GSE120714
Extracellular vesicle based therapeutic targeting of b-catenin to modulate anti-cancer immune responses in Hepatocellular Cancer
Combination therapy with anti PD-1 and ß -catenin siRNA delivered using biological nanoparticles provide an effective strategy for the treatment of Hepatocellular carcinoma. Overall design: A synthetic transgenic mouse of experimental HCC induced by MET/ ß-catenin expression, and extracellular vesicles as a therapeutic delivery agent were used to evaluate the efficacy of directly targeting ß-catenin on response to anti-PD-1.  This series includes data only for anti-PD-1.