GSE202073
EHF and CDX1 co-operate to drive extensive transcriptional reprogramming and chromatin remodelling in CRC cells [RNA-seq]
EHF and CDX1 co-operate to drive differentation of CRC cells. To identify the transcriptional changes induced by these transcription factors, EHF and CDX1 were stably re-expressed in poorly differentiated HCT116 CRC cells and RNA sequencing analysis performed. Overall design: HCT116 CRC cells were stably transfected with empty-vector control, EHF, CDX1, or EHF plus CDX1 and RNA-Seq analysis performed on each cell line.