GSE170686
Single cell sequencing of e13 Embryonic Thymuses
Purpose: To identify and compare all the cell subsets present in Normal and 22q11.2 DS Hypoplastic thymus We have identified 17 distinct cell clusters in normal e13 embronic thymus. While both normal and 22q11.2 DS Hypoplastic thymus have same number of cell clusters, the trancriptome pattern varies significantly between them. Our scRNA sequencing results provide mesenchymal cells driven thymus hypoplasticity in 22q11.2 DS thymus. Overall design: scRNA seq is performed using e13 embryonic thymuses from control, Tbx1neo2/neo2 and Foxn11089/1089 thymuses