GSE137282
Differential RNA expression profiling in response to TET inhbition
Ten-to-Eleven Translocation (TET) family of proteins oxidize 5mC in to 5hmC on the genomic DNA and act as interesting class of epigenetic medulators. A novel small molecule inhbitor of TET enzymatic activity, C35 is developed. Overall design: Mouse Embryonic Fibroblasts are treated with C35 for 7 days and total mRNA sequecning is performed.