Whole exome sequencing of mouse endometrial cancer cell lines and matched primary tumors (PRJCA020376)
we established endometrial cancer genetically engineered mice PTEN flox/+; STK11 flox/flox; LTF-Cre (PSC) and constructed corresponding epithelial cell lines using their uterine tumor tissues isolated using conditional reprogramming techniques, which were successfully passaged, frozen, and preserved in a biobank, Further whole exome sequencing assays were performed on mouse endometrial cancer cell lines and matched primary tumors to observe gene profile characteristics.
we established endometrial cancer genetically engineered mice PTEN flox/+; STK11 flox/flox; LTF-Cre (PSC) and constructed corresponding epithelial cell lines using their uterine tumor tissues isolated using conditional reprogramming techniques, which were successfully passaged, frozen, and preserved in a biobank, Further whole exome sequencing assays were performed on mouse endometrial cancer cell lines and matched primary tumors to observe gene profile characteristics.