ena-STUDY-FZB-08-02-2019-11:01:07:458-256
No cross resistance between PAS and TMP-SMX in MTB
The study aimed to investigate if known para-aminosalicylic acid resistance mechanisms cause cross resistance against trimethoprim-sulfamethoxazole. Both target the folate pathway and are used to treat M/XDR-TB patients. ThyA deletion mutants and clincial MTB isolates were analaysed.
The study aimed to investigate if known para-aminosalicylic acid resistance mechanisms cause cross resistance against trimethoprim-sulfamethoxazole. Both target the folate pathway and are used to treat M/XDR-TB patients. ThyA deletion mutants and clincial MTB isolates were analaysed.