GSE123490
Small molecule inhibitor of PRC1 E3 ligase activity induces differentiation of leukemia initiating cells [RNA-Seq]
We have developed small molecule inhibitors of PRC1. These inhibitors target PRC1, decrease H2A ubiquitination and differentiation of TEX cells. Overall design: TEX cells treated with DMSO or 25uM WY332 compound for 6 days or 10 days and gene expression was profiled using RNA sequencing.