Antigen-presenting B cell promote TFC1+ PD1- stem-like CD8 T-cell proliferation in glioblastoma
The study investigates how B cells and dendritic cells differ in T cell activation and proliferation. B-cell-based-vaccine (BVax) promoted highly proliferative T cells in-vitro that had a stem-like memory T cell phenotype characterized by CD62L+CD44- expression, high TCF-1 expression, and low PD-1 and granzyme B expression. The findings of this study suggest that BVax and DC could generate distinctive CD8+ T cells, which potentially serve multiple purposes in cellular vaccine development.