EWSR1::ATF1 Orchestrates the Clear Cell Sarcoma Transcriptome in Human Tumors and A Mouse Genetic Model [RNA-Seq 1]
A particular fusion protein that drives the rare, but deadly pediatric cancer, clear cell sarcoma. The fusion protein was expressed in mice, leading to the formation of similar tumors as those it causes in humans. This permitted the study of fusion protein function in these tumors. Overall design: To investigate the transcriptome Clear Cell Sarcoma, We performed RNA-seq on 5 frozen human CCS tumor, and used 3 human muscle samples from study GSE163434 (GSM4618168, GSM4618167 and GSM4618170) as control.