GSE208350
Effect of depletion of KLB or various combinations of FGFR1, FGFR3, and FGFR4 on gene expression in HuH-7 and JHH-7 cells
To investigate the impact of FGFR redundancy in regulating gene expression, we established HuH-7 and JHH-7 cell lines in which each target gene has been knocked out by CRISPR. Overall design: Comparative gene expression profiling analysis of RNA-seq data for HuH-7 and JHH-7 cells and its KO derivatives (sgKLB, sgFGFR4, sgFGFR3/4 and sgFGFR1/3/4).