The_genome_evolution_of_parasitism_in_trypanosomatid_flagellates-sc-3919
The_genome_evolution_of_parasitism_in_trypanosomatid_flagellates
Two groups of kinetoplastids parasitise vertebrate and cause major neglected tropical diseases of mankind â€“ the African and American trypanosomes (sleeping sickness and Chagas disease), and many species of Leishmania causing cutaneous and visceral leishmaniases. These two groups have evolved independently from a diverse, ubiquitous clade of trypanosomatid parasites of arthropods by acquiring a vertebrate host in addition to the arthropod, switching from a monoxenous to dixenous lifecycle. The aim is to build draft genomes for  the major lineages of monoxenous trypanosomatids to study the evolution of parasitism and the origins of the vertebrate-infective dixenous groups of trypanosomatids.   This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Whole-genome shotgun sequence data from major lineages of monoxenous trypanosomatids, analysis of assemblies of these data will shed new light on the evolution of this group, and the origins of the vertebrate-infective dixenous groups of trypanosomatids.