GSE112671
Single cell RNA-seq analysis in dermis of SM22rtTA; tetO-Cre; R26-Tomato (SM22-Tomato, control) and SM22rtTA; tetO-Cre; R26-SmoM2/Tomato (SM22-SmoM2/Tomato, forced Hh activation in wound dermis) at 3 days after complete reepithelialization
We found dermal Hh activation is sufficient to induce hair follicle neogenesis in wounded skin. We analyzed gene expression profile at single cell level in the dermis of SM22-Tomato (control) and SM22-SmoM2/Tomato (Hh activation in dermis). Overall design: Single-cell RNA-sequencing libraries of Single cell RNA-seq analysis in dermis of SM22rtTA; tetO-Cre; R26-Tomato (SM22-Tomato, control) and SM22rtTA; tetO-Cre; R26-SmoM2/Tomato (SM22-SmoM2/Tomato, forced Hh activation in wound dermis) at 3 days after complete reepithelialization