Heme-mediated gene expression and micro-RNA alterations in human choroid plexus epithelial cells
The choroid plexus and ependyma are predominantly affected by extravasated blood upon intraventricular hemorrhage in preterm infants causing the breakdown of the blood-brain-barrier. Hence, the impact of hemorrhage on choroid plexus epithelium is critical in potential brain damage following IVH. We characterized the cellular, inflammatory, and oxidative responses in human choroid plexus epithelial cells exposed to heme among in vitro conditions.