Study of the effects of AZA and its combination with autophagy inhibitor, spautin-1 on the transcriptome of AML cell lines [II]
AZA treatment in AML cell lines led to a delayed expression of ERE transcripts. Autophagy inhibition resulted in a greater abundance of ERE transcripts, triggered pro-inflammatory responses, and improved the cytotoxic activity of AZA. Overall design: AML cell lines were treated with indicated treatments and cells were collected on Day4