GSE130737
Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium
Endothelial ERK1/2 pathway plays a crucial role in maintenance of endothelial homeostasis.  Its suppression results in activation of TGF? signaling, leading to hypertension, renal failure, fibrosis and sudden death, findings similar to those observed in patients treated with anti-VEGF agents. Overall design: Examination of siERK1/2 (N=19) and siSCR (N=18) in HUVEC cells