Single-cell multiome of human RPE and choroid
We present a joint scRNA-seq and scATAC-seq atlas of adult human retinal pigment epithelium (RPE) and choroid. We integrate this atlas with a HiChIP enhancer connectome to predict noncoding variants with causal roles in age-related macular degeneration (AMD). Overall design: Single-cell RNA-seq, single-cell ATAC-seq, and HiChIP