KO bone marrow. Infiltrating cells were collected when pancreatic tumor was detected to approximately 300 mm^3