Development of multi-target PlURI-Cut & TAG detection technology and analysis method for single-cell chromatin (PRJCA040171)
Development of library construction strategies for single-cell spatial transcriptome and PlURI-Cut &Tag. Collaborate with the spatial transcriptome developed in this project to optimize the library construction strategy, achieve the joint detection of single-cell spatial transcriptome and Pluri-CUT&Tag, develop new software to realize the mapping between CUT&Tag and spatial transcriptome data, and analyze the dynamic changes of histone modifications and transcription factors during development and disease occurrence.