GSE126107
Spatial and Temporal Mapping of Human Innate  Lymphoid Cells Reveals Elements of Tissue  Specificity
We provide a map of human ILC heterogeneity across multiple  anatomical sites. Tissue-specific distinctions    are particularly apparent for ILC1 populations, whose  distribution was markedly altered in obesity or aging.    Furthermore, the degree of ILC1 population hetero-  geneity differed substantially in lymphoid versus    mucosal sites. Together, these analyses comprise a  comprehensive characterization of the spatial and    temporal dynamics regulating the anatomical distri-  bution, subset heterogeneity, and functional poten-  tial of ILCs in non-diseased human tissues. Overall design: We present a quantitative analysis of ILC distribution and  heterogeneity in lymphoid, mucosal, and metabolic tissues  obtained from a diverse cohort of 44 previously non-diseased  organ donors over a wide range of ages and body mass indexes  (BMIs).