PRJNA515914
FOXM1 Controls Leukemia Stem Cell Fate in MLL-Rearranged AML
Using mouse model, acute myeloid leukemia (AML) patient samples and xenografts, Sheng et al show that Foxm1 loss or inhibition significantly impairs the maintenance of human and mouse MLL-fusion -driven LSCs in vivo by promoting cycling and inducing apoptosis of leukemia stem cells (LSCs). Targeting FOXM1 suppresses disease progression in patient AML xenograft models.