GSE168283
Effect of Jmjd6 knockout on gene expression and mRNA splicing in Lin-Sca+Kit+ haematopoietic cells
The 2-oxoglutarate dependent protein JMJD6 acts as a lysyl hydroxylase on specific residues of the splicing factor U2AF2.  To understand the molecular roles of JMJD6 in normal haematopoiesis and identify any role of JMJD6 in splicing, we performed RNA-sequencing on Lin-Sca1+Kit+ (LSK) haematopoietic stem and progenitor cells (HSPCs) derived from young mice. Overall design: One sample per mouse was taken from 4 WT vs 4 KO mice.