Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation
To investigate the molecular mechanisms of neuroendocrine (NE) transformation, adenocarcinomas (LUAD) to small cell lung cancer (SCLC), in lung cancer. Overall design: We performed EPIC (methyl-capture) in transformed lung adenocarcinoma and small cell lung cancer clinical specimens, together with control, never-transformed lung adenocarcinomas and small cell lung cancer.