GSE186101
Time-lapse hippocampal transcriptomic profiling after fear conditioning in Tob WT and KO mice
Fear conditioning induces immediate changes in the mouse hippocampal transcriptome profile. Here, we performed RNA sequqencing in mice hippocampi at 15 minutes, 1 hour and 3 hours post-fear conditioning in addition to non-conditioned mice. Tob gene has been shown to affect cellular stress and behavior. In order to understand the role of Tob gene in the hippocampal stress and fear machinery, we compared hippocampi of Tob WT and KO mice. This dataset shows the temporal transcriptomic changes in mouse hippocampus induced by fear conditioning. Also, it shows the changes occurred after Tob deletion. Overall design: HIppocampal RNA profiles of 8-12 weeks old wild type (WT) and Tob knockout (KO) mice without fear conditioning (No), and at 15 min (0hr), 1hr and 3hr after fear conditioning. Each condition had three biological replicates.