PRJNA792732
IBS colon epithelium transcriptome from water avoidance stressed  BALB/c &  C57BL/6J mice
Glucocorticoids (GCs) are major hormone signals shared by stress and circadian, GCs dysregulation by stress leads to circadian misalignment and impaired gut-brain axis causing IBS. GR maintains intestinal epithelium homeostasis and barrier function via transcriptional regulation of target genes including core circadian gene Nr1d1 and circadian controlled genes. We profiled BALB/c &amp; C57BL/6J colon epithelium transcriptome in response to water avoidance stress. BALB/c strain-specific WAS decreased Nr1d1 and multiple differentially expressed genes (DEGs) relevant to circadian and IBS were detected.