GSE130956
Investigation of ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines
We identified that upregulation of ST8SIA1 promotes melanoma brain metastasis. The goal of this RNA-seq is to analyze the ST8SIA1 expression in icaritin-treated and untreated melanoma cell lines (DP-0574 and WP-0614 cell lines) In vitro functional studies demonstrate that ST8SIA1 overexpression promotes cell proliferation and colony formation and that this can be halted by icaritin treatment. Overall design: mRNA profiles of icaritin-treated or control untreated cells were generated by deep sequencing using Illumina NextSeq 550, in triplicate.