Modeling and modulation of RHO signaling in human iPSC-derived retinal organoids from patients with RHO-CNV
To investigate the effects of RHO-CNV in human iPSC-derived retinal organoids. Furthermore Photoregulain3 (PR3) was added to media for 7 days to modulate RHO levels. We then performed gene expression profiling analysis D300+ retinal organoids. Overall design: Comparative gene expression profiling analysis of RNA-seq data for organoids with RHO-CNV, control and PR3 treated RHO CNV retinal organoids.