GSE203257
Induced-pluripotent stem-derived vascular endothelial cells in Down syndrome
To investigate the physiological characteristics of endothelial cells (EC) harboring trisomy 21 (T21), we establised isogenic pairs of T21-iPSCs and corrected disomy 21 (cDi21)-iPSCs We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 different iPSC-derived ECs. Overall design: Comparative gene expression profiling analysis of RNA-seq data for two independent iPSC-derived EC lines of patients with DS (T21 and T21'), two independent iPSC-derived EC lines of HC_1 and HC_2, and an isogenic iPSC-derived EC line of cDi21.