PRJNA415825
Sibling subtraction method in C. elegans
Investigation to identify suppressor mutations using in C. elegans, we developed an approach termed the Sibling Subtraction Method (SSM). This method works by eliminating variants present in both mutants and their non-mutant siblings, thus greatly reducing the number of candidates. SSM is a powerful approach for identifying causal mutations in any genetic background and provides an alternative to current methods.