GSE138748
Transcriptome data from human endocrine cells recovered from mouse grafts with pre-engraftment controls
We examined the transcriptomes of alpha and beta cells recovered from mouse sub-renal capsule grafts of human islets as compared to alpha and beta cells from the same islet preps pre-engraftment. We found that after three to four weeks in the graft the human islets were still glucose responsive, secreting insulin following glucose challenge. In addition, gene expression was largely unchanged from the pre-engraftment control samples. Overall design: Bulk and single-cell RNA-Seq analysis of human endocrine cells recovered from mouse engraftment