Gut microbiome and fecal metabolome dysregulation in pedi-atric atopic eczema (PRJCA048645)
This study employed an integrated multi-omics approach to investigate the gut eco-system in pediatric AE. Fecal samples from affected children and matched controls were analyzed using 16S rRNA gene sequencing to profile the gut microbiota and liq-uid chromatography-mass spectrometry (LC-MS)-based metabolomics to characterize the fecal metabolome. Significant gut microbial dysbiosis was observed in children with AE, marked by reduced species diversity and altered community structure.