Integrated Metagenomic and Metabolomic Profiling Reveals Gut Microbiota Dysbiosis and Metabolic Dysregulation in IgA Nephropathy and Membranous Nephropathy (PRJCA039250)
Immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) are primary glomerular diseases with increasing incidence, yet their pathogenesis and non-invasive diagnostic approaches remain insufficiently understood. In this study, we integrated metagenomic and untargeted metabolomic profiling to explore gut microbiota alterations and metabolic disturbances in 24 IgAN patients, 20 MN patients, and 17 healthy controls.