Genome instability caused by reduced dUTPase expression in Saccharomyces cerevisiae
This project examines the genomic consequences of reduced dUTPase expression in Saccharomyces cerevisiae. Whole-genome sequencing was performed on passaged dUTPase knockdown strains, their derivative strains, control strains, red-white sectored colonies, and three-generation passaging lines from three dUTPase knockdown strains. The data were used to characterize single-nucleotide variants, small insertions and deletions, structural alterations, aneuploidy, and loss-of-heterozygosity events.