GSE138932
RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells
The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th1 cells upon deletion of the cofactor NCOR1. Overall design: mRNA expression profiles of WT and NCOR1f/f,Cd4Cre in vitro-generated Th1 cells were generated by deep sequencing