Phage mutants that escape bacterial retron-Eco7 defense system (PRJCA042769)
This study focuses on Retron-Eco7, which integrates retron-based sensing with the effector module of Septu, a characterized antiphage system in which the PtuAB complex mediates nuclease-dependent defense. However, the activation mechanism of this hybrid system remains unclear. To decipher the activation mechanism of Retron-Eco7, we isolated phage mutants capable of evading defense and identified the phage triggers that activate Retron-Eco7.
This study focuses on Retron-Eco7, which integrates retron-based sensing with the effector module of Septu, a characterized antiphage system in which the PtuAB complex mediates nuclease-dependent defense. However, the activation mechanism of this hybrid system remains unclear. To decipher the activation mechanism of Retron-Eco7, we isolated phage mutants capable of evading defense and identified the phage triggers that activate Retron-Eco7.