GSE139003
RNA-seq timecourse of p53 activation with Nutlin-3a in IMR90 cells
To investigate the dynamics of the p53 response, we treated IMR90 cells with Nutlin-3a, a small molecule that inhibits the interaction between p53 and its inhibitor Mdm2, for 6, 9, or 12 hours. Overall design: RNA-seq in IMR90 cells treated with Nutlin-3a (inhibitor to Mdm2-p53 interaction) for 6, 9, or 12 hours or treated with a DMSO control.