Genomic_epidemiology_of_Clostridium_difficile_in_Latin_America-sc-5072
Genomic_epidemiology_of_Clostridium_difficile_in_Latin_America
Whole-genome sequencing will be performed over 450 strains to comprehensively assess the genetic diversity of C. difficile in Latin America, by applying standard phylogenomics and comparative pan-genome analyses coupled with association studies to relevant metadata. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Clostridium difficile is the leading cause of healthcare-associated infectious gastrointestinal disease. Here, we apply whole-genome sequencing, phylogenomics and comparative pan-genome analyses coupled with metadata association to understand the epidemiological dynamics of C. difficile in the Latin American region. The dataset consists in C. difficile strains isolated from retrospective outbreaks occurred in Latin American countries. The analysis of this data as well as its integration with genomic information from global collections will allow a better understanding of the epidemiology and genomic evolution of C. difficile.