PRJNA522276
Mouse 2 Cell Embryos
The goal of this study was to identify changes in gene expression due to the loss of EZH2 activity in preimplantation mouse development. Mouse embryos were either untreated (control), treated with an RNA Polymerase II inhibitor (alpha-amanitin), or treated with an inhibitor of EZH2 activity (GSK343). Embryos were collected at the mid- to late- 2 cell stage for RNA-sequencing.