GSE160802
Therapeutic PYY/GLP-1 receptor co-agonism in obese-diabetic mice
Therapeutic PYY/GLP-1 receptor co-agonism in obese-diabetic mice synergistically activates discrete hypothalamic and brainstem neuronal circuitries for weight reduction, increased insulin sensitization, recovery of pancreatic ß-cell function and diabetes remission. GLP1-R agonism (IP118) and PYY-2R agonism (PY115) in combination yield surprising synergistic effects on energy homeostasis in mammals.  To better understand the genesis of these effects, RNAseq profiling was performed on key brain regions following an acute dose of IP118+PY115. Overall design: Gene expression profiles of brain regions in mice four hours following IP injection of a single acute systemic administration of IP118/PY115 or vehicle