Clusterin-Mediated Polarization of M2 Macrophages: A Mechanism of Temozolomide Resistance in Glioblastoma Stem Cells
Glioblastoma remains one of the most lethal malignancies, largely due to its resistance to standard chemotherapy such as temozolomide. This study investigates a novel resistance mechanism involving glioblastoma stem cells (GSCs) and the polarization of M2-type macrophages, mediated by the extracellular vesicle (EV)-based transfer of Clusterin