GSE167972
(Pro)renin receptor inhibition reduces plasma cholesterol and triglycerides but does not attenuate atherosclerosis in atherosclerotic mice
Purpose: to clarify the transcriptomic changes in aortic arch of inhibiting the (pro)renin receptor using (P)RR G-ASOs Overall design: Aortic arch isolated from non treated 8 week-old LDLR-/- mice (0 week control),  8-week-old LDLR-/- mice that received saline treatment and fed with WTD for 4 weeks, and 8-week-old LDLR-/- mice that received (P)RR G-ASOs treatment and fed with WTD for 4 weeks