Inertia-driven, self-powered electrotherapy for enhanced wound regeneration
This study presents a miniaturized, inertia-driven triboelectric nanogenerator (TENG)-based electroceutical platform designed to accelerate wound regeneration by delivering motion-modulated electrical stimulation. We investigated the therapeutic mechanisms of this self-powered system, focusing on its ability to enhance keratinocyte-derived exosome secretion and promote directional cell migration. To evaluate the biological impact on the wound microenvironment, we performed full-length 16S rRNA gene sequencing (V1-V9 regions) to analyze shifts in the skin microbiome and its stabilization during the healing process. Additionally, miRNA sequencing was conducted on exosomes to identify qualitative changes in their molecular cargo induced by electrical stimulation, providing a comprehensive multi-omics perspective on electrically-guided tissue repair.