GSE117409
Effect of DNA binding small molecules on the genomic distribution of nucleosomes with H3K27Ac
Small molecule CBL0137 destabilizes nucleosome directly via binding to DNA. Effect of CBL0137 on nucleosomes with mark specific for more open chromatin characteristic for promoters and enhancers versus all nucleosomes H3 was measured. Overall design: HT1080 cells were treated with 3uM of CBL0137 for 6 hours