Modulation of neural gene networks by estradiol in old rhesus macaque females
The postmenopausal decrease in circulating estradiol levels has been shown to contribute to several adverse physiological and psychiatric effects. To elucidate the molecular effects of estradiol on the brain, we examined differential gene expression and DNA methylation patterns in the nonhuman primate brain (occipital cortex and prefrontal cortex) following ovariectomy and subsequent subcutaneous bioidentical estradiol chronic treatment.