Korn_lab_01.19_Treg_Tcon_mouse_CSF_blood
Gene expression profile of Treg cells in secondary lymphoid tissue and in the inflamed central nervous system
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. We investigated gene expression of Treg cells and conventional T (Tcon) cells in the central nervous system (CNS) and in secondary lymphoid tissues during CNS autoimmunity. We also assessed the gene expression profile of CNS derived Blimp1-deficient Treg cells as compared to their wild-type counterparts
Foxp3+ regulatory T (Treg) cells restrict immune pathology in inflamed tissues; however, an inflammatory environment presents a threat to Treg cell identity and function. We investigated gene expression of Treg cells and conventional T (Tcon) cells in the central nervous system (CNS) and in secondary lymphoid tissues during CNS autoimmunity. We also assessed the gene expression profile of CNS derived Blimp1-deficient Treg cells as compared to their wild-type counterparts