ena-STUDY-XYY-123-06-12-2018-07:50:45:419-274
Effects of phycocyanin on modulating intestinal microbiota in mice
This study was conducted to investigate the effects of different dose of PC on modulating the intestinal microbiota and intestinal barrier in mice. Six-week-old male C57 BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention and the microbiota were analyzed by 16S rRNA high-throughput sequencing. The bacterial abundance and diversity increased after PC interventions. Saccharolytic bacteria of the Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, were increased by PC treatments. Rikenellaceae, hydrogen-producing bacteria were also increased after PC interventions. PC treatment reduced intestinal permeability and increased intestinal barrier function, demonstrated by hematoxylin-eosin staining and decreased serum lipopolysaccharides levels. And the modulate effects of intestinal microbiota were more favorable in the low dose PC group.
This study was conducted to investigate the effects of different dose of PC on modulating the intestinal microbiota and intestinal barrier in mice. Six-week-old male C57 BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention and the microbiota were analyzed by 16S rRNA high-throughput sequencing. The bacterial abundance and diversity increased after PC interventions. Saccharolytic bacteria of the Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, were increased by PC treatments. Rikenellaceae, hydrogen-producing bacteria were also increased after PC interventions. PC treatment reduced intestinal permeability and increased intestinal barrier function, demonstrated by hematoxylin-eosin staining and decreased serum lipopolysaccharides levels. And the modulate effects of intestinal microbiota were more favorable in the low dose PC group.