Genomic landscape of environmental pan-azole resistant Aspergillus fumigatus in Ohio, United States
Aspergillus fumigatus is a ubiquitous environmental fungus and an opportunistic pathogen responsible for serious infections in humans and animals. Rising resistance to triazole antifungals, driven in part by environmental selection of tandem repeat mutations, has become a growing global public health concern. To better understand the distribution of resistant strains in the United States, we conducted environmental surveillance at 75 sites across Ohio and performed whole-genome sequencing of A. fumigatus isolates. These genomes were compared with publicly available U.S. clinical and environmental isolates to assess population structure