GSE184555
Regulation and role of glycophagy in skeletal muscle energy metabolism
We report that short-term knockdown of the enzyme alpha-acid glucosidase in mouse C2C12 myotubes modifies genes involved in PPAR and PI3K-AKT signaling. Overall design: C2C12 myoblasts were transfected with shscrambled or shGAA lentivirus, puromycin selected, and then differentiated into myotubes which were then harvested for RNA sequencing.