GSE185465
Gene expression in Cdc42f/f and PgrCreCdc42f/f mice oviduct
Our results indicated that conditional knockout of Cdc42 in the epithelial cells of the oviduct isthmus led to defective embryo transport, resulting in blastocytes retention in oviduct, and contributing to the pregnancy failure in PgrCreCdc42f/f mice. To further determine the role of CDC42 in oviduct, RNA-seq analysis was applied in the Cdc42f/f and PgrCreCdc42f/f mice oviduct on day 2 of pregnancy. Overall design: mRNA profiles of Cdc42f/f and PgrCre/+Cdc42f/f mice oviduct on D2 of pregnancy.