PRJNA714625
Dissection of transcriptional networks in breast cancer
More than one million putative transcriptional regulatory elements (TREs) have been catalogued in the human genome, yet their functional relevance in specific pathophysiological settings still remains to be determined. This is critical to understand how oncogenic transcription factors (TF) engage specific TREs to impose a transcriptional programs underlying malignant phenotypes. Here, we functionally survey around 15000 TREs for their contribution to gene regulation and cell fitness in Estrogen Receptor (ER)-positive breast cancer cells as a prototypical model of addiction to an oncogenic TF.