GSE171228
A Thrombin-PAR1/2 Feedback Loop Amplifies Thrombo-Inflammatory Endothelial Responses To The Viral RNA Analogue Poly(I:C)
This study describes a positive feedback mechanism by which thrombin sustains and amplifies the prothrombotic and proinflammatory function of endothelial cells exposed to the viral RNA analogue, poly(I:C) via activation of PAR1/2. Overall design: Triplicate cultures of HUVEC were treated for 3h with poly(I:C) and/or thrombin and subjected to transcriptional profiling