Disruption of RNAPII transcription elongation links Oncogenic splicing factor mutations to replciation stress and targetable alterations in chromatin landscape [H3K36me3 ChIP-Seq]
To investigate changes in the H3K36me3 distribution across different conditions, we peformed ChIP-seq using antibody against the H3K36me3 in K562 cells at 4 days after modified allele expression We then performed coverage plot analyses using data obtained from ChIP-seq from IP  fractions to investigate H3K36me3 distribution changes Overall design: ChIP-seq against H3K36me3 in K562 cells across different conditions at 4 days post doxycycline induction