ena-STUDY-University Hospital Marques de Valdecilla-07-11-2014-08:37:18:642-751
Whole genome comparative analysis of Klebsiella pneumoniae strains with increased antimicrobial resistance isolated from the same patient.
The whole genome of four K. pneumoniae isolates (LB1, LB2, LB3, and LB4) with increased antimicrobial resistance and obtained from different samples of sputum of a patient with pneumonia at Massachusetts General Hospital (Boston, Mass) have been resolved in this study. These four isolates were isolated in a period of time of three months and were previously characterized by Martinez-Martinez et al. in terms of biotype, plasmid content, lipopolysaccharide, and genetic resistance features.The studied isolates of K. pneumoniae vary in terms of resistance towards antibiotics in a sort period of time from the same patient and therefore it is of great interest to uncover and to assess the role of different genetic elements involve in their pathogenesis.
The whole genome of four K. pneumoniae isolates (LB1, LB2, LB3, and LB4) with increased antimicrobial resistance and obtained from different samples of sputum of a patient with pneumonia at Massachusetts General Hospital (Boston, Mass) have been resolved in this study. These four isolates were isolated in a period of time of three months and were previously characterized by Martinez-Martinez et al. in terms of biotype, plasmid content, lipopolysaccharide, and genetic resistance features.The studied isolates of K. pneumoniae vary in terms of resistance towards antibiotics in a sort period of time from the same patient and therefore it is of great interest to uncover and to assess the role of different genetic elements involve in their pathogenesis.