GSE171296
Introns encode dsRNAs undetected by RIG-I/MDA5/interferons and sensed via RNase L
RNA-seq of cytoplasmic RNAs in RNase L KO A549 cells shows increased intron load compared to WT cells. Overall design: WT and RNase L KO A549 cells treated with lipofectamine for 12h, cytoplasmic fraction was collected, followed by ribosome depletion and directional RNA-seq.