GSE137313
Genetic variability in response to Amyloid beta deposition influences Alzheimer's disease risk
The purpose of this project was to compare whole genome expression in 5 transgenic mice that show either amyloid plaques or tangle pathology to the expression in wild-type control mice at different stages of disease progression (2, 4, 8 or 18 months of age). Mouse genes with expression correlating to pathology were then compared to human genes showing DNA variation in human population associated with dementia (from GWAS). Overall design: Five transgenic lines: TAS10-mice, TPM-mice, HET-TASTPM-mice, HO-TASTPM-mice and Tau-mice. Control line: C57Bl/6J wild-type mice. Four ages: 2, 4, 8 and 18 months.