GSE172322
Genome-wide enhancer analysis reveals the role of AP-1 transcription factor in head and neck squamous cell carcinoma [RNA-Seq]
Head and neck squamous cell carcinoma (HNSCC) is one of the most common types of human cancer. It causes significant morbidity and mortality, with a low 5-year survival rate. we used RNA-Seq to analyze the tumor and normal tissues of the head of the Tgfbr1/Pten 2cKO mouse model. RNA-Seq analysis found enhanced keratinization, cell proliferation, angiogenesis, inflammation and immune response, TNF signaling pathway, NF-kappa B signaling pathway, and p53 signaling pathway in tumor tissues,which ultimately contribute to HNSCC progression. Overall design: mRNA profiles of the tumor and normal tissues of the head of the Tgfbr1/Pten 2cKO mouse model