Molecular mechanism of Forsythia suspensa glycoside promoting innate immunity by activating ER stress.
Forsythia suspensa glycoside is a phenylethanoid glycoside extracted from the bark, leaves, flowers, fruits, and seeds of the Oleaceae plant Forsythia suspensa. As a major active ingredient in the Chinese herbal medicine Forsythia suspensa, it has a wide range of pharmacological activities. It not only inhibits various Gram positive and negative bacteria that cause infections, but also has strong antiviral effects. However, the role of Forsythia suspensa glycosides in innate immunity is not yet clear. Overall design: Expose C. elegans to 10 µM Forsythia and place the nematodes in Pseudomonas aeruginosa to test their innate immune ability.