GSE130522
A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression and cell death
DUX4-induced gene expression was compared in the presence vs. absence of the p300 inhibitor, iP300w Overall design: LHCN-M2 immortalilzed human myoblasts carrying rtTA and a dox-inducible DUX4 gene were cultured in the presence of dox and presence or absence of inhibitor.  Negative control was the parent line carrying rtTA only but not DUX4.  This eliminated any potential dox-specific effect.