GSE125719
Transcriptomic analysis of LSD1i-sensitive and resistant AML cells
The goal of this study is to identify the molecular mechanisms underlying the resistance/sensitivity of AML cells to lysine specific demethylase 1 (LSD1) inhibitor. Overall design: We performed the transcriptomic analysis at the earliest detected and last tested time points in which mTOR was regulated secondary to LSD1i (i.e. 6 and 72h in sensitive KASUMI-1 cells and 24 and 72h in resistant THP-1 cells)