GSE212034
RNA-seq  analysis of functionally distinct HLADR+CD38+ CD8 T cells from acute dengue febrile patients
A discrete population of the CD8 T population with HLADR+ CD38+ phenotype expand massively during the acute febrile phase of natural infection with dengue virus. Although about a third of these massively expanding HLADR+ CD38+ CD8 T cells were also CD69high when examined ex vivo, only a small fraction made IFNg upon in vitro peptide stimulation. Here we analyse the transcriptional profile of CD69+IFNg+, CD69+IFNg-, CD69-IFNg-, unstimulated HLADR+ CD38+ and HLADR-CD38- subsets upon peptide stimulation using RNA seq. Overall design: Expression analysis of HLADR+CD38+CD69+IFNg+, HLADR+ CD38+CD69+IFNg-, HLADR+ CD38+ CD69-IFNg-, unstimulated HLADR+ CD38+, HLADR-CD38- CD8 T cell subsets