GSE174784
Role of Cop1 on chromatin accessibility in 4T1 mouse triple negative breast cancer cells
Cop1 regulates stability of transcription factors. We determined the role of Cop1 in the regulation of Cebpd transciptional output. We generated 4T1breast cancer cells with CRISPR/Cas9 mediated Cop1 (gene symbol RFWD2) knockout. We treated control sgRosa26 and sgCop1 cells with vehicle or IFNgamma (20ng/ml) for 24 hours and did ATAC-seq. Overall design: ATAC-seq on Cop1-replete or -deficient 4T1 cells that were treated with vehicle or 20ng/ml IFN?.