GSE134650
Biphasic response of Protein Kinase A to cyclic adenosine monophosphate triggers distinct epithelial phenotypes
We postulated that the ability of bPAC-generated cAMP to induce the biphasic response of PKA might have profound and distinct effects on the cellular transcriptome. To test this hypothesis, we carried out mRNA sequencing of MDCKI and MDCKI+bPAC cells under no, low, or high cAMP inputs (0%, 1.7% and 33% blue light duty cycle) Overall design: Examination of the effect of three light doses, for 2 hours,  in parental MDCKI and MDCKI+bPAC cells