Gene expression profiling in salivary glands by BMP-2.
Bone Morphogenetic Protein (BMP), a bone induction factor, belongs to the TGF-ß superfamily, and more than 15 types of BMP family molecules have been reported in mammals. They are known to enhance osteoblast differentiation and their osteogenic effects, and also promote differentiation into chondrocytes. While the effects of BMPs on hard tissues are varied and numerous reports have been reported, only a few have reported the effects of BMPs on salivary glands. The aim of this study was to investigate the function of BMP-2 in the formation of salivary glands. Overall design: To investigate the function of BMP-2 on the formation of salivary glands, we treated 300 ng/ml of BMP-2 with salivary gland primordia of Embryonic day 13.5, and