GSE121536
TFAP2C signalling in human fibroblasts
Our work has shown that the transcription factor TFAP2C is upregulated in fibroblasts that generate an anisotrophic extracellular matrix. To determine what is acting downstream of TFAP2C we compared fibroblasts that had been mock transfected, or treated with a non-targeting siRNA control or siRNA against TFAP2C. Overall design: Vulval carcinoma associated fibroblasts (VCAF8) underwent a mock transfection (Ctrl_Tfn) or were treated with a non-targeting control siRNA (Ctrl_AllS), or siRNA against TFAP2C (siTFAP2C1) in biological replicates.