DRP004973
RUNX3 promotes the development of MDS via suppressing expression level of Runx1 and enhancing activation of Myc pathway in the absence of Tet2.
Analysis of Hematopoietic stem and progenitor cells (HSPCs) expressing Runx3. The RUNX transcription factors have a critical role in normal and malignant hematopoiesis including myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Results provide insight into the role of Runx3 in the development of MDS.
Analysis of Hematopoietic stem and progenitor cells (HSPCs) expressing Runx3. The RUNX transcription factors have a critical role in normal and malignant hematopoiesis including myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS). Results provide insight into the role of Runx3 in the development of MDS.