DRP007061
Single cell RNA-sequencing analysis of human neuronal cells derived from isogenic human ES cells with 16p11.2 deletion
16p11.2 deletion is one of the most influential copy number variations associated with autism spectrum disorder (ASD). To investigate how this CNV affects transcriptional profiles of human neuronal cells, we generated isogenic human ES cells with 16p11.2 deletion using CRISPR/Cas9 system. We differentiated these cells into 2-dimensional neurons and performed transcriptome analysis.