Transcriptomic analysis of young aortic tissue in a mouse model of Loeys-Dietz Syndrome Type II harboring a G357W mutation in the Tgfbr2 gene
Loeys Dietz Syndrome (LDS) is a connective tissue disorder caused by mutations along the TGF-beta signaling pathway and characterized by severe aortic aneurysm and craniofacial anomalies. Patients with LDS Type II (LDS2), caused by mutations in the TGFBR2 gene also exhibit enamel defects. A mouse model for LDS2, harboring a G357W mutation in the Tgfbr2 gene, recapitulates the cardiovascular, craniofacial and dental phenotype of the disease. As part of our transcriptomic analysis aimed at identifying genes that are differentially regulated in the enamel organ of Tgfbr2-G357W/+ mice at postnatal day 11, we peformed a similar analysis on the aorta transcriptome at the same age. Total RNA was extracted from aortic arches from six Tgfbr2-G357W/+ mice (LDS2, Het) and five Tgfbr2-+/+ wild-type littermates (WT). This dataset provides a comprehensive list of genes affected in the aorta of an LDS2 mouse model at a young age. Overall design: Total RNA from aortic arches dissected from six Tgfbr2-G357W/+ mice (LDSR2, Het) and five Tgfbr2-+/+ wild-type littermates (WT), at postnatal day 11, was collected for bulk RNA-seq analysis.