GSE107980
RING-finger protein 6 amplification activates JAK/STAT3 pathway by modifying SHP-1 ubiquitylation and associates with poor outcome in colorectal cancer
To elucidate whether  RNF6 plays a role in  colorectal cancer tumorigenesis, a RNA-seq analysis was performed to compare the gene expression profiles of  RNF6 siRNA and control siRNA transfectants. Overall design: RNA-seq was performed in HT29  colorectal cancer cells after RNF6 knock down