Genomic diversity in Leishmania donovani in Indian subcontinent.-sc-2010-04-01
Genomic diversity in Leishmania donovani in Indian subcontinent.
The KalaDrug-R project is producing a reference Leishmania donovani  genome and carrying out a preliminary exploration of population structure. The GeMInI project aims to characterize the populations of Leishmania donovani in Nepal and India that are causing clinical polymorphism despite apparent genomic homogeneity. To understand this diverse severity we characterize the diversity in these pathogen populations on 2 levels; genomics and metabolomics level. This data will be integrated and linked back to clinical polymorpism to allow design of better tools and thus globally boost disease control.  . This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Gemini project aims to characterize the populations of Leishmania donovani in Nepal and India that are causing clinical polymorphism despite apparent genomic homogeneity.  To understand this diverse severity we characterize the diversity in these pathogen populations on 2 levels; genomics and metabolomics level. We will integrate the genomics and metabolomics data and finally link it back to the clinical polymorphism. The better we understand clinical polymorphism, the better the clinical management, we can use the integrated gemini data to design better tools and thus globally boost disease control.