GSE134173
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance
RNA-seq analysis of the transcriptome of K562 cells in which PTPN2 or DCAF15 had been disrupted by CRISPR/cas9 gene editing. Overall design: K562 cells expressing cas9 were infected with lentiviruses expressing sgRNAs against a control gene, PTPN2 or DCAF15. Two weeks after sgRNA infection cells were plated at 0.33M cells/ml and either left alone or treated with 10ng/ml IFNg for 24hrs