Faecal microbiota in Nf1 +/- mice
Faecal samples from male and female neurofibromin (Nf1) +/- and +/+ mice were examined for changes in their microbiota composition using full-length 16S rRNA sequencing with Oxford Nanopore.This research was carried out as the first investigation into the microbiota-gut-brain axis in this mouse model of Neurofibromatosis type I (NF1). Specifically, the study investigated the link between the brain, cognition and behaviour, and gut microbiota alterations, with the long-term goal of opening new therapeutic avenues for brain-related symptom complexes in NF1.