Driving Intracellular Metal Ions of Human Induced Pluripotent Stem Cells with Intense Terahertz Pulses
Terahertz (THz) radiation has been exploited for biomedical applications for non-invasive manipulation of living cells. Here we describe an apparatus to apply high-field THz excitation on highly environmental sensitive human induced pluripotent stem cells (hiPSCs), and manipulate the gene expression networks associated with zinc-finger (ZNF) transcription factors. Overall design: We analyzed cDNA library generated from 585A1 hiPSCs treated with THz light.