GSE159053
Integrin a5-SRC signaling induces TET1 mediated hydroxymethylation of genes critical for maintenance of hepatic polarity.
Conclusions:1? ITGa5-SRC signalling regulates the CLDN1 expression and hepatic polarity.2?ITGa5-SRC signalling regulates the TET catelyzed DNA 5hmc/5mc level. 3?Itga5 regulates hydroxymethylation level of genes critical for polarity in vivo. 4?Excessive deposition of ECM blocks the regulatory effect of ITGa5 on CLDN1 in vitro and in vivo. Overall design: Examination of liver tissues from 3 control KD mice and 3 integrin a5 KD mice.