Glutaminase-1 Inhibition Alleviates Senescence of Wharton's Jelly-derived Mesenchymal Stem Cells via Senolysis.
we attempted to identify the genetic changes in the remaining MSCs after BPTES treatment and identified senescence-related candidate genes that recovered after BPTES treatment. The transcriptomes of U-MSCs and rS-MSCs were analyzed to determine the genetic significance of replicative senescence in WJ-MSCs Overall design: Comparative gene expression profiling analysis of RNA-seq data for U-MSCs and rS-MSCs with BPTES treatment Comparative gene expression profiling analysis of RNA-seq data for 3lots of U-MSCs and rS-MSCs