GSE168195
Identification of intrinsically immunogenic small cell lung carcinoma (SCLC) subpopulations
SCLC is molecularly and immunologically heterogenous. Here, using transcriptional and epigenomic profiling of plastic SCLC states in human and mouse cell lines, and patient samples, we define the phenotype of a SCLC population marked by increased MHC Class I antigen presentation. Overall design: Examination of paired transcriptome and H3K27Me3 ChIP-seq in isogenic SCLC cell lines, and transcriptomes of MHC Class I high vs. low SCLC cell lines and patient samples