ena-STUDY-NATIONAL CENTRE FOR CELL SCIENCE-22-05-2021-09:37:32:537-372
Gut microbiome and metabolome of transverse aortic constriction (TAC) induced mice
Growing evidence suggests an altered gut microbiome in patients with heart failure (HF), which may play a modulatory role in disease manifestation. Mice were subjected to transverse aortic constriction (TAC) to induce HF. Fecal (on days 0, 7, 14, 42) and ileal (on day 42) bacterial diversity was analyzed by high-throughput sequencing of 16S rDNA amplicons. Circulating metabolites were correlated to bacterial populations, and differentially abundant metabolic pathways were assessed.
Growing evidence suggests an altered gut microbiome in patients with heart failure (HF), which may play a modulatory role in disease manifestation. Mice were subjected to transverse aortic constriction (TAC) to induce HF. Fecal (on days 0, 7, 14, 42) and ileal (on day 42) bacterial diversity was analyzed by high-throughput sequencing of 16S rDNA amplicons. Circulating metabolites were correlated to bacterial populations, and differentially abundant metabolic pathways were assessed.