GSE202642
Single-cell RNA sequencing shows the heterogeneity of cancer-associated fibroblast in HBV-related hepatocellular carcinoma
We identified 5 distinct fibroblast subsets by sequencing 74957 single cells derived from 7 HBV-related HCC tissues, of which the CD36+ CAFs were highlighted, with enriched lipid metabolism and secreting high levels of macrophage migration inhibitory factor (MIF). CD36+ CAFs had tight interactions with CD33+ MDSCs through MIF/CD74 axis. Overall design: We performed scRNA-seq derived from 7 HBV-related HCC tissues and 4 adjacent liver tissues