GSE107919
Chromatin remodeler CHD8 in CNS myelination and remyelination
Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause a set of Autism Spectrum Disorders (ASD). We found that CHD8 is highly expressed in myelinating oligodendrocytes (OL) and their progenitors in the developing central nervous system (CNS). We performed CHD8 chIP-seq analysis in cultured oligodendrocytes. Overall design: 11 samples: RNA-seq:2 Control  Samples vs 2 cKO samples; ChIP-seq: 2 Chd8samples, 1 chd7 sample; H3K4me3 ChIP-seq: 1 control vs 1 Ch8cko; ATAC-seq 1 control vs 1 Chd8cKO