PRJNA771765
GPR174 acts as a novel prognostic biomarker for patients with sepsis via regulating inflammatory response
RNA-seq showed that Gpr174 deficiency induced a marked phenotypic shift toward multiple immune response pathways in septic mice. Potential mediators of immune response, including dendritic cell-specific transmembrane protein and macrophage mannose receptor 1 were highly upregulated, while interleukin-12 subunit alpha and Sialoadhesin downregulated in Gpr174-KO mice after CLP challenge.