DRP005251
Hmga2 functions as an oncogene upon the deletion of Tet2 and promotes the pathogenesis of myelodysplastic syndrome.
High Mobility Group AT-hook 2 (HMGA2) has been found in a subset of patients with myeloid malignancies including myelodysplastic syndrome (MDS). Recent genome sequencing studies reveal the emergence of clonal hematopoiesis during aging as healthy aged people often harbor mutations of epigenetic modifiers including TET2 gene, which are often observed in MDS and myeloproliferative neoplasm (MPN) in patients. In order to understand how HMGA2 promotes the transformation of hematopoietic stem and progenitor cells, we generated a Hmga2-expressing Tet2-deficent mice model and explored the molecular mechanism of the pathogenesis of MDS.