Suppression of Notch during efferocytosis prevents macrophages inflammatory polarization [RNA-seq.Mouse]
We investigated the mechanism of suppression of Notch during efferocytosis. Genetically activation of Notch or ablation of Rubicon in marophages induced pro-inflammatory polarization and enhance anti-tumor effect. Overall design: We performed RNA seq of tumor associated macrophages isolated from wt or notch overactivated mice.