ENU_mutagenesis_in_Melanoma-sc-3124
ENU_mutagenesis_in_Melanoma
The study will use a chemical mutagen to induce mutations in  population of BRAF mutant melanoma cells, these will undergo drug selection pressure and surviving clones will be analysed using two strategies  1) pooled and compared to ENU only treated cells   2) expanded and picked as individual clones and assessed for phenotype.
To discover novel resistance causing mutations in BRAF mutant melanoma utilising the chemical mutagen ENU.