GSE210842
Effect of loss of HNF4A in liver and effect of ectopic expression of HNF4A in mouse fibroblast cells
To understand how HNF4A loss affects gene expression in mouse liver. We used control and HNF4A KO mouse livers for RNA sequencing. In addition, we also examined the effect of HNF4A gain in mouse fibroblast cells by ectropically expressing HNF4A in NIH3T3 cell to identify genes that are regulated by HNF4A. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at two time points.