GSE175595
The MLL-Menin interaction is a molecular dependency in NUP98-rearranged AML [ChIP-Seq]
Using mouse and human models of NUP98-rearrranged leukemia, we demonstrate that inhibition of MLL-Menin impairs leukemogenic gene expression and  disrupts chromatin binding of MLL1 and NUP98 fusion proteins at a critical subset of genes that is essential for sustaining the undifferentiated leukemia phenotype. Overall design: Examination of gene expression changes in mouse leukemia cells treated with the MLL-Menin inhibitor VTP50469