PRJNA771373
LRPPRC regulates redox homeostasis via mitochondrial metabolism and circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis
LRPPRC promoted UCB tumorigenesis by regulate the intracellular ROS homoeostasis. Mechanically, LRPPRC promoted both the production of ROS by stabilizing mt-mRNA, and the detoxification of ROS via regulation of FOXM1. LRPPRC exerts critical roles in regulating UCB redox homoeostasis and tumorigenesis, and is a prognostic factor, suggesting that LRPPRC may serve as an exploitable therapeutic target in UCB.