Larval fathead minnow exposure to dexamethasone and fluticasone
In this study, fathead minnow larvae were exposed to eight concentrations of two glucocorticoid receptor agonists, dexamethasone and fluticasone, and assessed transcriptome-wide gene expression changes using RNA-seq. A goal of this study was to assess whether transcriptomic profiling can effectively detect shared mechanisms of action between related compounds using an environmentally relevant aquatic species. The findings of this work support the utility of RNA-seq data in read-across approaches for chemical risk assessment and highlight the conserved molecular responses to glucocorticoid receptor activation in fathead minnows.