Transcriptome analysis in the uterus of Esr2 knockout mice with age
We histologically analyzed the uterine structure in Esr2KO mice with age. In the uterus of Esr2KO mice, dilation of the uterine glands with squamous-like epithelial cells was accelerated and the collagen was accumulated in the stroma. To study the factors accelerating the uterine glandular dilation and collagen accumulation in Esr2KO mice, the comprehensive gene expression in the uteri of Esr2KO mice at 3 and 9 months was analyzed by RNA-seq.