ena-STUDY-COLUMBIA UNIVERSITY MEDICAL CENTER-29-01-2019-20:09:29:502-8398
Novel germline alleles predicted by cAb_Rep database
cAb_Rep is a public database that contains 293 B cell repertoires from 108 human healthy, vaccinated, and autoimmune disease donors. The database includes a total of ~4.2 and 1.2 million curated full length V(D)J heavy and light chain transcripts respectively, which were annotated with gene origins, subtypes, mutations, and other information. By applying IgDiscover, we identified 5 novel heavy chain alleles, 2 novel lambda chain alleles, and 1 kappa chain allele, each of which were found in two or more donors.
cAb_Rep is a public database that contains 293 B cell repertoires from 108 human healthy, vaccinated, and autoimmune disease donors. The database includes a total of ~4.2 and 1.2 million curated full length V(D)J heavy and light chain transcripts respectively, which were annotated with gene origins, subtypes, mutations, and other information. By applying IgDiscover, we identified 5 novel heavy chain alleles, 2 novel lambda chain alleles, and 1 kappa chain allele, each of which were found in two or more donors.