GSE162324
Comparing mRNA expression of Myc/NrasG12V and Myc/Akt1 driven liver tumors
To analyze mRNA expression of Myc/NrasG12V and Myc/Akt1 driven liver tumors (HCC), we generated HCCs with elevated MYC expression and activated Raf-MEK-ERK or Akt1 signaling. To trigger tumor development, we co-delivered transposable elements encoding for Myc and oncogenic NrasG12V or myristoylated Akt1 via hydrodynamic injection into the hepatocytes of C57BL/6 wildtype mice and analyzed the transcriptomes of the developed tumors. Overall design: mRNA expression of Myc/NrasG12V and Myc/Akt1 driven liver tumors was compared via mRNAseq analysis