ena-STUDY-HOSPICES CIVILS DE LYON-17-03-2020-10:16:54:824-6
M. tuberculosis micro-diversity persistence and antibiotic tolerance
Mycobacterium tuberculosis (Mtb) genetic micro-diversity in clinical isolates and its evolution during the course of tuberculosis (TB) disease may underline mycobacterial adaptive response. Here, we investigated the genetic micro-diversity of persistent clinical Mtb isolates and its dynamics during controlled stress experiments chosen to mimic the course of TB disease.
Mycobacterium tuberculosis (Mtb) genetic micro-diversity in clinical isolates and its evolution during the course of tuberculosis (TB) disease may underline mycobacterial adaptive response. Here, we investigated the genetic micro-diversity of persistent clinical Mtb isolates and its dynamics during controlled stress experiments chosen to mimic the course of TB disease.