GSE173478
NKG2A educates uterine NK cells to optimise pregnancy outcomes in humans and mice
We report abnormal pregnancy outcomes in mice lacking NKG2A, including altered placental transcription. In humans, we find HLAB-21T snp to be associated with an increased risk of pre-eclampsia. Overall design: We compared placental mRNA expression at E15.5 in genetically-matched fetuses who were closest to their litter mean weight, from Klrc1-/- and C57BL/6 dams. Samples were run in 2 batches, with a SAVANT correction for batch effect.