PRJNA767789
Nephrotoxicity of Calcineurin Inhibitors in kidney epithelial cells is independent of Calcineurin and NFAT signalling.
Cyclosporine A (CsA) induces Calcineurin inhibitor toxicity in the kidney independent of the NFAT axis. We could show in vivo that mice treated with p38 kinase inhibitors (SB203580 and SB202190) show similar upregulation of nephrotoxic gene expression compared to CsA treated animals. Mice treated with a NFAT inhibitor (11R VIVIT) resemble the control, so no increased nephrotoxic gene expression.