GSE160369
RNA sequencing data from patients with drug reaction with eosinophilia and systemic symptoms to antibiotics
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a cutaneous drug hypersensitivity reaction (DHR) with internal organ involvement and associated mortality, often caused by antibiotics. Despite the risk of severe systemic involvement, no robust diagnostic test to identify causative drug exists. To identify potential biomarkers, we evaluated changes in gene expression following exposure of PBMCs to a culprit antibiotic (cefoxitin, teicoplanin, vancomycin, dapsone) and developed a molecular assay test (MAT). Overall design: Transcriptome profile comparisons of drug-stimulated PBMCs against media control from 5 antibiotic-DRESS cases 24-hour in vitro  exposure to culprit drug (culprit drugs: cefoxitin, teicoplanin, vancomycin, dapsone)