PRJNA257562
Human oral microbiome associated with OC regiment
Quantitative assessment of anti-gingivitis methods based on the microbiota holds great potential yet remains challenging. Although anti-gingivitis efficacy of different oral care products has been studied from clinical outcomes, we know little about their impacts on oral microbiota and its metabolic capabilities. Here, ninety one adults underwent controlled transitions from naturally occurring gingivitis, to healthy gingivae using different anti-gingivitis products. Oral care product regimen, which contains stannous chloride in toothpaste and cetylpyridinium chloride in mouthwash, showed significant better anti-plaque and anti-gingivitis efficacy than placebo toothpaste in twenty seven days parallel study. Microbial diversity for regimen group was significantly decreased from Baseline Day 0 to Day 27. Meanwhile, plaque microbiota structure exhibited a continuous transition along the first principal component, which correlated with changes of Mazza Gingival Index and Plaque Index. Thirteen oral bacteria tend to be affected by two antibacterial activess. Metabonomic analysis of saliva indicates reduced anaerobic fermentation and tissue degradation of oral microbiota. Interestingly, microbial parameters demonstrate the ability to predict treatment effects of different product and regression of gingivitis symptom. Thus, our study provided novel insight into impacts of oral care products on microbial clades and metabolic pathways of gingivitis.