GSE115608
Transcriptional profiling of Ishikawa cells treated with H3B-5942, E2, or standard of care compounds
The objective of this experiment was to determine the affect of H3B-5942 treatment on global  gene expression in an estrogen-deprived setting (agonist mode) and to compare to treatment with a saturated analog of H3B-5942, GDC-0810, and standard of care agents tamoxifen and fulvestrant. Overall design: 7 conditions were assessed  (H3B-5924, H3B-9224, E2, fulvestrant, tamoxifen,  GDC-810, and DMSO as negative control). Compounds were added at 2 concentrations (3nM and 30nM). Two samples of each condition were collected.