phs000702
Allelic Spectrum in Common Disease:Sequence from participants in the FUSION study
This study is part of a re-sequencing project to identify variants associated with metabolic syndrome traits in a Finnish cohort. Metabolic syndrome (MetS) increases the risk of cardiovascular disease and diabetes, and prevalence is estimated to be as high as 25% in the United States. MetS is characterized via measure of triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FG), body mass index (BMI) and waist-to-hip ratio (WHR). Closely related traits include low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), fasting plasma insulin (FI) and height (HT).  Seventeen loci associated with TG, HDL-C, LDL-C, TC, FG, and FI (Kathiresan et al. 2008, Willer et al. 2008, Sabatti et al. 2009, Dupuis et al. 2010, Teslovich et al. 2010) were prioritized for sequencing. At each locus, protein-coding regions and 5'' and 3'' untranslated regions of genes... (for more see dbGaP study page.)