The effect of myeloid STING knockout on gene expression in colitic mice
Myeloid-derived STING has been recognized to play a vital role in mediating the development of colitis. We here report that myeloid-specific knockout of STING in adult mice ameliorates DSS-induced acute colitis through inhibiting macrophage maturation, reducing DC cell activation, and suppressing pro-inflammatory Th1 and Th17 cells. Overall design: Tmem173fl/fl mice and Tmem173fl/flLzym-Creert2 mice were injected intraperitoneally with tamoxifen for five continuous times before 7d-DSS administration. Total colonic RNA was extracted and RNA-sequecing was performed.