GSE175374
HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer
We performed HDAC5 knockdown in pancreatic cancer cell line (PANC-1). The expression profiling showed NF-?B signaling as a potential HDAC5 targets and the conclusions were futher validated in vivo and in vitro. Overall design: RNA sequencing in PANC-1 cell lines with shControl or shHDAC5