Establishement of CD8-positive T cell and IFN-gamma dependent oral lichen planus-like mouse model (RNAseq) (PRJCA044192)
Oral lichen planus (OLP) is a common inflammatory disease with malignant potential. It is currently considered to be a cytotoxic CD8+ T cell-mediated disease targeting basal keratinocytes, characterized histopathologically by a subepithelial band-shaped infiltrate and apoptosis of basal cells. Animal models are indispensable for hypothesis testing and investigating the pathogenesis of OLP. In this study, we adapted the well-established contact hypersensitivity model to develop a type IV hypersensitivity-induced oral lichenoid reaction in mice, serving as a model for OLP. Key OLP-like features, including band-like CD8+ T cell infiltration, liquefaction, and basal cell apoptosis, were identified histologically. We performed bulk RNA sequencing (RNAseq) of OXA-treated labial mucosa and EtOH-applied control labial mucosa. The RNAseq data were deposited here.