PRJNA415187
Mouse ES cell line single cell transcriptome changes upon replication stress
To understand whether activation of ATR-dependent replication stress response could result in global transcriptional alterations similar to that of 2C-like cells, we performed single cell whole transcriptional profiling on the E14 mouse ESC line upon aphidicolin treatment or aphidicolin + ATR inhibitor treatment. For comparison we also did single cell whole transcriptome profiling of the E14 cell line without any treatment.