GSE196430
The central clock suffices to drive the majority of circulatory metabolic rhythms
This dataset was generated to investigate the independence of the central clock in regulating hepatic transcriptional rhythms. Overall design: The core clock gene Bmal1 was knocked out using a floxed STOP codon (KO mice). By crossing these mice with Syt10-Cre mice we were able to rescue the Bmal1 expression in the suprachiasmatic nucleus (RE mice). These mice were compared with mice expressing Bmal1 in all tissues (WT). Livers were collected at 6 time points over the circadian 24-hour period.