PRJNA482646
whole genome sequencing of Leishmania infantum mutants submitted to chemical mutagenesis and selected for resistance to paromomycin or miltefosine
Leishmania infantum parasites were mutagenized by treatment with ethyl methanesulfonate prior to their exposure to paromomycin or miltefosine. The genome of clones growing under paromomycin or miltefosine pressure were sequenced and the mutations identified were functionally characterized.