Transcriptomic profiling of granulosa cells in cyclophosphamide-induced premature ovarian insufficiency mice treated with embryonic stem cell-derived extracellular vesicles
This project investigates transcriptomic changes in ovarian granulosa cells in a cyclophosphamide-induced premature ovarian insufficiency mouse model and evaluates the effects of embryonic stem cell-derived extracellular vesicle treatment. Granulosa cells were isolated from mouse ovaries from different experimental groups and subjected to bulk RNA sequencing. These data were generated to characterize gene expression alterations associated with ovarian injury and recovery, and to provide a resource for exploring molecular pathways involved in the therapeutic effects of embryonic stem cell-derived extracellular vesicles on premature ovarian insufficiency.