GSE168787
Transcriptomic evaluation of age-associated CNS-resident CD8 memory T cells identifies CD200R1 as an important regulator of T cell entry and activation
We report a novel role for the CD200-CD200R1 pathway in regulating the basal entry and activation of resident memory phenotype CD8 T cells in the brain and other non-lymphoid tissues. Overall design: Brain and spleen CD8 T cells (CD44HiCD62LLo)  were isolated by FACS, Cells were stimulated with or without PMA/ionomycin for 2 hours to were subjected to RNA-sequecing