GSE202470
RNA-seq analysis of SIRT6 and STAT6 regulated genes in intestinal epithelial cells (IECs)
To investigate the roles of SIRT6 and IL4/IL13-STAT6 pathway in intestinal epithelium homeostasis, we generated IEC-specifc Sirt6 knockout mice and transgenic mice with IEC-specific overexpression of constitutively activated STAT6 (STAT6vt). IECs from these mice were isolated and RNA were extracted and performed RNAseq analysis. Overall design: Comparative gene expression profiling analysis of RNA-seq data for IECs from Sirt6 knockout/LoxP mice and IECs from STAT6vt transgenic/WT mice