Homo sapiens Transcriptome or Gene expression
Targeting PARP activity can supplement the molecular defects of DDR and potentially target the most critical genetic characteristic, especially in SCLC. To figure out compensatory pathways induced by PARP inhibition, we performed RNA sequencing s in 2 varied types of SCLC cell lines, H69 and H82, treated with either vehicle or the most effective PARP inhibitor BMN673 for 24 hours.