GSE173546
Huntington's disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization
We identify cerebrospinal fluid extracellular vesicle miRNAs in Huntington's Disease that are enriched for targeting G3BP1 and show aberrant G3BP1 granule dynamics in HD mice and human brain tissue. Overall design: miRNA isolated from extracellular vesicles from the cerebrospinal fluid of 10 Huntington's Disease patients and 10 control individuals