Single-cell Gene Expression Flex analysis on patient derived xenografts (PDX) of lung cancer cells with minimal host tumor microenvironment (TME) cells
To goal of the experiment is to assess whether we can profile enough cells corresponding to the host TME. In this PDX model, most of the cells correspond to the xenograft material, with limited amounts of host TME cells. To this aim we loaded 16 times more cells hybridized with the mouse probe set compared to the human hybridization.