Whole_genome_sequencing_of_genetically_manipulated_Plasmodium_strains-sc-3618
Whole_genome_sequencing_of_genetically_manipulated_Plasmodium_strains
Experimental genetics approaches are routinely used to delete or alter specific genes within the genome of Plasmodium species, and the effect on parasite growth, metabolism and biology then measured using a range of in vitro and in vivo assays. In order to establish that any phenotype observed is the result of the specific mutation that has been engineered, whole genome sequencing is used to assess the presence of any additional mutations that may have accumulated during the culture and manipulation of the line in question. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Resequencing of modified standard lab strains of Plasmodium falciparum, P. knowlesi and P. berghei.