PDE4B deficiency attenuates epidural fibrosis through activating Saa3-primed M1 macrophages (PRJCA047570)
This study investigates the mechanism by which macrophage-specific PDE4B upregulation promotes epidural fibrosis following laminectomy. We demonstrate that SAA3 stimulation drives the pro-fibrotic phenotypic shift in macrophages via PDE4B overexpression.