Git2 deficiency promotes MDSCs recruitment in intestine  and ameliorates necrotizing enterocolitis.
Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal  disease in newborns. Myeloid-derived suppressor cells (MDSCs) play an important role in immunosuppressive function and ameliorate NEC. G protein-coupled receptor kinase-interacting protein 2 (GIT2) has been implicated in multiple immune processes. Our study demonstrates that Git2 deficiency in mice can promote MDSCs recruiment in intestine. This data will reveal that the mechanism of MDSCs' intestinal gathering in Git2-knockout mice compares to wilde type mice. Overall design: Intestinalepithelialcells (IEC) from Git2-knockout mice and wild type mice. All included samples are enteroid from 12 days mice.