GSE160485
Usp16 deletion-induced gene expression in MEFs
To determine the molecular signaling pathways responsible for USP16 regulation of cell growth, RNA sequencing was conducted on MEFs with or without Usp16 deletion Overall design: SV40T-immortalized K-rasG12D/Usp16+/+ and K-rasG12D/Usp16flox/flox MEFs were infection with Ad-Cre to activate K-rasG12D expression and delete the floxed Usp16 alleles. These cells denoted by K-rasG12D;Usp16+/+/SV40T (KS) and K-rasG12D;Usp16-/-/SV40T (UKS). The gene expression profiling in the MEFs with or without Usp16 deletion were analyzed by RNA-seq.