GSE120857
MYCN knock-down leads to DNA-repair deficiency in human neuroblastoma (Mnase-Seq)
We knock down MYCN in human neuroblastoma cell line by RNAi. MYCN knock-down caused global epigenome change, including nucleosome gain on key DNA-repair genes and promoter H3K9ac down regulation. Overall design: Mnase-seq of nucleosome positioning in ctrl/N-myc_kd neuroblastoma cell line BE2C