Sirtuin 2 inhibition selectively induces senescence in ATRX-deficient malignant gliomas by modulating chromatin landscapes genome-wide [ChIP-Seq]
To investigate the effect of SIRT2 inhibition on global epigenome profile, we inhibited SIRT2 using AGK2 and performed ChIP-seq analysis for enhnacers, transcription and repressor histone marks Our analysis reports global epigenome changes that is responsible for phenotype-reversal of gliomas as well as induction of terminal differentiation program. Overall design: Comparative epigenome profiling analysis of ChIP-seq-seq data for murine neuroprogenitor cells (Tp53-/- and Atrx-/- ) and HDAC inhibitiors (AGK2)