Comparative Whole Genome Sequencing of Candida albicans and Lactobacillus spp. from Pregnant Women with Vaginal Infection
This research focuses on the high-resolution genomic characterization of the vaginal microbiome during pregnancy, specifically investigating the interplay between the opportunistic pathogen Candida albicans and the commensal Lactobacillus spp. By utilizing Whole Genome Sequencing (WGS), the study aims to identify key virulence factors, antimicrobial resistance genes, and metabolic pathways that govern the transition from commensalism to infection.Furthermore, the comparative genomic analysis seeks to elucidate how specific strains of Lactobacillus maintain or lose their protective niche in the presence of fungal overgrowth. Through advanced bioinformatics pipelines, this work provides a comprehensive map of the genetic determinants influencing maternal health. Ultimately, the findings aim to identify novel diagnostic biomarkers and therapeutic targets to improve clinical outcomes for both mothers and neonates.