GSE160806
Hippocampal GR and pCREB binding analysis of glucocorticoid enhanced memory formation [ChIP-seq]
Aim: We investigated whether glucocorticoid effects on memory are associated with genomic interactions between the GR and pCREB in the hippocampus. Methods: Adult male rats received 3 minutes of object exploration training or no training either with a 3.0mg.kg post-training corticosterone injection or vehicle injection to study the molecular effects underlying enhanced memory formation. Hippocampi were dissected 45 minutes after injection and snap-frozen. Subsequently, Chromatin ImmunoPrecipitation was performed for GR and pCREB and the ChIP samples were sequenced. Overall design: Hippocampal genomic binding of GR and pCREB in male rats studying glucocorticoid enhanced memory formation.