GSE132705
KAP1/TRIM28 maintains the transcriptional state of cancer cells
We report the genome-wide effects of KAP1 loss on the transcriptome, the chromatin state, and on recruitment of various components of the transcription machinery in the colon colorectal cancer cell line HCT116. Overall design: Genome-wide binding profiles of total and phosphorylated Pol II, CDK9, and NELFE in Ctrl vs KAP1 KO cells. Nascent and steady-state RNA expression levels in Ctrl vs KAP1 KO cells. Nucleosome occupancy profiles (MNase-seq) in Ctrl vs KAP1 KO cells