GSE120064
Single-cell mRNA sequencing of TAC-model mouse heart tissue
We studied the cell compositon of mouse heart by single-cell sequencing on TAC-model mice. Distint subgroups of cardiac muscle, fibroblast cell and endothelial cell were detected. We drawed a cell-cell interaction network using specific expressed ligands and receptors of cells. And we also observed the change of interaction and cell transformation with progress of the disease. Overall design: Extract cells from left ventricle of mouse heart and conduct single-cell sequencing