GSE182752
ATAC-seq of MORC3 deficient BLaER1 monocytes [ATAC-seq]
We have identified MORC3 as a negative regulator of Type I Interferon (IFN), whose absence induces IFN and interferon-stimulated genes (ISGs). To study the global effects of MORC3 on DNA accessibility, we deleted MORC3 in IFNAR1-/- IFNAR2-/- BLaER1 monocytes and performed ATAC-seq. Overall design: Monoclonal gene-deficient BLaER1 monocytes in three independent experiments.