PRJNA758048
Deep Sequencing CRISPR edits
CRISPR-based allelic-drive to replace a resistant kdr mutation with a susceptible wild-type counterpart in population cages. This successful proof-of-principle opens up numerous possibilities including targeted reversion of insecticide-resistant populations to a native susceptible state or replacement of malaria-transmitting mosquitoes with 18those bearing naturally occurring parasite resistant alleles.