Global transcriptome analysis of cytokine overexpression in mouse spleen
To evaluate the overall impact of IL-33 overexpression in spleen, we performed unbiased global transcriptome analysis following IL-33 HDD and analyzed cell type enrichment. Consistent with other experimental observations, IL-33 HDD led to a general depletion of B cell populations and increase of plasma cells. These effects were compared to overexpression of other cytokines (L-25, IL-13, TSLP, IL-4, and IL-9).