GSE184584
Causality of gut bacteria Klebsiella pneumoniae to hypertension development
Purpose: we conducted this study to investigate whether gut K.pn is a causal factor for HTN pathogenesis and the potential mechanism Methods: Renal transcriptome changes were assessed by RNA-sequencing Results: significant upregulation of several genes related to HTN pathogenesis were observed Conclusions:These results provide evidence that the enrichment of K.pn acts as a direct contributor for hypertension pathogenesis Overall design: Renal transcriptome profiles of germ-free mice and antibiotic pretreated mice receiving K.pn