RNA-sequencing of kidney tissue from mice with cisplatin-induced acute kidney injury treated with Rhei Radix et Rhizoma (rhubarb) and Salviae Miltiorrhizae Radix et Rhizoma (danshen) combination therapy
This study investigates the transcriptomic changes in mouse kidney tissue following cisplatin-induced acute kidney injury (AKI) and the potential protective effects of a combined treatment with two traditional Chinese medicines: rhubarb (Rhei Radix et Rhizoma) and danshen (Salviae Miltiorrhizae Radix et Rhizoma).Male mice were divided into three groups:Normal control (vehicle-treated)Cisplatin-induced AKI model (cisplatin alone)Cisplatin + combined rhubarb and danshen treatmentKidney tissues were collected for RNA extraction and high-throughput sequencing. Raw sequencing data (e.g., FASTQ files) are provided here. These data enable identification of differentially expressed genes, biological pathways, and potential molecular mechanisms underlying the renoprotective effects of rhubarb and danshen combination against cisplatin nephrotoxicity.