GSE158322
Polycomb  complexes in skin epithelium development II
Polycomb group (PcG) proteins are essential epigenetic transcriptional regulators. Traditionally, PcG proteins function as two multi-subunit complexes, Polycomb repressive complex 1 (PRC1) and PRC2, which largely overlap in their genomic binding and cooperate to establish repressive chromatin domains demarcated by H2AK119ub and H3K27me3. Here, using the developing skin epidermis as a paradigm, we uncovered a  functional redundancy between Polycomb complexes in the repression of unwanted non-lineage genes. Overall design: Newborn mouse epidermal progenitor cells  were FACS purified. Immunoprecipitated chromatin was analyzed by ChIP-seq.