GSE185647
CECR2 Drives Breast Cancer Metastasis by Suppressing Macrophage Inflammatory Responses
Purpose: Metastasis are responsible for the most majority of cancer-related deaths due to the lack of effective targeted therapies. Therefore, specific targets which tackle that complex process are needed to improve the therapeutic outcomes of metastatic breast cancer. Methods: ATAC-Seq analysis of CECR2 knockout and control LM2 cells. Results: CECR2 knockout  regulate chromatin accessibility of  NF-kB target genes . Conclusions: Our work confirmed that CECR2 knockout attenuates chromatin accessibility at promoters or enhancers of the downstream NF-kB target genes. Overall design: ATAC-seq analysis in LM2 cell lines