Effect of 5-aminolevulinic acid-mediated photodynamic therapy on oral microbiota
Periodontitis, a chronic infectious disease leading to gingival atrophy and potential tooth loss through alveolar bone resorption, is closely linked to the oral microbiome. Photodynamic therapy combined with 5-aminolevulinic acid has been reported to be bactericidal against Pseudomonas aeruginosa and Staphylococcus aureus. We aimed to investigate the bactericidal potential of PDT combined with 5-aminolevulinic acid against oral microbiota.