GSE66160
RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021
We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a systems biology approach, we found that LXR interacts with ß-catenin and that LXR activation inhibits the activity of the Wnt/ß-catenin pathway Overall design: Three replicates each of control, GW3965-treated, CT990212 treated, and combined GW3965+CT99021 treated