Colonic Biomarkers for Premotor Parkinsons Disease
Human FFPE colonic mucosal tissue was assessed via immunostaining and 16S rRNA gene amplicon sequencing for biomarkers pertaining to gut leak, inflammation, oxidative stress, alpha-synuclein protein aggregation, and microbial dysbiosis. Study groups consist of tissue collected from healthy controls, premotor PD, and diagnosed PD patients.