PRJNA488983
Somatic Mutations and Immune Alternation in Rectal Cancer
Whole exome sequencing of 14 locally advanced rectal cancer (LARC) patients samples showed that nCRT induced new mutations compared to the paired priorpre-treatment biopsies as evidenced by appearance of a neoantigen landscape. An striking association was identified between the mutation burden and enrichment of immune activation-related pathways.