PI3K/AKT Signaling Protects Against Cardiomyocyte Apoptosis in Pulmonary Hypertension (PRJCA050815)
PI3K/AKT signaling is compensatorily activated during PH-induced RV remodeling and provides partial protection against apoptosis. However, this response fails to offset apoptotic cell loss, contributing to RV dysfunction. Precise modulation of PI3K/AKT signaling may represent a potential therapeutic approach for PH-associated right heart failure.