GSE125953
Genome-wide identification of miRNAs associated with alcoholism endophenotypes - Full LXS recombinant inbred panel
We conducted a high-throughput sequencing study to measure whole brain miRNA expression levels in alcohol naïve animals in the LXS panel of recombinant inbred (RI) mouse strains. We then combined the sequencing data with genotype data, microarray gene expression data, and data on alcohol-related behavioral phenotypes such as 'Drinking in the dark', 'Sleep time', and 'Low dose activation' from the same RI panel. Overall design: This dataset includes small RNA NGS sequencing data from 59  strains from the Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) Recombinant inbred  mouse whole brain RNA samples. 175 mice (2-3 from each strain) were untreated (naive). The naive samples were provided by Boris Tabakoff, University of Colorado Anschutz Medical Campus. All expression data generation and analysis were conducted by the Kechris Group,  University of Colorado Anschutz Medical Campus.