Genetic Variants of Phospholipase C-?2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer's Disease [bulk RNA-seq]
The PLCG2 variants bidirectionally modulate disease pathology by inducing distinct transcriptional programs that identify microglial subpopulations associated with protective or detrimental phenotypes Overall design: We performed RNAseq using cortex samples from 7.5-month-old 5xFAD, 5xFADM28L, and 5xFADP522R mice