PRJNA433989
Clonal expansion and myeloid Leukemia progression modeled with multiplex gene editing of murine hematopoietic progenitor cells.
The goals of this study were to examine mutational profiles in mice transplanted with hematopoietic stem cells (HSCs), edited by a ribonucleoprotein-based CRISPR/Cas9 system. This model should prove useful in tracking the progression of Myeloid Leukemia and related diseases.