GSE174234
Single-nucleus sequencing of liver cells from hepatocyte-specific Nampt knockout mice and WT littermates reveals major changes to the hepatocyte transcriptome in mice with necrosis
Single-nucleus RNAseq was performed to investigate whether transcriptomics changes observed in bulk RNAseq could be attributed to specific hepatic cell populations. Overall design: We isolated nuclei from 3 hepatocyte-specific Nampt knockout (HNKO) mice and 3 WT littermates, and sequenced 4,250 nuclei/sample