The impact of NR1H3 deficiency on gene expression in ovarian cancer cells
NR1H3 is significantly influences cancer progression. Here, we identified the critical role of NR1H3 in the diagnosis and prognosis of ovarian cancer through bioinformatics analysis. Further functional experiments demonstrated that NR1H3 significantly promotes ovarian cancer progression through RPL29. RNA-seq analysis revealed that differentially expressed genes downstream of NR1H3 are significantly enriched in the TNF signaling pathway, which was validated by Western blot. In summary, our data provide new molecular insights into ovarian cancer. Overall design: The NR1H3 SINC, NR1H3 SI, NR1H3 OENC and NR1H3 OE ovarian cancer cell lines were used for 3v3v3v3 RNA-seq.