GSE161939
Transcriptome Analysis of treated cells in Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia
To elucidate the transcriptomic effects of targeted therapy on Ph-like ALL cells, we performed RNA sequencing of the three Ph-like cell lines treated with venetoclax, TKI, or both drugs in combination for 72 hours. This allowed us to analyze differentially expressed genes and global transcriptomic shifts after inhibitor therapy in several Ph-like ALL models. Overall design: Differential gene expression comparing vehicle, single agent, or combined venetoclax and tyrosine kinase inhibitor treatment in Ph-like ALL cell lines