phs000611
Whole Genome Comparisons of Breast Cancers and Their Xenotransplants
Early passage breast cancer xenografts have been proposed as alternatives to cell lines as model systems for studying the basic biology of tumors and for advancing therapy development. This study explores the relatedness of primary disease genomes to their matched xenotransplants. Using paired-end massively parallel sequencing 13 matched progenitor tumor, xenograft and normal trios were sequenced to at least 30-fold coverage with diploid coverage of at least 95% of the genome as determined by SNP array concordance. The xenografts were derived from a spectrum of tumor samples from patients with both early and advanced breast cancer.