PRJNA482256
human nasopharyngeal metagenome Raw sequence reads
Chronic rhinosinusitis (CRS) is a major human health problem that significantly reduces the quality of life. While various microbes have been implicated, there is no clear understanding of the role they play in CRS pathogenesis. Previous work has highlighted the large variation in the sino-nasal microbiota among CRS-affected individuals. Another equally important observation made for CRS patients is that the epithelial barrier in the sino-nasal cavity is defective. In this study, the underlying drivers of microbial heterogeneity in CRS were therefore explored by investigating impairments in the epithelial barrier along with local inflammatory responses. This study contributes to ongoing efforts to understand the underlying drivers of CRS.