PRJNA230664
TALEN-mediated MeCP2 Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
We report Transcription Activator-like Effector Nucleases (TALEN)-mediated mutagenesis of the Rett Syndrome gene, methyl-CpG binding protein 2 (Mecp2), in non-human primates (NHPs). We conclude that TALEN-mediated mutagenesis greatly facilitates disease modeling in NHPs.