GSE132340
Hierarchy of mono- and bi-allelic TP53 alterations in Multiple Myeloma cell fitness
Comparison of the TP53 wild-type myeloma cell line AMO1 with the CRISPR/Cas9 engineered AMO1 cell line named UMC901. UMC901 harbors bi-allelic alterations to TP53:  TP53 del/mut. Analysis of impact of TP53 alterations on gene transcription and identification of affected pathways by transcriptome-wide differential gene expression analysis. Overall design: Triplicates for each cell line, comparison of UMC901 against AMO1 as reference. Circa 50 million single-end 75 nt reads per sample