Polycomb Repressive Complex 2 regulates basal cell fate during adult olfactory neurogenesism [scRNA-seq]
We show that Polycomb repressive complexes (PRCs) regulate lineage choice between neural and non-neural fates in the olfactory epithelium. Conditional loss of Polycomb repressive complex 2 perturbs lesion-induced neurogenesis and misexpression of lineage-specific transcription factors in multipotent olfactory globose basal cells. Overall design: Single cell 3' RNAseq of olfactory epithelium from 3 Eed-KO and 3 pooled Eed-Het mice using the 10X Genomics Chromium platform and sequenced on Illumina Novaseq 6000