GSE137874
Day23_exon7lines_scRNAseq
Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD), predicting gene regulatory network (GRN) imbalances. Here, we define transcriptional responses to reduced transcription factor dosage in human iPSCs heterozygous or homozygous for loss of the CHD gene TBX5. Overall design: Single cell RNA sequencing of day 23 cells from 3 lines (PGP1, TBX5Het_exon7 and TBX5Hom_exon7)