E-MTAB-6885
miRseq Analysis of Human Macrophages Co-cultured with MCF-7 Breast Cancer Cells
Tumor-immune cell interactions shape the immune cell phenotype, with  microRNAs (miRs) being crucial components of this crosstalk. How they are transferred, and how they affect their target landscape, especially in tumor-associated macrophages (TAMs), is largely unknown. Here we aimed to define miRome of TAMs and identify novel miRs those are deferentially expression in TAMs and decipher their functional relevance in disease settings.
Tumor-immune cell interactions shape the immune cell phenotype, with  microRNAs (miRs) being crucial components of this crosstalk. How they are transferred, and how they affect their target landscape, especially in tumor-associated macrophages (TAMs), is largely unknown. Here we aimed to define miRome of TAMs and identify novel miRs those are deferentially expression in TAMs and decipher their functional relevance in disease settings.