Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience IV
Pharmacological inhibition of cGAS with TDI-6570 protected against the synaptic loss and cognitive deficits in P301S tauopathy model, likely via enhancing MEF2C transcriptional network and associated cognitive resilience Overall design: Droplet-based single nuclear RNA sequencing of mouse hippocampus with and without P301S Tau and TDI-6570 treatment.