PRJNA534155
fecal microbiota Metagenome
Gut microbiota is considered as an important endocrine organ and has remarkable influence on the metabolic phenotype of host. Significant changes occurred in intestinal microenvironment of cirrhotic patients under the influence of gut-liver axis. Hepatic encephalopathy is one of the common complications of cirrhosis. In this study, four patients of cirrhosis accompanied with hepatic encephalopathy (CHE) were enrolled, with their healthy relatives as the controls, and paired comparison analysis was carried out. Fresh fecal samples were collected from participants, and subjected to Illumina MiSeq high throughput sequencing of 16S rRNA regions.