Distinct oral and fecal microbiota composition in preschool children with overweight/obesity, an cross-section study
Childhood obesity has become a pressing concern globally with rising prevalence and long-lasting adverse health consequences. Recent studies have found that the microbiota in the digestive tract play a crucial role in the occurrence and development of obesity. However, there is a limited study that associated the changes between oral and intestinal microbiota in children with obesity/overweight. This findings provided that, compared with normal weight children, the relative abundance of Fusobacterium, Neisseria and Veillonella in oral microbiota were significantly higher in the obesity/overweight children; whereas Firmicutes, Streptococcus and Aggregatibacter were decreased. In fecal microbiata, the relative abundance of Ruminococcus were more abundant in the obesity/overweight children, and Verrucomicrobiota, Akkermansia, Blautia, Eubacterium_hallii were less abundant. The ratios of Firmicutes/Bacteroidetes (F/B) in oral and fecal microbiota between two groups showed no significant differences.