PRJNA767238
Tracing and tracking the emergence, epidemiology and dispersal of dengue virus to Africa during the 20th century
Dengue infections, caused by the four distinct dengue virus serotypes (DENV1 to DENV4), elicit a high burden of disease throughout the tropical and sub tropical regions of the world. Nevertheless, their precise epidemiological history in Africa, including when and where they originated and were distributed during the 20th century, remains unclear. Accordingly, we have conducted a time-scaled molecular epidemiological reconstruction using publicly available and newly sequenced dengue virus genomes of African origin representing all four serotypes to deduce the most likely temporal and spatial transmission routes of each DENV serotype from their ancestral regions to, within and from Africa.