phs000489
Comprehensive Genomic Characterization of Human Glioblastoma
The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate our understanding of the molecular basis of cancer through the application of genome analysis technologies. Glioblastoma, the most common type of adult brain tumor, was the first cancer studied by TCGA. In this article, Comprehensive genomic characterization defines human glioblastoma genes and core pathways (The Cancer Genome Atlas Research Network, 2008; PMID: 18772890), tumors and matched-normal controls are used to identify aberrations in DNA copy number, sequence, methylation, and gene expression.  This dbGaP submission contains copy number variation and somatic single-nucleotide polymorphisms in 215 primary glioblastomas as well as clinical data. Other data in the article (The Cancer Genome Atlas Research Network, 2008) are not included in this submission but are available at the TCGA Data Portal, Comprehensive genomic characterization defines human glioblastoma... (for more see dbGaP study page.)