Histone Modification in Cerebral Arteriovenous Malformation
Cerebral arteriovenous malformations (AVMs) are the most common vascular malformations worldwide and the leading cause of hemorrhagic strokes that result in crippling neurological deficits. Here, using newly generated mouse model, we discovered that genome-wide ocuppancy of H4K8ac and H3K27me3 decreased in mouse cerebral AVMs. Overall design: Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) to discover histone modification of H4K8ac and H3K27me3 in mouse model of cerebral arteriovenous malformations.