Effect of EZH2 inhibition on NUT carcinoma gene expression over time
To determine roughly the time point at which most transcriptional changes occur in response to tazemetostat (taz, aka EPZ-6438 (EPZ)) treatment of NUT carcinoma cells, we performed RNAseq over a time course. Overall design: Comparative gene expression profiling analysis of RNA-seq data for PER-403 and 10-15 NUT carcinoma cells treated with taz for 36h, 72h, 96h, and 144h.