GSE184287
RNA-seq of homogenized lungs of APOE knock-in mice during COVID-19 I
Here we analyze the transcriptional profiles of homogenized lungs resected from APOE2, APOE3, and APOE4 knock-in mice in the absence of infection (day 0) and on days 2 and 4 post infection with SARS-CoV-2 MA10. Weighted gene co-expression analysis identified gene modules enriched for genes implicated in T and B cell activation to be downregulated in APOE2 and APOE4 mice during COVID-19 progression. Overall design: Weighted gene co-expression network analysis and pathway analysis of RNA-sequencing data.