Oleic Acid Induces Tissue-Resident FOXP3 Regulatory T Cell Suppressive Functions (single-cell RNA)
Comparing the transcriptomic program induced by oleic acid to that of the pro-inflammatory arachidonic acid, we find that Tregs sorted from peripheral blood and adipose of healthy donors transcriptomically resemble the oleic acid in vitro treated Tregs, whereas Tregs obtained from the adipose tissue of relapsing-remitting MS patients more closely resemble an arachidonic acid profile Overall design: Peripheral blood and adipose tissue were collected from eight healthy donors and eight multiple sclerosis (MS) patients. Two of the MS patients were untreated (> ~1.5yrs since last treatment at the time of the procedure), and the rest had previously received disease modifying treatments (DMTs) (> 6 months prior to the procedure, but off treatment at the time of the procedure). Height and weight (and therefore BMI) are self-reported. Donor group abbreviations: HC = healthy conrols, MS.NoTrt and MS.PrevTrt = MS patients, untreated or previously treated, respectively.