PRJNA770849
Amelioration of AOM/DSS-induced murine colitis-associated cancer by Evodiamine intervention is primarily associated with gut microbiota-metabolism-Inflammatory signaling axis
Colorectal cancer (CRC) can be effectively detected and prevented before malignant transformation. However, most cases are diagnosed in an advanced stage and have poor overall survival. The etiology of CRC is multifactorial, including mutations, inflammatory bowel disease (IBD), gut microbiota and diet. Among these, inflammation is a critical player in the development, progression and metastasis of both CAC and sporadic CRC. Therefore, understanding the pathogenesis of colitis promoting CAC will provide novel therapy strategies for CRC. The intestinal microbiota may act as a link between colon cancer-promoting factors and the stages of carcinogenesis. Alteration in microbial composition and diversity is considered essential for the promotion of inflammation, proliferation and neoplastic progression. Studies evaluating the composition of the microbiota in CRC identified that bacteria such as Bacteroides, Parabacteroides, Alistipes and Staphylococcaceae are commonly increased, and such as Bifidobacterium, Lactobacillus and Roseburia are consistently decreased. As a result, methods that can selectively manipulate the microbiota have emerged as a strategy that may aid in the prevention of cancer.