Transcriptomic characterization of LRRC15+ cancer associated fibroblasts in human and mouse tumors via bulk and single-cell RNA sequencing (PRJCA049462)
Cancer-associated fibroblasts (CAFs) are a critical and heterogeneous component of the tumor microenvironment, playing diverse roles in tumor progression. Here, we identify LRRC15+ CAFs as a tumor-specific CAF subset in lung cancer and propose LRRC15 as a potential therapeutic target. We provide a valuable resource for understanding the the phenotype, function, and conservation of LRRC15+ CAFs across human and mouse systems.