ena-STUDY-ANAND-31-03-2017-12:44:29:003-178
Host Transcriptomics and gut microbiome analysis in broilers with contrasting Feed Conversion Ratio (FCR).
World population leading to consequent high pressure placed on animal biotechnologists/ researcher to increase the yield of current food crops and livestock, while identifying new and alternative food sources. In today's economically fast growing world poultry industry is also feeling its pace to be increased. Identification of genes associated with fatness or leanness will help in selection of individuals with better performance and thereby results in profitable poultry farming. In addition, Whole transcriptome shotgun sequencing or RNA-seq is an efficient and reliable technology for transcriptomic analysis so as to reveal genetic architecture, to identify sequence variation, and to quantify gene expression. The ultimate aim is to identify the genes which are associated with feed conversion ratio. The biomarkers identified will be useful for selection of birds with low FCR. The host genetic responses associated with weight gain and feed conversion efficiency have also played a role in changes in the physiology and gut microbial structure of birds. Therefore, shot gun and amplicon sequencing will be carrying out of each metagenomes. The ultimate aim is to detect possible association between FCR and gut microflora. The bacteria identified could be useful for feed formulation for broiler. Successful completion of project will result in identification of novel/ unigene associated with FCR in broiler. Based on identified unique/ novel gene, selection of good feed efficient birds can be done that will result in to economic production of broilers in shorter duration and profitable meat production. Also emergent microbial strains will identified by metagenome analysis and their association with good FCR birds.
World population leading to consequent high pressure placed on animal biotechnologists/ researcher to increase the yield of current food crops and livestock, while identifying new and alternative food sources. In today's economically fast growing world poultry industry is also feeling its pace to be increased. Identification of genes associated with fatness or leanness will help in selection of individuals with better performance and thereby results in profitable poultry farming. In addition, Whole transcriptome shotgun sequencing or RNA-seq is an efficient and reliable technology for transcriptomic analysis so as to reveal genetic architecture, to identify sequence variation, and to quantify gene expression. The ultimate aim is to identify the genes which are associated with feed conversion ratio. The biomarkers identified will be useful for selection of birds with low FCR. The host genetic responses associated with weight gain and feed conversion efficiency have also played a role in changes in the physiology and gut microbial structure of birds. Therefore, shot gun and amplicon sequencing will be carrying out of each metagenomes. The ultimate aim is to detect possible association between FCR and gut microflora. The bacteria identified could be useful for feed formulation for broiler. Successful completion of project will result in identification of novel/ unigene associated with FCR in broiler. Based on identified unique/ novel gene, selection of good feed efficient birds can be done that will result in to economic production of broilers in shorter duration and profitable meat production. Also emergent microbial strains will identified by metagenome analysis and their association with good FCR birds.