PRJNA552905
Canine exome
Human breast cancer(HBC) is a very complex disease with both genetic and non-genetic factors as well as the heterogeneity of human populations need to be addressed and overcome to discover missing high-risk genes in HBC. To better understand both human breast cancer(HBC) and canine mammary tumor(CMT), we performed exome sequencing in the 20 pairs of normal and tumor tissues of CMT from multiple canine breeds to explore both germline and somatic variants associated with CMTs across different breeds. Such comparative studies may allow us to better understand both HBC and CMT, and lend new insight into the development of biomarkers and targets for both of these cancers.