GSE120282
RNA-sequence data of liver sinusoidal endothelial cells from control and endothelial RBPj-deficent mice with liver fibrosis
Endothelial notch signaling dominantly regulates liver physiology and pathology. To further explore the role and mechanisms of endothelial notch in modulating development and progression of liver fibrogenesis, we established endothelial RBPj conditinal knock-out mice to specifically block notch activity in endothelium. After development of CCl4-induced liver fibrosis, SECs from control and RBPj knock-out mice were isolated and processed for RNA-seq. Overall design: mRNA profiles of SECs in control and endothelial RBPj knock-out mice with liver fibrosis were generated by RNA sequencing, in triplicate, using Illumina HiSeq 3000