GSE194362
HyperTRIBE uncovers MSI2 RNA binding activity and the effect of Ro, GSK-591 and combination in Z-138 cells
Identifying MSI2 RNA-direct binding targets in B-cell lymphoma and evaluating how MSI2 binding activity can be affected by the inhibition of PRMT5 using GSK-591 and the MSI2 inhibitor, Ro and the combination of the two agents. Overall design: Z-138 cells overexpressing MSI2-ADA or MIG (empty vector) were treated for with DMSO, Ro, GSK-591 and combination for 24h and harvested for RNA-seq to look for A-G editing events.