PRJNA760239
mouse gut metagenome Raw sequence reads
The drug therapy for diabetes mellitus (DM) is effective in controlling hyperglycemia, but it has significant side effects. Therefore, it is important to find effective alternatives with nature, low toxicity and few side effects. Dietary polysaccharides may play an important role in lowering blood sugar. We started to focus on pumpkin polysaccharides whether have the hypoglycemic activities and how. Therefore, an animal model of type 2 diabetes mellitus (T2DM) with C57BL/6J mice (6 weeks old) was established and used to determine their hypoglycemic and hypolipidemic effects in vivo, and the underlying mechanisms related to the regulation of gut microbial.