PRJNA489697
The small molecule rhodomyrtone suppresses TNF-a and IL-17A-induced keratinocyte inflammatory responses
Rhodomyrtone is a bioactive plant extract from Rhodomyrtus tomentosa, with established anti-proliferative effects. This study assessed the potential of rhodomyrtone for curtailing TNF/IL-17A-driven inflammation. RNA-seq analysis was conducted on monolayer primary keratinocytes (NHK ) treated with IL-17A/TNF and/or rhodomyrtone. NHK were pretreated with rhodomyrtone (50-600 ng/ml) for 1 h before stimulation with recombinant human 20ng/ml IL-17A and 10 ng/ml TNF-a (both R&amp;D Systems) for 24 h.