PRJNA381114
Exome mutation spectrum in eighteen hepatocellular carcinoma (HCC) cell lines with definite metastatic potentials and tropisms
In this study we investigate the mutation spectrum in 18 HCC cell lines with different metastatic potentials and organ-tropisms. Among them, HCC cell lines Huh7, Hep3B, SNU398, SMMC-7721,Bel-7402,HepG2,PLC-5exhibitlow metastasis abilities in nude mice model, while MHCC-97L, MHCC-97H, CSQT-1, CSQT-2, HCCLM3, LM1-S3, LM1-S4, LM1-S5, LM1-S11, LnM1-S11, LnM1-S13 exhibit high metastasis abilitiesin nude mice model.LM1-S3, LM1-S4, LM1-S5, LM1-S11 derived from the parent cell line HCCLM3 have higher metastasis abilities specific to lung, and LnM1-S11, LnM1-S13 are specific to lymph node metastasis. We aim to explore driver mutants involved in the process of HCC metastasis and organ-specific metastasis, and identify their biological functions.