GSE110325
Mycobacterium tuberculosis tRNA induces IL-12p70 via synergistic activation of pattern recognition receptors within a cell network.
Analysis of gene expression profiles identified a mycobacterial tRNA-induced innate immune network resulting in the robust production of IL-12p70, a cytokine required to instruct an adaptive Th1 response for host defense against intracellular bacteria. Overall design: Gene expression profiles induced by microbial ligands in human PBMC (three independent donors), at three timepoints.