Microbial diversity of skin and gut of infants and toddlers with atopic dermatitis and/or food allergy.
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It usually manifests itself in childhood. The development of AD is multifactorial. Genetic predispositions, environmental influences and the microbiome contribute to its development. AD is often associated with other allergic diseases, such as food allergy (FA). FA is a potentially life-threatening reaction to generally harmless food antigens, most commonly cow's milk. The main objective of this work is to find new predictive biomarkers associated with changes in the composition of the gut and skin microbiome of pediatric patients with AD with or without FA that could help predict the course of these diseases. Further objectives: To compare the gut and skin microbiome of patients with AD with or without FA compared to healthy controls. Correlation of changes in the gut and skin microbiome with specific markers for AD and FA. Evaluation of the immune response to microbial antigens in patients with AD with or without FA compared to healthy controls. To clarify the influence of microbiome composition on the development of AD and FA symptoms in a gnotobiotic experimental mouse model.