GSE203335
Gene expression in the thyroarytenoid muscle in Pink1 knockout female rats
Parkinson's disease (PD) is a degenerative disease with prodromal pathology hypothesized to manifest in lower brainstem regions as well as within peripheral systems. Behaviorally, vocal deficits including soft monotone speech appear early and are present in 90% of PD patients. However, the pathology mediating voice deficits is unknown. The Pink1-/- rat is a mitochondrial dysfunction model of prodromal PD. In this study, we used RNA sequencing to examine gene expression within the vocal fold muscle of female Pink1-/- rats as compared to age-matched wildtype controls. Comparative gene expression profiling analysis using data obtained from the RNA-sequencing between the two genotypes (Pink1-/- and WT). Overall design: Eight month old Long Evans rats; 7 female (n=3 Pink1-/-, n=4 WT).