PRJNA481726
Hypoxia-driven LDHA enhances mRNA m6A modification
N6-methyladenosine (m6A), the most prevalent modification in mRNA, plays critical roles in RNA biology. However, little is known about the regulatory mechanism of RNA m6A in response to stimulus. Here, we show that hypoxia-driven LDHA enhances m6A mRNA methylation through local conversion of 2-ketoglutarate to 2-hydroxyglutarate to suppress FTO activity.