GSE183208
TIPE1 regulation on macrophage polarization
Macrophages perform key and distinct functions in maintaining tissue homeostasis through finely tuning their polarization state.Here, we found that tumor necrosis factor-a-induced protein 8-like 1 (TIPE1) was highly expressed in macrophages and Tipe1 depletion impeded M2 polarization of macrophages.  The goals of this study are to compare BMDMs from LyzM-Cre; Tipe1f/f or Tipe1f/f mice to have a further view of the potential difference. Overall design: Examination of 2 different bone marrow derived macrophages from LyzM-Cre; Tipe1f/f or Tipe1f/f mice respectively