GSE158292
Distinct exhausted CD8 T cell populations are linked to C-peptide preservation in alefacept-treated, recent onset T1D subjects
Bulk RNA-sequencing of sorted CD8 T cells from recent-onset T1D subjects treated with alefacept. Overall design: 30 recent-onset T1D subjects were enrolled in the T1DAL trial of alefacept. Blood draws were taken at baseline (pre-treatment) and weeks 11, 24, 35, 52, 78 and 104 post-treatment. CD8 T cells were FACS-sorted and analyzed by bulk RNA-sequencing.