GSE172119
TNFR2/14-3-3e signaling complex instructs macrophage plasticity in inflammation and autoimmunity
To elucidate the molecular mechanisms by which 14-3-3e and PGRN regulates macrophage plasticity, we performed unbiased RNA-seq on BMDMs isolated from WT, PGRN-/- and 14-3-3e-/- mice stimulated with pro-inflammatory LPS/IFN? or anti-inflammatory IL-4. Overall design: mRNA frofiles of WT, PGRN-/- and 14-3-3e-/- BMDMs polarized to M1 or M2 macrophages