GSE132467
The RNA exosome nuclease complex regulates human embryonic stem cell differentiation [RNA-Seq rescue_SS]
This work shows that the exosome modulates the levels of LINE-1 retrotransposons, miRNAs, lncRNAs and specific mRNAs that encode developmental regulators or affect their expression. The exosome restrains differentiation in part by degrading transcripts encoding FOXH1, a transcription factor crucial for mesendoderm formation. Overall design: RNA profiles of shEXOSC3-expressing hESCs carrying an shRNA-resistant EXOSC3 transgene (EXOSC3r) or an empty vector (PB)