Pyruvate dehydrogenase complex integrates the metabolome and epigenome in memory T cell differentiation in vitro [ATAC-Seq]
The chromatin landscape was assessed in effector and memory T-cells obtained from wildtype and pyruvate dehydrogenase knockout mouse. Disruption of the metabolic processes involving pyruvate dehydrogenase can affect T-cell differentiation through epigenetic and metabolic mechanisms. Overall design: Comparison of chromatin structure between wildtype and TPdh-/- (pyruvate dehydrogenase knockout) mice using ATAC-seq data contributor: NISC Comparative Sequencing Program