Identification of Constipation With Frailty
Importance: Extensive research has explored the associations between gut microbiota and constipation. However, the distinctions in microbiota distribution and associated functions between constipation patients with frailty and those without frailty remain enigmatic.  Objectives: This study aims to identify intestinal microbiota signatures associated with constipation in individuals with frailty and those without frailty.  Design: This cross-sectional study was conducted from December 2021 to February 2023.   Setting: Patients with constipation and healthy people as control were enrolled in this study at Beijing Hospital of Traditional Chinese Medicine, Capital Medical University.  Participants: According to Rome ? criteria and Frail Scale, all participants(n=61) were divided into 21 constipation patients with frailty, 25 constipation patients without frailty, and 15 healthy individuals.