Integrated analysis of gut microbiota structure and metabolic function in patients with cirrhosis and refractory ascites (PRJCA045355)
This study combined 16S rRNA sequencing and GC-MS-based untargeted metabolomics to investigate gut microbial composition and metabolite profiles in 70 patients with refractory ascites due to cirrhosis (OB group) and 70 healthy individuals (NC group). Analyses included microbial diversity evaluation, taxonomic comparison, functional prediction, metabolite screening, and disease association mapping.