PRJNA662695
Highly multiplexed quantifications of 299 somatic mutations in colorectal cancer patients by automated MALDI-TOF mass spectrometry
We detected somatic mutations by MADLI-TOF mass spectrometry in 299 colorectal cancer tissues and performed mutation analysis by a targeted NGS method covering 532 genes in 13 samples. Automated MALDI-TOF MS offers an efficient and cost-effective platform for highly multiplexed quantitation of 299 somatic mutations, which may be useful in studying the biological and clinical significance of somatic mutations with large numbers of cancer tissues.