Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability
Autophagy is a conserved process of cellular self-digestion that promotes survival during nutrient stress. In yeast, methionine starvation is sufficient to induce autophagy. One pathway of autophagy induction is governed by the SEACIT complex, which regulates TORC1 activity in response to amino acids through the Rag GTPases Gtr1 and Gtr2 This work identifies an unexpected yet critical role for Xrn1 in nutrient sensing and growth control that extends beyond its canonical housekeeping function in RNA degradation and indicates an avenue for RNA  metabolism to function in amino acid signaling into TORC1. Overall design: Comparative gene expression profiling analysis of RNA-seq data in cells lacking Xrn1 under methionine-replete or -depleted conditions.