GSE137207
Pattern occupation of HDACs on chromatin determines PI3K/AKT inhibitor resistance in cancers [ChIP-seq]
Blocking BRD4 or HDACs induces paradoxically similar gene expression, comparably attenuates PI3K/AKT inhibitor resistance in multiple cancer cells. Overall design: To determine the distribution changes of H3K27-ac and BRD4 in PC-3-GDC-R cells (w/o iCBP112 and SAHA treatments), we performed ChIP-seq for H3K27ac and BRD4 in PC-3-control+vehicle, PC-3-GDC-R+vehicle, PC-3-GDC-R+iCBP112 and PC-3-GDC-R+SAHA cells.