GSE211586
Expression data from rat hippocampus with chronic intermittent hypoxia exposure
Obstructive sleep apnea syndrome (OSA) is a common sleep disorder. OSA is an independent risk factor for cognitive impairment. Chronic intermittent hypoxia (CIH) is the main characteristic of OSA and the main potential culprit of OSA-induced hippocampal damage. The mechanism of CIH in the development of cognitive impairment remains unclear  The microarray was used to investigate the differentially expressed long non-coding RNAs(lncRNAs), microRNAs (miRNAs) and mRNAs in the hippocampus of  control and CIH-exposed rats. The rats in control group and CIH group were exposed to normoxia for 4 weeks and CIH for 4 weeks, respectively. Overall design: Examine the hippocampus of  control and CIH-exposed rats.  For RNA-seq, the total RNA was harvested using TRIzol reagent (Invitrogen, Carlsbad, CA, USA). The amount and quality of RNA were determined using a NanoAnalyzer and Agilent 2100 biological analyzer (Thermo Fisher Scientific, Ma, USA). The mRNA expression profiling was measured using BGISEQ-500/ MGISEQ-2000system (BGI Co., Shenzhen, China).