GSE137106
Identification of Notch1 regulated genes in A549 NSCLC cell line
Notch signaling is an evolutionarily conserved signaling pathway. Notch1 signaling has been shown to potentially paly an important role in cancer development and progression. To illustrate the underlying regulating mechanisms of Notch1 activation in NSCLC, the intracellular domain of Notch1 receptor (NICD1) was overexpressed in A549 cell line and the RNA-sequences were performed. Overall design: Transcriptomes profiles of A549-NICD1 and A549-vector were generated by Illumina NovaSeq 6000.