Treponema_Pallidum_genomic_diversity_within_and_between_patients_in_Ghana-sc-6304
Treponema_Pallidum_genomic_diversity_within_and_between_patients_in_Ghana
Yaws, caused by the bacterium Treponema pallidum subspecies pertenue (TPE), is the target of a current WHO eradication campaign, but the global prevalence and genomic diversity is poorly understood. TPE sequencing frequently utilises targetted sequencing methods directly from clinical samples, and these data inherently contain information on within-sample diversity. To date, there has been little analysis on the reproducibility and reliability of minority variant calling for understanding this diversity. In this study conducted in Ghana, we prospectively collected multiple longitudinally sampled TPE positive swabs from different lesions on the same patients to allow robust analysis and validation of diversity within and between patients.  This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Yaws, caused by the bacterium Treponema pallidum subspecies pertenue (TPE), is the target of a current WHO eradication campaign, but the global prevalence and genomic diversity is still poorly understood. TPE sequencing frequently utilises targetted sequencing methods directly from clinical samples, and these data inherently contain information on within-sample diversity. In this study conducted in Ghana, we prospectively collected longitudinally sampled TPE positive swabs from different lesions on the same patients to allow robust analysis and validation of diversity within and between patients.