Spatial transcriptomics aided finding: modifying glucose metabolism reverses memory defects of Alzheimer's disease model at late stages (PRJCA023205)
We described a novel finding in which episodic-like memory defects in AD mice (APP/PS1) at late stages when Aß plaques were widespread in the brain were reversed by ferul enanthate (SL) treatment. Spatial transcriptomics identified a cluster of genes with aging-AD-rescue (AAR) expression rule that covered signalling pathways of Glut1 expression and glucose metabolism in the dendritic region of the hippocampus, which were further confirmed by immunoblotting and immunofluorescent studies. These findings suggest an intriguing possibility that disease progression of AD at late stages can be still reversed by targeting aging-dependent multiple pathologies of AD.