YWHAZ is Downregulated in the Proliferative Eutopic Endometrium in Endometriosis and Is Required Downstream of Progesterone Receptor and STAT3 Signaling.
We performed RNA sequencing on proliferative-phase eutopic endometrium from women with endometriosis (n = 4) and without endometriosis (n = 4). Histological dating of endometrial samples was performed by a certified pathologist. Transcriptomic analysis identified 44 differentially expressed genes, including 13 upregulated and 31 downregulated transcripts in women with endometriosis compared with controls, indicating a distinct transcriptional profile associated with endometriosis. This dataset provides a resource for understanding molecular pertubations associated with the disease. Overall design: Human eutopic endometrial biopsies were collected from women with and without endometriosis during the proliferative phase, stored in RNA-later until  total RNA was isolated for RNA-seq analysis. Control (n = 4); Endometriosis (n = 4).