PRJNA805092
LEP-MCH conditioned childhood obesity
Next-generation DNA sequencing of central genes in the leptin-melanocortin pathway was performed in 1508 children and adolescents with and without obesity, aged 2-19 years. The gene panel included leptin and melanocortin pathway genes responsible for energy balance (AGRP, LEP, LEPR, MC3R, MC4R, NPY, NPY1R, NPY5R, PCSK1, PCSK2, POMC).