GSE126687
Transcriptom analysis of ZFP708 loss and overexpression in preimplantation embryos and embryonic stem cells
This work describes the function and targets of a maternal KRAB-Zinc finger protein, ZFP708, which specifically mediates maintenance of DNA-methylation at a subset of LTR retrotransposons during embryonic epigenetic reprogramming. Overall design: This dataset contains RNA-seq analysis of wildtype and maternal ZFP708 knock out GV oocytes, zygotes, 2-cell stage embryos, blastocysts and embryonic stem cells derived from maternal/zygotic ZFP708 embryos. It further contains expression analysis of ZFP708 overexpressing mouse embryonic stem cells.