Dissecting_the_Leishmania_macrophage_interaction-sc-5299
Dissecting_the_Leishmania_macrophage_interaction
Several species of parasites belonging to the Leishmania genus are known to cause Leishmaniasis in humans.  Leishmania spp. are transmitted from host to host by the bite of a sand fly in which parasites are egested into the blood and are ingested by components of the innate immune response (neutrophils and macrophages).  Despite the ability macrophages to kill foreign pathogens, Leishmania spp. survive and proliferate within the macrophage.  This project will aim to investigate if there are key proteins that permit parasites to infect the macrophage of the human host, by using macrophage libraries in which individual genes have been deleted using CRISPR Cas9 editing.    This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
The aim of this study is to determine the role of macrophage proteins in Leishmania infection.