GSE201054
A novel class of early responder T cells are indispensable for neuroprotection and functional recovery after ischemic stroke
We report that CD8+CD122+CD49dlow regulatory-like T cells (CD8+TRLs) are among the earliest lymphocytes to infiltrate mouse brain after ischemic stroke, temper inflammation, and confer neuroprotection. Overall design: CD8+CD122+CD49dlow TRLs were FACS-isolated directly into a plate with lysis buffer from the brain and blood of young male mice 3 days after transient (60 min) middle cerebral artery occlusion (tMCAO) or blood of sham operation and subjected to RNA-sequencing analysis.