GSE211114
Transcriptional changes induced by ADH5 knocking out in HeLa cells.
ADH5 encodes for the protein GSNOR, an alchol dehydrogenase acting as a denitrosylase. GSNOR reduces S-nitrosoglutathione (GSNO) to an unstable intermediate, S-hydroxylaminoglutathione, which then rearranges to form glutathione sulfonamide, or in the presence of GSH, forms oxidized glutathione (GSSG) and hydroxylamine Overall design: Four biological replicates were analyzed for each of the 2 genotypes