GSE126073
Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21
Method: Analysis of the transcriptomal changes of EV-GFP uptake by microglia after implantation of glioma cells into miR-21 null mouse brain. Result: miR-21 is transferred from glioma to microglia through EV, resulting in downregulation of miR-21 target mRNAs Overall design: mRNA expression of microglia isolated from control and tumor-bearing miR-21 null brains analyzed by RNAseq, using Illumina Nextseq.