GSE184348
RNA-seq of skeletal muscle of young, old, and senolytics treated mice
We report RNA-seq of skeletal muscle (quadriceps) of young (6-month), old (24-month), and senolytic (Dasatinib + quercetin) treated mice Overall design: C57BL/6 mice were separated into three groups: Young (6 months), Old-Vehicle (24 months, treated with vehicle), and Old-DQ (24 months, treated with senolytic). For senolytic treatment, mice were gavage with vehicle (10% ethanol, 30% polyethylene glycol, and 60% Phosal 50) or dasatinib (5 mg/kg) plus quercetin (50 mg/kg) for 3 continuous day treatment per 2 weeks for from 20-month to 24-month. After treatment, mice were euthanized and quadriceps muscle was collected for RNAseq.