GSE128240
Transcriptome Analysis of Cyclophosphamide Effects on Ovarian Development in Mice
The role of cyclophosphamide (CTX) as a first-line chemotherapy drug in the reproductive health of young women with cancer has been controversial, especially considered to increase the risk of premature ovarian failure (POF). Therefore, in this study, c57bl/6 mice were treated by a single intraperitoneal injection of CTX.Our study suggests that CTX mainly regulates ovarian development by activate transcription factors, while reduce cholesterol production and lipid metabolism. Overall design: mRNA profiles of control and cyclophosphamide (CTX) were generated by deep sequencing, in triplicate, using Illumina HiSeq 2000