PRJNA794197
Human and insect cell-produced rAAVs show differences in ITR heterogeneity and content in empty particles
AAV-GPseq analyses reveals that AAV vectors produced by the HEK293 human cell platform and the Sf9 insect cell-baculovirus platform show differences in genome heterogeneity and packaging of short DNA fragments in particles that are attributed to a high degree of unresolved ITRs in packaged virions.