GSE123674
Axl targeting in experimental unilateral ureteral obstruction
We investigated if Axl receptor tyrosine kinase was up-regulated in unilateral ureteral obstruction (UUO) and if blocking of Axl by a small molecule called BGB324 (also called Bemcentinib) reduces fibrosis development in the ligated kidney as compared to treatment with its vehicle alone. Overall design: Two treatment groups of C57Bl/6JOaHSD mice (both groups n=6), which were treated with either BGB324/Bemcentinib or its vehicle (0.5% hydroxylpropyl-methylcellulose in 0.1% Tween 80).