Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance
Here we describe patients with an autosomal recessive form of HIES due to loss-of-function mutations of a previously uncharacterized gene, ZNF341. Overall design: Examination of gene expression in EBV-B cells from healthy and ZNF341 patients stimulated with IL-21, IL-6, IL-23, IL-10, and IFNa