Deep phenotyping the right ventricle to establish translational MRI biomarkers for characterization of adaptive and maladaptive states in pulmonary hypertension
We performed molecular phenotyping of RV remodelling in pulmonary hypertension (PH), using transcriptome analysis of RV tissue obtained from SuHx-induced male rats.When compared to human RV decompensated PH, the molecular characterisation of these rats showed that ECM and collagen fibrillar organisation were highly upregulated in SuHx rats and human profiles along with responses to cytokines. Moreover, growth differential factor was found common in SuHx and RV human samples. Overall design: RNA sequencing was performed on rat RV tissues which were classfied as maladaptive SuHx (n=3) as well as healthy RV from control rats (n=3).