SC_I2795_Genome_sequencing_of_serially_passaged_Treponema_pallidum_in_rabbits_to_determine_the_evolutionary_trajectories_of_host_adaptation-sc-4923
SC_I2795_Genome_sequencing_of_serially_passaged_Treponema_pallidum_in_rabbits_to_determine_the_evolutionary_trajectories_of_host_adaptation
Syphillis is a sexually transmitted infection caused by Treponema pallidum sub-species pallidum (TPP), a nonculturable Spirochaete bacteria. In recent years, global Syphillis prevalence has been increasing, with an estimated 12 million cases annually. The syphilis genome was sequenced in 1998, and is 1.14Mbp in length, with approximately 1090 open reading frames. However, sequencing and genomic epidemiology to date has been restricted because the bacteria cannot be robustly cultured in vitro. Fortunately, a well-established rabbit model exists for in vivo culture of TPP, and this provides an opportunity to use an experimental evolutionary approach to exploring the selective pressures that act upon TPP within the host.   This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Syphillis is a sexually transmitted infection caused by Treponema pallidum sub-species pallidum (TPP), a nonculturable Spirochaete bacteria. In recent years, global Syphillis prevalence has been increasing, with an estimated 12 million cases annually. The syphilis genome was sequenced in 1998, and is 1.14Mbp in length, with approximately 1090 open reading frames. However, sequencing and genomic epidemiology to date has been restricted because the bacteria cannot be robustly cultured in vitro. Fortunately, a well-established rabbit model exists for in vivo culture of TPP, and this provides an opportunity to use an experimental evolutionary approach to exploring the selective pressures that act upon TPP within the host.