GSE112200
Joint single-cell chromatin and protein profiling reveals environmental regulation of epigenomic heterogeneity [K562_GATA2]
A novel scATAC-seq approach, Multi-Index single cell ATAC-seq (MI-ATAC), in which we not only index the accessible chromatin of individual cells, but also index their protein expression using index Fluorescence Activated Cell Sorting (FACS). Overall design: K562 cells were fixed, nuclei isolated and then permeabilized. Nuclei were then stained for GATA2 and transposed, then sorted into single wells of a 96 well plate for MI-ATAC