GSE117881
A Role for Chromatin Remodeling in Cohesin Loading onto Chromosomes
The RSC chromatin remodeling complex recruits the cohesin loader Scc2-Scc4 by a direct protein interaction. Nucleosome-free DNA is the substrate for the cohesin loading reaction. Overall design: MNase-seq analysis of the nucleosome positioning comparing wild type to Sth1Degron cells and Sth1Degron cells expressing either Sth1 wild type or Sth1K501R following Sth1 depletion.