PRJNA275799
Senescent cell Hi-C sequencing
We investigate whether senescence associated changes in chromatin regulation cause alterations to the 3D organization of chromosomes.  We conducted Hi-C in replicatively senescent,non-synchronous proliferating, and serum starved quiescent cells. Our results demonstrate that while proliferating and quiescent cells display a conserved 3D organization of chromosomes, senescent cells exhibit a gain of short range interaction and loss of long-range interactions.