Transmissible Dog Cancer-sc-2010-05-19
Transmissible Dog Cancer
Six transmissible dog cancer genomes isolated from tumours from geographically distinct regions will be sequenced at ~1x coverage and mapped back to the draft assembly of the dog genome. Structural rearrangements such as translocations and large insertions and deletions will be identified in the cancer genomes. Eight lanes of Illumina GAIIx sequencing will be performed on each cancer.
Canine transmissible venereal tumour is a transmissible cancer that affects dogs worldwide. It is clonally derived and transmitted by the physical transfer of living cancer cells. By sequencing the genomes of tumours collected from different geographical areas, we aim to identify somatic structural rearrangements that have occurred in the evolution of this cancer, the oldest known somatic cell clone.