GSE171098
TooManyPeaks identifies drug-resistant-specific regulatory elements from single-cell leukemic epigenomes [ChIP-seq]
Purpose: To investigate the impact of GSI resistance on epigenome of Notch-mutated T-ALL Methods: We generated scATAC-seq and H3K27ac ChIP-seq in parental and GSI-resistant cells Results: Using TooManyPeaks, a novel algorithm for scATAC-seq analysis, we identified subpopulation of epigenetically resistant-like parental cell. Overall design: ChIP-seq of H3K27ac was used to characterize enhancer activity in parental and resistant NOTCH1-mutated T-ALL DND-41 cells