Transcriptome sequencing for MC38 tumour samples
This study aims to determine if various lipid nanoparticles (LNPs) delivering mRNA or siRNA can improve STING downstream singnlling in vitro and in vivo.1. For MC38 tumour cell transcriptome sequencing,MC 38 tumour cells were treated LNP co-encapsulating siRab27a and mSTING, or PBS2. For MC38 tumour tissue transcriptome sequencing,MC 38 tumour were treated with lipid nanoparticles (LNPs) co-encapsulating siRab27a and mSTING-miR-122, LNPs co-encapsulating a scrambled siRNA and mSTING-miR-122, or PBS