PRJNA283635
Homo sapiens Exome
We describe targeted exon sequencing data derived from a case of atypical promyelocytic leukemia associated with a STAT5B-RARA fusion gene, as well as a small deletion in RARA exon 9 and a RARA R276W substitution that have been linked to resistance to all-trans retinoic acid. The case highlights how next generation sequencing can help to establish diagnoses in difficult cases and guide selection of therapy.