PRJNA681082
PARPi-resistant SUM149PT BRCA1 amplicon sequencing
SUM149PT harbours a homozygous 1-bp frameshift deletion in BRCA1. We performed deep amplicon DNA sequencing on this locus in parental and talazoparib- resistant clones, as well as a non-malignant BRCA1 wildtype cell line, MCF10A.