ena-STUDY-Jianghan University-11-02-2015-04:42:36:537-25
Gut microbiota and physical indices  was investigated before and after treatment with acarbose in pre-diabetes
To explore the changes of proportion and diversity of gut microbiota before and after treatment with acarbose in pre-diabetes, we designed a randomized, double-blind and controlled crossover trial in which 52 pre-diabetes aged 30-60 years with BMI 18-35 kg/m2 by OGTT in China were randomly allocated to treatment with acarbose or placebo for 3 months. Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. The alpha diversity was estimated by Shannon index, chao1 index and the beta diversity was estimated by PCA analysis
To explore the changes of proportion and diversity of gut microbiota before and after treatment with acarbose in pre-diabetes, we designed a randomized, double-blind and controlled crossover trial in which 52 pre-diabetes aged 30-60 years with BMI 18-35 kg/m2 by OGTT in China were randomly allocated to treatment with acarbose or placebo for 3 months. Gut microbiota characterizations were determined with 16S rDNA-based high-throughput sequencing. The alpha diversity was estimated by Shannon index, chao1 index and the beta diversity was estimated by PCA analysis