GSE136158
CSF1R inhibitor-mediated microglial depletion prevents reductions in striatal volume, extracellular matrix alterations, and perineuronal net loss in a mouse model of Huntington's disease
This dataset allows for the exploration of gene expression of microdissected striatum from 11 week old wild-type and the R6/2 mouse model of Huntington's disease, in the presence or absence of microglia.  Microglia were depleted via dietary administration of the CSF1R inhibitor PLX3397 from 6 to 11 weeks of age. Overall design: R6/2 and Wild-type mice treated with vehicle or PLX3397 (275 ppm in chow), to deplete all microglia, from 7 to 11 weeks of age. Brains microdissected into striatum. 3 mice/group