GSE183201
Adrenomedullin promotes the migration of interneurons in a human forebrain assembloid model for hypoxic interneuronopathy of prematurity.
We developed a model for hypoxic injury of migrating human cortical interneurons using forebrain organoids and forebrain assembloids derived from hiPSCs. Overall design: Human subpallial organoids at day 46 in culture were exposed to hypoxia (<1% oxygen) for 12 and 24 hours. Some samples were exposed for 24 hours and  subsequently reoxygenated for 72 hours. Samples were immediately collected and snap frozen for processing.