GSE119757
Targeting FOXA1-mediated repression of TGF-ß signaling suppresses castration-resistant prostate cancer progression [RNA-Seq]
our study establishes FOXA1 as an important regulator of lineage plasticity mediated in part by TGF-ß signaling and supports a novel therapeutic strategy to control lineage switching and potentially extend clinical response to antiandrogen therapies. Overall design: RNA-seq examination of LNCaP cells with control and FOXA1 knockdown