GSE211208
Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner [1]
Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact. Overall design: Peritoneal macrophages from  mutant and control mice were isolated by FACS.  Total RNA was subjected to next generation mRNA sequencing.