PRJNA524718
Cellular Senescence in Progenitor Cells Contributes to Diminished Remyelination Potential in Progressive Multiple Sclerosis
We find that transcriptomic analysis of oligodendrocyte progenitor cells (OPCs), treated with conditioned media from iPS-derived neural progenitor cells (NPCs) from primary progressive multiple sclerois (PPMS) patients, reveals an increase in senescence-associated genes and epigenetic-associated genes compared to OPCs treated with control NPC conditioned media. We also identfied that blocking HMGB1 in the PPMS NPC conditioned media inhibited the upregulation of most senesence-associated genes and epigenetic-associated genes in the OPCs.