GSE163456
Transcriptome changes in human endothelial cells with constitutively active YAP, TAZ and TEAD mutants
Transcriptome profiling of human umbilical vein endothelial cells (HUVECs) overexpressing constitutively nuclear YAP (YAP S127A), TAZ (TAZ S89A) or TEAD-binding deficient YAP (YAP S94A/S127A) or TAZ (TAZ S51A/S89A) to identify YAP and TAZ target genes. Overall design: Analysis of HUVECs transduced with a lentivirus encoding for a nuclear YAP and TAZ mutant compared to HUVECs transduced with a control lentivirus (Ctrl). Expression analysis was performed 48h post doxycycline induction.