Clinical Value of HPV Integration Testing as a Triage Biomarker for HPV-Positive Patients (PRJCA044643)
o investigate the dynamic characteristics of HPV genomic integration during cervical lesion progression,evaluate the clinical value of HPV integration detection in stratifying HPV-positive patients,and explore its molecular mechanisms in cervical carcinogenesis. Methods: A prospective cohort study was conducted on HPV-positive women who underwent cervical screening at two hospitals in Nanjing from July 2022to July 2024. Cervical exfoliated cell samples were collected and analyzed using HPV whole-genome targeted capture and high-throughput sequencing. Integration patterns,host gene functional region distributions,and pathway enrichment features were compared across different cervical lesion grades (normal,CIN1,CIN2,CIN3,cervical cancer).