Transcriptional Regulators SP110 and SP140 Modulate Inflammatory Response Genes in Mycobacterium tuberculosis-Infected Human Macrophages
Transcriptional regulatory genes SP110 and SP140 are the homologs of Sp110 and Sp140, respectively, encoded within the mouse super susceptibility to tuberculosis 1 (Sst1) locus. we investigated the gene regulatory function of SP110 and SP140 in human macrophages infected with Mycobacterium tuberculosis. The genome-wide transcriptional profile of THP-1 macrophages revealed that the induction of gene expression associated with inflammatory responses, IFN response genes, upon M. tuberculosis infection were impaired by the depletion of SP110 and/or SP140 genes. suggesting human SP110 and SP140 genes as positive regulator for genes associated with inflammatory responses in M. tuberculosis-infected macrophages.