GSE194347
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells [PRO-seq washout]
We acutely depleted the BCL11A protein by using the dTAG PROTAC technology, then performed a drug washout and and assessed its immediate consequences nascent transcription. Overall design: Examination of changes in Nascent transcription that occur imminently upon washout of drug to restore transcription factor BCL11A in two clones.