ena-STUDY-University Medical Center Groningen-17-03-2021-10:11:04:014-1835
Evaluation of whole-genome sequencing data analysis approaches for both short-read and long-read sequencing of Mycobacterium tuberculosis
Our study evaluated different bioinformatics approaches for genomes (n=25) of 22 different MTB isolates using either short-read (SR) or long-read (LR), or both combined. We give an overview of the mostly used bioinformatics tools employed for both SR and LR sequencing data for anti-TB drug resistance and phylogenomic analysis of MTB to guide investigators to choose the appropriate tools depending on their requirements/aims/settings.
Our study evaluated different bioinformatics approaches for genomes (n=25) of 22 different MTB isolates using either short-read (SR) or long-read (LR), or both combined. We give an overview of the mostly used bioinformatics tools employed for both SR and LR sequencing data for anti-TB drug resistance and phylogenomic analysis of MTB to guide investigators to choose the appropriate tools depending on their requirements/aims/settings.