Single-cell RNA-seq analysis of IL-17a conditional knockout and floxed control mouse olfactory epithelium during inflamm-aging (PRJCA050812)
This project investigates the transcriptomic changes in the olfactory epithelium (OE) of IL-17a conditional knockout (Cko) and floxed control (Flox) mice under inflamm-aging conditions using single-cell RNA sequencing. Samples collected at day 7 and day 14 were analyzed to explore the molecular mechanisms by which IL-17a-mediated inflammatory signaling and immune infiltration influence epithelial regeneration and sensory neuronal loss. The dataset provides valuable insights into age-associated olfactory dysfunction and identifies IL-17a as a potential therapeutic target for aging-related olfactory impairment.