GSE125941
FET fusion oncoprotein-regulated genes in HT1080 cell line
Some specific sarcomas and leukemias are defined by characteristic FET (FUS, EWSR1, TAF15) fusion oncogenes. Myxoid liposarcoma and Ewing sarcoma are the most common entities characterized by FUS-DDIT3 and EWSR1-FLI1, respectively. Here, we performed whole transcriptome analysis of HT1080 cells with either ectopic FUS-DDIT3 or ectopic EWSR1-FLI1 expression. Overall design: Four different variants of HT1080 fibrosarcoma cells were analyzed using RNA sequencing: native HT1080 cells, HT1080 cells expressing EGFP, HT1080 cells expressing FUS-DDIT3-EGFP and HT1080 cells expressing EWSR1-FLI1-EGPF were analyzed (n = 3 -4).