GSE160928
NOP10 predicts NSCLC prognosis and its associated small nucleolar RNAs drive proliferation and migration [ncRNA-seq]
Non-coding RNAs are critical players in non-small cell lung cancer (NSCLC). In the present study, we investigate the role of H/ACA box snoRNA and snoRNA-bound ribonucleoproteins (RNP) in the tumorigenesis of NSCLC. Overall design: We used small RNA-Seq to determine the expression profile of small nucleolar RNA (snoRNA) in 7 matched tumor and normal samples from paraf?n-embedded tissue from non-small cell lung cancer (NSCLC) patients. To further investigate the role of NOP10, we analyzed A549 cell line with CRISPR Cas9 knock out of NOP10.