PRJNA670454
miRNA-seq of WT and calpain-1 KO mice
We were particularly interested in miRNAs related to neurodegenerative disorders, since we have proposed that calpain-1 is neuroprotective, as down-regulation of calpain-1 is associated with enhanced susceptibility to neurodegeneration in mice, dogs and humans. Utilizing miRNA-seq, we identified 45 differentially expressed miRNAs (DE miRNAs) in the brain of calpain-1 KO mice, as compared to wild-type. In particular, among all DE miRNAs, 7 neurodegenerative-related miRNAs were found to be down-regulated in KO mice.