GSE138284
Studies on Trim71 in mouse embryonic stem cells
We studies on Trim71 regulates mouse embryonic stem cells by identifying the transcriptome-wide RNA targets of Trim71. Moreover, through inhibiting specific Trim71:mRNA interactions, we determined how Trim71 modulate miRNA activity in mouse embryonis cell cells Overall design: Transcriptome-wide Trim71 target mRNAs were identified through CLIPseq, and the functional significance of target Trim71:mRNA interactions were determined through RNA-seq and smallRNA-seq in the WT and mutant mouse embryonic stem cells.