GSE160400
Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade II
We report results of transcriptional profiling of ex vivo MC38 murine organotypic tumor spheroids following programmed death-1 (PD-1) blockade compared to isotype control IgG treatment by bulk and single-cell RNA-sequencing after 6 days of treatment. Additionally, we report results from single-cell RNA-sequencing of MC38 tumors treated in vivo with PD-1 blockade versus isotype control IgG to validate ex vivo workflow. Overall design: Transcriptional profiling of residual MC38 tumor cells after PD-1 blockade