GSE194220
Next Generation Sequencing Facilitates Quantitative Analysis of control, TNFa and TNFa+JNK I treated GSCs Transcriptomes
Among 830 TNFa-induced genes (at least 1.5 folds of upregulation in TNFa-treated TPC2-4 cells compared with control), the expression of 268 genes is significantly suppressed by JNKi treatment (TPC2-4 TNFa+JNKi/TPC2-4 TNFa, JNKi: JNK-IN-8, a kinase inhibitor specific for JNK (c-Jun N-terminal kinase) that inhibited phosphorylation of c-JUN) Overall design: The mRNA profiles of TPC2-4 con, TPC2-4 TNFa, TPC2-4 TNFa+JNKi