7df82247-1d41-4982-ae5e-030e4f240a5a
Osteoarthritis metagenome dataset
The gut microbiota plays an essential role in the regulation of the immune system and the etiology of human autoimmune diseases. However, a holistic understanding of the gut bacteriome, mycobiome, and virome in patients with osteoarthritis (OA) remains lacking. Here we explored the gut microbiota of 20 OA patients and 28 healthy volunteers via deep whole-metagenome shotgun sequencing of their fecal samples. The gut bacteriome and mycobiome were analyzed using a reference-based strategy. Gut viruses were identified from the metagenomic assembled contigs, and the gut virome was profiled based on 9,140 non-redundance viral operational taxonomic units. We showed that the multi-kingdom signatures are effective in discriminating the OA patients from healthy controls, suggesting the potential of gut microbiota in the prediction of OA and related diseases.
The gut microbiota plays an essential role in the regulation of the immune system and the etiology of human autoimmune diseases. However, a holistic understanding of the gut bacteriome, mycobiome, and virome in patients with osteoarthritis (OA) remains lacking. Here we explored the gut microbiota of 20 OA patients and 28 healthy volunteers via deep whole-metagenome shotgun sequencing of their fecal samples. The gut bacteriome and mycobiome were analyzed using a reference-based strategy. Gut viruses were identified from the metagenomic assembled contigs, and the gut virome was profiled based on 9,140 non-redundance viral operational taxonomic units. We showed that the multi-kingdom signatures are effective in discriminating the OA patients from healthy controls, suggesting the potential of gut microbiota in the prediction of OA and related diseases.