GSE124757
Phosphatase inhibitor PPP1R11 modulates resistance of human T cells towards Treg-mediated suppression of TCR signaling
We have performed RNAseq analysis of human T cells upon PPP1R11 siRNA silencing. We have explored the role of PPP1R11 for the first time in primary human T cells and discovered that PPP1R11 is a novel negative mediator of T cell activation. Overall design: CD4+ T cells from 3 donors were treated with either control or PPP1R11 siRNA for 4.5 days and either stimulated with cross linked CD3/CD28 for 6h or left unstimulated for RNAseq analysis