GSE160854
RNA-Seq of distal colonic homogenates from intestinal epithelial-specific Sprouty2-deleted mice versus littermate controls
We asked whether Sprouty2 controls secretory cell differentiation in the distal colon. Loss of Sprouty2 leads to expansion of tuft and goblet cell populations. Sprouty2 loss induced PI3K/Akt signaling, leading to GSK3ß inhibition and epithelial IL-33 expression Overall design: Comparing the profiles of distal colonic gene expression from VillinCre/Sprouty2-floxxed and littermate Sprouty2-floxxed controls