Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation [RNA-seq]
To investigate molecular changes occurring during lung adenocarcinoma to squamous carcinoma transformation. Overall design: We performed RNAseq in transforming lung adenocarcinoma and squamous carcinoma clinical specimens, together with control, never-transformed lung adenocarcinomas and squamous carcinomas.