Transcriptome analysis of QPRT silencing in breast cancer cells
We identified quinolinate phosphoribosyltransferase (QPRT) as a prognostic factor in breast cancer. Transcription profiling analysis was performed in breast cancer cells transfected with control or QPRT shRNA. Overall design: QPRT expression was depleted in BT-20 and MDA-MB-468 human breast cancer cells by shRNA interference. Total RNA was extracted following QPRT knockdown and submitted to RNA sequencing.