GSE124728
Single cell multi-omics analysis reveals novel roles for DNA methylation in sensory neuron injury responses
We used single cell multi-omics method to simultaneously  profiled both DNA methylome and mRNA transcriptome from single DRG sensory neurons under either control or peripheral nerve injury condition. Overall design: In this study, we performed sciatic nerve injury surgery on C57BL/6 and CAST/Ei crossing mice at different ages, and performed scMT-seq, µRNA-seq (low-input RNA-seq)  and µWGBS (low-input WGBS) on sensory neurons under intact and injured condition.  Bioinformatic analysis revealed novel role for DNA methylation in sensory neuron injury responses.