PRJNA527171
mouse gut metagenome Raw sequence reads
Once the mucosal barrier is breached, luminal antigens and microorganisms might entry the submucosa, leading to the intestinal dysbacteriosis. In our present study, PCA analysis of microbial taxa from cecal content samples distinctly separated the four experimental groups, suggesting a regulatory property of LL-LFCA on gut microbial composition. As expected, DSS treatment significantly reduced diversity indices (Shannon) of gut microbiota[51], administration of LL-LFCA compromised the reduction of diversity induced by DSS treatment, which indicates the positive effect of LL-LFCA on the maintenance of intestinal ecosystems.