GSE136186
Genome wide map of H3K27me3 histone mark remeains unaltered after silecing of lncRNA SCIRT
We generated genome wide map of H3K27me3 histone mark in mammospheres where we silenced lncRNA SCIRT, PRC2 member EZH2. We discovered that upon silencing of lncRNA SCIRT and EZH2, the distribution of this histone mark does not change. This  indicates that lncRNA SCIRT is important for EZH2 function that is independant of its activity as a histone methyltranspherase. Overall design: The genome-wide H3K27me3 profile in MDA-MB-231 mammospheres after siRNA downregulation of lncRNA SCIRT and EZH2.