GSE130617
Whole genome bisulfite genome analysis of OX40L-Jagged-1 expanded Treg and Teff cells
NOD mice were treated with PBS or OX40L and Jagged-1 proteins once a week for three weeks. A week after final treatment CD4+CD25- Teff cells and CD4+CD25hi Treg cells were sorted by FACS. Genomic DNA isolated from sorted cells and differences in DNA methylation pattern in these cell types between PBS and OX40L-Jagged-1 treated mice was analyzed by whole genome bi-sulfite sequencing. Overall design: Examination of methylation pattern in Teff vs Treg cells  between PBS and OX40L-JAG1 mice.