Memory B cell development elicited by mRNA booster vaccinations in the elderly
The study examined antibody and memory B cell responses to SARS-CoV-2 mRNA booster vaccination in the elderly and showed a decrease in memory B cell numbers with an altered antibody repertoire that may contribute to a higher risk for severe disease in the elderly. Overall design: Peripheral blood mononuclear cells (PBMC) were enriched for B cells, then incubated in Fluorescence-activated cell sorting (FACS) and analyzed using scRNAseq.