NES_functional_survivin vs NES_mutated_survivin exposed or unexposed to temozolomide (TMZ)
Investigation of the impact of survivin subcellular localisation on gene expression upon TMZ in glioblastoma cell clones, ectopically expressing either cytoplasmic or nuclear survivin-GFP. In case of nuclear survivin-GFP, survivin is trapped in the nucleus, because the nuclear export sequence (NES) has been mutated Overall design: Examination of different survivin subcellular localisation in glioblastoma cells (Grade IV) upon TMZ exposure