GSE134067
RNA Sequencing of Wild Type and CCR2-/- mouse esophageal tumor transcriptomes
Wild type and CCR2-/- C57 mice were gavaged with carboxyl methyl cellulose (1%) or N-nitrosomethylbenzylamine(NMBA) 0.25 mg/kg body weight (BW) twice per week for 5 weeks. At the end of Week 25, the forestomach were harvested to carry out RNA resequencing. We found that CCR2 mediated monocyte infiltration promoted tumor evasion through activating PD-1 signaling pahtway. Overall design: Mouse forestomach mRNA profiles of esophageal cancer mouse models were generated by sequencing, using Illumina Hiseq.