DRP006767
Suberoyl bis-hydroxamic acid induced KSHV reactivation
Suberoyl bis-hydroxamic acid (SBHA), a histone deacetylase inhibitor, induced Kaposi sarcoma-associated herpesvirus reactivation on PEL cells in a dose-dependent manner. Next-generation sequencing analysis elucidated that more than 40% of all transcripts expressed in SBHA-treated PEL cells were originated from KSHV genome, but less than 1% in untreated cells.