The Role and Mechanistic Basis of CXCR6 Signaling in Radiotherapy-Induced Remodeling of the Glioblastoma Immune Microenvironment (PRJCA049755)
This project explores how CXCR6 affects the tumor microenvironment in glioblastoma after radiotherapy. We found that loss of CXCR6 reduces T-cell infiltration, increases immunosuppressive TGFBI+ macrophages, and activates TGF-ß signaling, leading to tumor cell clustering and progression. The study aims to clarify the role of the CXCL16-CXCR6 axis and identify new targets to improve radiotherapy outcomes in GBM.