Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming (PRJCA049463)
The photoperiod cycle provides a critical predictive environmental cue affecting fertility. Previous studies reported that circadian rhythm disorders affect ovarian function by interfering with follicle development, ovulation, and hormone secretion. Experimental animals exposed to non-standard light cycles, like constant darkness or constant light, results in oocyte meiotic defects and quality deterioration. However, with the widespread use of artificial light sources, individuals are often exposed to prolonged illumination, as long photoperiod. Whether this kind of circadian disruption affects ovarian function and the underlying mechanisms remain unclear. We, therefore, aim to verify the role of long photoperiods exposure on ovarian function.