GSE210415
Cell atlas of mouse colon tissue from the initial stage of colitis
Inflammation dramatically alters the gut microenvironment. To investigate the composition and transcriptome changes of various intestinal cell populations during the initial phase of inflammation, and the underlying cellular interactions, we delineated a single-cell atlas of the mouse colon treated with DSS on the day 2 of colitis. Overall design: 7-week-old SPF mice received clean water or 3% DSS for two days, and the mid-colon tissues were harvested for single-cell RNA sequencing.