Small RNA profile of 2 biofluids from healthy individuals
Endogenous and exogenous extracellular RNAs will be characterized in two body fluids (plasma and CSF) collected at the same time from 180 healthy subjects ranging in age from 31 to 101 years old.  Small RNAs contained in these samples will be profiled by small RNA-seq using unfractionated biofluids and purified extracellular vesicles. Overall design: smRNA-seq of plasma and CSF samples from 180 healthy individuals, no replicates