GSE200973
Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity
CARM1 Y149F, Y334F or Y149F/Y334F mutants have decreased activtiy to dimethylate RUNX1. Overall design: CARM1 Y149F, Y334F or Y149F/Y334F mutations were introduced into HEL cells. ChIP-seq analyses for RUNX1 and RUNX1 R319me2a were performed in wild type and CAMR1 mutant HEL cells.