GSE61916
Genome-wide maps of PARP-1-bound nucleosomes (human)
PARP-1 binds to specific nucleosomes to regulate gene activity. While PARP-1''s role in transcription inititaion is known, a surprising finding here was that PARP-1 is highly enriched at exon-intron and intron-exon boundaries, sort of demarcting exons. Thius indicating a role in alternative splicing. Overall design: ChIP-seq of PARP-1-bound nucleosomes