GSE172029
Developmental chromatin programs determine oncogenic competence in melanoma [RNA-seq]
Transcriptional profile of human ES-cell (hPSC) derived melanoma cell models Overall design: Human ES cells were differentiated into neural crest (NC), melanoblast (MB) or melanocytes (MC). These were either WT or triple knockout (3xKO) for p53, p16, RB1. A dox-inducible cassette was integrated into the cells to activate the BRAFV600E oncogene upon addition of doxycyline.