PKCz-YAP1 Feedback Loop Drives Mitochondrial Dyshomeostasis and Persistent Fibroblast Activation in Hypertrophic Scars.
Mitochondrial remodeling plays an adaptive role during early wound repair; however, persistent disruption of mitochondrial homeostasis drives sustained fibroblast activation and pathological fibrosis, ultimately leading to hypertrophic scar (HS) formation, and the underlying molecular mechanisms remain incompletely understood.