GSE130248
The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1
We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity, and map the transcriptome-wide targets of wild-type TRIM71, NHL domain mutant TRIM71, and RING domain mutant TRIM71. Overall design: CRAC (crosslinking and analysis of cDNAs) analysis of Trim71 wild-type, NHL mutant and RING mutant in mouse embryonic stem cells.