GSE201315
Adaptive evolution of gene promoters driven by primate-specific KRAB zinc finger proteins
RNA analysis of CRISPR/Cas9 ZNF519 knockout (KO), ZNF441 knockout (KO), ZNF468 knockout (KO) and wild type hESC-derived cortical organoids and ChIP-seq analysis of CRISPR/Cas9 ZNF519 knockout (KO) and wild type hESC-derived cortical organoids, and HEK293 cells with ZNF519 overexpression (OE). Overall design: RNA analysis of CRISPR/Cas9 ZNF519 knockout, ZNF441 knockout, ZNF468 knockout and wild type hESC-derived cortical organoids and ChIP-seq analysis of CRISPR/Cas9 ZNF519 knockout  and wild type hESC-derived cortical organoids, and HEK293 cells with ZNF519 overexpression.