PRJNA770448
A core omnigenic non-coding trait governing DEX-induced osteoporotic effects identified without DEXA
This work demonstrated differential sensitivity towards epigenetic changes along a unified GC-regulated osteogenic pathway may likely explain variant genetic susceptibility towards GC-induced osteoporosis. Genetic loci associated with eBMD are strongly enriched for the targets of clinically relevant osteoporosis therapies, the identification of new genetic loci and the biological pathways they implicate may help scientists identify drug targets for the prevention and treatment of fragility fracture.