Effect of eperisone pretreatment on TNF-alpha-stimulated gene expression in mouse primary peritoneal macrophages
This study aims to investigate the transcriptional response of mouse primary peritoneal macrophages following eperisone pretreatment and subsequent TNF-alpha stimulation. Primary peritoneal macrophages were isolated from mice and pretreated with eperisone at concentrations of 50 uM and 100 uM for 1 hour, followed by stimulation with TNF-alpha for 6 hours. Control groups included untreated cells and cells treated with TNF-alpha alone. RNA-seq was performed to profile gene expression changes. This dataset provides insights into the immunomodulatory effects of eperisone on macrophage activation and inflammatory signaling pathways.