Whole Exome Sequencing to find candidate variants for the prediction of kidney transplantation efficacy
Whole Exome Sequencing to find candidate variants for the prediction of kidney transplantation efficacy
Kidney transplantation is the optimal treatment strategy for end-stage renal disease (ESRD) and its efficacy and graft survival after transplantation depend on several elements.  To ensure the minimal risk of graft rejection, the human leukocyte antigens (HLAs) matching should be done. However, there are more genes involving in graft survival and we analysis exon loci variants based on a high-resolution NGS method in kidney graft recipients. Employing the WES procedure, we identified the genetic causes that can predict the efficacy of transplantation. Moreover, some protective variants are suggested.
Kidney transplantation is the optimal treatment strategy for end-stage renal disease (ESRD) and its efficacy and graft survival after transplantation depend on several elements.  To ensure the minimal risk of graft rejection, the human leukocyte antigens (HLAs) matching should be done. However, there are more genes involving in graft survival and we analysis exon loci variants based on a high-resolution NGS method in kidney graft recipients. Employing the WES procedure, we identified the genetic causes that can predict the efficacy of transplantation. Moreover, some protective variants are suggested.