GSE127881
IRF5 produced by kidney macrophages promotes polycystic kidney disease
We show that Pkd1 mice have higher levels of kidney IRF5 compared to control mice and that IRF5 expression is found predominantly in macrophage populations in the kidney. Suppressing IRF5 with an antisense oligonucleotide (ASO) decreased kidney IRF5, the total number of kidney macrophages, pro-inflammatory cytokine production, and attenuated kidney cyst growth. Overall design: CrePlus and CreMinus Pkd1 mice with and without unilateral nephrectomy were compared for differential gene expression by RNASeq methods.