The_Malaria_Cell_Atlas__a_comprehensive_reference_of_single_parasite_transcriptomes_across_the_complete_Plasmodium_life_cycle-sc-5469
The_Malaria_Cell_Atlas__a_comprehensive_reference_of_single_parasite_transcriptomes_across_the_complete_Plasmodium_life_cycle
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. Here we profile the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then use our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a complex eukaryotic parasite and an open access reference data set for the study of malaria parasites. This data has been described in the following article https://www.biorxiv.org/content/10.1101/527556v1 and its further analysis can be freely submitted for publication. For information on the proper use of data shared by the Wellcome Trust Sanger Institute (including information on acknowledgement), please see http://www.sanger.ac.uk/datasharing/
The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete Plasmodium life cycle