ena-STUDY-Kuwait University-08-04-2018-07:44:41:192-1746
Azole-resistant C. blankii as a cause of fungemia
A case of candidemia by Candida blankii in a preterm very low birth-weight neonate is described. The yeast was repeatedly isolated from bloodstream. The isolates formed cream-colored colonies with smooth surface and entire margins. Microscopic examination of wet mounts revealed ovoid budding yeast cells with pseudohyphae. The isolates showed reduced susceptibility (MIC = 12-16 µg/ml) to fluconazole by Etest. Species-specific identification was achieved by PCR-sequencing of rDNA. The presence of C. blankii DNA was also detected directly in a blood sample. Despite combination antifungal treatment with amphotericin B and caspofungin for 5 days, the patient expired.
A case of candidemia by Candida blankii in a preterm very low birth-weight neonate is described. The yeast was repeatedly isolated from bloodstream. The isolates formed cream-colored colonies with smooth surface and entire margins. Microscopic examination of wet mounts revealed ovoid budding yeast cells with pseudohyphae. The isolates showed reduced susceptibility (MIC = 12-16 µg/ml) to fluconazole by Etest. Species-specific identification was achieved by PCR-sequencing of rDNA. The presence of C. blankii DNA was also detected directly in a blood sample. Despite combination antifungal treatment with amphotericin B and caspofungin for 5 days, the patient expired.