PRJNA285816
Danio rerio Raw sequence reads
Here we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic OP compound, chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the aspects of this toxidrome in humans, including acetylcholinesterase inhibition, NMDA-receptor activation, calcium dysregulation and inflammatory and immune response.