GSE108016
RNAseq of hypnozoites and schizonts in the MPCC system
Upon P. vivax infection, dormant liver stage forms, hypnozoites, linger for weeks to months and then relapse to cause recurrent blood stage infection. Very little is known about the hypnozoite: Definitive biomarkers are lacking and in vitro platforms that support phenotypic studies have not been available. Here, we recapitulate the entire liver stage life cycle of P. vivax in vitro in a multiwell format and assay the hypnozoite transcriptome Overall design: Determination of differentially expressed genes between hypnozoite enriched and mixed populations