GSE117624
Transcriptional profiles of [ESI+]
We profile the transcriptional landscapes associated with acquisition of [ESI+], a prion scaffolded by Snt1, a core component of the Set3C histone deacetylase. We find that acquisition of [ESI+] leads to expression of otherwise silent, heterochromatic loci, proposing a new molecular means by which silent transcriptional states might be reversed. Overall design: mRNA sequencing of mid-logarithmically grown naïve and [ESI+] diploid cells