Inulin-induced changes in gut microbiota composition in Functional Constipation
This study was a randomized, double-blind, placebo-controlled, cross-over trial, assessing the effect of four-week daily 12 g chicory inulin intake in 39 individuals, with functional constipation according to Rome III Criteria. Fecal samples were collected at four timepoints, which were during run-in, after the first study period, during the washout and after the second study period. Gut microbiota compositional changes were assessed through 16S rRNA sequencing, to be related to other outcomes, which were stool consistency, frequency and constipation-related quality of life (PAC-QOL) and symptoms (PAC-SYM).