ena-STUDY-Leibniz Institute for Farm Animal Biology (FBN)-19-08-2019-14:49:47:384-75
Total RNA transcriptome of metabolically active tissues in cattle with divergent protein accretion capacity
Genomic regions associated with divergent livestock feed efficiency have been found predominantly outside protein coding sequences. Long non-coding RNAs (lncRNA) can modulate chromatin accessibility, gene expression and are supposed to act as important metabolic regulators in mammals. By integrating phenotypic, total RNA transcriptomic and metabolomic data with QTL data in prioritizing co-expression network analyses, we aimed to identify and functionally characterize lncRNAs with a potential key regulatory role in metabolic efficiency in cattle.
Genomic regions associated with divergent livestock feed efficiency have been found predominantly outside protein coding sequences. Long non-coding RNAs (lncRNA) can modulate chromatin accessibility, gene expression and are supposed to act as important metabolic regulators in mammals. By integrating phenotypic, total RNA transcriptomic and metabolomic data with QTL data in prioritizing co-expression network analyses, we aimed to identify and functionally characterize lncRNAs with a potential key regulatory role in metabolic efficiency in cattle.