PRJNA686143
Sexual Dimorphism of Gut Microbiota in a Hyperlipidemic Diversity Outbred F1 Mouse Population
Sex is one of the most powerful modifiers of disease development. Changes in the gut microbiota have been associated with the development of obesity, type 2 diabetes, and atherosclerosis, suggesting that gut microbiota may be key mediators driving the sexual dimorphism in disease progression. However, the effects of gut microbiota on sex-specific susceptibility in atherosclerosis are not yet clear. We studied sexual dimorphism in cardiometabolic traits and gut microbiota composition using a hyperlipidemic eight inbred founder strains and Diversity Outbred mouse model.