PRJNA837184
CRISPR/Cas9 screening and transcriptome sequencing targeting the drug induced acute kidney failure susceptivity gene factors in HK-2 cells
The occurrence of drug-induced kidney injury (DKI) is hindering the treatment of patients need medical interventions and even directly lead to the death of patients. We employed genome wide CRISPR/Cas9 screens and transcriptome sequencings in drug induced nephrotoxicity cell model. Through the combined analysis of CRISPR/Cas9 screening and RNA-seq, we provided a series of genes and critical functional theme clusters potentially responsible for DKI susceptibility.