H3K27Ac ChIP-seq to investigate the role of ACLY pathway in senescent cells.
H3K27Ac ChIP-seq analysis revealed that the inhibition of ACLY pathway supressed the expression of proinflammatory SASP Overall design: Examination of H3K27Ac occupancy in proliferative (Pro), oncogene-induced senescent (Sen), and ACLY-knockdowned Sen IMR-90 cells.