GSE118301
Cyclin D1 levels induces global transcriptional downregulation in malignant lymphoid cells and correlate with total RNA levels in mantle cell lymphoma cell lines
Study of the transcriptional role of cyclin D1 in lymphoid tumor cells with cyclin D1 oncogenic overexpression. We perform global transcriptional analysis of four mantle cell lymphoma cell lines and we observed a correlation between the cyclin D1 levels and the transcriptional output. We confirmed our hypothesis using a lymphoblastic cell lines (JVM-13) cyclin D1 negative, where the overexpression of a mutant, more stable, form of cyclin D1 downregulated the transcriptome globally. Overall design: mRNA profiles of 4 mantle cell lymphoma and two transduced lymphoblastic cell lines (mutant cyclin D1  or empty vector) by deep sequencing, using Illumina MiSeq instrument.