Inducible heart specific MPC1 knockdown in adult mice
We report that knocking down the Mitochondrial Pruvate Carrier 1 (MPC1) in the hearts of adult mice is sufficient to induce hypertrophy and heart failure. Overall design: Ventricular mRNA profiles of  both WT and MPC1CKO mice at 8 weeks and 16 weeks post KO induction.