PRJNA678402
Clonal hematopoiesis detects early-staged colorectal neoplasia
Blood test has a better uptake for colorectal cancer (CRC) screening than stool test and colonoscopy. Suboptimal detection of early-staged colorectal neoplasia (CRN) of blood test limits its application. . Here, we established a novel blood test for better detecting early-staged CRN using the error-corrected sequencing by comparing the clonal hematopoiesis of 63 CRN patients and that of 32 risk-matched controls. By machine-learning (ML) approach, early-stage CRNs were detected with a AUC, sensitivity and specificity of 0.988, 94.2% and 99.3%, respectively. The model was validated in independent 21 CRNs and 10 controls with an accuracy, sensitivity, and specificity of 95.2%, 95.3, and 90%, respectively. In summary, our finding established a test via peripheral blood genetic variant identification to detect early-staged CRN with an optimal performance. The blood test may not only increase screening uptake but also improve the detection of early-staged CRN.