GSE183979
RNA-seq of limmmunocompetent mice in response to  Aspergillus fumigatus conidia and hyphae
We bulit a pulmonary aspergillosis model in immunocompetent mice.  Mice were inoculated intratracheally with 50 µL suspension of conidia , hyphal fragments or normal saline, respectively, after anesthesia.  Lungs from were harvested and ground for RNA extraction 24 hours after fungal inoculation. The  result of RNA-seq indicated both conidia and hyphae can activate  a series of  immunologically relevant pathways and these pathways were much more strongly activated by hyphae. Hyphae  could promote Th2 cell differentiation and suppress Th1 cell differentiation. Both hyphae and conidia could activate Th17 cell differentiation. Overall design: RNA profile of pulmonary aspergillosis in response to different states of A. fumigatus