GSE108526
IRF5 and IRF3 regulate distinct immune programs in plasmacytoid dendritic cells
Transcriptomic analyses of pDCs show that the partitioning of TLR/IRF5 and RLR/IRF3 pathways confers differential gene expression and immune cytokine production in pDCs, linking IRF5 with immune regulatory and proinflammatory gene expression. Overall design: mRNA-seq profiling of plasmacytoid dendritic cells treated with TLR7/8 agonist R848 vs. vehicle; also PAMP (pU/UC) and controls (xRNA) vs. no RNA