GSE168114
FRCs promote Treg function in acute graft-versus-host disease (aGvHD)
Knockout of MHC class II on Ccl19 expressing fibroblastic reticular cells results in the hyper-activation of allogenic CD4+ T cells in the effoctor phase of aGvHD, due to the dyregulation of regulatory T cells (Tregs). Overall design: CD4+ CD90.1+ T cells mRNA profiles of allo-HCT (FVB to B6 model) at day +30 in B6.H2-Ab1fl and MHCII?Ccl19 mice