Evaluation of the effect of Fangyu acid lowering granules on improving Hyperuricemia (PRJCA021666)
Hyperuricemia (HUA) is a metabolic disorder characterized by an unusually high level of uric acid (UA), the main product of purine metabolism, in the blood. High levels of UA in blood may induce excessive deposition of UA crystals in the body, which can cause gout. HUA is also a risk factor for renal damage, diabetes hypertension, and dyslipidemia. Fangyu acid lowering granules contains celery (Pimpinella brachycarpa (Kom.) Nakai), corn silk, and Chlorella pyrenoidosa. Celery can reduce swelling and diuresis, lower blood sugar levels and blood pressure, alleviate oxidative stress, and has antitumor properties. Corn silk contains various compounds, including flavonoids, isorhamnetin, phenolics, alkaloids, and tannins. C. pyrenoidosa was one of the earliest commercially developed algal species and is often used as a dietary supplement as it provides a significant quantity of protein and is rich in pigments, fatty acids, growth factor, vitamins, and minerals. C. pyrenoidosa helps to clear heat and dampness; celery has a significant effect in reducing UA and relieving pain; and corn silk promotes diuresis. Thus, the combination of these three ingredients helps to degrade UA crystals, increase urine volume, facilitate the excretion of UA, thereby reducing UA levels. In this study, we investigated the effects and possible mechanisms of Fangyu acid lowering granules on HUA. The HUA rat model was used to confirm that Fangyu acid lowering granules can decrease UA levels, and the underlying mechanism was explored from the viewpoint of changes in the gut microbiota. This study will lay the foundation for the development of natural substances to prevent or ameliorate HUA and provide an effective treatment strategy for patients with HUA.