Pharmacological Inhibition of TAK1 Prevents and Induces Regression of  fibrosis
To evaluate the effects of TAK1 inhibition on TGF-beta regulated fibrosis using a novel small molecule inhibitor of TAK1. Overall design: Comparative gene expression profiling analysis of RNA-seq data for foreskin fibroblast and treated with TGFb1 and TAK1 inhibitor (Control, TGFb1 and TAK1 inhibitor (HS-276)+TGFb1).