PRJNA835628
BCP-ALL cell line NALM6 with additional chromosome 21
A common finding in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells that chromosome 21 is never lost and often BCP-ALL cells have gained an extra chromosome 21. This implies an important role for chromosome 21 in the pathobiology of BCP-ALL. We therefore developed a BCP-ALL cell line (Nalm-6, a DUX4-rearranged cell line) with an addi-tional chromosome 21 by means of microcell-mediated chromosome transfer.