PRJNA416948
miRNA expression profiles of eighteen hepatocellular carcinoma (HCC) cell lines with definite metastatic potentials and tropisms
In this study we investigate the miRNA expression profiles in 18 HCC cell lines with different metastatic potentials and organ-tropisms. Among them, HCC cell lines Huh7, Hep3B, SNU398, SMMC-7721,Bel-7402,HepG2,PLC-5 exhibit low metastasis abilities in nude mice model, while MHCC-97L, MHCC-97H, CSQT-1, CSQT-2, HCCLM3, LM1-S3, LM1-S4, LM1-S5, LM1-S11, LnM1-S11, LnM1-S13 exhibit high metastasis abilities in nude mice. LM1-S3, LM1-S4, LM1-S5, LM1-S11 derived from the parent cell line HCCLM3 have higher metastasis abilities specific to lung, and LnM1-S11, LnM1-S13 are specific to lymph node metastasis. We aim to explore differentially expressed genes involved in the process of HCC metastasis and organ-specific metastasis, and identify their biological functions.