Transcriptomics of lung cancer illustrating mPTP impact on ferroptosis
We aimed to systematically investigate the impact of mPTP (especially CypD which is encoded by PPIF gene) on ferroptosis using lung cancer cell NCI-H1299. CypD knockout and control H1299 cells were generated using CRISPR gene editing strategy. Cells were treated with RSL3 to induce ferroptosis and DMSO were used as negative control. Three replicates were collected in each group.