GSE117836
ARID3a Gene Profiles are Strongly Associated with Human Interferon Alpha Production
Percentages of ARID3a-expressing low density neutrophils in SLE patients correlate with lupus disease activity and Type I IFN production. ARID3a protein levels also correlate with interferon expression in plasmacytoid dendritic cells. Gene profiles mechanistically link ARID3a with inflammatory pathway regulation. Overall design: Correlation analysis of genes associated with IFNa and/or ARID3a protein levels in neutrophils and pDCs of SLE patients.