PRJNA287208
H3K4me3 pattern of rostral and caudal cortex derived from E14.5 NMRI
"Recent advances in neuroscience support the importance of epigenetic modifications, such as methylation, acetylation and ubiquitylation of histones, for function and development of the central nervous system. Histone modifications are known to regulate gene transcription and they can be inherited to subsequent cell generations.In this context the aim is to determine histone modification marks that are associated with restricted cell fate of neuronal progenitors in the developing cerebral cortex of the mouse. We detected expression changes between rostral (motor) and caudal (visual) cortex for H3K4 trimethylation (H3K4me3), a modification linked to transcriptional activation. Therefore, we performed ChIP-Seq with regard to H3K4me3 patterns.Understanding these signatures is one step in achieving a comprehensive view on the epigenetic impact on cortical development and in identifying new therapeutic targets or strategies."