GSE210529
Transcriptome data of bone marrow hematopoietic stem cells (HSCs) with aging
HSC aging is a well-described paradigm for the investigation of stem cell aging. However, the mechanistic interrelationships and hierarchical orders of these characters of HSC aging have not yet been clarified. To identify the underlying mechanisms and phenotype switching in HSC aging, we performed RNA-seq of HSCs from the bone marrow (BM) of mice at 2 mouths old (2 mo) and 12 mouths old (12 mo). Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of BM HSCs (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-) of mice at 2 mo or 12 mo.