GSE135995
Lin28R192G mutation in Parkinsons's disease
mRNA-seq analyses for the differentially expressed genes (DEGs) between Parkinsons's disease patient (holding Lin28 R192G hetero mutation)-iPSC (Pt-iPSC) derived neural stem cell vs  Lin28 R192G hetero mutation corrected-iPSC (Corrected Pt-iPSC) derived neural stem cell. To gain further molecular insight into the observed Lin28R192G mutation in Parkinsons's disease (PD) patient iPSC-derived neural stem cell (NSC) functions, we performed mRNA-sequencing (RNA-seq) analysis of the PD patient (holding Lin28 R192G hetero mutation)-iPSC (Pt-iPSC) derived NSC and  Lin28 R192G hetero mutation corrected-iPSC (Corrected Pt-iPSC) derived NSC. Overall design: 2 human samples: PD patient (Lin28 R192G het) iPSC derived-NSC (Pt-iPSCs) and  Lin28 R192G het mut-corrected PD patient iPSC derived-NSC (corrected Pt-iPSCs)