Genomic_and_metabolomic_profiling_of_drug_tolerance_mechanisms_in_experimentally_induced_miltefosine_resistant_clinical_Leishmania_parasites_-sc-3544
Genomic_and_metabolomic_profiling_of_drug_tolerance_mechanisms_in_experimentally_induced_miltefosine_resistant_clinical_Leishmania_parasites_
We have generated whole-genome shotgun sequence data for two isolates of Indian Leishmania donovani with different wild-type antimony sensitivity phenotypes. Sequence data was generated for clones of these isolates both before, during and after in vitro induction of resistance to Miltefosine, and compared with matched metabolomic data, to study how the genetic bases of sensitivity to these two drugs might interact. This has important implications for the introduction of mlltefosine as a first-line treatment for visceral leishmaniasis in the Indian subcontinent, where antimony resistance is well established. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Whole-genome shotgun sequencing of antimony resistant- and sensitive isolates of Indian Leishmania donovani, before and during in vitro induction of resistance to Miltefosine.