Exploring the Mechanisms of the Impact of Colonic Microbes During the Early Development of Pigs on Muscle Development (PRJCA046578)
The gut microbiota is intricately linked to host phenotypes, yet its influence on early development of the organism, especially regarding the formation of meat quality traits remains poorly understood. The purpose of this study is to identify microorganisms associated with early development and to further explore their regulatory effects and mechanisms on muscle development. In this study, we delved into the relationship between gut microbiota and host development using multi-omics approaches. Specifically, we performed multi-omics analyses on the gut microbiota, metabolome, and the transcriptomes of muscle and colon tissues in Jinhua pigs during their rapid development phase. Subsequently, a mouse model was employed to verify the causal relationships of the key microorganisms identified. The results showed that, at 90 days of age, Jinhua pigs exhibited remarkable increases in gut microbiota diversity, along with heightened activities of carbohydrate and butyric acid metabolism.
The gut microbiota is intricately linked to host phenotypes, yet its influence on early development of the organism, especially regarding the formation of meat quality traits remains poorly understood. The purpose of this study is to identify microorganisms associated with early development and to further explore their regulatory effects and mechanisms on muscle development. In this study, we delved into the relationship between gut microbiota and host development using multi-omics approaches. Specifically, we performed multi-omics analyses on the gut microbiota, metabolome, and the transcriptomes of muscle and colon tissues in Jinhua pigs during their rapid development phase. Subsequently, a mouse model was employed to verify the causal relationships of the key microorganisms identified. The results showed that, at 90 days of age, Jinhua pigs exhibited remarkable increases in gut microbiota diversity, along with heightened activities of carbohydrate and butyric acid metabolism.