GSE173571
Chromatin state changes induced by targeted degradation of MLL-AF9 are phenocopied by combined DOT1L and MENIN inhibition.  [SLAM-Seq]
Using SLAM-seq we examined the nascent transcriptional changes following MLL-AF9 degradation in MLL-AF9-HA-FKBP12 transformed hCD34+ cells (HCB1) after 15, 30, 60, and 120 minutes Overall design: Nascent Gene expression changes were assessed in the MLL-AF9-HA-FKBP12 transformed hCD34+ cells (HCB1) following MLL-AF9 degradation after 15, 30, 60, 120 minutes of 500nM dTAG-VHL treatment, compared to DMSO control