GSE109580
Capturing the onset of PRC2-mediated repressive domain formation[ChIP-Seq, 3]
Our study defines nucleation and spreading regions for Polycomb repressive complex 2 (PRC2), demonstrating the principle of PRC2 domain formation in mammals. We elucidate the role of genome architecture in formation of these domains and identify JARID2 and MTF2 as being crucial for full recruitment of PRC2 to chromatin. Overall design: In this experiment, we performed ChIP-seq with the indicated antibodies and genotpyes of mESCs.