GSE184858
Glycosyltransferase Extl1 promotes CCR7-mediated dendritic cell migration to restrain infection and autoimmunity [treated vs. untreated]
Purpose: mRNAs sequencing of the gene expression differences in CCR7-stimulated mDC. The goals of this study are to investigate the biological effect of glycosyltransferase Extl1 in regulating dendritic cell function. Overall design: Bone marrow cells from wild-type mice were cultured with GM-CSF and IL-4 for 6 days to generate bone-marrow derived DC (BMDC). BMDC were stimulated with or without CCR7 ligand CCL19 and CCL21 for 12 h