Trial of Infant Probiotic Supplementation (TIPS/DIMES)
Stool samples from the Trial of Infant Probiotic Supplementation (TIPS; ClincialTrials.gov ID: NCT00113659) clinical trial and Development of Infant Microbial Evolution (DIMES) birth cohort were profiled to understand the microbial taxa, functions, and metabolic impact involved in allergic disease development in the first year of life. Recruitment for TIPS was carried out in the San Francisco Bay Area and consisted of infants at high-risk of childhood asthma development based on atopy diagnosis of one or both parents. Infants were randomized in this double blind placebo controlled trial of daily oral Lactobacillus rhamnosus GG supplementation, and stool samples were collected at birth, 1, 3, 6, 9, and 12-months of age.