GSE201692
Evidence for toxic CAG trinucleotide repeats contributing to Huntington's disease though RNA interference
Mutant huntingtin CAG trinucleotide repeat mimetic hairpins are loaded into the RISC and kill cells through RNAi Overall design: NB7 cells were transfected with different HP mimicking two different mHTT variants or CAG contorl siRNAs. Subsequently, Ago protein associated short RNAs were pulled down using a GW182 peptide and subjected to smRNA Seq