GSE184210
An inhibitor-mediated beta cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation
We have determined that chemical FoxO1 inhibition can effectively mimic many aspects of beta cell dedifferentiation in vitro and that this can be countered by loperamide treatment. Overall design: RNAseq results of murine beta cell line, Min6, treated for 48h with DMSO, AS1842856 (FoxO1 inhibitor), loperamide and in combination.