Gender Differences in the Transcriptomics of Mice with Myocardial Infarction and the Mechanism of Shengyu Decoction on Improving Cardiac Function in Female Mice
Previous results of the research group showed that female mice with myocardial infarction had a higher survival rate than male mice with myocardial infarction. Small animal ultrasonography revealed that the ejection fraction (EF) of the female model group was higher than that of the male model group. In addition, the blood-entering components of Shengyu Decoction were mainly enriched in substances related to estrogen synthesis and metabolism. Network pharmacology indicated that Shengyu Decoction may exert favorable therapeutic effects on myocardial ischemia. On this basis, this study utilized transcriptomics to compare the differences in apical ischemic tissues among female sham-operated group, female myocardial infarction model group, high-dose Shengyu Decoction group, male sham-operated group and male myocardial infarction model group.