GSE122405
DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice
Knock out of Dnmt3a in AgRP neurons leads to a sedentary, adiposity-prone adult phenotype associated with widespread changes in DNA methylation and gene expression. Overall design: Genome-wide bisulfite-seq and RNA-Seq of FACS-sorted neural (NeuN+) nuclei from the arcuate nucleus of the hypothalamus.