PRJNA669305
FTO functions as a tumor suppressor in colorectal cancer by regulating tumor metastasis via m6A-dependent manner
The N6-methyladenosine (m6A) enzymes was found participating in the development of various types of cancers. Here, we found that m6A demethylase fat mass and obesity-associated protein (FTO) played tumor suppressor roles in human colorectal cancer (CRC) metastasis. Applying RNA-seq and Me-RIP seq in HCT116 and DLD1 cells, we identified MTA1 was a downstream target gene of FTO.