PRJNA772782
Somatic targeted mutation profiling of colorectal cancer precursor lesions
Most colorectal cancers (CRC) arise from precursor lesions. We aimed to characterize the mutation profile of 90 CRC precursor lesions in a Brazilian population by next-generation sequencing. The genetic ancestry of the patients was estimated. A high degree of ancestry admixture was observed in the population, with a predominance of European followed by African components. The mutation profile of Brazilian colorectal precursor lesions exhibits a similar landscape to other populations. These results bestow the knowledge of CRC's biologic history and may contribute to a molecular screening approach.