PRJNA866671
TCR-seq data of bone marrow regulatory T cells sorted from mice with physiological and premature aging
Bone marrow (BM) is normally maintained in an immune-privileged and anti-inflammatory state, kept in check principally by regulatory T cells (Tregs). Thus, it is reasonable to expect that Tregs will help shield hematopoietic stem cells (HSCs) from excessive inflammation and thereby counteract HSC aging. Understanding how BM Tregs are adapted to the aged BM and whether they are endowed with unique functions to modulate HSC aging will identify targets for prevention of HSC aging. To identify the phenotype switching and function variation in BM Tregs with physiological and premature aging, we performed TCR-seq of Tregs from the BM of mice at three months post irradiation (IR) and their age-matched control mice (Ctrl), as well as mice at 12 mouths old (12 mo).