GSE97389
Stabilization of NIK suppresses MLL-AF9-induced acute myeloid leukemia
Comparison of transcriptome between control and NIK-stabilized leukemia stem cells Overall design: murine MLL-AF9 acute myeloid leukemia was generated using bone marrow progenitor cells (lin-cKit+) from NIKERT2 mice (crossing Rosa-loxp-STOP-loxp-NIK mice with Rosa-CreERT2 mice). Leukemia stem cells were sorted by FACS from tamoxifen treated (LSPCT group) and untreated (LSPC group) fully developed leukemia mice and used for RNAseq analysis.