The Tumor-Sentinel Lymph Node Immune Migratome Reveals a Key Role for Migratory CCR7+ Dendritic Cells in Response to Immunoradiotherapy
To investigate the effects of tdRT on the SLN, WT animals bearing 4MOSC1 tumors were treated with tdRT -> aPD-1 and subjected to SLN mapping (Figure 5A). Bulk-RNA sequencing of the SLN revealed significant upregulation of immune response pathways post-treatment, including those related to antigen processing, phagocytosis, and cell recognition, indicating enhanced immune activation.