PRJNA758252
Clinical and genetic correlates of the gut  microbiome and relation to cardiometabolic risk
The human gut harbors trillions of microbes that play dynamic roles in health. While the microbiome contributes to many cardiometabolic traits by modulating host inflammation and metabolism, there is an incomplete understanding regarding the extent and mechanisms by which individual microbes impact risk and development of cardiovascular disease (CVD). The Framingham Heart Study (FHS) is a multi-generational observational study following participants over decades to identify risk factors for CVD by correlating genetic and phenotypic factors with clinical outcomes. As a large-scale population-based cohort with extensive clinical phenotyping, FHS provides a rich landscape to explore the relationships between the gut microbiome and cardiometabolic traitsAvailable data sets:1. Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol. This data set, consisting of metagenome FASTQ data from 594 of the 624 FHS participants used for analysis, was released in conjunction with PMID: 32544460. The reduced number posted is due to consent restrictions.