Mesaconine alleviates doxorubicin-triggered cardiotoxicity and heart failure by activating PINK1-dependent cardiac mitophagy
We have recently found that mesaconine, a main cardiotonic component derived from Fuzi, is effective in multiple cardiomyopathy models.In order to explore the mechanism underlying the protective effects of mesaconine in DOX-induced myocardial injury, we examined the gene expression profile of heart tissues.