Shigella_evolution_in_India-sc-5025
Shigella_evolution_in_India
O139 serogroup of Vibrio cholerae appeared in early 1990s and then disappeared by 2006. While it was circulating, it dominated the surveillance charts but its sudden extinction surprised everyone. This study will look at the genomic changes that led to its success and decline over time. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
While a lot of progress has been made in understanding global Shigella evolution and spread, little epidemiological data has been available from India. We are collaborating with the Christian Medical College to understand the evolution and AMR in Shigella infections in Southern India. We envisage using whole genome sequencing and compare the data with the global framework that Sanger Institute already has. The collection, a mix of S. flexneri, S. sonnei and S. dysenteriae, spans more than 20 years and is particularly interesting because it comes from a relatively better developed part of India.