GSE134720
Transcriptomic profile of human kidney epithelial cells - derived from cysts of ADPKD donors
We utilized primary cyst cultures derived from human ADPKD donors transfected with RGLS4326 to demonstrate the human translational potential of RGLS4326.  Results show that RGLS4326 treatment globally de-repressed mRNAs of predicted miR-17 target genes in primary human ADPDK cyst cells. Overall design: Primary cyst cultures derived from human ADPKD donors were transfected with RGLS4326 at 100 nM for 24 hrs and harvested for RNA-seq analysis