PRJNA870968
Two novel lactic acid bacteria, Limosilactobacillus fermentum MN-LF23 and Lactobacillus gasseri MN-LG80, inhibited Helicobacter pylori infection in C57BL/6 mice
We screened dozens of lactic acid bacteria for the efficacy to inhibit H. pylori growth in vitro, and tested the therapeutic effects of candidate strains in vivo. The results showed that L. fermentrum MN-LF23 and L. gasseri MN-LG80 could significantly attenuate H. pylori infection-induced gastritis and systemic inflammation, and robustly regulated gastric microbiome.