PRJNA260985
Homo sapiens Targeted Locus (Loci)
We used IgH amplicon sequencing to study B cells and antibody secreting cells (ASC) from patients with systemic lupus erythematosus, post vaccination (flu or tetanus), IgG4-RD, and Pemphigus. Our goal was to analyze B cell population relationships and determine the repertoire diversity, autoreactivity and cellular origin on ASC expansions in SLE.