KEAP1 mutation in lung adenocarcinoma promotes immune evasion and immunotherapy resistance [RNA-seq]
Immune cells were isolated from the lungs of mice bearing KEAP1 mutant or wildtype tumors. We found that in KEAP1 mutant tumors there is a reduction in CD103 DCs and early activated T cells as well as an increase in exhausted CD8 T cells in comparison to WT controls. Overall design: KEAP1 mutant (n=3) or wildtype (n=3) murine KP lung cancer cells were injected IV into C57BL/6 mice. Lungs were harvested and tumor were sorted by GFP reporter. RNA was extracted and processed for RNA-seq