GSE157983
Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus
We studied conditional knockout mice in which the vast majority of dentate granule cells (DGCs) fail to develop – including nearly all DGCs in the dorsal hippocampus – secondary to eliminating Wntless (Wls) in a subset of cortical progenitors with Gfap-Cre. Overall design: Bulk RNA-seq and single nuclei RNA-seq were preformed on hippocampi from adult control, Gfap-Cre;Wlsfl/+, and mutant, Gfap-cre;Wlsfl/- mice.