GSE212086
MacroH2A2 modulates the self-renewal of glioblastoma cells
Self-renewal is a crucial property of glioblastoma cells and is enabled by the choreographed function of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could represent an important step toward developing new and effective treatments for this universally lethal cancer. Here we uncover a targetable epigenetic axis of self-renewal mediated by the histone variant macroH2A2. Overall design: ChIP-seq of macroH2A2-FLAG in endogenously tagged primary glioblastoma cells