PRJNA838818
mRNA m5C modification of cisplatin-resistant A549 cells
In this study, we compared the parental A549 cells with the constructed cisplatin-resistant A549 (A549/CDDP) cells at the levels of transcription and mRNA m5C methylation through RNA-Seq and RNA-BisSeq, respectively. Our data suggested that global changes occurred in cisplatin-resistant NSCLC cells and the median level of mRNA m5C modification in the A549/CDDP cells decreased compared to the A549 cells.