Gut microbiota metagenomic sequencing in mouse models of depression under ketogenic diet.
This dataset contains fecal metagenomic sequencing data from two distinct mouse models of depression: the chronic restraint stress (CRS) model and the chronic social defeat stress (CSDS) model. The project aims to investigate how a ketogenic diet (KD) remodels the gut microbiome to alleviate depression-like behaviors. The data include shotgun metagenomic sequences from control mice and depressed mice treated with either a standard control diet (CD) or a ketogenic diet. These sequences were used to identify key microbial species and their associated metabolic functions in the regulation of bile acid profiles and brain FXR signaling.