PRJNA528522
Homo sapiens Raw sequence reads
The development of hepatic models capable of long-term expansion with competent liver functionality in a personalized setting is technically challenging. We developed a novel method to efficiently and reproducibly generate functionally mature human hepatic organoids derived from human pluripotent stem cell. To validate the maturity of the organoids, we analysed their transcriptome profiles during organoid generation compared with that of adult liver tissue using RNA-sequencing-based analysis.