ena-STUDY-NATIONAL INSTITUTE FOR HEALTH AND WELFARE-05-09-2018-12:22:25:908-192
Whole genome analysis of Mycobacterium tuberculosis isolates  from recurrent episodes of tuberculosis,Finland, 1995–2013
Recurrent tuberculosis (TB) is caused by an endogenous re-activation of the same strain of Mycobacterium tuberculosis (relapse) or  exogenousinfection with a new strain (re-infection).Recurrence of TB in Finland was analysed in a population-based,19-year study,and genotyping  wasused to de fine  relapse and re-infection.The M.tuberculosis  isolates from patients with suspected relapse were further analysed by  whole genome sequencing  (WGS)  to determine the number  and type of mutations occurring  in the bacterial  genome between the first   and second  disease  episodes.
Recurrent tuberculosis (TB) is caused by an endogenous re-activation of the same strain of Mycobacterium tuberculosis (relapse) or  exogenousinfection with a new strain (re-infection).Recurrence of TB in Finland was analysed in a population-based,19-year study,and genotyping  wasused to de fine  relapse and re-infection.The M.tuberculosis  isolates from patients with suspected relapse were further analysed by  whole genome sequencing  (WGS)  to determine the number  and type of mutations occurring  in the bacterial  genome between the first   and second  disease  episodes.