ADAM8 in Macrophages Exacerbates Sepsis-induced Cardiomyopathy by Impeding Efferocytosis (PRJCA039449)
This study focuses on exploring the critical role of ADAM8 in macrophages during SICM. We hypothesize that during SICM, ADAM8 in macrophages may be activated and affect macrophage phagocytic function and inflammatory response by influencing specific membrane proteins such as MerTK, thereby regulating cardiac function. Through in-depth research on the mechanism of ADAM8's role in SICM, we aim to provide new targets and ideas for the treatment of this disease, ultimately contributing to improving the prognosis of septic patients.
This study focuses on exploring the critical role of ADAM8 in macrophages during SICM. We hypothesize that during SICM, ADAM8 in macrophages may be activated and affect macrophage phagocytic function and inflammatory response by influencing specific membrane proteins such as MerTK, thereby regulating cardiac function. Through in-depth research on the mechanism of ADAM8's role in SICM, we aim to provide new targets and ideas for the treatment of this disease, ultimately contributing to improving the prognosis of septic patients.