PRJNA431725
Targeted sequencing of FL patients
Purified FL B cells compared to normal GC B cells does not identify a distinct FL signature but rather found substantial revision of normal GC expression driving most likely by numerous genetic and epigenetic somatic modification. In nonfunctional CREBBP FLs induction of PRDM1 in response to IL-21 could be recovered through the use of pan-HDAC inhibitors. Collectively, our data uncover a new mechanism by which pan-HDAC inhibitors may act positively to treat FL patients.