DogGeneCatalog2017
Similarity of the dog and human gut microbiomes in gene content and response to diet
Gut microbes influence their hosts, modulating the link between                 diet and obesity. Here we study the relationship between the                 gut metagenomes of dogs, humans, mice, and pigs. By building a                 gene catalog (containing 1,247,405 genes) we show that the dog                 microbiome is closer to the human microbiome than the pig or                 mice microbiomes in gene content. We further demonstrate the                 similarity of the dog microbiome to the human one with a                 randomized trial of two diets (high-protein/low-carbohydrate                 vs. lower-protein/higher-carbohydrate). Diet has a large,                 reproducible, effect on the microbiome, independent of dog                 breed or sex. Diet responses were in agreement with those                 observed in previous human studies, leading to the conclusion                 that findings in dogs may be predictive of human microbiome                 results. In particular, a novel finding is that overweight or                 obese dogs experience larger compositional shifts than lean                 dogs in response to a high protein diet.
Gut microbes influence their hosts, modulating the link between                 diet and obesity. Here we study the relationship between the                 gut metagenomes of dogs, humans, mice, and pigs. By building a                 gene catalog (containing 1,247,405 genes) we show that the dog                 microbiome is closer to the human microbiome than the pig or                 mice microbiomes in gene content. We further demonstrate the                 similarity of the dog microbiome to the human one with a                 randomized trial of two diets (high-protein/low-carbohydrate                 vs. lower-protein/higher-carbohydrate). Diet has a large,                 reproducible, effect on the microbiome, independent of dog                 breed or sex. Diet responses were in agreement with those                 observed in previous human studies, leading to the conclusion                 that findings in dogs may be predictive of human microbiome                 results. In particular, a novel finding is that overweight or                 obese dogs experience larger compositional shifts than lean                 dogs in response to a high protein diet.