GSE124388
Cryptochromes-mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved signaling mechanism
Purpose: The goal of this study is to analyze the Cryptochrome-Cop1 axis in mammals Methods: mouse embryonic fibroblasts treated with dexamethasone, KL001 and/or Cop1 knockdown. Results: The transcriptomic analysis helps us to support our finding that the Cryptochromes-dependent repression of the glucocorticoid receptor is mediated by Cop1. Overall design: All samples generated by deep sequencing in triplicate