Identification_of_driver_mutations_in_Pax5_driven_ALL-sc-2011-01-12
Identification_of_driver_mutations_in_Pax5_driven_ALL
Analysis of ENU-induced mutations in a mouse       model of acute lymphoblastic leukemia. In this experiment we       treated mice heterozygous for the transcription factor Pax5 with       the mutagen ENU (N-ethyl-N-nitrosourea). These mice ultimately       developed progenitor B-cell disease. Here we have sequenced the       exomes of these tumors to identify driver mutations that       co-operate with mutant Pax5 in the development of B-cell       disease.This data is part of a pre-publication release. For       information on the proper use of pre-publication data shared by       the Wellcome Trust Sanger Institute (including details of any       publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Analysis of ENU-induced mutations in a mouse model of acute lymphoblastic leukemia. In this experiment we treated mice heterozygous for the transcription factor Pax5 with the mutagen ENU (N-ethyl-N-nitrosourea). These mice ultimately developed progenitor B-cell disease. Here we have sequenced the exomes of these tumors to identify driver mutations that co-operate with mutant Pax5 in the development of B-cell disease.