GSE194080
Epigenome-wide profiling uncovers novel pathway networks in human pulmonary arterial hypertension [pul36]
Pulmonary arterial hypertension (PAH) is a progressive pulmonary vascular disease that culminates in right heart failure. Vascular pathology in PH is characterized by pulmonary vasoconstriction and progressive vascular remodeling processes that affects all layers of the vascular wall (intima, media and adventitia). Overall design: Transcriptome profiling on pulmonary artery adventitial fibroblasts (PAAF) isolated from 4 PAH afflicted patients were treated with gene-specific siRNAs or scrambled siRNAs.