PRJNA532733
Expression regulation by Phc1 in mouse embryonic stem cells
Polycomb group (PcG) proteins maintain cell identity by transcriptionally silencing developmental genes during embryogenesis. Phc1 is a subunit of cPRC1 known for gene repression, in the maintenance of pluripotency. To further explore how Phc1 might regulate the pluripotency of mESCs in both PRC1-dependent and PRC1-independent manners, we performed RNA-sequencing of the wildtype, Phc1-/- and Phc1-/- + Nanog overexpression mESCs.