GSE113465
Evaluation of HSP90 inhibitor expsosure on Immune Cell Gene Expression
We report RNA-sequencing analysis of human peripheral blood mononuclear cells exposed to clinically recommended doses (500 nM) of the HSP90 inhibitor ganetispib. Global analysis of the expression profiles of treated cells revealed wide spread changes in gene expression, specifically, upregulation of protein folding and assembly pathways, with downregulation of antigen presentation through MHC Class I and Class I. Overall design: Examination of PBMCs treated with vehicle or ganetispib for 24 hrs