GSE121698
UTX Impairs Cartilage Anabolism and Aggravates Osteoarthritis by Deregulating PRC2-IGF2-Wnt10a Axis
This study is the first manifesting a deregulation among UTX, PRC2, and H3K27me3 assembly adverse to cartilage integrity and osteoarthritis development. Overall design: Examination of H3K27me3 histone modifications of chondrocyte in WT and Col2a1-UTX KO mice.