GSE168974
Transcriptomic expression profiling of blood stages of Plasmodium berghei of wild-type and ?HspJ62 line.
The transmission of the malaria parasite between mosquitoes and mammals requires translational repression to ensure that only the proper proteins are expressed and correct folded at the right time, it will need for the next developmental stage.Due to their essential role for malaria transmission, gametocytes represent prime targets for transmission-blocking strategies intended to prevent spread of the deadly disease. In this study, we generate HspJ62 gene knockout line (?HspJ62) that is gametocyte non-producing lines. Transcriptional profiling of wild type Plasmodium berghei and genetic KO Hspj62 genes at single time points during erythrocytic parasite development. Overall design: We performed Next Generation sequencing to compare transcriptome profiles of wild-type and ?HspJ62 of blood stages of Plasmodium berghei