GSE19622
GSE19622: Individual-specific and allele-specific chromatin signatures in diverse human populations
Summary: Using DNase I hypersensitivity (DNase-seq) and CTCF binding (ChIP-seq) assays, we obtained genome-wide chromatin signatures for two lymphoblastoid parent-child trios from distant populations that have been resequenced by the 1000 Genomes Project.We found that up to 10% of active chromatin sites were specific to a set of individuals and these were often inherited. Variation in active chromatin sites between individuals was correlated with variation in gene expression. Between 7% to 11% of chromatin sites were allele-specific, meaning one allele was preferentially active over the other.  Overall Design: DNase-seq and ChIP-seq
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