Effect of heterozygous deletions on dosage compensation in Arabidopsis thaliana
Heterozygous deletions are often produced by the induction of mutations, which can include a large number of genes. To assess the effect of heterozygous deletions on phenotypic changes, the induction of gene dosage compensation should be considered. This mechanism is normally known to balance the expression levels of genes with different copy numbers in sex chromosomes, but is also known to operate in autosomes. In this study, RNA-seq analyses of 14-day-old plants and 40-day-old leaves and flower buds of 12 A. thaliana mutants with heterozygous deletions were performed, which showed no dosage compensation occurred in any stage or tissue tested.