Investigation of UPR-dependent gene expression profiles induced by stimulation of mouse keratinocytes with imiquimod
Mouse keratinocytes are known to lack TLR7 and NLRP3 inflammasome pathways. The goals of this project are to identify TLR7- and NLRP3-independent gene expression profiles induced by imiquimod. We pretreated keratinocytes with 4m8c, an inhibitor of IRE1, followed by stimulation with imiquimod.