Does_IL_6_blockade_impact_on_the_composition_of_the_intestinal_microbiota_in_mice_spontaneously_developing_innate_immune_mediated_colitis_-sc-3128
Does_IL_6_blockade_impact_on_the_composition_of_the_intestinal_microbiota_in_mice_spontaneously_developing_innate_immune_mediated_colitis_
TRUC mice were treated with anti-IL-6 (neutralizing mAb) or isotype control mAb. Colitis outcome and changes in the composition of the intestinal microbiota were determined. These data are part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
TRUC mice with chronic intestinal inflammation were treated with an anti-IL-6 (neutralizing mAb) or isotype control mAb. Faecal samples were acquired from study animals prior to treatment and following completion of treatment. The impact of neutralizing a key cytokine involved in regulating host immunity at the interface intestinal microbiota was determined.