WGS_of_the_Nubpl1_mouse_line-sc-5358
WGS_of_the_Nubpl1_mouse_line
The mouse line Nubpl1 was found to have a strong infection phenotype when challenged with Salmonella.  However when this line was moved to faculty breeding and re-challenged it was noticed that the phenotype segregated away from the Nubpl1 genotype suggesting that there was a secondary mutation.  There are very few genes which have such a strong Salmonella phenotype and none to our knowledge that have this phenotype when heterozygous.  This could potentially be an extremely important gene for controlling infection
The mouse line Nubpl1 was found to have a strong infection phenotype when challenged with Salmonella.  However when this line was moved to faculty breeding and re-challenged it was noticed that the phenotype segregated away from the Nubpl1 genotype suggesting that there was a secondary mutation.  There are very few genes which have such a strong Salmonella phenotype and none to our knowledge that have this phenotype when heterozygous.  This could potentially be an extremely important gene for controlling infection