GSE112560
ChIP-sequencing to investigate occupancy of wild-type and fusion ZNF384 proteins in murine pre-B cells
We report the changes in chromatin occupancy between HA-tagged wild-type ZNF384 and the two leukemogenic fusion proteins, TAF15-ZNF384, and TCF3-ZNF384, in Arf-/- pre-B cells. Using ChIP-sequencing we found that 2298 peaks have new or increased binding while 495 peaks have decreased or lost binding of the fusion proteins compared to wild-type ZNF384. Overall design: 2 technical replicates of 3 genetically-modified cells lines