PRJNA378604
Drosophila melanogaster Raw sequence reads
Our manuscript addresses the question of whether either of the canonical transduction components, beta-catenin or TCF, can be bypassed when the Wnt pathway is activated. By using somatic cell genetics in Drosophila cells (via CRISPR/Cas9 editing) in combination with RNA-seq and STARR-seq (Self-transcribing-active-regulatory-region-sequencing) as functional read-outs, we provide firm evidence against the existence of distal branches in the Wnt pathway.