MLL methyltransferases regulate H3K4 methylation to ensure CENP-A assembly at human centromeres
To investigate the function of KMT2A and KMT2F in the regulation of gene transcriptiom,siRNA based  knock-down of KMT2A and KMT2F was performed in U2OS cells. Overall design: Gene expression profiling analysis  was performed using data obtained from RNA-seq of Control- and KMT2A/KMT2F- siRNA treated  cells.