ena-STUDY-UNIVERSITY HOSPITAL ZURICH-06-03-2018-11:37:44:388-2319
Transcriptomic data from ear pinnae tissue of 8 week-old wild-type and Card14delE138 mice
Card14 is encoded by a gene expressed predominantly in keratinocytes but also placenta and some immune cells. Mutations in this gene have been found to cause psoriasis and other skin diseases in human patients. Heterozygous mice harbouring a deletion of amino acid E138 in the Card14 gene (generated using CRISPR/Cas9 technology) results in transgenic mice that spontaneously develop a chronic psoriatic skin phenotype particularly on the ear and tail. RNAseq was performed to compare the transcriptome of 8 week-old heterozygous Card14delE138 mice against wild-type littermates.
Card14 is encoded by a gene expressed predominantly in keratinocytes but also placenta and some immune cells. Mutations in this gene have been found to cause psoriasis and other skin diseases in human patients. Heterozygous mice harbouring a deletion of amino acid E138 in the Card14 gene (generated using CRISPR/Cas9 technology) results in transgenic mice that spontaneously develop a chronic psoriatic skin phenotype particularly on the ear and tail. RNAseq was performed to compare the transcriptome of 8 week-old heterozygous Card14delE138 mice against wild-type littermates.