GSE106552
H3K27Ac in MCF7 Y537S ER mutant cells and RNAseq with and without treatment with THZ1
H3K27Ac ChIP-seq in MCF7 Y537S ER mutant cells RNAseq analysis of MCF7 Y537S ER mutant cells treated with veh and THZ1 Overall design: H3K27ac ChIP-seq in MCF7 cells with DOX-inducible expression of the Y537S ER mutant in cells without induction of the mutation in E2 stimulated conditions and cells with DOX induction of the mutation in hormone deprived conditions RNAseq of cells with DOX-induced expression of the Y537S mutation with veh treatment and THZ1 treatment for 6 hrs and 24 hrs