PRJNA860830
Transcriptome sequencing of the effects of chitosan oligosaccharides on rat skin fibroblasts
Chitooligosaccharides (COS) is an alkaline amino oligosaccharide with small molecular weight obtained by enzyme or chemical degradation of chitosan. With the characteristics of biocompatibility, water solubility and degradability, it has attracted more and more attention in the fields of biomedicine. In the present study, we used COS to treat deep second degree burn wounds of rat skin, and found that COS was able to promote the healing of wounds. We also revealed that COS could promote the proliferation of fibroblasts. Analysis of transcriptome sequencing was performed on COS-treated fibroblasts, in an attempt to identify underlying mechanisms.