GSE161231
NOP10 predicts NSCLC prognosis and its associated small nucleolar RNAs drive proliferation and migration [PSI-seq]
Non-coding RNAs are critical players in non-small cell lung cancer (NSCLC). In the present study, we investigate the role of H/ACA box snoRNA and snoRNA-bound ribonucleoproteins (RNP) in the tumorigenesis of NSCLC. Overall design: We used Psi-Seq to determine the pseudouridylation modification profile of ribosomal RNA in 7 matched tumor and normal samples from paraf?n-embedded tissue from non-small cell lung cancer (NSCLC) patients. To further investigate the role of NOP10 we analyzed A549 cell line with CRISPR Cas9 knock out of NOP10.