GSE162743
Knockdown of Akt1/2 by CRISPR/Cas9 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo
Our findings will initially map out the downstream signal pathways of Akt and AR mutual feedback to regulate CaP metastasis through the study of these scientific assumptions, which will provide targets for the development of new precise treatments for prostate cancer. Overall design: we knockout Akt1 and Akt2 genes in CaP CWR22rv1 cells to study effects of Akt1/2 knockout on metastasis in CaP CWR22rv1 cells in vitro and in vivo.