Effect of intrinsic chicory root fiber on individuals at risk for type 2 diabetes and with overweight/obesity by affecting microbial butyrate-producing pathways
In this 12-week randomized, placebo-controlled trial in individuals at risk for type 2 diabetes and with overweight/obesity (NCT04714944), we investigated the effect of 12-week daily 30g dried chicory root intake on the human gut microbiome. Fecal samples were collected at baseline, and after 2, 6, 9, and 12 weeks, DNA was extracted, and changes in community structure and function were analyzed by using V4-16S rRNA gene amplicon and shotgun metagenomic sequencing.