Thiamine-Mediated S100A9 Regulation of AKT/AMPK-Dependent Mitochondrial Energy Metabolism to Improve Sepsis-Associated Acute Kidney Injury: A Mechanistic Study (PRJCA033503)
Sepsis-associated acute kidney injury (S-AKI) is one of the most common and life-threatening complications in critically ill patients and is closely associated with poor outcomes. However, there are currently no effective drugs to prevent or treat S-AKI. The applicant's previous research has found that thiamine is associated with improved outcomes in patients with ventilator-associated pneumonia and sepsis in the intensive care unit. Therefore, in response to the urgent need for pharmacological treatment of S-AKI in clinical practice, this project aims to combine real-world clinical research with bioinformatics, network pharmacology, and basic experiments to explore the specific targets and mechanisms of action of thiamine in the treatment of S-AKI, providing a new direction for treatment.