Long non-coding RNAs Kcnq1ot1 and Lncpint are involved in skeletal muscle atrophy induced by the space exposome
Long non-coding RNAs (lncRNAs) play an important role in the regulation of skeletal muscle transcriptional processes, but their involvement in spaceflight- or inactivity-induced muscle atrophy remains poorly understood. To address this gap, we simulated the space environment by combining microgravity, irradiation and stress in a mouse model. Our results provide novel insights into the contribution of lncRNAs to muscle atrophy caused by the space exposome and has broader implications for understanding and combating muscle atrophy in clinical scenarios of prolonged inactivity. Overall design: Entire soleus muscle of one of the hind-limbs from a two-group experimental design. Each group had 10 mice and the experimental group was subjected to 14-d HLU, radiation and stress (through diet). The control group was sham-radiated and kept under similar conditions.