GSE115550
Spatially Constrained Tandem Bromodomain Inhibition Bolsters Sustained Repression of BRD4 Transcriptional Activity for TNBC Cell Growth
We performed RNA-seq of MDA-MB-231 cells that were treated with MS645 or JQ1 at 50 nM and 500 nM in an effort to understand how MS645 exerts such a profound cell growth inhibition on cancer cells. Overall design: MDA-MB-231 cells were treated with DMSO and different concentrations of JQ1 and MS645 for 18 hrs to compare the compounds' effect in transcriptional regulation.