PRJNA682323
WGS of established CYH33-resistant ESCC cells and corresponding parental cells.
To identify genomic adaptation to Phosphoinositide-3 kinase alpha-specific inhibitors (PI3K-alpha i), we applied whole-genome sequencing and detected gene mutation and amplification in four lines of esophageal squamous cell carcinoma (ESCC) cells established with adapted resistance to a novel PI3K-alpha i CYH33.