GSE211642
Epigenetic Control over IFN Type-I Response antagonizes self-renewal in acute myeloid leukemia (RNA-seq)
To investigate the impact of PHF8 demethylase activity and PHF8 phosphorylation changes in blocking AML cells progression. We established THP1-wt, THP1-PHF8 and THP1-F279S cell lines for demethylase activity studies and THP1-PHF8AA and THP1-PHF8DD for phosphorylation studies. Overall design: Comparative gene expression profiling analysis of RNA-seq data for THP-1 cells and its derivatives (THP1-PHF8 and THP1-F279S or THP1-PHF8AA and THP1-PHF8DD).