Effects on left ventricle gene expression of a metabolo-hypertensive stress in mice and the myocardial thereafter.
In order to study the capacity of the myocardium to recover from a stress causing several features of heart failure with preserved ejection fraction, C57Bl6/J male and female mice received or not for 28 days an angiotensin II (AngII; 1,5 mg/kg/day) continuous infusion in combination with a high fat diet (HFD). Half of the animals were then euthanized. The remaining ones had the AngII infusion stopped and their diet normalized. In addition, voluntary exercise was initiated by introducing a running wheel in the animals cage for an additional 28 days. Overall design: Comparative gene expression profiling analysis of RNA-seq data for mouse left ventricle samples of both sexes from various groups (Controls, metabolo-hypertensive stress (MHS) and left ventricle reverse remodeling (RR).