PRJNA433763
The coding regions of germline mRNAs confer sensitivity to Argonaute regulation in the C. elegans germline
Some C. elegans transgenes resist piRNA silencing. Seth et al. map resistance to endogenous sequences within transgenes and show that artificially increasing piRNA targeting can incrementally reduce expression without silencing. Their findings identify coding regions as part of a rich piRNA regulatory landscape within perinuclear nuage.