GSE191049
Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
This study demonstrates that TS5-p45 induces endothelial cell (EC) apoptosis in a caspase-dependent manner via its cell surface receptor Nucleolin (NCL). To unravel how this apoptosis mechanism is induced in ECs, we performed RNA-seq using TS5-p45-treated ECs. Transcriptional changes under TS5-p45 treatment was further evaluated to highlight some of the caspase-dependent apoptosis-inducing and -suppressing genes which are altered in favor of apoptosis. Overall design: Total RNA samples from (12 h) TS5-p45-treated ECs and control ECs, in triplicates