PRJNA734029
Molecular mechanism of hyperprogression induced by  CCND1/FGF3/FGF4/FGF19 co-amplification
To investigate the impact of CCND1/FGF3/FGF4/FGF15 co-overexpression on the transcriptome expression profiles after anti-PD-1 mAb treatment, we performed RNA sequencing (RNA-seq) on tumor tissues of Hepa1-6/Vector and Hepa1-6/co-Amp tumor-bearing mice treated with IgG or anti-PD-1 mAb