HNF4A-induced lncRNA MIR194-2HG derived miR-194 and miR-192 coordinatively inhibit gastric cancer progression by targeting BTF3L4
LncRNA MIR194-2HG and derived miR-194 and miR-192 were transcriptionally induced by HNF4A. The oncogenic driver BTF3L4 is identified to be a common target gene of miR-194 and miR-192. Our finding highlights that MIR194-2HG inhibits GC progression through activating the expression miR-192 and miR-194 and repressing BTF3L4 expression. Overall design: To reveal the target genes of miR-194 and miR-192, we transfected two human GC cell lines with miR-194/miR-192 mimics, respectively. The transcriptome sequencing studies were performed by deep sequencing, using Illumina HiSeq 4000. The RNA-seq data of miR-194 was available in GSE134308.