GSE95837
Single cell gene expression in Dlxi1/2b::eGFP+ cells before and after migration, 4 weeks
We report the expression of selected genes associated with cortical, striatal and olfactory interneurons in hSS-derived Dlxi1/2::eGFP cells before (in hSS) and after migration (in hCS). By fusing hiPSC-derived fusions that were separately patterned to generate either human subpallial spheroids (hSS) or human cortical spheroids (hCS) we are able to model human interneuron migration in vitro. The aim of this experiment is to examine the gene expression of hSS-derived Dlxi1/2::eGFP cells before and after migration. Overall design: Examination of 88 cells Dlxi1/2::eGFP cells in hSS (not migrated) and 93 Dlxi1/2::eGFP cells in hCS (migrated).