GSE97695
H3K27me3 localization during B cell differentiation
B cells are poised to differentiate into antibody secreting plasma cells however the remodeling of repressive epigenetic modifciations are not well understood during this cell fate transition.  Therefore, ChIP-seq was performed for H3K27me3 in naive splenic B cells and LPS induced splenic antibody secreting plasmablasts.  These data define a role for Ezh2 dependent H3K27me3 in the regulation of murine B cell differentiation in vivo. Overall design: H3K27me3 ChIP-seq insplenic B cells and LPS induced splenic plasmablasts