GSE116982
Cancer associated mutants of eIF1A impair Rps3/Rps10 binding and enhance scanning of cell cycle genes [Mars-seq]
The Ribo-seq analysis demonstrated that eIF1A is predominantly essential for translation of genes with long 5''UTR genes including cell proliferation and cell cycle progression genes. eIF1A depletion causes broad stimulation of initiation in 5'UTRs at near-cognate AUG codons that diminshes the translation initiation fidelity Overall design: Mars-seq analysis was performed either in contol or eIF1A knockdown MEFs