Muribaculum intestinale-derived Tryptophanol driven by N-Carbamylglutamate attenuates premature ovarian failure through inhibiting oxidative stress (PRJCA050465)
This study using the cyclophosphamide (Cy)-induced POF mouse model, and demonstrated that dietary modulator N-carbamylglutamate (NCG), a widely used for its antioxidant pharmacological properties, has beneficial effects in alleviating POF symptoms and restoring the intestinal mucosal barrier through gut microbiota-metabolite crosstalk.