"To EXPLORING MITONUCLEAR GENETIC FACTORS IN LEBER'S HEREDITARY OPTIC NEUROPATHY: INSIGHTS FROM COMPREHENSIVE PROFILING OF UNIQUE CASES".
This study investigated the genetic basis of thirty distinct LHON cases through comprehensive sequencing to identify mito-nuclear genetic factors involved in the disease pathogenesis. Our findings highlight the significance of nuclear gene involvement in cases of LHON exhibiting secondary mutations or inconclusive mtDNA mutations