PRJNA834561
Co-existence of a novel translocation t(11;22)(q23;q12.1) with PML-RARA
Additional genetic alterations can enhance the leukemic potential of PML-RARA, leading to leukemia progression or therapy resistance in 40% of APL cases. KMT2A rearrangement with PML-RARA is extremely rare, and we revealed a new KMT2A recombinome by total RNA sequencing.