GSE185977
AR cooperates with SMAD4 to maintain muscle homeostasis
The goal of this study was to determine the mechanism of androgne in driving muscle hypertrophy programmes. CONCLUSION: AR transcriptionally cooperates with SMAD4 and this affect is lost in the presence of expansion of the polyglutamine repeat in the AR gene. Overall design: RNA-seq was performed in quadricpes femoris from SBMA (spinal bulbar muscular atrophy) AR100Q mice treated with AAV vectors expressing BMP7 or GFP mock control. Untreated wild-type mice (C57BL/6) were analysed in parallel as additional controls.