ena-STUDY-Institute of Biotechnology, Univerity of Helsinki-13-05-2016-10:02:33:856-4
Comparative genomics of Propionibacterium freudenrechii,  a GRAS organism with industrial applications and probiotic potential
Propionibacterium freudenreichii was traditionally used as a secondary starter in Swiss type cheese, from which it was first isolated. In the recent years it gained considerable attention owed to its industrial applications and probiotic potential. Because of the high G+C content and regions of repeated sequences in its DNA, P. freudenreichii posed a problem to NGS platforms and to this day only three complete genome sequences for the species are available. In this study, 19 complete genome sequences obtained with PacBio RSII platform were subjected to comparative genomics analysis in an attempt to characterize the species against the out-group of 3 Propionibacterium acidipropionici genomes, a related species with similar industrial properties.
Propionibacterium freudenreichii was traditionally used as a secondary starter in Swiss type cheese, from which it was first isolated. In the recent years it gained considerable attention owed to its industrial applications and probiotic potential. Because of the high G+C content and regions of repeated sequences in its DNA, P. freudenreichii posed a problem to NGS platforms and to this day only three complete genome sequences for the species are available. In this study, 19 complete genome sequences obtained with PacBio RSII platform were subjected to comparative genomics analysis in an attempt to characterize the species against the out-group of 3 Propionibacterium acidipropionici genomes, a related species with similar industrial properties.