RNAseq_analysis_of_diel_rhythms_in_Schistosoma_mansoni-sc-5339
RNAseq_analysis_of_diel_rhythms_in_Schistosoma_mansoni
The Earthâ€™s rotation forced life to evolve under cyclic day and night environmental changes. To anticipate such daily cycles, prokaryote and eukaryote free-living organisms evolved intrinsic clocks that regulate physiological and behavioural processes. Daily rhythms have also been observed in organisms living within hosts, such as parasites.  But whether parasites have intrinsic molecular clocks or whether they simply respond to host rhythmic physiological cues remains unknown. Recently it has been shown by RNAseq analysis that Trypanosoma brucei, a single celled eukaryote and the causative agent of human sleeping sickness, has an intrinsic circadian clock that regulates its metabolism, and that there are daily changes in the parasites sensitivity to the drug commonly used to treat this infection (Rijo-Ferreira et al 2017).   This study uses RNAseq analysis of the parasitic trematode flatworm Schistosoma mansoni to look for diel rhythmicity in core circadian clock genes and other genes, providing insight into how this metazoan parasite synchronises its biology to that of its hosts.    This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Transcriptomics study of diel rhythmicity in core circadian clock, and other, genes of Schistosoma mansoni