GSE113368
Medial prefrontal cortex (mPFC) transcriptome analysis of Shank3-overexpressing mice
Shank3 is a core excitatory postsynaptic protein expressed in multiple brain regions including the medial prefrontal cortex, striatum, and hippocampus. We have previously generated and characterized Shank3-overexpressing transgenic mice, and found that these mice exhibited manic-like behavioral phenotypes. To understand molecular mechanisms underlying the behavioral changes, we performed transcriptome (RNA-sequencing) analysis of the mPFC tissues from 10 to 12-week-old wild-type and Shank3 transgenic mice. Overall design: Medial prefrontal cortex (mPFC) transcriptome of 10 to 12-week-old wild-type and Shank3 transgenic (TG) mice.