PRJNA379542
Human Endometrium and Blood Raw sequence reads
Gene expression profiles are different in the endometrium of RIF, RM and fertile women during the window of implantation. Women with RIF and RM have both been reported to have altered expression of endometrial receptivity markers. This is an observational prospective study. In total 9 subjects were recruited, 3 RIF, 3 RM, and 3 controls. Paired samples (endometrium and peripheral blood) from the same subjects were precisely timed on the 7th days after luteal hormone surge (LH+7). There was a medium level correlation between transcriptome in peripheral blood and endometrium during the window of implantation. But the results of transcriptome in peripheral blood cannot be used to characterize women with recurrent implantation failures (RIF) and unexplained recurrent miscarriage (RM) instead of transcriptome study of the endometrium. The correlation of gene expression may provide a potential of identifying more non-invasive markers for embryo implantation and differentiation of implantation disorders, though the differential transcriptome patterns in blood are not representative of that in endometrium.