GSE168862
PTIR1 acts as a suppressor of immunoproteasome and promotes cancer immune resistance
Cancer cells evade host immune surveillance by virtue of poor immunogenicity. We identify a novel oncogene that acts as a promotor of tumor immune resistance, designated as PTIR1. Tumor-intrinsic PTIR1 is induced by RNA splicing and highly correlated with poor outcome of patients with cancer. Overall design: Study of  tumor infiltration lymphocytes in Mock or PTIR1 expressing CT26 tumors using 10x scRNA-seq technologies.