Whole transcriptome sequencing of the lung tissues in a mouse model of bleomycin-induced pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a common chronic interstitial lung disease (ILD) characterized by diffuse alveolar inflammation, remodeling of lung architecture, and excessive deposition of extracellular matrix (ECM). Recently, an increasing number of studies have contributed greatly to our understanding of the dysregulation of RNAs in the pathogenesis of IPF. In the current study, we aimed to identify the dysregulated RNAs associated with the development of BLM-induced pulmonary fibrosis (PF). These data were then used to construct the potential competing endogenous RNA (ceRNA) networks that provides therapeutic targets for patients with IPF.