GSE193769
Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade
We assessed global gene expression changes in THP1 cells overexpressing inducible RRM2 non-degradable mutant versus empty vector upon doxycycline induction Overall design: Expression profiling data in THP1 cells transduced with iRxI/AxA mutant (4 replicates) were compared to MOCK control cells (4 replicates) by RNA sequencing