Analyze the transcriptional signature of kidney glomerular cells in male, female wild-type mice and in female mouse models of estrogen knockout
We found that RPC contributed to the sexual dimorphism of kidney disorders in an ERa-dependent manner. To study the mechanisms controlling these differences we characterized the transcriptional signature of glomeruli isolated from male, female wild type and female RPC ERa-knockout mice. Overall design: Transcriptional signature of glomeruli isolated from male, female wild type and female RPC ERa-knockout mice.