PRJNA805249
Somatic disruption of human Lp(a) with CRISPR/Cas9 potently lowers apo(a) in transgenic mouse model
We then used a combination of Genome-wide, Unbiased Identification of Double-strand breaks Enabled by Sequencing (GUIDE-seq) and Chromosomal Aberrations analysis by Single Targeted LM-PCR (CAST-seq) to determine the sgRNAs specificity to LPA in transgenic animal and in HEK293T.