PRJNA513065
Epigenetic Regulation of REX1 Expression and Chromatin Binding Specificity by HMGNs
HMGN proteins localize to chromatin regulatory sites and modulate the cell-type specific transcription profile; however, the molecular mechanism whereby these ubiquitous nucleosome binding proteins affect gene expression is not fully understood. Here we show that HMGN1 and HMGN2 (HMGNs) regulate the expression of Rex1, one of the most highly transcribed genes in mouse embryonic stem cells (ESCs), by recruiting the transcription factors NANOG, OCT4 and SOX2 to a ESC-specific super enhancer located in the 5'region of Rex1.