PRJNA504701
Streptococcus pyogenes strain:M75 Genome sequencing
A multifaceted characterisation of a controlled human infection model candidate strain, M75 611024, compared to two other GAS strains: GAS M12 611025, and CDC SS-496, an M1 strain administered to 88 subjects in 1970s pharyngitis controlled human infection model studies ('SS-496'). This study provides the rationale for the initial deployment of M75 611025 in a modern controlled human infection model, with the aim of safely and successfully causing pharyngitis in healthy adult volunteers.