RNA-seq analysis of HepG2 cells after treatment with PBS or LukS-PV.
We previously reported that LukS-PV, a component of Panton-Valentine interleukin (PVL), has anti-leukaemic activity, inducing differentiation, increasing apoptosis and inhibiting proliferation of acute myeloid leukaemia (AML) cells. In addition, our study showed that LukS-PV could inhibit the progression of hepatocellular carcinoma (HCC) by targeting C5aR. To investigate the biological mechanisms involved, we performed RNA-seq analysis on PBS/LukS-PV-treated HCC cells to search for important downstream regulators.