Blood transcriptome sequencing of cynomolgus monkeys
We generated PSEN1 mutant macaques by genomic deletion of exon 9 using two guide RNAs targeting the upstream and downstream intron sequences of PSEN1 exon 9, respectively. Here, blood transcriptome sequencing was performed on these 5-month-old control and mutant monkeys to assess the potential impact of familial Alzheimer's disease-associated PSEN1 mutations on juvenile monkeys.