ATAC-seq data of CGRP restrains CD4+ T cell responses and allergic sensitization (PRJCA046606)
This project uses ATAC-seq to investigate how the neuropeptide CGRP regulates CD4 T cell responses during allergic sensitization. ATAC-seq profiling showed that CGRP-RAMP1 signaling changes chromatin accessibility and transcriptional programs, enforcing a hyporesponsive state and reducing Tfh related gene expression. These findings provide mechanistic insight into how neuroimmune interactions shape adaptive immunity and suggest that CGRP treatment can reduce allergic sensitization and asthma by limiting CD4 T cell activation.