Cut&Tag HD KI Q140 2,6,10 months
Temporal epigenomic analysis of HD KI Q140 mouse striatal neurons using CUT&TAG on purified sorted neuronal nuclei. Overall design: NeuN+/- nuclei from mixed male and female animals, WT and HD KI Q140 mice striatum were used (50000 nuclei). Two different histone marks were evaluated: H3K27ac and H3K27me3 coming from the same sample. Rabbit IgGs were used as control.