GSE168347
Gene expression analyses of COCs treated with N-Cadherin antagonist CRS-006
N-Cadherin is a cell surface protein that is critical for cell-cell adhesion and is essential for structural integrity of tissues. In the ovary, it is expressed by granulosa cells and cumulus cells junctions throughout ovarian development. Importantly, it is also present between oocyte (egg) and surround cumulus cells, and is the only physical type of communication that is present between the egg and its surrounding cells. Overall design: RNA-seq was performed on pooled COCs (n=100) treated with either CRS-066 or 0.1% DMSO vehicle during In Vitro maturation assay for comparitve analyses