Spatial Landscape of the CNS T-cell Receptor Repertoire in Virally Suppressed Persons with HIV
To characterize the neuro-immunological landscape during treated HIV infection, we performed high-throughput bulk TCR $\alpha/\beta$ sequencing on matched CNS tissues and PBMCs from the Last Gift rapid autopsy cohort. This study defines the clonal diversity and spatial distribution of T-cell populations within the central nervous system despite long-term viral suppression.