PRJNA454483
16S rRNA sequences of human fecal microbiota of mother-child pairs from Southern Brazil
This project contains sequences for 2 groups of mother-child pairs: i - HIV infected mothers and their HIV exposed but uninfected (HEU) children; ii - HIV uninfected mothers and their uninfected and unexposed children. The study goal was to evaluate alterations in the gut microbiota of HEU children, compared to unexposed and uninfected children. With the improvements in antiretroviral treatment and the development of programs to prevent the vertical transmission of HIV, the population of HEU children has been increasing in the past years. Although not infected by HIV, HEU children show several immune system alterations and a significantly higher number of infectious diseases, besides compromised growth and increased mortality rates. As the gut microbiota has an important impact in general host homeostasis and in the immune system development and modulation, we sought to evaluate if HEU children present alterations in the gut microbiota, and if these alterations could be related to the increased morbidity and the immune system disorders presented by them.