GSE138774
RNA-seq analysis using glomeruli isolated from control and podocyte-specific bPIX deficient mice
We found that podocyte-specific bPIX deficient (KO) mice developed progressive proteinuria starting at ~8 weeks of age, and glomerulosclerosis and podocyte loss by 13 weeks of age. To investigate the mechanism of podocyte loss induced by bPIX deficiency, we analyzed mRNA expression by RNA-sequence using isolated glomeruli from control (CTRL) and KO mice. Overall design: mRNA profiles of glomeruli isolated from 3 CTRL and 3 podocyte-specific bPIX KO mice were generated.