Using mcfDNA-seq to detect and predict pathogens
Bloodstream infection (BSI) is one of the most lethal infections, and undetermined or delayed etiologic diagnoses often result in inadequate treatment and increased mortality and morbidity. New diagnostic methods are crucial to improve clinical outcomes. We conducted culture and sequential mcfDNA-seq on blood samples from ICU participants at high risk of BSI to evaluate the diagnostic performance of mcfDNA-seq and exploring whether it could identify etiologic agents before BSI develops.