GSE135880
EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP and senescence pathways
PRC2 catalyzes tri-methylation of histone H3 lysine residue K27 (H3K27me3), and then H3K27me3 recruits downstream regulatory factors to create a transcriptionally repressive chromatin environment. PRC2 is involved in diverse biological processes, including cell growth, cell differentiation and the maintenance of cell identity. Here, to study the role of PRC2 on oligodendrocyte myelination and remyelination, we performed  RNA-seq and ATAC-seq analysis of isolated control and Eed cKO mouse OPCs. Overall design: RNA-seq: 2 Control vs 2 Eed cKO; ATAC-seq: 2 Control vs 2 Eed cKO