Bile acid modulation influences gut epithelial responses in colorectal cancer
Elevated levels of secondary bile acids produced by the gut microbiome accelerate the development of colorectal cancer under adverse dietary conditions. However, their effects on the intestinal epithelium in vivo have not been studied in detail. To determine epithelial responses to the modulation of bile acids in the gut, we used targeted colonization of gnotobiotic mice followed by single-cell RNA sequencing.