79689ffe-e21b-4f63-821c-09d7756425e3
Ghrelin treatment restores alpha-diversity of the colonic microbiome of bile duct-ligated mice
C57BL/6J mice with bile duct ligation (BDL) or sham surgery were treated with ghrelin or solvent for 9 days. Amplicon metagenomic sequencing was employed to analyze bacterial 16S rRNA from colonic stool samples.Reduced alpha-diversity of the microbiome was observed in solvent-treated mice with BDL but not in ghrelin-treated animals.
C57BL/6J mice with bile duct ligation (BDL) or sham surgery were treated with ghrelin or solvent for 9 days. Amplicon metagenomic sequencing was employed to analyze bacterial 16S rRNA from colonic stool samples.Reduced alpha-diversity of the microbiome was observed in solvent-treated mice with BDL but not in ghrelin-treated animals.