GSE114449
Genetic analyses reveal the signaling and transcriptional mechanisms of stomach stromal stem cell niches. [ChIP-Seq]
We demonstrate the conserved Hh-GLI2-mediated chromatin and transcriptional regulation of both stomach and intestinal stromal stem cell niche signals. Analyses of H3K27ac marks demonstrate GLI2-mediated transcription regulation of stem cell niche signals such as Wnt ligand genes, through enhancers conserved between the stomach and intestine. Overall design: Examination of Gli2, H3K27ac, and H3K36me3-bound DNA in E17.5 Sufu;Spop double knockout mouse stomach