GSE135997
Cyclophosphamide (CTX) Enhances Cancer Antibody Immunotherapy in the Resistant Bone Marrow Niche by Modulating Macrophage Fc?R Expression
Purpose: To understand the molecular mechanisms underlying the CTX synergization with antibody therapies in resistant niche-specific organs and BM-resident tumors Overall design: Humanized mice were treated with CTX or PBS. Two days post treatment, mouse and human macrophages in the spleen and bone were sorted and applied to RNAseq.