PRJNA863080
EP300 facilitates human trophoblast stem cell differentiation.
R. Keijser, A. J. van Voorden, G.B. Afink. To investigate the role of EP300 and CREBBP in trophoblast differentiation, we downregulated EP300 and CREBBP in human trophoblast stem cells using siRNA. We induced extravillous trophoblast differentiation in these cells and performed transcriptome sequencing. The dataset contains 4-5 experimental replicates for EP300, CREBBP and non-targeting control siRNA.