GSE202072
EHF and CDX1 co-operate to drive extensive transcriptional reprogramming and chromatin remodelling in CRC cells [ATAC-seq]
EHF and CDX1 co-operate to drive differentation of CRC cells. To identify the change in chromatin remodelling induced by these transcription factors, EHF and CDX1 were stably re-expressed in poorly differentiated HCT116 CRC cells and ATAC-seq analysis performed. Overall design: HCT116 CRC cells were stably transfected with empty-vector control, EHF, CDX1, or EHF plus CDX1 and ATAC-seq analysis performed on each cell line.