Changes and difference Analysis of DNA methylation profile of whole testicular Genome during Reproductive degeneration of Magang geese induced by long Light Exposure (PRJCA021186)
Geese reproduction is associated with light, and prolonged light exposure can lead to reproductive suppression. To explore the effect of DNA methylation on reproductive activity in Magang geese under long light exposure, we performed whole genome bisulfite sequencing (BS-seq) and transcriptome sequencing (RNA-seq) of Magang goose testes at three different reproductive stages.DMRs-related genes were more inclined to be differentially expressed in testis, predicting a regulatory role of DNA methylation on gene expression, and changes in DNA methylation showed a significant negative correlation with changes in gene expression. In summary, our study revealed the changes of DNA methylation related to spermatogenesis inhibition and its potential effects on gene expression in Magang geese induced by long light, which laid a foundation for further study on the initiation and regulation of STRA6 in testes and its effects on androgen synthesis and secretion.