GSE162095
Evaluation of the interplay between the ADAR editome and immunotherapy in melanoma
We evaluated the editome of melanoma cell lines generated from patients pre- and post-immunotherapy with immune checkpoint inhibitors by RNAseq. Our results reveal a differential editing in Alu sequences between samples pre-therapy and relapses during therapy with immune checkpoint inhibitors Overall design: RNA sequencing of 12 immunotherapy naive and 11 immunotherapy relapsed unpaired melanoma cell cultures was analysised for gene expression differences and RNA editome differences.