DRP005521
RNA-seq and ChIP-seq to study meiotic initiation in mouse testis
In mammalian germ cells, meiosis is initiated in response to retinoic acid (RA), which induces the expression of Stra8 and its binding partner MEIOSIN. To study meiotic initiation , transcriptomes of whole testes were compared between WT, Stra8 KO and Meiosis KO by RNA-seq. ChIP-seq were done to identify MEIOSIN binding sites on mouse genome.