GSE159141
Gene expression profiles of paired endoscopic tumor biopsy (initial diagnostic assessment) and subsequent surgically resected specimens.
Ongoing immunomodulatory strategies in tumors characterized by an overall hot immune phenotype may improve prognosis of head and neck squamous cell carcinomas (HNSCC). Our objective was to develop a reliable and stable scoring system for the identification of immunologically hot HNSCC and to evaluate its association with response to immunotherapies. A Hot Oral Tumor (HOT) score was developed using data from The Cancer Genome Atlas. HOT score was then computed in 27 patients with HNSCC in paired perendoscopic tumor biopsy (initial diagnostic assessment) and subsequent surgically resected specimen. None of the patients was treated with neoadjuvant therapy. Concordance and correlation of the HOT score was high in paired samples. Overall design: In 27 patients,  paired endoscopic biopsies  and subsequent surgically resected head and neck squamous cell carcinomas (HNSCC) were analyzed for gene expression profiles using formalin-fixed paraffin embedded tissues and HTG EdgeSeq technology (Oncology Biomarker Panel (OBP).