GSE194203
Transcriptome changes in 11 organs after endogenous melatonin reduction
We knocked out the Aanat gene of mice by CRISPR CAS technology, and performed RNA-seq on brain, heart, liver, kidney, lung, skin, stomach, spleen, testis, skeletal muscle, and EWAT of 10-week-old wild-type(WT) and Aanat knockout(Aanat-/-) mice. Through the analysis of differentially expressed genes, we found the genes related to disease and tissue development. Finally, these differential genes were verified by qRT-PCR Overall design: 11 organs mRNA profiles of 10-week-old wild type (WT) and Aanat-/- mice