GSE193539
Transcriptomic analysis reveals rescue of dysregulated genes in SBMA muscle upon silencing of AR co-factors
Purpose: The goal of this study is to evaluate the rescue of SBMA phenotype upon modulation of AR co-factors expression Results: NGS analysis of the transcriptome of quadriceps isolated from SBMA mice upon treatment reveal the rescue (partial or total) of assemblies of genes involved in SBMA pathogenesis Conclusion: targeting overexpressed AR co-regulators is a new therapeutic approach for SBMA to attenuate the toxic GOF without exacerbating AR LOF Overall design: RNA from quadriceps of wt and AR100Q (mouse model of SBMA) +/- silencing of AR co-factors