VAT ans SKM miRNA expresion
Obesity and type 2 diabetes mellitus (T2DM) are widely connected, being obesity the principal risk factor for the development of T2DM. Visceral adipose tissue (VAT) and skeletal muscle (SKM) are important endocrine organs, which though cytokines and adipokines secretion modu-lates not only the inflammatory but also the metabolic environment. In this study, we aimed to investigate the differential VAT and SKM miRNA expression profile of obese patients, regarding on the development of T2DM. For this, we analyzed by next generation sequencing the VAT and SKM miRNA expression profile of six women, three of them also with T2DM.