The_identification_of_novel_OmpR_regulated_genes_in_Salmonella_enterica_serovar_Typhi-sc-142
The_identification_of_novel_OmpR_regulated_genes_in_Salmonella_enterica_serovar_Typhi
S. typhi chIP-seq. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
The intracellular pathogen Salmonella Typhi employs a wide variety of mechanisms to invade and survive within the host. In this study we use chIP-seq analyses to further define the regulon of the virulence essential regulator OmpR. We have identified genes that are differentially expressed in an OmpR mutant and encode upstream OmpR binding sites. Further characterisation of differentially expressed hypothetical genes has identified genes with virulence potential. Minimal media assays suggest these genes are involved in metabolism of the peptidoglycan component, N-acetyl muramic acid. These combined approaches provide a more detailed insight into genes required for Salmonella's complex lifestyle. http://www.sanger.ac.uk/resources/downloads/bacteria/salmonella.html