GSE185744
An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer [rnaseq_ht115]
Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We therefore aimed to characterize a key factor that blocks intestinal differentiation, define its transcriptional and epigenetic program, and provide preclinical evidence for therapeutic targeting in CRC. Overall design: Examination of 6 different SOX9 overexpression RNA-seq experiments with two replicates each. M303 is a truncated version of SOX9.