ena-STUDY-KIS-04-05-2015-13:09:38:641-146
Exome sequencing in an family from Sweden with developmental dyslexia
Developmental dyslexia is a relatively common learning disorder in children, with problems difficulties in reading and writing. These problems are likely due to a complex interaction of genetic and environmental factors, resulting in reduced power of studies of the genetic factors underlying developmental dyslexia. Our approach in the current study was to perform exome sequencing of affected and unaffected individuals within an extended pedigree with a familial form of developmental dyslexia. In total sample of 10 individuals were sequenced on a Ion Proton platform. One novel genetic variant segregated in all affected individuals and were missing in all available unaffected individuals.
Developmental dyslexia is a relatively common learning disorder in children, with problems difficulties in reading and writing. These problems are likely due to a complex interaction of genetic and environmental factors, resulting in reduced power of studies of the genetic factors underlying developmental dyslexia. Our approach in the current study was to perform exome sequencing of affected and unaffected individuals within an extended pedigree with a familial form of developmental dyslexia. In total sample of 10 individuals were sequenced on a Ion Proton platform. One novel genetic variant segregated in all affected individuals and were missing in all available unaffected individuals.