GSE158651
RNA sequencing of human breast cancer cells with CUL4B knockdown
Approximately 30% of cases are resistant to TAM, which has become a major obstacle for breast cancer therapy.In this study, we demonstrated that CUL4B promotes TAM resistance in breast cancer cells through miR-32-5p/ER-a36 axis. CUL4B is overexpressed in TAM-resistant breast cancer cells and positively correlates with the levels of ER-a36 protein in human breast cancer specimens. Mechanistically, CUL4B positively regulates ER-a36 expression by epigenetically repressing the transcription of miR-32-5p. These findings provide not only a mechanistic insight into the role of CUL4B in regulating TAM sensitivity but also a potential target for the therapy of breast cancer. Overall design: We generated transciptome data from human breast cancer cells that Knockdown CUL4B and its control