GSE163181
T11, AT3, PyMT-M, 2208L GEMM tumors treated with H3B-8800
The objective is to identify splicing and expression changes that occur after spliceosome inhibition in triple-negative breast cancer using immune competent GEMM tumors. Overall design: 4 different GEMM models of TNBC were transplanted orthotopically into C57BL/6 or Balbc females and then randomized onto 8800 or Vehicle. RNA was obtained from whole tumor. RNA from 3 or 4 biological replicate tumors were sequenced for each model for each condition.