PRJNA506222
Maternal Influence and Murine Housing Confounds Impact of NLRP1 Inflammasome on Microbiome Composition
The NLRP1 inflammasome attenuates inflammatory bowel disease (IBD) progression and colitis associated tumorigenesis. A possible mechanism postulates the lack of the NLRP1 inflammasome creates permissive niches in the gut for pathogenic bacteria to flourish, causing dysbiosis and increased IBD susceptibility. To evaluate this hypothesis, we characterized the gut microbiome of wild type, Nlrp1b-/-, and Asc-/- mice under naive conditions by sequencing the V3 region of 16s rRNA gene.