PRJNA556451
The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)
ORIGINS is a cohort study investigating the relationship between subgingival microbial community composition and impaired glucose metabolism. 300 participants were enrolled in the first wave of the study from February 2011 to May 2013. Inclusion criteria were as follows: 1) aged 20 to 55 y; 2) no diabetes mellitus (T1 or T2; based on participant self-report of no previously diagnosed disease), HbA1c values <6.5%, and fasting plasma glucose <126 mg/dL; and 3) no history of myocardial infarction, congestive heart failure, stroke, or chronic inflammatory conditions (participant self-report). The Columbia University Institutional Review Board approved the study protocol. All participants provided informed consent.