GSE128700
Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer
We found that targeting IDH1 in HGSC induces senescence by altering the repressive histone landscape of E2F target genes Overall design: Ovcar3 cells were infected with control or shIDH1. Cells were selected in 3ug/mL puromycin for 7 days. RNA was isolated and RNA-seq was performed comparing control and knockdown RNA.