Alginate oligosaccharides forestalling  intestinal inflammatory injury by modulating mucin glycosylation
Alginate oligosaccharides (AOS), marine-derived bioactive oligosaccharides, have been reported to protect intestinal barrier function, yet its effects on intestinal inflammation and the mechanisms remain unclear. In this study, the anti-inflammatory and its mechanism of AOS were investigated in lipopolysaccharide-induced inflammatory injury mice. Forty-eight 6-week-old C57BL/6J male mice were randomly allocated to four treatments: control group (CON), AOS group (AOS), model group (LPS), and AOS prevention group (AOS+LPS). The CON and LPS groups received drinking water, whereas the AOS and AOS+LPS groups received water supplemented with AOS. On day 21, mice in the LPS and AOS+LPS groups were intraperitoneally injected with LPS 6 h before sampling. 16s rDNA sequencing revealed that AOS reshaped the colonic microbiota.