PRJNA794072
Adar regulated transcripts in granulosa cells leads to
Adenosine deaminases acting on RNA-(ADAR) comprise a family of RNA editing enzymes that specifically catalyze adenosine to inosine (A-to-I) editing. A granulosa cell (GC) specific Adar1-depleted mouse model was utilized to evaluate the role of ADAR during ovulation. Loss of Adar1 in GCs leads to delayed ovulation, decreased ovulation counts, and subfertility. We have performed transcriptome analyses of granulosa cells from ADARFL/FL/Aromatase-Cre and littermate control mice stimulated with gonadotropin (PMSG 48h+ 4h hCG).