GSE138460
An androgen receptor switch underlies lineage infidelity to drive neuroendocrine prostate cancer
We generate transcription factor, histone modification and ATAC cistromes in castration-resistant prostate cancer (CRPC) and treatment-induced neuroendocrine prostate cancer (tNEPC) specimens. Overall design: ChIP-seq for AR, PRC2 subunits, and the histone marks H3K27Me3 and H3K27Ac, ATAC-seq for measuring chromatin accessibility, and RNA-seq for transcriptome profiling.