ena-STUDY-CLM-11-10-2014-04:28:54:488-162
The comparison of gut microbiota obtained from centenarian, elderly, and adults living in southwestern longevity belt in Korea
Centenarians have lived for long ages and survived from various death causing factors. Several studies were analyzed the factors of health maintaining in centenarians, while the longevity factors are not completely understood. Recent analyses of gut microbiota have been reported the association of microbiota with health, and some studies were reported the alteration of gut microbiota with aging. In this study, we analyzed the gut microbiota of centenarians in particular regions of Korea to understand their longevity factors. The gut microbiota of centenarians (n=30) was compared with elderly (n=17) and adults (n=9) using pyrosequencing based on 16S rRNA gene. The relative abundance of Bacteroidetes was decreased, while those of Firmicutes and Proteobacteria were increased with aging. However, the proportion of Bacteroidetes was higher in centenarians than elderly subjects. The difference of gut microbiota composition between centenarians and elderly could be generated by diet patterns. Although additional studies such as functional analyses of microbiota between groups were need to understand, this study can provide the information of longevity factors of centenarians.
Centenarians have lived for long ages and survived from various death causing factors. Several studies were analyzed the factors of health maintaining in centenarians, while the longevity factors are not completely understood. Recent analyses of gut microbiota have been reported the association of microbiota with health, and some studies were reported the alteration of gut microbiota with aging. In this study, we analyzed the gut microbiota of centenarians in particular regions of Korea to understand their longevity factors. The gut microbiota of centenarians (n=30) was compared with elderly (n=17) and adults (n=9) using pyrosequencing based on 16S rRNA gene. The relative abundance of Bacteroidetes was decreased, while those of Firmicutes and Proteobacteria were increased with aging. However, the proportion of Bacteroidetes was higher in centenarians than elderly subjects. The difference of gut microbiota composition between centenarians and elderly could be generated by diet patterns. Although additional studies such as functional analyses of microbiota between groups were need to understand, this study can provide the information of longevity factors of centenarians.