PRJNA492713
Zebrafish macroH2A variants analysis reveals distinct embryo localization and function-RNASeq Information
Most mouse and cell-based studies have shown that macroH2A histone variants predominantly associate with heterochromatin and have been associated with gene repression, and with an important function in cell differentiation and inhibiting acquisition of pluripotency of pluripotency. However fewer studies have analysed the role of macroH2A during early embryo development. In the project, transgenic zebrafish lines were developed expressing macroH2A isoforms (mH2A1 and mH2A2) fusion proteins (GFP) under endogenous identified promoters, to study their function during embryogenesis.