GSE117248
Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome
We report the generation of isogenic hPSC model of FXS and characterize the neurodevelopmental capacity of these cells, performed transcriptome profiling in FXS neurons and identified key pathways Overall design: Transcriptome profiling of FXS-derived neurons from hESC generated by RNA-seq in four replicates per genotype for using Illumina HiSeq4000. Control and FXS-derived neurons from hiPSC were generated by RNA-seq in 3 replicates per genotype.