GSE97197
RNA-Seq analyses with sorted ROSLow cells and ROSHigh cells
Recently, CICs were shown to be relatively resistant to therapy, perhaps due to increased expression of ROS defense genes. Additionally, in our previous study, the maintenance of low ROS levels within the HN-CICs was important for regulating stemness properties and conferring chemoresistance. Herein, we exploited RNA-Seq analyses with sorted ROSLow cells versus ROSHigh cells to obtain mechanistic insights into the role of the antioxidant defense system in CICs. Overall design: 2 samples analyzed by high throughput sequencing