Defective IRE1a Pathway Caused by Abnormal PAX6 Expression Led to Specific Human Diabetes
PAX6 is an important ß cell transcription factor. We used single cell RNA sequencing (scRNA-seq) to analyze the impact of PAX6 deficiency on ß cell transcriptomes. Overall design: human pluripoten stem cells-derived WT, PAX6+/- and PAX6-/- ß cells were analyzed using scRNA-seq