ena-STUDY-THE UNIVERSITY OF BIRMINGHAM-02-07-2021-17:04:31:966-1370
Ciprofloxacin-resistant Salmonella enterica serovar typhi from strains lacking RND efflux pumps have novel mutations in the gene encoding gyrA
The efflux status of Salmonella enterica serovar typhi alters which mutations are selected for in the presence of ciprofloxacin. Strains lacking RND efflux were found to have a novel G81C mutation in gyrA, which is not seen in wild-type strains and has not been described in clinical isolates. Modelling suggests that the G81C mutation affects the binding of DNA to DNA-gyrase.
The efflux status of Salmonella enterica serovar typhi alters which mutations are selected for in the presence of ciprofloxacin. Strains lacking RND efflux were found to have a novel G81C mutation in gyrA, which is not seen in wild-type strains and has not been described in clinical isolates. Modelling suggests that the G81C mutation affects the binding of DNA to DNA-gyrase.