GSE126675
Inhibition of TNBC metastasis by Gpx1
Gpx1 plays a vital role in the metastasis of TNBC cells by regulating cell adhesion. Depletion of Gpx1 reduces the survival, migration, and invasion of TNBC cells in vitro. Transcriptomic and signaling pathway analyses demonstrate that depletion of Gpx1 essentially impairs cell adhesion/spreading by down-regulating FAK/c-Src activation. Overall design: Examination of transcriptome on control and Gpx1-depleted TNBC breast cancer cell lines by deep sequencing, in replicate.