GSE121117
SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-dependent Tumors
We performed RNA sequencing analysis using NextSeq500 to identify drivers that mediate feedback RAS activation in BRAF(V600E) cells that are SHP2 independent. Overall design: mRNA expression of three BRAF (V600E) cancer cells was examined before and after treatment with vemurafenib (RAF inhibitor) using NextSeq500