Construction of lncRNA-miRNA-mRNA Competitive Endogenous RNA Network for Distinguishing Periodontitis from Peri-Implantitis Based on WGCNA Transcriptome Analysis (PRJCA047734)
Systematically compare the characteristics of lncRNAs and their mediated ceRNA regulatory networks in PD and PI states. Transcriptome sequencing was performed on gingival tissues from three groups of rats: a control group, a PD group, and a PI group, to obtain lncRNA and mRNA expression profile data. Differentially expressed genes (DEGs) were screened using R software, followed by functional and pathway enrichment analyses. Key genes associated with PD and PI were identified through weighted gene co-expression network analysis (WGCNA). The miRanda software was employed to predict mRNAs that bind to both lncRNAs and miRNAs, facilitating the construction of an lncRNA-miRNA-mRNA regulatory network.