p53 in mouse ES cells
Identify the binding sites of p53 in mouse embryonic stem cells using ChIP-seq
p53 regulates the differentiation of mouse embryonic stem cells. However, our knowledge to this critical tumor suppressive function is limited. Here, we use ChIP-seq to map the whole-genome binding sites of p53 and found a previous un-identified cross-regulatory network of p53-mediated gene network and ES cells stemness gene network.