GSE131798
Transcriptional analysis of tendons from mice with a tenocyte-specific deletion of IGF1R
We report RNA sequencing data from the plantaris tendons of adult male mice in the C57Bl/6 background that either have the IGF1 receptor (IGF1R) present in their tendons (Scx:IGF1R+) or mice in which IGF1R has been deleted in tenocytes expressing scleraxis (Scx:IGF1R-). Mice were created by crossing ScxCreERT2 mice with IGF1R flox/flox mice. Mice were treated with tamoxifen for 5 days to induce recombination at the IGF1R allele, and then subjected to a synergist ablation procedure in which the Achilles tendon is removed, resulting in compensatory growth of the plantaris tendon. Mice were analyzed either 7 or 14 days after synergist ablation. Control mice that did not undergo tamoxifen treatment or synergist ablation were also studied. Overall design: Differential expression of mRNAs were evaluated from the plantaris tendons of Scx:IGF1R+ and Scx:IGF1R- mice subjected to a growth stimulus for either 7 or 14 days, along with control mice that did not undergo a growth stimulus.