GSE162623
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
We report that loss of EZH2 provides leukaemia cells with a selective growth advantage, which mediates chemotherapy resistance. This resistance is conferred by up regulation of direct and indirect EZH2 target genes. Overall design: Description of expression changes due to EZH2 knockout in K562 cells.