High-quality genome of Chinese yellow rabbit
The Fujian yellow rabbit (Oryctolagus cuniculus, hereafter O. cuniculus-FJY) is a distinctiveness of China's only indigenous rabbit breed, known for its yellow coat, adaptability, and higher meat quality. However, comprehensive genomic datasets on O. cuniculus -FJY are lacking. In this study, we assembled the telomere-to-telomere (T2T) genome of O. cuniculus -FJY using PacBio HiFi, ONT ultra-long, and Hi-C data. The final genome size is 2.88 Gb, with a scaffold N50 of 148.90 Mb and BUSCO completeness of 98.3%. Repeats account for 47.09% of the genome. We identified 22,674 genes, with 99.74% functionally annotated. Additionally, we annotated 1,341 tRNAs, 922 rRNAs, 635 miRNAs, and 2,421 snRNAs. This genome represents the first T2T rabbit genome and the first successful assembly of the Y chromosome in O. cuniculus. It not only enhances our understanding of the genetic diversity and evolutionary history of the domestication of rabbits, but also provide crucial data support for future breeding research on Fujian yellow rabbit.