Study on oral multi-site microbiota in patients with papillary thyroid  carcinoma under different periodontal conditions (PRJCA046597)
This study aims to investigate the microbiota characteristics in different oral sites of papillary thyroid carcinoma (PTC) patients with varying periodontal conditions, identify differential bacteria, and explore their potential mechanisms. From May to December 2024, 40 PTC patients and 40 healthy controls were selected and divided into subgroups based on periodontal disease severity. General information, periodontal data, biochemical indicators, and microbiota samples from saliva, posterior tongue coating, and subgingival sites were collected. 16S rRNA sequencing and correlation analyses were performed. Results showed no significant differences in gender, age, BMI, or periodontal index between PTC and HC groups. However, PTC prognosis scores were positively correlated with periodontal severity, and certain lipid indicators were correlated with periodontal disease severity. Salivary microbiota showed significant beta diversity differences between groups, with increased abundance of specific genera like Porphyromonas in PTC patients. Tongue coating microbiota showed no significant diversity differences but had genus-level differences. Subgingival microbiota in the severe periodontitis subgroup of PTC patients showed significant beta diversity differences and increased abundance of specific genera. Oral microbiota was significantly correlated with thyroid hormone levels and lipid metabolism indicators in PTC patients. The study concludes that PTC patients exhibit significant changes in oral microbiota community structure, which is closely related to thyroid dysfunction and lipid metabolism abnormalities, suggesting that periodontal pathogens may contribute to PTC pathogenesis through these mechanisms.