PRJNA838487
Mus musculus Raw sequence reads
House mice (Mus musculus) exhibit significant variation in centromere satellite array size and sequence heterogeneity, but the amino acid sequence of CENP-A, a centromere-specific histone variant that is essential for specifying centromere identity, is completely conserved. Using CENP-A ChIP-seq in four diverse inbred mouse strains (C57BL/6J, CAST/EiJ, LEWES/EiJ, and PWK/PhJ), we measure sequence variation in CENP-A sequence association landscape with potential downstream consequences for meiotic drive and genome stability among Mus musculus strains.