Age Related Gut Microbiota Metabolite Trajectories in Rhesus Macaques Reveal Gut Liver Axis Dysregulation and Conserved Features of Human Longevity (PRJCA045927)
The gut microbiota and its associated metabolic alterations undergoes extensive changes throughout the life cycle. However, the dynamic changes in gut microbiota and metabolites corresponding to age-related shifts remain unclear, which hinders the development of healthspan interventions targeting gut microbiota or metabolites. Here, we utilized captive rhesus macaques (Macaca mulatta) across three age groups, conducting 16S sequencing and targeted metabolomics analysis of fecal. Our findings elucidate the dynamic changes of gut microbiota and metabolites with age, suggesting that interventions targeting liver metabolism may be key to achieving healthy aging and longevity. Our results also provide critical support for the use of rhesus monkeys as an animal model to study the role of gut microbiota in human aging.