ena-STUDY-masood.kayani-04-05-2015-12:52:10:262-77
Transmitted Extended-spectrum XDR Tuberculosis in Beijing
Drug-resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum XDR (XXDR) tuberculosis, resistant to most first and second-line agents. Correlation of whole-genome sequencing (WGS) and phenotypic testing was discordant, suggesting over-reliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.
Drug-resistance to tuberculosis remains a major public health threat. Here, we report two cases of extended-spectrum XDR (XXDR) tuberculosis, resistant to most first and second-line agents. Correlation of whole-genome sequencing (WGS) and phenotypic testing was discordant, suggesting over-reliance on WGS may miss clinically relevant resistance in extensively drug-resistant disease.