GSE124421
H3K9 acetylation and di-methylation changes in HL-60 cells following treatment with different compounds
We investigate the effects of GCN5 and LSD1 inhibition in acute myeloid leukemia. Therefore, we characterized acetylation and di-methylation changes by ChIP-seq in AML cells (AML M2 cell line HL-60) following treatment with ATRA, MB3, GSK-LSD1 and their combinations. Overall design: 15 samples in 3 groups: H3K9ac, H3K9me2 and Input DNA are provided for treatments with ATRA, ATRA+MB3, ATRA+GSK-LSD1, ATRA+GSK-LSD1 and ATRA+GSK-LSD1+MB3