GSE168236
The role of MacroH2A1.2 in cancer (RNA-Seq)
MacroH2A1.2 is a histone variant from H2A family. Expression of macroH2A1.2 is found to be dysregulated in cancer especially lung cancer. However, the role of macroH2A1.2 in lung cancer remains relatively unknown. Our study showed that macroH2A1.2 stabilized FASN expression, increased fatty acid production and hence improved rate of mitochondria respiration. As a result, the cancer cells with higher macroH2A1.2 expression were more metastatic. Overall design: MacroH2A1.2 is overexpressed stably in the PC-9 cells. RNA expression in the macroH2A1.2 overexpressed PC-9 is profiled by RNA-seq and compared with vector transfected PC-9.