Mir142 loss unlocks IDH2R140-dependent leukemogenesis through antagonistic regulation of HOX genes
Acute myeloid leukaemia (AML) is genetically a genetically heterogeneous condition.  It was observed that mutations in the micro RNA mir142 co-occurred with mutations in isocitrate dehdrogenase genes IDH1 and 2.  These experiments intend to investigate the interaction between miR142 and IDH in AML.