ena-STUDY-Public Health Agency of Sweden-29-03-2021-15:23:54:423-260
Detection of pyrazinamide heteroresistance in Mycobacterium tuberculosis
As of today, the accuracy of determining M. tuberculosis heteroresistance by traditional DST methods of known proportions of heteroresistance has not been reported for PZA. Therefore, we evaluated the capacity of BACTEC MGIT 960, Wayne's test and WGS in detecting the critical level of 10% PZA heteroresistance in experimentally mixed bacterial populations.
As of today, the accuracy of determining M. tuberculosis heteroresistance by traditional DST methods of known proportions of heteroresistance has not been reported for PZA. Therefore, we evaluated the capacity of BACTEC MGIT 960, Wayne's test and WGS in detecting the critical level of 10% PZA heteroresistance in experimentally mixed bacterial populations.