RNA-seq of DEN induced tumor in liver in SIX1 S225Kfl/fl and Alb-Cre;SIX1 S225Kfl/fl liver specific knockin mice
To investigate the SIX1 S225K-regulated gene compared SIX1 in DEN induced tumor in the liver specific knockin mice Overall design: To induce liver tumorigenesis, SIX1 S225Kfl/fl group and Alb-Cre;SIX1 S225Kfl/fl group liver specific knockin mice were injected intraperitoneally at 2 weeks of age with 25 mg/kg DEN for 28 weeks.