Cutting down steroid biosynthesis through SIRT6 induced H3K56ac deacetylation Fuels the osteogenic commitment of MSCs (RNA-Seq)
To detect the mechanism underlying osteogenic commitment and proliferation rate change of HDPCs driven by MDL-800, we performed gene expression profiling analysis for HDPCs with DMSO or MDL-800 pre-treatment under normal or osteogenic differentiation conditions. Overall design: Gene expression profiling analysis of RNA-seq data for HDPCs with DMSO or MDL-800(agonist for SIRT6 deacetylase) pre-treatment under normal or osteogenic differentiation conditions.