Effect of genetic deletion of TREM1 on gene expression during aging of primary peritoneal macrophage cells
To investigate the function of TREM1 in the regulation of innate immune cell metabolism, we established mice in which TREM1 target gene has been genetically deleted. We then performed gene expression profiling analysis using data obtained from RNA-seq of 500,000 different cells from young and old WT and TREM1-/-mice. Overall design: Comparative gene expression profiling analysis of RNA-seq data for TREM1 KO macrophages.