PRJNA866169
The RPL/RPS gene signature of melanoma CTCs associates with brain metastasis
Melanoma brain metastasis (MBM) is linked to poor prognosis and low overall survival. We hypothesized that melanoma circulating tumor cells (CTCs) possess a gene signature significantly expressed and associated with MBM. Employing a multi-pronged approach, we provide first-time evidence identifying a common genetic signature for ribosomal protein large/small subunits (RPL/RPS) which associate with MBM onset and progression