GSE106130
Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure
Aim: Identify molecular pathways controlling palate closure Methods: First pharygneal arch of wild-type and Grhl2-/- e10.5 moues embryos was subjected to RNAseq Results: Grhl2-/- PA1 displayed a shift from epithelial to mesenchymal gene expression Conclusions: Grhl2 maintains epithelial cellular identity during palate closure Overall design: First pharygneal arch mRNA profiles of e10.5 mouse embryos wre generated by deep sequencing, with 5 wild-type and 5 knock-out samples, using Illumina HiSeq technology