GSE194340
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells [DNA methylation]
We acutely depleted the BCL11A protein by using the dTAG PROTAC technology, and assessed its immediate consequences on DNA methylation, in the presence/absence of DNMT1 inhibitor AZAcytidine. Overall design: Examination of changes in HBG1/2 promoter DNA methylation that occur imminently upon depletion of the repressive transcription factor BCL11A in two clones.