GSE171091
BEND3 safeguards pluripotency by repressing differentiation-associated genes
We have uncovered that BEND3 is a heterochromatin-associated protein that functions as a transcription repressor.  Expression of BEND3 correlates with the state of pluripotency, with a significant decline in BEND3 levels in differentiated cells. Cells lacking BEND3 show defects in cell cycle progression with failure to enter S-phase. BEND3 affects the transcription of cellular genes that modulate chromatin organization and cellular differentiation and that downregulation of BEND3 is critical for cellular differentiation. Overall design: BEND3 LacZ and sh60 mRNA profile in Ntera-2 cell line