ena-STUDY-Universita' degli Studi di Padova-03-12-2014-14:38:54:411-161
Ultra-deep mutational analysis of ALK kinase in primary anaplastic large cell lymphoma
We analyzed ALK kinase mutational status in 36 paediatric ALK-positive ALCL specimens at diagnosis, to identify point mutations and gene aberrations that could impact on NPM-ALK expression, activity and sensitivity to crizotinib. Mutations at low levels were detected, including missense substitutions R291Q and R335Q and splicing INDEL mutations.
We analyzed ALK kinase mutational status in 36 paediatric ALK-positive ALCL specimens at diagnosis, to identify point mutations and gene aberrations that could impact on NPM-ALK expression, activity and sensitivity to crizotinib. Mutations at low levels were detected, including missense substitutions R291Q and R335Q and splicing INDEL mutations.