Whole_genome_sequencing_of_a_collection_of_Vibrio_cholerae_isolates_from_cholera_patients_and_aquatic_environments_in_Bangladesh-sc-4230
Whole_genome_sequencing_of_a_collection_of_Vibrio_cholerae_isolates_from_cholera_patients_and_aquatic_environments_in_Bangladesh
We propose to conduct whole genome sequencing of 100 diverse Vibrio cholerae isolates including pathogenic and nonpathogenic  strains belonging to O1, O139 and non-O1/O139 serogroups to understand the evolution of this important pathogen. Toxigenic V. cholerae normally exists in an aquatic ecosystem, but infects humans to cause devastating epidemics of cholera that causes 120,000 deaths and about 3.5 million cases worldwide every year. We seek to analyze strains isolated from both cholera patients and the aquatic environment in Bangladesh, where seasonal epidemics of cholera occur every year.This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
We seek to analyze strains isolated from both cholera patients and the aquatic environment in Bangladesh, where seasonal epidemics of cholera occur every year.This proposal concerns understanding the changes in V. cholerae genomes over time both in the aquatic environment and in the human host. The results obtained from the proposed studies are likely to provide important insights  of cholera epidemiology/ecology and strain emergence.