Strain-Level Genetic Heterogeneity and Colonization Dynamics Drive Microbiome Therapeutic Efficacy (PRJCA044560)
We established a longitudinal cohort of non-small-cell lung cancer patients treated with combined faecal microbiota transplantation (FMT) and immunotherapy. Donors (n = 37 faecal samples) and recipients (n = 66 samples collected pre- and post-FMT) were prospectively followed for up to 11 months. Metagenomic sequencing was performed to delineate the compositional dynamics of the gut microbiome and to correlate microbial signatures with clinical outcomes.