PRJNA551447
Understanding the genetic architecture of schizophrenia in Chinese population
In recent literature, there is evidence that mutations with low frequencies are an important contributor to genetic risk to schizophrenia. This application proposes to discover and test these mutations by whole-genome sequencing of multiplex Han Chinese families with affected and unaffected siblings. The application also plans to conduct comparative analyses to determine the shared and ethnic-specific factors between the Chinese and Caucasian populations.