GSE126598
Loss of Bap1 leads to an increased global methylation and decrease in H3K27AC enhancer marks around key lineage commitment genes in Xenopus laevis embryos [ChIP-seq]
We performed morpholino-mediated knockdown of Bap1 protein expression in Xenopus laevis developing embryos, and analyzed inhibiting  and activating histone marks . We find that inhibition of Bap1 leads to decrease in H3K27AC activating makrs around lineage  commitment genes, and increased global methylation. Overall design: Control and Bap1-depleted stage 12 frog embryos were analyzed by ChIP-seq for expression of H3K27AC, H3K27me3, H2Aub and H3K4me3 histone marks.