Effect of the reduced mTORC1 activity on gene expression in LAM cells
mTORC1 is inhibited by rapamycin or Torin1 in lymphangioleiomyomatosis (LAM) 621-101 (TSC2-deficient) cells, in which mTORC1 activity is elevated, and we compared these effects to inhibition of S6K and its target SRPK2. Overall design: To investigate the effect of mTORC1 inhibition on gene expression, we assessed the gene expression affected by Rapamycin, Torin1, an S6K inhibitor PF4708671(PF), an SRPK1 inhibitor SRPIN340 (SRPIN), or SRPK2 knockout(SRPK2KO) in LAM cells.