GSE157692
A549 vs. A549DDP miRNA and mRNA analysis using RNA-seq
This study aims to identify pathway involvement in the development of cisplatin (cis-diamminedichloroplatinum (II); CDDP) resistance in A549 lung cancer (LC) cells by utilizing advanced bioinformatics software. We developed CDDP-resistant A549 (A549/DDP) cells through prolonged incubation with the drug and performed RNA-seq on RNA extracts to determined differential mRNA and miRNA expression between A549/DDP and A549 cells Overall design: Examination of A549 parental cell line vs. A549-cisplatin resistant cell line