PRJNA869502
Mouse gut pH and its impact on microbiome in hypertension
Colon pH is naturally acidic due to the microbial production of SCFAs from dietary fibre. Such acidic pH is not only critical for normal gut microbial composition but also regulates host immune responses through activating proton-sensors, such as GPR65. In our study, we looked into the impact of gut pH on gut microbiota in a mouse hypertensive model and the potential involvement of GPR65.