GSE124817
Glucocorticoids Promote Breast Cancer Metastasis
Next Generation Sequencing was applied to investigate the heterogeneity between tumors and distant metastases in different models of Breast Cancer cell lines and primary-derived xenografts. Global transcriptional profiling of the primary tumor and matched distant metastases (lung, liver, spleen) as well as circulating tumor cells (CTCs) allowed to identify glucocorticoid signalling as a mediator of metastasis. Overall design: RNA-Seq in 4 different Breast Cancer models to investigate glucorticoid signalling role in metastasis