GSE118531
CCR7L-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF1a-mediated glycolysis (mRNA)
Purpose:  The purpose is to systemically identify RNA expression changes after lnc-Dpf3 knockdown in CCR7-stimulated mDCs Methods: We profiled RNA seq in mDCs transfected with si-Lnc-Dpf3 or si-NC and stimulated with or without CCR7 ligand CCL19 and CCL21. Results: CCR7 stimulation induced profound RNA expression changes in mDCs, and a set of genes were differentially expressed in lnc-Dpf3-knockdown DC Overall design: mDCs were transfected with si-Lnc-Dpf3 or si-NC and stimulated with or without CCR7 ligand CCL19 and CCL21 (CCR7L) for 12 h or left unstimulated (Med), and then subjected to RNA seq