gut microbiota-Tryptophanol-ovary axis in POF pathogenesis (PRJCA050512)
Premature ovarian failure (POF) affects 1-5% of women under 40 years old and is characterized by granulosa cell apoptosis and follicular atresia. However, the pathogenesis of POF is complex and lacks effective prevention and treatment strategies. This study using the cyclophosphamide (Cy)-induced POF mouse model, and demonstrated that dietary modulator N-carbamylglutamate (NCG), a widely used for its antioxidant pharmacological properties, has beneficial effects in alleviating POF symptoms and restoring the intestinal mucosal barrier through gut microbiota-metabolite crosstalk.