GSE201691
Evidence for toxic CAG trinucleotide repeats contributing to Huntington's disease though RNA interference
Mutant huntingtin CAG trinucleotide repeat mimetic hairpins are loaded into the RISC and kill cells through RNAi Overall design: Striatum of mouse brains of wt, 250CAG and 450CAg mice was lized. Subsequently, Ago protein associated short RNAs were pulled down using a GW182 peptide and subjected to smRNA Seq