Gut microbiota regulates hematopoietic homeostasis in patients with depression
We found that the L.R.S. strain is enriched for spermidine biosynthetic pathways, and spermidine plays an important regulatory role in maintaining hematopoietic stem cell function and hematopoietic homeostasis. In the gut microbiota of patients with depression, we observed a marked reduction in the abundance of this strain, which may lead to decreased systemic spermidine levels and ultimately contribute to disrupted hematopoietic homeostasis.