Homo sapiens strain:European Population Targeted Locus (Loci)
SLC6A15 is a neuron-specific neutral amino acid transporter that belongs to the solute carrier 6 gene family. Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. Therefore, this project aimed to explore potential functional variants in this gene that could influence the activity of the amino acid transporter and thus downstream neuronal function and possibly the risk for stress-related psychiatric disorders. DNA from 400 depressed patients and 400 controls was sequenced using a pooled targeted re-sequencing approach.