De novo assembly of high-quality goose genome reveals tea polyphenols response genes associated with mitochondrial energy metabolism and cell adhesion molecules (PRJCA015997)
High-quality genomes are crucial for understanding the DNA methylation reprograming landscape for tea polyphenols response. Here we incorporated long-read PacBio sequencing technologies and chromosome contact maps to present a high-quality genome of Wuzong goose. Making using of de novo and homology gene predictions as well as short-read transcriptomics from 10 tissues to yield 18,013 high-confidence predictions of encoded proteins. Transcriptomic analysis showed differently expressed genes involved cell adhesion, metal ion transport, energy metabolism and so on. Integrating RNA-seq with whole-genome bisulfite sequencing (WGBS), revealed that the hypomethylation gene upregulated in tea polyphenols treatment and mainly involved cell adhesion or cell to cell communication. Half of hypermethylation overlapped differently expressed genes (DEGs) were either upregulated or downregulate, suggesting that DNA methylation plays a dual role in tea polyphenols response by regulating associated gene expression. This assembly provides an important resource for studying epigenetic reprogramming to drive the DNA increase fitness in situation with diet changes.