GSE116702
Ikzf2/helios mutant cochlear RNA-seq analysis
Given the potential role of the helios transcription factor in postnatal outer hair cell gene regulation indicated by our RiboTag translatome analyses, our next goal was to identify and validate genes that are regulated by helios in outer hair cells by performing RNA-seq on P8 cello mutant animals compared to wild-type littermates. Overall design: Difference in cochlear gene expression between wild-type Ikzf2+/+ animals and mutant Ikzf2cello/cello littermates was analyzed by RNA-seq in biological duplicates.