Histiocytic sarcoma in dogs is associated with a gene signature resembling M2 polarization
Translational aspects of human and canine histiocytic tumors have previously been described. To further investigate the implications for the biological behavior of spontaneously regressing canine cutaneous histiocytoma (CCH) and progressive histiocytic sarcoma (HS), 9 CCH samples at different stages of regression and 3 HS samples were submitted for RNA sequencing and analyzed for immune-oncological implications.