16S rRNA sequencing of gut microbiota from ALS mouse model
These findings suggest that ALS-associated gut microbiota dysbiosis is characterized by a loss of beneficial SCFA-producing bacteria and an expansion of aromatic amino acid-metabolizing bacteria, which may promote the production of neuroactive microbial metabolites such as p-cresol derivatives. These metabolites, particularly p-cresol conjugates, are closely linked to global microbiota restructuring in disease, supporting their role as key mediators of microbiota-host metabolic interactions.