TL1A overexpression in mice alters Paneth cell biology and intestinal microbiota in promoting ileal inflammation
Ileal luminal and mucosal microbial profiles of SPF Tl1a-transgenic mice and WT littermate controls were assessed by 16S rRNA gene squencing. Luminal and mucosal ileal samples from gnotobiotic Tl1a-transgenic and WT mice colonized with SPF microbiota for 2 months were also sequenced.