GSE109320
Regenerating hair cells in human vestibular sensory epithelia
To investigate alterations in gene expression after Ad2-ATOH1-GFP transduction of human supporting cells, we measured transcriptome changes by RNA-seq. We compared gentamicin-treated tissue (to kill the hair cells) transduced with Ad2-ATOH1-GFP (to promote hair cell production) cultured for 5 days, versus control tissues only treated with gentamicin (cultured for 2 days, 8 days and 14-18 days). Overall design: Human utricle mRNA profiles after treatement with gentamycin alone or incombination with Atoh1 and untreated controls.