GSE171324
Bulk transcriptome analysis of conditional MYT1L-mutant ESC-derived human induced neurons.
We examined the effect of heterozygous MYT1L deficiency in human induced neurons. Increased expression of genes with MYT1L binding motifs and activation of non-neuronal genes were observed in human neurons along with deregulation of autism-associated risk genes upon depletion of MYT1L. Overall design: Bulk RNA sequencing of MYT1L (+/flox) ESC-derived human induced neurons upon cre-mediated depletion (+/-) compared to delta-cre transduced isogenic controls, 7 or 43 days after NGN2-mediated induced neurogenesis.