RNA-Seq of OSCC cells under Toosendanin
Toosendanin (TSN) is a natural extract with potential anticarcinogenic activity; however, its clinical application is limited by poor water solubility and low bioavailability. To address this, we developed TSN-loaded poly(lactic-co-glycolic acid) nanoparticles (TSN-PLGA NPs) to enhance its water solubility and potentially improve bioavailability. Furthermore, RNA sequencing (RNA-Seq) analysis was conducted on OSCC cells, including CAL27 and HN6, treated with TSN to investigate its molecular effects.