GSE210765
RBAP48 modulates the oral squamous cell carcinoma process through AR-dependent and independent mechanisms
Oral squamous cell carcinoma is a head and neck malignancy induced by multiple factors. The progression of OSCC involves epithelial cell proliferation from fibrosis to malignancy. However, the underlying molecular mechanisms that influence these processes remain unclear. Here, we identify RBAP48, an important AR co-activator involved in OSCC cancer progression. RBAP48 is highly expressed in OSCC tissues and has a poor prognosis. As a DHT-dependent AR coactivator, RBAP48 not only up-regulates the transcriptional activity of AR but also affects the transcription of target genes in the cell cycle and external stimulation pathways throughout the genome. RBAP48 can interact with SP1, AR, and other transcription factors in OSCC cells and co-recruit the promoter region of CCND1 and RAB31. Finally, we find that RBAP48 can promote the growth of OSCC cells, stimulate the response to drugs and external substances in vitro and in vivo, and ultimately promote cancer progression. These results suggest that RBAP48 may be an effective target for predicting the progression and treatment of OSCC cancer. Overall design: Examination the total RNA change of RBAP48 depletion in CAL-27 cells