Methylation mimic mutations of progesterone receptor AF1 impair gene-specific regulation through stabilized chromatin interactions
RNA-seq profiling was performed on MCF7-EV (empty vector control), MCF7-PRB, MCF7-PRB-FFF, and MCF7-PRB-QQQ cells following 6 hours of treatment with one of four conditions: ethanol (C), R5020 (R), estrogen (E2), or estrogen plus R5020 (E2R).