Teladorsagia_circumcincta_genome_sequencing-sc-3375
Teladorsagia_circumcincta_genome_sequencing
This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/  Teladorsagia circumcincta, the brown stomach worm, is the most important gastro-intestinal parasite of sheep in temperate regions and is present on 100% of sheep farms in the UK. Infection with T. circumcincta causes a spectrum of disease in the host, ranging from weight loss to death, and results in significant production losses. Parasitic disease is currently controlled by treatment with anthelmintics but resistance to these drugs is widespread and threatens the viability of the livestock industry. There are now well-documented cases of UK farms harbouring ‘triple-resistant’ T. circumcincta, which can no longer be controlled by any of the three major anthelmintic classes, forcing farmers to abandon sheep rearing. This project will combine high throughput sequencing data from multiple technologies to produce a high quality reference genome for T. circumcincta which will support research into the molecular basis of  anthelmintic resistance and ultimately inform future strategies for sustainable parasite control.
De novo assembly of a UK isolate of Teladorsagia circumcincta, using a combination of new sequencing technologies.