GSE212231
Genome-wide CRISPR/Cas9 Screens Reveal Shared and Bespoke Mechanisms of Resistance to SHP2 Inhibition [RNA-seq]
CRISPR/Cas9 screens identified unexpected hits in human AML cell lines whose loss of function causes resistance to SHP2 inhibition. Overall design: Transcriptomic analysis of INPPL1, or MAP4K5 KO compared with parental MOLM13 cells either under SHP099 treatment or Ctrl (DMSO) to identify key pathways causing resistance.