GSE116965
ATAC sequencing of sorted BCC cells after vismodegib treatment
K14Cre-ER; Ptch1fl/fl; p53fl/fl;Lgr5GFP mice were aged until the appropriate tumor density was achieved. Skin samples were taken from control mice (untreated) or mice treated for 6 days or 14 days at twice a day dosing with vismodegib (75mg/kg body weight). RNA was extracted from freshly FACS sorted tumor cells based on GFP intensity. The "SAMPLE_ID" sample characteristic is a sample identifier internal to Genentech. Overall design: Chromatin accessibility profiling of tumor cells from BCC mice sorted at 6 days and 14 days of vismodegib treatment compared to sorted tumor cells from untreated mice.