Transcriptome analysis in the lung of mice with bleomycin-induced pulmonary fibrosis. (PRJCA051034)
This study employed whole-transcriptome sequencing of lung tissues from 6 mice with pulmonary fibrosis. Transcriptomic analysis demonstrated that Mexo-cl-aT treatment upregulated the expression of multiple matrix metalloproteinases (MMPs) and restored the balance of the MMPs/tissue inhibitors of metalloproteinases (TIMPs) protease system. Furthermore, Mexo-cl-aT downregulated the expression of genes associated with oxidative stress, indicating its potential to effectively alleviate lung tissue damage.