GSE50925
Genomic localization of Cockayne syndrom B protein upon genotoxic stresses
Cockayne syndrome is an inherited premature aging syndrome associated with developmental and neurological disorders.  Mutations in the genomic locus encoding CSB are associated with 80% Cockayne syndrome cases.  CSB is invovled in relieving UV-induced and oxidative stree. To gain more insights into the fucntion of CSB under these stress, we  use ChIP-seq to determine the genomic localization of CSB 1 hour after UV irradiation and menadione treatment. Overall design: Genomic localization of CSB and remodeling deficient CSB?N1