PRJNA454697
Mixed tissue samples composed of cells from both human cancer cells and mouse stromal cells Raw sequence reads
We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its mitochondrial accumulation; this dramatically increases its potency and efficacy against highly metastatic lung cancer lines in vitro, and in orthotopic lung tumor xenografts and brain metastases in vivo. We used RNA-seq to study the molecular mechanisms underlying the efficacy of mito-HNK