GSE129636
MLL-Menin inhibition reverses pre-leukemic progenitor self-renewal induced by NPM1c mutations [ChIP-Seq]
Menin binding to MLL1 is required to maintain self-renewal properties of NPM1c progenitors at different stages of leukemia development Overall design: Mouse NPM1c knock-in cells and human AML cell lines  carrying NPM1c mutations were analyzed for the gene expression changes induced by NPM1c and in response to Menin inhibitor VTP-50469.