Gut microbiota-dependent protection of Lactobacillus reuteriagainst renal injury in brain-dead rats (PRJCA049273)
This project investigates the protective role of Lactobacillus reuteriagainst renal injury in a rat model of brain death (BD), with a specific focus on the involvement of the gut microbiota. Brain death triggers a systemic inflammatory response that can lead to remote organ dysfunction, including acute kidney injury, which is a significant concern in transplant medicine. Our study aims to determine whether the administration of L. reuterican attenuate BD-induced renal damage and to elucidate if this protective effect is dependent on modulation of the gut microbiome. We generated 16S rRNA gene sequencing data from fecal samples of experimental rats across different groups (e.g., Sham, BD, BD + L. reuteri). The data provided herein comprises the raw sequencing files essential for understanding the microbiota composition and dynamics associated with the observed phenotypic outcomes. This dataset will facilitate further insights into the gut-kidney axis and the potential therapeutic application of probiotics.