PRJNA734454
100 Aged High myopia panel
High myopia (HM) is associated with ocular complications including choroidal neovascularization, glaucoma, and retinal detachment, leading to blindness. Over 25 myopia loci and more than 100 genes related to these conditions have been discovered; however, these findings have remained unconfirmed in replication and experiment-based functional studies.We performed DNA sequencing of a compiled panel of 791 genes most frequently involved in common inherited nonsyndromic eye diseases by involving cataract patients with nonfamilial HM (n = 100) and those without HM (control, n = 91). We used a two-step approach: genetic analysis of all SNPs followed by per-SNP analysis.We included older adults who are more likely to have retinal complications than younger patients with myopia. Hence, combined with the fundus examination, this eye-disease gene panel would help find novel associations between HM genetic traits and clinical manifestations. We identified two novel SNPs associated with HM that can help understand the genetic basis of HM. These two SNPs were also associated with bilateral retinopathy. Our findings can be helpful in understanding the genetic factors involved in HM and myopic retinopathy development.Here we deposit the sequencing data of the HM (n=100) and control (n=91) samples in this database.