E-MTAB-8645
Shallow whole-genome sequencing of 13 mice injected with renal cancer cells
In order to discover molecular pathways and players in renal cancer development and metastasis, we developed a mouse model to generate sequentially more aggressive and specialized cell lines. Multiple cell lines for primary tumor growth, survival in the blood circulation and lung metastasis or metastatic spread from the primary tumor were generated and analyzed using a multi-layered approach which include large-scale transcriptome, genome and methylome analysis. These are the DNA whole genome sequencing data.
In order to discover molecular pathways and players in renal cancer development and metastasis, we developed a mouse model to generate sequentially more aggressive and specialized cell lines. Multiple cell lines for primary tumor growth, survival in the blood circulation and lung metastasis or metastatic spread from the primary tumor were generated and analyzed using a multi-layered approach which include large-scale transcriptome, genome and methylome analysis. These are the DNA whole genome sequencing data.