GSE185009
Transcriptome analysis of IPSC and NPC, derived from twins, discordant by PD
This submission contains a result of a study of transcriptiomic profiles of the IPSC and NPC, derived from PD discordant monozygous twins. Overall design: Examination of transcriptiomic profiles of the IPSC and NPC, derived from PD discordant monozygous twins. Two pairs of phenotypically and genetically monozygotic twins discordant for PD were enrolled in the study. These individuals (of Russian ethnic origin and residing in European Russia) were diagnosed at the State Public Health Institution Primorsk Regional Clinical Hospital No. 1 and did not have any family history of PD. The participants were assessed according to the International Parkinson and Movement Disorder Society-sponsored Unified Parkinson?s Disease Rating Scale and Hoehn?Yahr scores. The diagnosis of PD was based on the UK Parkinson?s Disease Society Brain Bank criteria. Patients were at stages 2?4 of the Hoehn?Yahr scale and had a mixed form of PD. The disease duration was at least 7 years. The healthy siblings did not have any signs of PD at the time of collection of the biological material. The twins lived in the same area, and their work was not associated with dangerous factors, such as pesticides or heavy metals. There was no information about the presence of head injuries in their history.