GSE171719
Klotho inhibits neuronal senescence in human brain organoids
We report the application of brain organoids to study cellular senescence, in particular Klotho declining in expresssion mediates neuronal senescence, bulk RNA-sequencing further identified the potenital downstream target tha may modulate cellular senescence in the brain. Overall design: Examination of 2 sets of human brain organoids with and without Klotho overexpression at wekk 13 of in vitro culture