GSE121506
A Small Molecule Activator of the TET2 Tumor Suppressor
TET2 protein is a dioxygenase that oxidizes 5-methylcytosine and is responsible for DNA demethylation. We found that a small molecule drug (3FM-dC) activates the enzyme activity of TET2. The sequencing data suggest that 3FM-dC induced global changes in DNA hydroxymethylation and gene expression. Overall design: To determine the effects of 3FM-dC on global gene expression, we performed RNA-seq on control and 3FM-dC treated K-562 cells.