E-MTAB-8623
Single-nucleus transcriptomics reveals functional compartmentalization in syncytial skeletal muscle cells
Nuclei of multi-nucleated skeletal muscle cells are functionally distinct to meet the needs for specialized gene expression in different compartments of the large syncytium. To systematically define this heterogeneity, we performed single nucleus RNA sequencing (snRNAseq) of isolated myonuclei from sedentary and regenerating muscle.
Nuclei of multi-nucleated skeletal muscle cells are functionally distinct to meet the needs for specialized gene expression in different compartments of the large syncytium. To systematically define this heterogeneity, we performed single nucleus RNA sequencing (snRNAseq) of isolated myonuclei from sedentary and regenerating muscle.