GSE120370
The tissue factor-thrombin axis drives pancreatic ductal adenocarcinoma through tumor cell-derived PAR-1
RNA-Seq analysis reporting the transcriptional changes induced by treatment of mouse pancreatic ductal adenocarcinoma cell lines with thrombin for 24h Overall design: Total mRNA profiles from C57Bl/6 mouse derived KPC [KRas-G12D; TRP53-R172H; Elas-CreER] pancreatic cancer cells or CRISPR/Cas9 generated KPC-Par1-KO cell lines 24h post treatment with either 1 U/mL thrombin or vehicle