Yeast_DNA_polymerase_point_mutants__Mutational_signatures_of_DNA_damage_and_repair_processes-sc-3329
Yeast_DNA_polymerase_point_mutants__Mutational_signatures_of_DNA_damage_and_repair_processes
Mutational signatures attributable to DNA polymerase point mutations will be determined. Mutant strains went through single-cell bottlenecks and either 2 or 18 independent propagation lines per strain were generated. 2 independent colonies per line and controls will be sequenced; 96 samples per lane.
This work is part of the broader WTSA investigating mutational signatures of DNA damage and repair processes.  Mutational signatures attributable to DNA polymerase point mutations will be determined.