PRJNA486887
Neisseria gonorrhoeae Genome sequencing
A2059G mutation on 23s rDNA mutation was responsible for high level azithromycin resistance in Neisseria gonorrhoeae. Four copies 23s rDNA A2059G mutation in high level azithromycin resistance ZJXSH89 clinical isolate and four copies 23s rDNA G2059A mutation in azithromycin sensitive ZJXSH86 clinical isolate had been made. The genome sequences of the wild type and mutant were compared to reveal whether secondary mutation exist or not.