GSE136216
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages
We investigated the function of EGR1 in macrophage differentiation and activation. We generated EGR1 CHIP-seq and CUT-and-RUN data during GM-CSF induced macrophage differentiation, paired with ATAC-seq. We performed RNA-seq and CHIP-seq for H3K27ac in EGR1-depleted differentiated macrophages.  Finally we generated RNA-seq data in activated macrophages with EGR1 overexpression. Overall design: Analysis of genome-wide activity of EGR1 in macrophage differentiation.