GSE161815
Transcriptome changes in human endothelial cells with reduced cMYC signaling.
Transcriptome profiling of human umbilical vein endothelial cells (HUVECs) transduced with lentiviruses encoding FLAG-CAS9 nuclease and control- (gCTL) or cMYC-targeting (gMYC) gRNAS to identify cMYC regulated genes. Overall design: HUVECs were engineered by CRISPR/CAS9 to ablate cMYC expression.  A pool of stable cells for control and MYC-depleted HUVECs was selected after puromycin treatment.