GSE200545
Blimp-1 moulds the epigenetic architecture of IL-21-mediated autoimmune diseases through an autoregulatory circuit
To unravel how Blimp-1 systematically manipulates the global transcriptional landscape in CD4 T cells to contribute to autoimmune progression, we performed RNA sequencing analysis in Blimp-1 transgenic (BTg) or Blimp1-deficient (CKO) NOD mice Overall design: Sorted total CD4 T cells from spleens of 12-week-old control, CKO and BTg NOD mice, without further T cell receptor stimulation