Transcriptomic effects of human STOX1B overexpression on the mouse placenta
STOX1B, the short protein-coding isoform of STOX1 (227 amino acids), has been shown to present opposite effects than the one of STOX1B in trophoblast cell models. Here, we investigate the overexpression of STOX1B in vivo in the mouse placenta. The changes accompany maternal effects on blood pressure and proteinuria reminiscent of preeclampsia, and effects of Intra Uterine Growth Restriction upon the foetuses.