the change of mRNA expression in SKOV3 cells after treated with placental extracellular vesicles
There is a cross-link between the placenta and cancer development, as the placenta is grown as a highly invasive tumour-like organ. However, placental development is strictly controlled. Although the underlying mechanism of this control is largely unknown, it is now well-recognised that extracellular vesicles (EVs) released from the placenta play an important role in controlling placenta proliferation and invasion, as placental EVs have shown their effect on regulating maternal adaptation. Better understanding the tumour-like mechanism of the placenta could help to develop a therapeutic potential in cancers. Overall design: treat SKOV3 ovarian cancer cells with placental extracellular vesicles, to investigate the change in the expression level of mRNA in SKOV3 cells