GSE194221
ATAC-seq comparatively analyse chromatin accessibility varition of control, TNFa and TNFa+JNK I treated GSCs
Among 3,673 TNFa-induced gain of accessibility (at least 2 folds of upregulation in TNFa-treated TPC2-4 cells compared with control), and most of the gained peaks were significantly suppressed by JNKi treatment (TPC2-4 TNFa+JNKi/TPC2-4 TNFa, JNKi: JNK-IN-8, a kinase inhibitor specific for JNK (c-Jun N-terminal kinase) that inhibited phosphorylation of c-JUN) Overall design: Examination  chromatin accessibility varition of TPC2-4 con, TPC2-4 TNFa, TPC2-4 TNFa+JNKi