GSE201122
Molecular profiling of CML CD34+CD38- cells 6h and 24h post stimulation with conditioned media (CM) derived from either CXCL14 overexpressed NIH3 (NIH3-CXCL14) cells or control cells.
We here by prospectively characterizing BM stormal cells from healthy donors and patients with chornic myeloid leukemia (CML) have found that CXCL14 is dysregulated in CML patient bone marrow niche. Further, CXCL14 promotes TKI therapy response to CML LSCs in vitro and in vivo. To further determine the molecular mechanisms of CXCL14 action, we performed RNA sequencing of CML CD34+CD38- cells 6-24h post stimulation with conditioned media (CM) derived from either NIH3-CTRL or NIH3-CXCL14 cells. Overall design: Molecular profiling of CML CD34+CD38- cells 6h and 24h post stimulation with conditioned media (CM) derived from either CXCL14 overexpressed NIH3 (NIH3-CXCL14) cells or control cells.