ena-STUDY-Institut Jules Bordet-03-10-2017-15:03:43:952-14
Whole genome sequencing of breast cancer diagnosed during pregnancy
Breast cancer diagnosed during pregnancy (BCP) is a rare disease associated with poor prognosis. In order to investigate the impact of pregnancy on theTo investigate the biology of and etiology of this conditionbreast cancer, we conducted an integrative  comparative analysis between interrogating an invaluable cohort of BCP by and non-pregnant control patients combining gene expression, copy number alterations , and whole genome sequencing data. Here we showed that BCP exhibit unique molecular characteristics that have not been previously described including . BCP harbored a higher frequency of mutations in mucin gene family as well as an enrichment of mismatch repair deficiency mutational signature. These results suggesting the importance implication of these processes features in promoting tumor growth progression during pregnancy that may explain their unfavorable behavior. Moreover, tThis study could potentially lead to the development of novel therapeutic strategies including immunotherapy in this setting. highlights new molecular aspects of BCP and supports the that these tumors could form a distinct biological entity, potentially opening novel therapeutic strategies for these patients.
Breast cancer diagnosed during pregnancy (BCP) is a rare disease associated with poor prognosis. In order to investigate the impact of pregnancy on theTo investigate the biology of and etiology of this conditionbreast cancer, we conducted an integrative  comparative analysis between interrogating an invaluable cohort of BCP by and non-pregnant control patients combining gene expression, copy number alterations , and whole genome sequencing data. Here we showed that BCP exhibit unique molecular characteristics that have not been previously described including . BCP harbored a higher frequency of mutations in mucin gene family as well as an enrichment of mismatch repair deficiency mutational signature. These results suggesting the importance implication of these processes features in promoting tumor growth progression during pregnancy that may explain their unfavorable behavior. Moreover, tThis study could potentially lead to the development of novel therapeutic strategies including immunotherapy in this setting. highlights new molecular aspects of BCP and supports the that these tumors could form a distinct biological entity, potentially opening novel therapeutic strategies for these patients.