GSE110097
Analysis of Th17 gene signature in the presence of CD28 costimulation in human CD4 naïve T cells
We determined differentially regulated gene expression profile in CD4 naïve T cells cultured in presence or absence of Th17 inducing cytokines (IL23+IL1ß) and anti-CD28. We reported that CD28 costimulation induced Th17-suppressive gene signature. Overall design: Human CD4 naive T cells were cultured as 4 different conditions (Th0, Th0CD28, Th17 and Th17CD28) to examine differentially expressed genes among conditions.