Spinal Cord Stimulation Ameliorates Chronic Pain With Cognitive Dysfunction via Targeting lnc-PCM1 in the Prefrontal Cortex (PRJCA047377)
Chronic pain with cognitive dysfunction (CPCD) involves impairments in learning, memory, and decision-making, which significantly affect patient's quality of life. Although spinal cord stimulation (SCS) effectively alleviates pain and improves cognitive function, its impact on CPCD and underlying mechanisms remain unclear. Research has suggested that long non-coding RNAs (lncRNAs) play a crucial role in chronic pain and cognitive issues, potentially serving as a mechanism and target for SCS in CPCD treatment. This study aimed to investigate the role of lncRNAs in SCS in improving CPCD.