DRP004333
Investigation of energy metabolism regulators in adipocytes and cancer cells
Cancer cells acquire certain important characteristics, including a unique metabolic phenotype, upon transformation and metastasis. Some of these characteristics are also associated with the regulation of preadipocyte function, as well as the differentiation of adipocytes, pointing to commonalities between the mechanisms of pathogenesis associated with oncogenesis and adipogenesis. To investigate the commonalities in p53-dependent metabolic regulation between adipocytes and cancer cells, we performed RNA-seq analysis with two distinct systems: 1) H1299 cells infected with adenoviruses expressing either p53 or LacZ and 2) preadipocytes treated with doxorubicin to induce DNA damage or untreated.