Single-cell transcriptome sequencing reveals the role of Capnocytophaga leadbetteri in remodeling the tumor microenvironment in a mouse model of oral squamous cell carcinoma. (PRJCA040831)
Our study first established an oral squamous cell carcinoma model in C3H mice by subcutaneously injecting the SCC-7 cell line. Subsequently, the successfully modeled mice were randomly divided into two groups, with control group mice receiving intratumoral injection of 1xPBS and experimental group mice receiving intratumoral injection of Capnocytophaga leadbetteri. Finally, tumor tissues were collected from both groups of mice (3 mice per group, totaling 6 mice) and subjected to single-cell transcriptomic sequencing to elucidate the role of intratumoral Capnocytophaga leadbetteri in remodeling the tumor microenvironment.