GSE160250
MicroRNA-221/222 modulate intestinal T helper 17 cell response as a negative feedback rheostat downstream of IL-23
MicroRNA-221/222 receive activation signal from IL-23 and suppression signal from TGFb, and target Maf and IL-23R for degradation, therebt acting in an inflammatory arm of Th17 response, and works as a negative feedback rheostat to constrain otherwise feed-forward loop of inflammatory Th17 response in the gut. Overall design: Next Generation Sequencing Based Quantitative Analysis of Wild Type and miR-221/222-/- CD4+ T cells including ChIP-seq, miRNA-seq, mRNA-seq and scRNA-seq