GDF15 in alcohol use disorder Raw sequence reads
This study aimed to clarify how chronic alcohol use triggers early liver and heart dysfunction and to identify biomarkers that reflect these changes. By integrating data from a mouse model and patients with alcohol use disorder (AUD), the research highlights the relevance of low-grade inflammation as a shared driver of early hepatic and myocardial damage. The findings position GDF-15 as a promising biomarker for detecting and understanding alcohol-related hepato-cardial impairment at an early, potentially reversible stage. Sequencing was performed at the Joint Microbiome Facility of the Medical University of Vienna and the University of Vienna under the project ID JMF-2206-10.