GSE115256
Low Cell-Matrix Adhesion Reveals Two Subtypes of Human Pluripotent Stem Cells
The human pluripotent stem cells cultured on Low-adhesion substrates formed two morphologically different subtypes (Monolayer and Domed).  The dome-like cells showed higher proliferation capacity and KLF4/5 expression than the monolayer cells. A serum response factor based regulatory double loop was proposed to explain how cell-matrix adhesion mediates the interaction between cell morphology and pluripotency genes Overall design: Compare the two type cells with RNA-seq to investigate the different expression