KDM5B genomic targets in cardiomyocytes
Cardiac hypertrophy is an intermediate stage in the development of heart failure. The structural and functional modifications occurring in cardiac hypertrophy involve extensive gene reprogramming which is dependent on epigenetic regulation including chromatin remodeling. We identified the histone lysine demethylase KDM5B  as a stress-responsive chromatin regulator in cardiac remodeling. Its genomic targets were identified using ChIP-seq experiments performed on chromatin from isolated cardiomyocytes of mouse hearts submitted or not to transverse aortic constriction (TAC) for 1 week..