GSE174820
miRNA regulated by Xanthohumol is linked to  cognitive impairment in mice
To explore whether the cognitive effect  of xanthohumol on mice is affected by the hypothalamic-pituitary-gonad system, and  to fully reveal the potential regulatory mechanism of xanthohumol on mice cognition,   we performed RNA-seq, miRNA-seq, and real-time qPCR to distinguish expression  differences between xanthohumol and saline treated mice brain cells in both HPG dysfunction/normal conditions.This study provides comprehensive miRNA and mRNA expression profile data of  xanthohumol and saline treated mice brain cells in HPG dysfunction and normal  conditions, which advances our understanding of the regulation of cognitive impairment mediated by miRNA. Overall design: Hippocampal tissues of ovariectomized and sham-operated mice treated with xanthohumol and normal saline