Visium spatial transcriptomics sequencing of the skin from cutaneous cGVHD patients
Cutaneous chronic graft-versus-host disease (cGVHD) is a significant complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT), adversely affecting patients quality of life and long-term outcomes. The pathogenesis of cGVHD is multifactorial, involving a complex interplay between donor immune cells and recipient tissues. However, the precise cellular interactions within the immune microenvironment in cutaneous cGVHD and their contribution to disease pathology remain inadequately understood. A detailed understanding of these molecular and cellular mechanisms is essential for developing targeted therapies to mitigate skin involvement in cGVHD and improve patient outcomes.