fly_rils_founder_data
Genetic Dissection of  Model Complex Trait Using the Drosophila Synthetic Population Resource
Genetic dissection of complex, polygenic trait variation is a key goal of medical and   evolutionary genetics. Attempts to identify genetic variants underlying complex traits   have been plagued by low mapping resolution in traditional linkage studies, and an   inability to identify variants that cumulatively explain the bulk of standing genetic   variation in genome-wide association studies (GWAS). Thus, much of the heritability   remains unexplained for most complex traits. Here we describe a novel, freely-available   resource for the Drosophila community consisting of two sets of recombinant inbred   lines (RILs), each derived from an advanced generation cross between a different set of   eight highly-inbred, completely resequenced founders. The Drosophila Synthetic   Population Resource (DSPR) has been designed to combine the high mapping   resolution offered by multiple generations of recombination, with the high statistical   power afforded by a linkage-based design. Here, we detail the properties of the   mapping panel of >1,600 genotyped RILs, and provide an empirical demonstration of   the utility of the approach by genetically dissecting alcohol dehydrogenase (ADH)   enzyme activity.
Resequencing of the 15 strains (and 3 related strains) used to found the Drosophila Synthetic Population Resource.  These strains are completely resequenced using PE data.  The strains were combined, allowed to randomly mate for 50 generations and the resulting material used to create a panel of ~1700 Recombinant Inbred strains suitable for dissecting complex traits.