Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma
We report the results of bulk RNA-seq from human Hürthle cell carcinoma (HCC) samples and matched normal thyroids. The bulk RNA-seq data reveals the molecular programs that are activated in HCC. These activated programs include mTOR and Myc signaling, the mitochondrial unfolded protein response, lipid peroxide scavenging, and amino acid biosynthesis. Overall design: Bulk RNA-seq in human Hürthle cell carcinoma (n=24) and matched normal thyroid (n=18) samples.