6d318531-fad6-4e6f-800c-a0d7265371cb
Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice
Maternal immune cells (called 'Maternal microchimeric cells' (short: MMc)) seed fetal brain tissue during pregnancy. We performed gene expression profiling analysis using data obtained from RNA-seq of fetal microglia cells to investigate the impact of MMc on fetal microglia in a mouse model of reduced brain MMc. Transcriptome analysis of fetal microglia revealed that 202 genes were differentially regulated between MMc-pos and MMc-low offspring. Genes suppressing inflammation were downregulated in microglia from MMc-low compared to microglia from MMc-pos.
Maternal immune cells (called 'Maternal microchimeric cells' (short: MMc)) seed fetal brain tissue during pregnancy. We performed gene expression profiling analysis using data obtained from RNA-seq of fetal microglia cells to investigate the impact of MMc on fetal microglia in a mouse model of reduced brain MMc. Transcriptome analysis of fetal microglia revealed that 202 genes were differentially regulated between MMc-pos and MMc-low offspring. Genes suppressing inflammation were downregulated in microglia from MMc-low compared to microglia from MMc-pos.