ena-STUDY-HUNAN NORMAL UNIVERSITY-22-05-2014-13:43:33:318-336
Age-related microRNAs profiling in rat brains using deep sequencing
This study has identified 171 novel miRNA candidates in rat brains, making evaluation of the full regulating mechanism for age-related genes or pathways feasible. This study has also revealed that age is a critical regulator for miRNA expression, and the age-related decline of miRNA expression is not a progressive process, but rather a biphasic one. Age-regulated miRNAs are predicted to target genes involving in nodes of signalling pathways relevant to brain aging and neurodegenerative diseases.
This study has identified 171 novel miRNA candidates in rat brains, making evaluation of the full regulating mechanism for age-related genes or pathways feasible. This study has also revealed that age is a critical regulator for miRNA expression, and the age-related decline of miRNA expression is not a progressive process, but rather a biphasic one. Age-regulated miRNAs are predicted to target genes involving in nodes of signalling pathways relevant to brain aging and neurodegenerative diseases.