GSE201523
Trisomy 21 human iPSC derived interneuron progenitors
Individuals with Down syndrome (DS, Ts21) have impaired neurogenesis during development. Using Ts21 human induced pluripotent stem cells (iPSCs) and isogenic controls, we carried out single cell RNA-sequencing of Ts21 interneuron progenitors . Overall design: Ventralized progenitors at Day 17 from one pair of isogenic Ts21 and control lines (WC24).Differentiation to interneuron progenitors was carried out as described (PMID: 23928500).