Solid-like Condensates Constrain Transcriptional Plasticity and Act As  a Barrier to Cell Fate Transition (PRJCA043743)
Liquid-like condensates are crucial for transcriptional control, but the functions of solid-like condensates in transcriptional regulation and cell fate determination remain unclear. Here, we demonstrate that ARID3B forms solid-like condensates that stabilizes the expression of cell cycle genes, thereby supporting embryonic stem cell (ESC) self-renewal and preventing their transition into a 2C-like cell (2CLC) state.
Liquid-like condensates are crucial for transcriptional control, but the functions of solid-like condensates in transcriptional regulation and cell fate determination remain unclear. Here, we demonstrate that ARID3B forms solid-like condensates that stabilizes the expression of cell cycle genes, thereby supporting embryonic stem cell (ESC) self-renewal and preventing their transition into a 2C-like cell (2CLC) state.