ena-STUDY-Institute of Ecology and Evolution-16-12-2020-08:08:48:592-91
Highly efficient production of versatile linear cupiennins in spider venom glands as identified by 454- and Illumina 3000 sequencing
The first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or antimicrobial peptides, is reported from the venom gland transcriptome of Cupiennius salei by 454- and Illumina 3000 sequencing. Four transcript families (A-D) with complex precursor structures are responsible for the expression of 179 linear peptides. The transcript families start with a signal peptide and after an anionic propeptide, cationic linear peptides are separated by anionic linkers, which are transcript family specific.
The first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or antimicrobial peptides, is reported from the venom gland transcriptome of Cupiennius salei by 454- and Illumina 3000 sequencing. Four transcript families (A-D) with complex precursor structures are responsible for the expression of 179 linear peptides. The transcript families start with a signal peptide and after an anionic propeptide, cationic linear peptides are separated by anionic linkers, which are transcript family specific.