Effects of a- and ß-amylin on gene expression in mouse embryonic fibroblasts (MEFs)
a- and ß-amyrin exhibit senolytic activity in MEFs. This study aimed to investigate the underlying pathways involved in this anti-senescent effect. Overall design: Non-senescent (passage 1) and senescent (P6) MEFs were stimulated with a-amyrin (20 µM) or ß-amyrin (20 µM) for 3 days. RNA expression was analyzed by RNA-sequencing.