Remodeling of tissue-resident macrophages by MEF2D-expressing cancer precursors primes for liver tumorigenesis
The premalignant liver specimen from three mice was detected using DSP(digital spatial profiling) .18 regions of interest (ROIs) per specimen were selected, and each ROI was autosegmented into PanCK-positive ,CLEC4F-positive and CD206-positive +CLEC4F-positive region. The PanCK-negative regions further autosegmented into CLEC4F+CD206- (KC1), CLEC4F+CD206+ (KC2) and other regions.