3D-Printed ROS-Scavenging and ImmunomodulatoryHydrogel Accelerates Diabetic Wound Healing throughSynergistic Microenvironment Regulation
Diabetic wound healing remains a major clinical challenge, largely due to its persistentand dysregulated pathological microenvironment. To address this, we developed aninnovative 3D-printed nanoparticle-incorporated bionic skin (3D-NEBS), whichintegrates multifunctional nanoparticles within a dynamic hydrogel matrix. This systemexhibits a pH-responsive release profile, enabling targeted delivery of therapeuticagents specifically under acidic wound conditions. This promotes effective reactiveoxygen species (ROS) scavenging, macrophage reprogramming, and enhancedangiogenesis-collectively contributing tomicroenvironment remodeling andaccelerated wound healing.