GSE172502
MicroRNA expression in a model of mouse corticogenesis
We established an in vitro model of mouse corticogenesis starting from mouse embryonic stem cells  (ESCs). We analyzed miRNAomes of dividing and post-mitotic ESC-cortical cells and miRNAomes of E12 and P0 mouse cortex.  By comparing  the microRNA expression profiles of  progenitors and precursors at different times of  in vitro differentiation to the microRNA expression profiles of E12 and P0 mouse cortex we validated the model of mouse in vitro corticogenesis and provided  microRNA expression datasets of  early mouse embryonic cerebral cortex. Moreover, by the miR-CATCH method we analyzed the enrichement of microRNAs after the binding to the 3'UTR of Satb2. This allowed  to identify microRNAs that directly inhibit SATB2 expression. Overall design: miRNAomes of developing mouse cortex, cortical progenitor and precursor cells, and Satb2-interacting miRNAs.