GSE133711
Sam68 regulation of alternative splicing in the developing cerebellum
We uncover a Sam68-dependent splicing program during cerebellar development. These events direct proper isoform expression of the genes required to guarantee the establishment of the correct spatial/temporal neural circuitry. The dysregulation in Sam68 null mice leads to functional defects in adult neurons Overall design: Examination of 3 different RNA from P1, P10 and P30 wild type cerebella of mouse, and 2 from P1 and P10 Sam68 null cerebella