iPSC-derived hypoimmunogenic T cells enriched with tissue resident memory T cells powerfully attack cervical cancer
We generated HLA-edited functionally rejuvenated human papilloma virus-specific CTLs (HPV-rejTs). These rejTs successfully suppressed recipient immune rejection, while retaining more robust cytotoxicity than that of original CTLs. To clarify this, single-cell RNA sequencing was performed. Overall design: Original HPV-CTL clone and HLA-editied HPV-rejTs were generated then analyzed using scRNA-seq