anti-Staphylococcus phages
Phage therapy is promising to treat bacteria frequently multi-resistant to antibiotics, such as Staphylococcus aureus and Staphylococcus non-aureus (SNA) species. However, the therapeutic potential of lytic anti-S. aureus phages of various genera (Kayvirus, Silviavirus and Rosenblumvirus) remains to be extensively characterized and compared. The activity of a collection of 20 anti-S. aureus phages was first evaluated against clinical isolates representative of the diversity of S. aureus (n=30) and SNA (n=66) species. A representative set of 6 phages was then selected for in-depth activity assessment combining solid- and liquid-based techniques against large panels of S. aureus (n=150) and SNA (n=66) clinical isolates.