GSE161949
Different forms of KLF5 transcriptionally regulate distinct sets of genes in prostate cancer cells [ChIP-Seq]
To identify which genes are directly regulated by KLF5 and its acetylation, we performed ChIP-Seq and bioinformatics analyses in KLF5-null prostate cancer cells expressing KLF5, KLF5KR, and KLF5KQ. Overall design: ChIP-Seq analyses were performed using KLF5 knockout DU 145 and PC-3 cells that ectopically expressed empty vector (EV), wildtype KLF5 (KLF5); acetylation deficient mutant KLF5K369R (KR), and acetylation mimicking mutant KLF5K369Q (KQ).