Elucidating the potential pathogenic role of key molecules in psoriasis using mouse models (PRJCA049896)
This project is dedicated to elucidating the pathogenic mechanisms of psoriasis by leveraging mouse models of the disease, including genetic knockout mouses.     We will systematically collect diverse biospecimens from these models for comprehensive multi-omics sequencing. The primary objective is to acquire a view of the molecular dysregulation during psoriatic pathogenesis. Through integrated bioinformatics analysis of the multi-omics data, we aim to identify and validate key driver molecules and delineate their regulatory functions within the inflammatory networks of psoriasis. Ultimately, this research seeks to uncover novel therapeutic targets and provide foundational insights for developing new intervention strategies.