GSE75683
GRa-independent transcriptional activity of hGRß in GR Liver Knockout Mouse
We used AAV as a vector to deliver hGRß to the liver of GR Liver Knockout mice. We collected liver samples for microarray analysis to investigate any phenotype as well as the underlying specific signaling pathway. In particular, we would like to determine if and how hGRß overexpression in liver affects mGRa's gene transcription profile in GR Liver Knockout  mice. Overall design: GR Liver Knockout mice were treated with PBS,  AAV-GFP and AAV-hGRB, respectively.  Each treatment group has four replicates.