GSE122291
Estrogen Signaling in Arcuate Kiss1 Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice
Purpose: To characterize the estrogen receptor a (ESR1)-dependent transcriptome of neurons in the arcuate nucleus that regulate female bone density Overall design: Method: Using RNA-Seq we compared gene expression profiles of microdissected arcuate nuclei from 3 control (Esr1fl/fl) and 3 conditional knockout (Esr1fl/fl;Nkx2-1-Cre) female mice.