GSE173336
Modeling sex differences in humans using isogenic induced pluripotent stem cells (RRBS)
We developed a cellular model to study sex differences in humans. Using somatic cells from a mosaic Kleinefelter patient, we generated isogenic human induced pluripotent stem cell lines with different sex chromosome complements – 47,XXY / 46,XX / 46,XY and 45,X0. Overall design: Reduced representation bisulfite sequencing (RRBS) of six isogenic hiPSC cell lines - XX1, XX2, XX3, XY1, XY2, XY3