ena-STUDY-Universitaetsklinikum Freiburg-02-10-2019-14:31:52:377-242
Colistin resistance in clinical Enterobacteriaceae isolates from the Western Cape of South Africa
Colistin resistant E. coli and Klebsiella spp. isolates were collected from the microbiology laboratory at Tygerberg Hospital during 2016 and 2017. Strains were mostly unrelated in 2016 based on rep-PCR, however the majority of the 2017 E. coli isolates were related based on rep-PCR, MLST and SNP analyses. mcr-1 was responsible for >50% of colistin resistance, but mutations in pmrB and disruption of mgrB were common in E. coli and Klebsiella spp. respectively.
Colistin resistant E. coli and Klebsiella spp. isolates were collected from the microbiology laboratory at Tygerberg Hospital during 2016 and 2017. Strains were mostly unrelated in 2016 based on rep-PCR, however the majority of the 2017 E. coli isolates were related based on rep-PCR, MLST and SNP analyses. mcr-1 was responsible for >50% of colistin resistance, but mutations in pmrB and disruption of mgrB were common in E. coli and Klebsiella spp. respectively.