Single-nucleus RNA sequencing of the mouse basolateral amygdala in depression models under ketogenic diet
This project contains single-nucleus RNA sequencing (snRNA-seq) data from the basolateral amygdala (BLA) of mouse models of depression. The overarching study investigates the neuroprotective mechanisms of a ketogenic diet (KD) against chronic stress. Specifically, this transcriptomic dataset explores how KD and subsequent alterations in the gut microbiome-bile acid axis modulate FXR signaling in GABAergic neurons. The dataset includes raw sequencing data from mice subjected to chronic stress and fed with either a standard control diet or a ketogenic diet, providing high-resolution insights into the microbiota-gut-brain axis and antidepressant responses.