Reprogramming of 3D genome structure underlying HSPC development in zebrafish (PRJCA022262)
We described the chromatin structure of nascent HSPC, fetal HSPC and adult HSPC of zebrafish. Reprogramming was detected at all layers of structure, including compartments, TADs and loops. We identifed a series of TF may regulating HSPC development through mediating chromatin loops. Of these, PU.1 was supported by public data.