HG_RNASeq_of_cellular_DDD_models_pilot-sc-5607
HG_RNASeq_of_cellular_DDD_models_pilot
Exome sequencing in children with developmental disorders has identified numerous causative mutations in novel disease genes.  Using engineered loss of function alleles, we are modelling these disorders in human IPSC and derived neural cells. To understand the molecular and cellular mechanisms underpinning these neurodevelopmental disorders, we are carrying out RNA-sequencing of the cellular models.
Exome sequencing in children with developmental disorders has identified numerous causative mutations in novel disease genes.  Using engineered loss of function alleles, we are modelling these disorders in human IPSC and derived neural cells. To understand the molecular and cellular mechanisms underpinning these neurodevelopmental disorders, we are carrying out RNA-sequencing of the cellular models.