Recurrent Fertilization Failure After ICSI
This project investigates the genetic basis of recurrent fertilization failure after intracytoplasmic sperm injection (ICSI) in infertile couples. Targeted sequencing was performed on nine couples with unexplained repeated fertilization failure. The analysis identified rare genetic variants, including several in genes associated with primary ciliary dyskinesia (PCD), suggesting a potential role of ciliary and centrosomal proteins in fertilization. The dataset supports research into the genetic causes of fertilization failure and the broader impact of PCD-related genes on human reproduction.