PRJNA272344
RNA-Seq of osteoclasts derived from WT and Chmp5 CKO mice
The activities of osteoclasts to break down bone and osteoblasts to build bone are coupled, and this coupling is a key determinant of physiologic bone remodeling. In this study, we discovered that charged multivesicular body protein 5 (CHMP5) is a key regulator of bone turnover and osteoclast/osteoblast coupling.