Complete genome sequence of a fast-growing methylotroph, Methylobacillus sp., isolated from soil
Transitioning from fossil-based to bio-based chemical production is essential for achieving carbon neutrality. Methanol represents a promising sustainable feedstock, as it can be synthesized from CO2 or non-food biomass and is globally available at a low cost. In this study, we isolated a Methylobacillus sp. strain from soil that exhibits rapid growth on methanol minimal medium. While phylogenetic analysis identifies Methylobacillus glycogenes as its closest relative, only draft genomes have been available for this species. Here, we present the first complete genome sequence of this lineage, determined via hybrid sequencing technology. The assembly resulted in a circular genome of 3,397,625 bp (Contig count: 1). This genomic resource will facilitate metabolic engineering of this strain for the production of value-added chemicals from methanol.
Transitioning from fossil-based to bio-based chemical production is essential for achieving carbon neutrality. Methanol represents a promising sustainable feedstock, as it can be synthesized from CO2 or non-food biomass and is globally available at a low cost. In this study, we isolated a Methylobacillus sp. strain from soil that exhibits rapid growth on methanol minimal medium. While phylogenetic analysis identifies Methylobacillus glycogenes as its closest relative, only draft genomes have been available for this species. Here, we present the first complete genome sequence of this lineage, determined via hybrid sequencing technology. The assembly resulted in a circular genome of 3,397,625 bp (Contig count: 1). This genomic resource will facilitate metabolic engineering of this strain for the production of value-added chemicals from methanol.