The pro-inflammatory cytokine IL6 suppresses mitochondrial function via the gp130-JAK1/STAT1/3-HIF1a/ERRa axis
We found IL6+IL6R but not TNFa could reduce mitochondrial function in RPE-1 hTERT cells. To explore the underlying mechanism, we treated RPE-1 hTERT cells (n=5 in each treatment) with IL6(100ng/ml)+soluble IL6R(100ng/ml), or TNFa(100ng/ml), or mock treatment (vehicle dH2O control) for 3 days. Samples were harvested for bulk RNA sequencing profiling