PRJNA790919
Effects of exercise on tissue gene expression in a mouse model for T2D
Regular exercise training is a useful tool for the prevention and treatment of type 2 diabetes (T2D). However, the ability to improve glycemia in response to exercise is highly heterogeneous, with some individuals being unable to benefit from exercise interventions. Mouse models for T2D are commonly used to investigate the molecular determinants for the response to exercise. Here, we aimed to investigate the metabolic response to exercise in New Zealand Obese (NZO) mice, an established polygenic T2D mouse model. As one of the readouts, we assessed transcriptome analysis in skeletal muscle and liver tissue from sedentary and trained NZO subgroups. The results of this study can contribute to the identification of predictive markers for exercise response in future precision medicine approaches.