16S rRNA sequencing of feces from Control and MI/RI mice
Cardiovascular diseases are one of the greatest threats to the health of Chinese residents. Research indicates that myocardial ischemia-reperfusion (MI/RI) can lead to various damages such as hemodynamic disturbances, deterioration of cardiac function, and cardiomyocyte apoptosis. The gut-heart axis, a bidirectional network connecting the gut and the cardiovascular system, has recently emerged as a critical factor in the pathophysiology of MI/R. Increasing evidence suggests a complex interaction between the composition of gut microbiota and cardiovascular diseases, providing new insights into the mechanisms underlying the effects of myocardial ischemia-reperfusion. Disruption of the gut-heart axis, including gut dysbiosis and impaired intestinal barrier integrity, leads systemic inflammation driven by gut-derived metabolites, exacerbating the progression of MI/RI.