Obesity_and_leukemia_onset_in_mice-sc-4325
Obesity_and_leukemia_onset_in_mice
Hematopoietic stem cells are cloned from mice, either with or without a PML-RAR mutation, that have been on a high-fat diet or standard diet (control group). Whole genome sequencing is performed on clones and tail DNA to assess mutation numbers and patterns in the hematopoietic lineage in these experimental conditions.
This study explores the link between obesity and leukemia onset. Mutation patterns and numbers are explored in obese and non-obese mice.