Global chromatin changes associated with early developmental experience in Caenorhabditis elegans
This study shows that adult C. elegans that transiently      passed through the alternate dauer larval stage exhibit distinct gene      expression profiles and behaviors, as compared to adult animals that      bypassed this stage. Using genome-wide chromatin immunoprecipitation      experiments coupled with massively parallel sequencing, we find that      genome-wide levels of specific histone tail modifications are markedly      altered in post-dauer animals. Mutations in genes implicated in      chromatin remodeling abolish, or alter, the observed gene expression      changes in post-dauer animals. Modifications to the epigenome as a      consequence of early experience may contribute to adult phenotypic      plasticity and variation in an isogenic population