PRJNA282161
Whole exome sequencing on metastatic experimental model systems
We have sequenced and compared the exomes of five transplantable metastasis experimental models. These models were previously generated using heterogeneous human breast cancer (MDA-MB_231), lung cancer (H2030, PC9), and renal cancer (786-O, OS-RC-2) cell lines. These lines were compared to matched in vivo selected highly metastatic derivative cell populations that reproducibly form organotropic metastases in mice.