GSE174608
Identification of 5'isomiR in HCC patients.
The microRNA (miRNA) processing is a critical step for production of mature miRNAs. Its dysregulation leads to the increase of miRNA isoforms with heterogenous 5' ends (isomiRs), recognizing distinct target sites with a shifted seed sequence. Although some miRNA genes display productive expression of their 5'-isomiRs in cancers, how the production is controlled and how they impact on tumor progression are unexplored yet. In this study, we identified tumor-specific production of isomiRs and investigated biological function of isomiRs in liver cancer. Overall design: 15 Normal liver (NL), 60 HCC (TG1=10, TG2=25, TG3=19, HPC=6) samples who underwent small RNA-Seq