Collaborative Cross maternal diet
This study examines how early-life environmental factors, such as antibiotics, protein deficiency, and vitamin D deficiency, influence adult health, particularly the gut microbiome. We used genetically identical mice, except for parent-of-origin factors, to assess genetic impacts. Results indicated lasting effects on offspring's growth and gut microbiome, varying with genetic background. Early-life exposures affected specific bacterial groups, and parent-of-origin significantly influenced gut microbiome and growth. These findings suggest interactions between early environmental factors and genetics shape gut microbiome composition and growth, potentially affecting long-term health outcomes.