Exploring Population Differences in the Human Gut Microbiome: From Microbial Abundance to Genomic Variants (PRJCA041694)
The gut microbiota exhibits population-specific variations influenced by host genetics, diet, and lifestyle, yet prior studies have largely overlooked microbial genomic diversity due to limited reference genomes. Most catalogs are biased toward Western populations, lacking robust representation of the Han Chinese population, which displays significant regional dietary and lifestyle diversity. To address this, we constructed a high-quality gut reference genome catalog.
The gut microbiota exhibits population-specific variations influenced by host genetics, diet, and lifestyle, yet prior studies have largely overlooked microbial genomic diversity due to limited reference genomes. Most catalogs are biased toward Western populations, lacking robust representation of the Han Chinese population, which displays significant regional dietary and lifestyle diversity. To address this, we constructed a high-quality gut reference genome catalog.