Choroid plexus RNAsequencing from awake, sleeping and sleep disrupted male mice
The choroid plexus produces cerebrospinal fluid, is regulated by circadian rhythms, and functionally impaired with age and neurodegenerative disease. The aim of this study was to investigate the changes in gene expression in the choroid plexus with time of day, and whether this was modulated by sleep in young, healthy animals. Then we examined whether this was changed in aged animals, or in the presence of amyloid-beta pathology (pathological characteristic of Alzheimer's disease).