POSTN secreted from glioblastoma stem cells can recruit microglia and upregulate CD70 expression in microglia through the aVß3/PI3K/AKT/NF?B pathway [HMC3_ChIP-seq]
Glioblastoma (GBM), classified as a grade 4 glioma, is the most prevalent intrinsic malignancy of the central nervous system. Glioblastoma stem cells (GSCs) are small populations of GBM cells with self-renewal and multilineage differentiation capabilities and are considered responsible for the tumorigenesis and development of GBM. POSTN secreted from glioblastoma stem cells can recruit microglia and upregulate CD70 expression in microglia through the aVß3/PI3K/AKT/NF?B pathway, which in turn promotes Treg development and functionality and supports the formation of an immunosuppressive tumor microenvironment. Overall design: Chromatin immunoprecipitation DNA-sequencing (ChlP-seq) for NF?B in microglia cells.