GSE168344
Epigenetic crosstalk
We report a direct interaction between RNA epigenome and  DNA epigenome. We demonstrate that m6A methyltransferase METTL3 regulates DNA methylation levels co-transcriptionally. We observed a genome-wide correlation between m6A / METTL3 and occupancy by the DNA demethylase TET1, and m6A reader physically interacts and recruits TET1 to m6A-associated chromatin regions. Our results demonstrates an original but unheeded feed-back regulatory mechanism from RNA epigenome to DNA epigenome and detect a new aspect of epigenetic crosstalk to regulate gene expression. Overall design: Examination of m6A methylation and DNA methylation levels