GSE133160
The oncogenic action of NRF2 depends on de-glycation by Fructosamine-3-kinase (FN3K)
We show that NRF2 activation drives hepatocellular carcinoma development in vivo.    Moreover, NRF2 undergoes glucose dependent modification called glycation and requires the de-glycating enzyme FN3K to maintain NRF2' oncogenic functions. Overall design: Gene expression analysis in MYC-driven murine HCC with and without NRF2 activation.  NRF2 is activated by targeting  its negative regulators Keap1 or Cul3 or targeting NRF2 ETGE motif by sgRNA/Cas9 editing.