PRJNA559066
Functional Oocytes Derived from Granulosa Cells
Generation of genome stable and functional oocytes would hold great potential in fertility preservation and restoration of ovarian function. We examined genomic stability by Exome-seq analysis of gPSC lines (Chemical-induced iPS from granulosa cells ), and compared with high-quality ESC line, OG4-ESCs. Furthermore, to assess the genomic stability during PGCLC induction, we performed Exome-seq between E12.5 PGCs and gPSC4/15-PGCLCs and between Wild-type/natural GV oocytes and GV oocytes derived from gPSC-pups.