GSE137871
Day6_exon3lines
Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD), predicting gene regulatory network (GRN) imbalances. Here, we define transcriptional responses to reduced transcription factor dosage in human iPSCs heterozygous or homozygous for loss of the CHD gene TBX5. Overall design: Single cell RNA sequencing of day 6 cells from exon3 lines (WTC11, Control, TBX5Het and TBX5Hom) in duplicate Please note that the 'Day6_Day11_Day23_matrix.csv' processed data was generated from Day6_exon3lines, Day11_exon3lines, and Day23_exon3lines_rep1 datasets together (as detailed in the sample data processing field).