GSE169527
Inhibition of epigenetic modifiers LSD1 and HDAC1 blocks rod photoreceptor death in mouse models of Retinitis Pigmentosa.
In retinitis pigmentosa mouse models inhibitors of histone modification enzymes LSD1and HDAC1 blocked rod degeneration, preserved vision and affected the expression of multiple genes including maintenance of rod-specific transcripts and downregulation those involved in inflammation, gliosis and cell death. Overall design: Total 11 samples of mouse retina at PN24: 2 wild type controls C57Bl/6J, 3 rd10 B6.CXB1-Pde6brd10/Jrd10, 3 wild type treated with GSK2879552 (LSD1 inhibitor) from PN9 till PN24 and 3 rd10 treated with GSK2879552  from PN9 till PN24