PRJNA671512
Transcriptional profiling of the iron deficiency response in bloodstream stage African trypanosomes
The goal of this project was to investigate global transcriptional changes in bloodstream stage Trypanosoma brucei parasites upon iron deficiency induced by two orthogonal approaches: (i) treatment with iron chelator deferoxamine and (ii) silencing of the main iron import machinery the transferrin receptor. Following either treatment, total RNA was purified and deep-sequenced.