DNA_methylation_and_gene_expression_in_Dinoponera-sc-2013-05-15T14:23:46Z-2628
DNA_methylation_and_gene_expression_in_Dinoponera
These data are part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/ In this study we aim to assess the epigenetic and genome-wide expression changes accompanying caste differentiation in brain of the Dinoponera dinosaur ant. All the samples  are genome-wide ligation based proximity samples, as described in thes publication: Methods. 2012 Nov;58(3):268-76 and PLoS One. 2011;6(10):e26426.
We will associate gene expression changes with DNA methylation pattern in brain of  Queen and Worker castes of  Dinoponera . Dinosaur ant  primitive social organisation shows highter phenotype plasticity at adult stage compare to highly social organisation of bees (Patalano et al., Curr Opin Cell Biol. 2012 Jun;24(3):367-73). DNA methylation has been previously show to play a role in Worker versus Queen differentiation during larva stage (Kucharski et al., Science. 2008 Mar 28;319(5871):1827-3)but no study has yet associated the dynamic changes of DNA methylation and  gene expression with adult behaviour.