GSE135410
HERV1-env dependent unfolded protein response activation is a potential initiator of T cell autoreactivity in autoimmune liver disease.
Here we report Human Endogenous Retrovirus 1 (HERV1-env) induction of endoplasmic reticulum (ER) stress with Unfolded Protein Response (UPR) activation, through its interaction with ATF6.ATF6a up-regulates RORC, STAT3 and TBX21 and induces IL-17A and INF-? production in Tregs by binding to promoter sequences. Overall design: ChIP-DNA from FACS-sorted memory Tregs from 5 subject groups