ena-STUDY-Instituto Murcia de Investigacion Biomedica-15-03-2019-09:37:50:289-14
Microbiome data for ColPortal, an integrative multiomic platform for analysing epigenetic interactions in colorectal cancer.
Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidences point out a causative role of microbiota and altered microRNA expression in CRC carcinogenesis but their relationship with the pathological drivers or molecular phenotypes are not clearly established. The joint analysis of clinical and omics data can contribute to clarify such relations. We present ColPortal,a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphologicalmanifestation of a complex molecular change. The current cohort consists of Caucasians patients from Europe. For each patient demographic information, location, histology, TNM, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal permits to perform multiomics analyses for groups of patientsselected by their clinical data.
Colorectal cancer (CRC) is the third leading cause of cancer mortality worldwide. Different pathological pathways and molecular drivers have been described and some of the associated markers are used to select effective anti-neoplastic therapy. More recent evidences point out a causative role of microbiota and altered microRNA expression in CRC carcinogenesis but their relationship with the pathological drivers or molecular phenotypes are not clearly established. The joint analysis of clinical and omics data can contribute to clarify such relations. We present ColPortal,a platform that integrates transcriptomic, microtranscriptomic, methylomic and microbiota data of patients with colorectal cancer. ColPortal also includes detailed information of histological features and digital histological slides from the study cases, since histology is a morphologicalmanifestation of a complex molecular change. The current cohort consists of Caucasians patients from Europe. For each patient demographic information, location, histology, TNM, tissue prognostic factors, molecular biomarker status and clinical outcomes are integrated with omics data. ColPortal permits to perform multiomics analyses for groups of patientsselected by their clinical data.