GSE168354
scRNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors
Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. Tumors generated from this mouse model were dissociated and a 10X genomics library preparation was performed. The barcoded library was then deep sequenced. Overall design: scRNA Sequencing of Epithelioid Hemangioendothelioma Tumors in Mouse