GSE117206
Alternative splicing controls Leucine-rich repeat domain modularity in NOD-like receptors
Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins that function in development and immunity. Somatic recombination of LRR sequences evolved to create diversity in jawless vertebrate adaptive immunity, yet the role repetitive LRR-encoding exons in humans remains unknown.  We performed this RNA Seq study to understand how alternative splicing of NOD-like receptors (NLRs) at the locus encoding a LRR domain can regulate NLRs function, with a focus on NLRP3. Overall design: RNA Seq of GM-CSF differentiated human monocyte derived macrophages from 5 individuals