E-MTAB-10212
RNA-seq of early pregnant (GD6.5) or non-pregnant uterine arteries from stroke-prone spontaneously hypertensive (SHRSP) and wistar kyoto (WKY) rats
Chronic hypertension during pregnancy affects both mother and infant but its pathological mechanisms are unclear. Due to ethical limitations human data is available in term tissue only- so deeper understanding of the vascular changes during early pregnancy are unknown. This study utilises a known rat model of chronic hypertension to study changes in gene expression at an early gestational time point. After 6 days of pregnancy animals were sacrificed and main uterine arteries harvested for RNA-Seq (or age-matched virgin rats as controls).
Chronic hypertension during pregnancy affects both mother and infant but its pathological mechanisms are unclear. Due to ethical limitations human data is available in term tissue only- so deeper understanding of the vascular changes during early pregnancy are unknown. This study utilises a known rat model of chronic hypertension to study changes in gene expression at an early gestational time point. After 6 days of pregnancy animals were sacrificed and main uterine arteries harvested for RNA-Seq (or age-matched virgin rats as controls).