GSE185880
Three-dimensional analysis of genome organization in CTCF-WT and CTCF-KO dendritic cells (ChIP-seq)
Purpose: The goals of this study are to analyze global transcriptional, epigenetic and topological changes in dendritic cells under LPS treatment condition and to investigate how CTCF regulates three-dimensional chromatin interaction in inflammatory response. Conclusions: Our study provides the detailed analysis of transcriptional, epigenetic and topological genome profiles in mouse dendritic cells under LPS treatment condition. Moreover, our data show how three-dimensional enhancer networks control gene expression during DC activation. Overall design: LPS treated and non-treated ChIP-seq profiles of CTCF-WT and CTCF-KO cells with biological replicates.