Effect of depletion of ATP3 and ATP22 on gene expression of C. glabrata
To uncover the underlying mechanism of fluconazole resistance upon genetic depletion of ATP3 and ATP22, we performed transcriptomic analysis by RNA-seq for atp3?, atp22?, and WT cells during standard log phase growth. Overall design: We conducted three independent replicates and compared the transcriptomes of atp3? and atp22? with that of WT cells to profile the differentially expressed genes (DEGs).