PRJNA668278
H2A.Z acetylation by lincZNF337-AS1 via KAT5 implicated in the transcriptional misregulation in cancer signaling pathway in hepatocellular carcinoma
Background: In eukaryotes, histones and their variants are essential for chromatin structure and function; both play important roles in the regulation of gene transcription as well as development of tumors.Methods: we performed RNA-seq using HCC cells (HepG2) from H2A.Z and H2A.Z knockdown.For further research, we conducted the RIP-seq of H2A.Z acetylation.The above experiment shows the gene expression after H2A.Z knockdown and the target genes regulated by H2A.Z acetylated protein