GSE129962
Exercise Reverses Dysregulated Gene Expression in a Desmoplakin Haplo-insufficient Mouse Model of Arrhythmogenic Cardiomyopathy
Mutations in desmosome genes cause arrhyythmogenic cardiomyopathy (ACM). Using desmoplakin haploinsufficient  mouse model of ACM, we evaluated the effects of treadmill exercise on cardiac myocyte transcritional profile.  Strand specific, ribosome depleted paired end  RNA sequencing of cardiac myocytes from wild type and Myh6-Cre:DspW/F were  generate using  Illumina HiSeq 4000. Overall design: Total RNA Sequencing of cardiac myocytes from wild type and Myh6-Cre:DspW/F mice at 3 months of age  at 6 months of age either with regular activity or 3 months post endurance treadmill exercise (n=5) was performed.