ena-STUDY-ROBERT KOCH INSTITUT-19-08-2020-16:31:09:995-290
Re-assembly of 19th-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the United States
According to a recent article published in Genome Biology , Duggan and coworkerssequenced and partially assembled five genomes of smallpox vaccines from the 19 thcentury. No information regarding the ends of genomes was presented, and they areimportant to understand the evolutionary relationship of the different smallpox vaccinegenomes during the centuries. We re-assembled the genomes, which include thelargest genomes in the vaccinia lineage and one true horsepox strain. Moreover, theassemblies reveal a diverse genetic structure in the genome ends. Our dataemphasize the concurrent use of horsepox and horsepox-related viruses as thesmallpox vaccine in the 19 th century.
According to a recent article published in Genome Biology , Duggan and coworkerssequenced and partially assembled five genomes of smallpox vaccines from the 19 thcentury. No information regarding the ends of genomes was presented, and they areimportant to understand the evolutionary relationship of the different smallpox vaccinegenomes during the centuries. We re-assembled the genomes, which include thelargest genomes in the vaccinia lineage and one true horsepox strain. Moreover, theassemblies reveal a diverse genetic structure in the genome ends. Our dataemphasize the concurrent use of horsepox and horsepox-related viruses as thesmallpox vaccine in the 19 th century.