RNA-seq analysis reveals developmental arrest following Dnmt3b and Dnmt3l silencing in early mouse embryos
This study investigates the effects of Dnmt3b and Dnmt3l silencing on early mouse embryo development using RNA sequencing. Gene silencing was performed to examine the role of DNA methyltransferases in embryonic progression. RNA-seq analysis was conducted to identify differentially expressed genes and disrupted molecular pathways associated with developmental arrest. The results provide insights into the epigenetic regulation of early embryogenesis.