ena-STUDY-INSTITUTO NACIONAL DE SALUD-09-05-2018-17:42:54:476-1807
K. pneumonia and Acinetobacter baumannii are a Gram-negative bacteria that had become one of the most difficult pathogens to treat. A. baumannii contains a chromosomal class D ß-lactamase gene, blaOXA-51 that can have the ability to confer carbapenem resistance. Additionally, mechanisms of carbapenem resistance have emerged that derive from the importation of the distantly related class D ß-lactamase genes blaOXA-23 and blaOXA-58, and recently New-Deli-metallo beta-lactamase. K. pneumoniae has become a substantial clinical problem, most typically attributed to production carbapenemases genesis KPC- and NDM-type.
This study is focused in the identification and subsequent analysis of the main molecular mechanisms of carbapenem resistance in K. pneumoniae and A. baumannii clinical isolates. The project includes of genome sequencing and genomic compares between clinical isolates of these bacterial specie.
This study is focused in the identification and subsequent analysis of the main molecular mechanisms of carbapenem resistance in K. pneumoniae and A. baumannii clinical isolates. The project includes of genome sequencing and genomic compares between clinical isolates of these bacterial specie.