GSE185257
Neuronal Dot1ll is a broad mitochondrial gene-repressor associated with human brain aging via H3K79 hypermethylation II
Role of Dot1l in the transcriptional programming of midbrain dopamine neurons Overall design: Examination of three groups: 1) Pitx3-Cre/+;Dot1l-+/+;Rosa-lox-stop-lox-YFP  2) Pitx3-Cre/+;Dot1l-Floxed/+;Rosa-lox-stop-lox-YFP 3) Pitx3-Cre/+;Dot1l-Floxed/Floxed/;Rosa-lox-stop-lox-YFP. Material is FACS sorted (YFP) to isolated the Pitx3-Cre positive cells ( YFP positive) (midbrain dopamine neurons) for differential gene expression analysis at developmental stage E15.75.