GSE212182
Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects
High baseline CTLs in TEdef+ tumors result from the aberrant activation of the Nucleic Acid Sensing-TBK1-CCL5/CXCL9 signaling cascade, which induces an immunosuppressive microenvironment with increased regulatory T cells and exhausted CTLs. Overall design: 2 Control, 2 Flavopiridol teated