GSE66456
Targeted bisulfite sequencing to detect TALE-DNMT mediated targeted DNA methylation in human cells
We use NGS to assess the ability of TALE-guided DNA methyltranferases to make targeted changes to DNA methylation Overall design: Targeted bisulfite sequencing of cells infected with wild-type or mutant TALE-DNMT constructs directed to the CDKN2A (p16) locus