GSE120703
RNA isoform screens reveal the essentiality and tumor suppressor activity of ultraconserved poison exons
Paired gRNA/Cas9 delivery facilitates the removal of alternative exons and reveals splicing dependent phenotypes. Overall design: RNA-seq of HeLa/iCas9 and PC9-Cas9 cells treated with pgRNA vectors. Untreated controls (HeLa and PC9) are also included.