GSE109100
Single cell expression profiling of murine p53-/- shPU.1 AML cells following PU.1 restoration
We have utilized advanced RNAi technology to dynamically restore endogenous PU.1 expression in p53-deficient AML cells. Overall design: RNA-seq was performed on individual clone 2 AML246 cells either untreated or treated with doxycycline for 14 days, compared with normal mouse peripheral blood neutrophils.