USB1 promotes myeloid differentiation in acute myeloid leukemia by inhibiting the Notch signaling pathway through regulation of ZNF138 alternative splicing
This study focuses on U6 snRNA phosphodiesterase biosynthetic enzyme 1 (USB1), systematically analyzing its expression patterns, biological functions, and the post-transcriptional regulatory pathways through which it mediates the arrest of myeloid differentiation in clinical samples and cell lines from patients with acute myeloid leukemia (AML).