GSE193380
Targeting Histone Demethylase LSD1 for Treatment of Deficits in Autism Mouse Models [RNA-seq]
We performed RNAseq experiments to examine genome-wide transcriptional changes in PFC of Shank3 +/?C mice with or without GSK-LSD1 treatment. Overall design: mRNA via RNAseq analysis of two 6- to 8-week-old Shank3 +/?C mice with GSK-LSD1, and two 6- to 8-week-old Shank3 +/?C mice with vehicle, and two 6- to 8-week-old control (WT; C57BL/6 x C3H) mice with vehicle from PFC tissue were compared.