Transcriptomic analysis of Japanese flounder embryos after exposed PS-MPs & BDE-209 (PRJCA050513)
The global issue of pollution from micro- and nano- plastics (MNPs) has intensified due to the widespread use of plastic materials. Beyond their intrinsic toxicity, microplastics in marine environments can interact with persistent organic pollutants (POPs), leading to enhanced adverse effects on marine organisms. Consequently, the combined toxic effects of MNPs and POPs in natural water bodies are receiving increased scholarly interest. This study focuses on the enrichment toxicity of polystyrene microplastics (PS-MPs) through both in vivo and in vitro assessments in Japanese flounder (Paralichthys olivaceus), a vital marine species in the Western North Pacific. We also investigate the potentiating effect of BDE-209, a persistent organic pollutant identified under the Stockholm Convention in 2017, on PS toxicity. Our comprehensive analysis, which integrates  transcriptomic data, aims to clarify the mechanisms of toxicity associated with PS-MPs and BDE-209.