ena-STUDY-Universidad del Rosario-28-01-2021-18:32:10:080-353
Analysis of population structure of  Leishmania infantum from Colombian strains
L. infantum is one of four Leishmania species, included in the Leishmania donovani complex, responsible of Visceral Leishmaniasis (VL). Until date different studies have demonstrated the low plasticity and intra-specific genomic variability of this specie in different regions of the world, however the genomic variability at the whole genome of L. infantum stains of Colombia have not been studied. This study focused in analyzing the whole-genome of four different L. infantum isolates collected from humans and dogs in two regions of Colombia, evaluating the genomic variation among them (ploidy changes, structural variations, and single point mutations), as well as its phylogenetic relationships.
L. infantum is one of four Leishmania species, included in the Leishmania donovani complex, responsible of Visceral Leishmaniasis (VL). Until date different studies have demonstrated the low plasticity and intra-specific genomic variability of this specie in different regions of the world, however the genomic variability at the whole genome of L. infantum stains of Colombia have not been studied. This study focused in analyzing the whole-genome of four different L. infantum isolates collected from humans and dogs in two regions of Colombia, evaluating the genomic variation among them (ploidy changes, structural variations, and single point mutations), as well as its phylogenetic relationships.