PRJNA484091
Integration sites for viruses produced in the presence of LEDGIN CX014442
LEDGINs inhibit HIV-1 integration by targeting the interaction between the HIV integrase and the cellular co-factor LEDGF/p75. Previously it was shown that residual integrants were retargeted out of active transcription units upon addition of LEDGIN CX014442 during infection of the cells. Now integration sites were determined for viruses that were produced in the presence of LEDGIN CX014442.