Precision Nutrition-Impacts of Durian Consumption on Human Microbiome and Metabolome in Healthy Staff Volunteers from SingHealth (DURIOME)
This study investigates the impact of durian consumption on the human gut microbiome and host inflammatory system. We conducted a longitudinal intervention trial with 40 participants across four time points: baseline, first week of low-dose durian intake (100g/day), second week of high-dose intake (200g/day), and a washout period. This dataset contains 16S rRNA gene sequencing data (V3-V4 region) from 159 fecal samples. The goal of this sequence data is to characterize taxonomic shifts and microbial diversity changes induced by durian-derived nutrients. These data are part of a multi-omics integration-including plasma and fecal metabolomics, and Olink inflammatory proteomics-aimed at elucidating the 'durian-microbiome-host' axis and its role in regulating systemic inflammation and lipid metabolism.