GSE108612
Single cell RNA sequence discover the musculoskeletal tissue cell atlas during limb development
By using single cell RNA-seq,We dissect the cellular heterogeneity and transcriptome profiles during limb development, and reveal the characteristic features of limb development and musculoskeletal stem/progenitor cell populations involved in limb lineage development. Our study therefore systematically decoded molecular markers and cellular program of limb development that would shed lights on limb developmental biology. Overall design: We performed high throughput single-cell RNA sequencing on cells from E10.5, E12.5 and E15.5 murine limbs to dissect the cellular heterogeneity and transcriptome profiles during limb development.