GSE104608
Epigenetic Inactivation of Cysteine Dioxygenase Type 1 Contributes to ROS-dependent Progression of Colorectal Cancer
We performed a comprehensive investigation to understand the clinical and biologic significance of CDO1 methylation under various circumstances in CRC tissues and cell lines. The restoration of CDO1 function impaired ROS detoxification and changed the effect of ROS on cell viability. We performed RNA-seq which reveals the differential transcriptome profiles to interpret those changes following the restoration of CDO1 function. Overall design: Examination of gene expression profiles between CDO1-overexpression KM12 and mock cells with three replicates each group.