DRP004053
Expression analysis of intestinal tumor organoids derived from different driver gene genotypes
Apc (A), K-Ras (K), Tgfbr2 (T), and p53 (P) are four of the most frequently mutated driver genes in human colorectal cancer (CRC). We have generated  compound mutant mice in combination, which carry mutations in A, AK, AKP, AKT, ATP, or AKTP.  The purpose of this project is to elucidate the relationship between genotypes, phenotypes and  expression profiles through comparative sequencing analysis of these mouse tumor-derived organoids.
Apc (A), K-Ras (K), Tgfbr2 (T), and p53 (P) are four of the most frequently mutated driver genes in human colorectal cancer (CRC). We have generated  compound mutant mice in combination, which carry mutations in A, AK, AKP, AKT, ATP, or AKTP.  The purpose of this project is to elucidate the relationship between genotypes, phenotypes and  expression profiles through comparative sequencing analysis of these mouse tumor-derived organoids.