The oncogenic role of HBV-targeted gene MLL4 in pancreatic cancer
By using a high-throughput viral integration detection approach (HIVID), a total of 425 HBV integration sites are identified, among which mixed lineage leukemia gene 4 (MLL4) is found to be repeatedly targeted by HBV in both HCC and PDAC. We found a critical role for MLL4 in promoting PDAC growth and metastasis.