GSE196462
Differentially expressed genes in CMR-treated PANC-1 cells
To explore the potential mechanism through which CMR regulates PANC-1 cells, a transcriptome sequencing analysis was performed to profile the difference between CMR-treated cells and control cells. Two thousand six hundred seventy-two differentially regulated genes were identified, of which 1678 and 1872 were up- and down-regulated, respectively. Subsequently, we conducted a Gene Ontology (GO) analysis of CMR targets. The results indicated that these targets were broadly distributed in the cytoplasm, nucleus, endoplasmic reticulum, and Golgi apparatus. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis predicted that CMR was involved in various signaling pathways, including mammalian target of rapamycin (mTOR), PI3K-AKT, AMPK, MAPK, FoxO, VEGF, WNT, autophagy, apoptosis and so on. Overall design: Examination of different expressed genes in PANC-1 cells with or without CMR-treated.