GSE183069
RNAseq of pedriatic IBD and XIAP-deficient biopsy samples
Deficiency in the X-linked inhibitor of apoptosis protein (XIAP) is the cause for the X-linked lymphoproliferative syndrome 2 (XLP2). About one third of all patients suffers from severe and therapy refractory inflammatory bowel disease (IBD), but the exact pathogenesis remains undefined. We examined the differences in gene expression of pediatric XLP2 patients with IBD to healthy controls and  pediatric IBD patients. Overall design: RNA was isolated from patient FFPE samples and subjected to RNAseq