16S rRNA amplicon sequencing of the human upper respiratory mucosa microbiome
The goal is to investigate microbial dysbiosis in the upper respiratory mucosa of rheumatoid arthritis patients and its associations with rheumatoid arthritis-related clinical features. Nasopharyngeal swab samples of 46 rheumatoid arthritis patients and 17 controls were sequenced for microbiome profiling using the V3 and V4 region of the 16S rRNA gene.