GSE136077
Chromatin Immunoprecipitation (ChIP) sequencing to explore Androgen Receptor (AR) binding in activated ß-catenin (Ctnnb1) driven murine prostate tumours relative to wildtype prostate tissue.
We report genomic binding of AR in murine prostate tumours with oncogenic activation of ß-catenin and heterozygous loss of tumour suprresor,Pten using AR specific ChIP-sequencing Overall design: AR ChIP followed by sequencing was carried out in 3 independent age-matched wildtype prostate tissues and prostate tumours obtained from Ctnnb1pcex3(?)/+Ptenpc-/+ mice at 9 months of age. Input from each sample was also sequenced.