ena-STUDY-Britto-30-09-2017-15:30:09:923-24
Evidence of an in vivo transfer of a blaCTX-M14-harboring plasmid under antibiotic pressure, Geneva, Switzerland
Horizontal transfer of plasmid-mediated antibiotic resistance is frequently observed under antibiotic pressure in vitro, however, in vivo evidence remains rare. We present here evidence of transfer of a blaCTX-M-14 harbouring plasmid from a gut-colonizing E. coli to the hypervirulent K. pneumoniae ST23 in a patient who had received cefuroxime therapy.
Horizontal transfer of plasmid-mediated antibiotic resistance is frequently observed under antibiotic pressure in vitro, however, in vivo evidence remains rare. We present here evidence of transfer of a blaCTX-M-14 harbouring plasmid from a gut-colonizing E. coli to the hypervirulent K. pneumoniae ST23 in a patient who had received cefuroxime therapy.