Biological effects of EGFR activating mutations to the response to immune checkpoint inihibitors (PRJCA038433)
To evaluate the biological effects of EGFR activating mutations to the response to immune checkpoint inihibitors, three different cell lines originated from mus musculus were stably transduced with EGFR/Egfr activating mutations and subcutaneously transplanted to C57BL/6 mice model. The mice were then treated with anti-mouse PD1 antibody or IgG isotype, and the subcutaneous tumors were subjected to bulk RNA-sequencing after completion of treatment.