PRJNA837984
Gut microbiome analysis between different responsiveness to EPO  of hemodialysis patients with anemia
EPO hyporesponsiveness in hemodialysis patients is still unclear. We analysis gut microbiota between different responsiveness to EPO in hemodialysis patients with anemia using 16s rDNA sequencing. The poor-responsivenes s(PR) patients displayed a characteristic composition of the gut microbiome that clearly differed from that of good-responsiveness (GR) patients. 9 genera (Neisseria, Streptococcus, Porphyromonas, Fusobacterium, Prevotella_7, Rothia, Leptotrichia, Prevotella, Actinomyces) we identified could excellently predict EPO hyporesponsiveness. In contrast, 5 genera (Faecalibacterium, Citrobacter, Bifidobacterium, Escherichia-Shigella, Bacteroides) identified present a good protective effect against EPO hyporesponsiveness.