GSE172512
Hyperactive RAS/MAPK introduces cancer-specific mitotic vulnerabilities
We performed tanscriptional profiling of ARPE19 and four isogenic transformed cells lines in which   Ras or two downstream pathways, MAPK or PI3K/mTOR, were up-regulated. The purpose of this study is to understand how Ras signaling impacts kinetochore function. Overall design: mRNA-seq transcriptome profilng performed in triplicate on each of the five cell lines.