GSE194345
Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells [PRO-seq early]
We acutely depleted the BCL11A protein by using the dTAG PROTAC technology, and assessed its immediate consequences on nascent transcription, DNA methylation, Protein expression and HIstone modification and chromatin accessibility. Overall design: Examination of changes in Nascent transcription that occur imminently upon depletion of the repressive transcription factor BCL11A in two clones.