ena-STUDY-UNIVERSITY OF ZURICH-23-06-2021-16:30:57:844-1138
Gene expression analysis in Ewing sarcoma upon treatment with fimepinostat
The aim of this study was to investigate the influence of fimepinostat on gene expression in Ewing sarcoma with a focus on EWS-FLI1 target genes expression. We previously showed that fimepinostat destabilizes EWS-FLI1 oncoprotein stability and RNAseq data demonstrated that the drug treatment did not significantly affect EWS-FLI1 mRNA expression but induced differential expression of one third of EWS-FLI1 target genes, via reduction of its protein levels.
The aim of this study was to investigate the influence of fimepinostat on gene expression in Ewing sarcoma with a focus on EWS-FLI1 target genes expression. We previously showed that fimepinostat destabilizes EWS-FLI1 oncoprotein stability and RNAseq data demonstrated that the drug treatment did not significantly affect EWS-FLI1 mRNA expression but induced differential expression of one third of EWS-FLI1 target genes, via reduction of its protein levels.