GSE169332
Single cell RNA-seq analysis of endothelial cells during diabetic atherosclerosis
Single-cell RNA sequencing (scRNA-seq) was performed on the  CD31-mircrobeads enriched endothelial cells isolated from aorta and heart from eight-week-old, male Ldlr-/- mice fed standard chow (Chow) or diabetogenic high-fat diet with 0.15% cholesterol (DDC) diet for 12 weeks. This study report the changes of EC subpopulations, fractions, transcriptomic and metabolic profiles during diabetic atherosclerosis. Overall design: Examination of the transcriptomic profiles of endothelial cells isolated from aorta and heart pooled  from three Ldlr-/- mice fedstandard chow (Chow) or diabetogenic high-fat diet with 0.15% cholesterol (DDC) diet for 12 weeks