ena-STUDY-UCL-11-06-2018-11:06:09:466-3803
Adenovirus genomes recovered from Bangladeshi children with acute gastroenteritis
Novel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic E. coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel recombinant species D virus (genotype P33H27F67) was identified, new sequences from genotypes A61 and F40 were generated, and the partial genome of a putative recombinant species B virus was recovered. Knowledge of the diversity of adenovirus genomes circulating world-wide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.
Novel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic E. coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel recombinant species D virus (genotype P33H27F67) was identified, new sequences from genotypes A61 and F40 were generated, and the partial genome of a putative recombinant species B virus was recovered. Knowledge of the diversity of adenovirus genomes circulating world-wide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.