DRP008558
UTX deficiency renders hematopoietic cells highly susceptible to leukemia
To investigate the effect of UTX deficiency on leukemogenesis, we performed retrovirus-insertional mutagenesis using MOL4070A, a replication-competent retrovirus capable of inducing leukemias. We revealed that Sox4 over expression cooperate with Utx deficiency to promote acute transformation.