Transcriptomic profiling of liver tissue in a rat model of MASH treated with Sacubitril/Valsartan
This project investigates the transcriptomic changes in liver tissue from a rat model of metabolic dysfunction-associated steatohepatitis (MASH) treated with Sacubitril/Valsartan. Total RNA was extracted from liver samples and analyzed using next-generation sequencing. The study aims to identify differentially expressed genes and signaling pathways involved in fibrosis and inflammation. The findings will provide insights into the molecular mechanisms underlying the therapeutic effects of Sacubitril/Valsartan in MASH and may contribute to the development of novel treatments for liver diseases.