GSE168266
Identification of intrinsically immunogenic small cell lung carcinoma (SCLC) subpopulations [patient]
SCLC is molecularly and immunologically heterogenous. Here, using transcriptional and epigenomic profiling of plastic SCLC states in human and mouse cell lines, and patient samples, we define the phenotype of a SCLC population marked by increased MHC Class I antigen presentation. Overall design: Examination of paired transcriptome and H3K27Me3 in isogenic SCLC cell lines, and transcriptomes of MHC Class I high vs. low SCLC cell lines and patient samples