GSE111640
Deletion of Lats 1 and 2 in mouse pancreatic acinar cells
Mice with adult pancreatic acinar cell–specific deletion of Lats1&2 genes by using CreER/LoxP were generated. Pancreata were collected and profiled using RNA-seq. The RNA-sequencing data identified upregulation of pro-inflammatory and pro-fibrotic genes in Lats1&2 null pancreata, which may play important roles in stimulating PSC activation and promoting pancreatic fibrosis. Overall design: 6-12 week old mice with Lats 1 & 2 double knockout (PL) were used in the study