scRNA-seq of CD45-CD31- mesenchymal stromal cells isolated from mouse adipose tissue after tissue lesion
Regenerative capacities are very limited in adult mammals at the benefit of scarring. Mesenchymal stroma cells (MSCs), shared by all organs and tissues, represent a key element in maintaining tissue architecture integrity and repair processes. They display high phenotypic plasticity and represent a heterogeneous population. We hypothesize that in the very early steps of tissue repair, regenerative and non-regenerative processes are associated with distinct qualitative change in MSCs heterogeneity that determine the repair final outcomes.