PRJNA476326
Therapeutic ablation of gain-of-function mutant p53 in colorectal cancer inhibits Stat3-mediated tumor growth and invasion
Panel NGS sequencing including TP53 from colon/rectal cancer patient using histological FFPE-DNA to identify missense p53 mutants which highly stabilize their p53 protein to increase Stat3 signaling. Result: CRC patients with stabilized missense p53 mutants exhibit enhanced Jak2/Stat3 signaling and poorer survival