GSE171403
Single Cell sequencing of tumor infiltrating immune cells upon E2 treatment
Estrogens (E2) has been shown to affect growth, differentiation and polarization of different immune cell types in different context. To understand how E2 treatment affects immune microenvironment during cancer (melanoma) progression, we profiled tumor infiltration immune cells from placebo and E2 treated tumors isolated from female mTyrCreERT2;BrafCA/WT;Ptenf/f. We identified diverse immune cell types and their underlying transcriptomic changes that are manifest upon E2 treatment in the tumor microenvironment. Overall design: Single Cell sequencing of tumor infiltrating immune cells upon E2 treatment