PARP1-mediated circRNA detection in RNA-seq data
PARP1 has been shown to play roles in alternative splicing yet the role of PARP1 in circRNA biogenesis is unknown. Here we determine PARP1's role in backsplicing. Overall design: Three conditions, wild type (WT), PARylation inhibition using PJ34 (PARPi), and PARP-1 knockdown (KD), were examined with three replicates per condition.