PRJNA449246
Whole-exome sequencing of 28 paired large cell lung cancer samples and  normal lung tissues
We report the identification of somatic mutations for large cell lung cancer in 28 tumor-normal pairs through exome sequencing. These genes were sequenced by whole-exome sequencing with a mean depth of 68.81×. There were a variety of types of mutations identified, with T > A transversion being the most common nucleotide substitution.After filter analysis and exclusion of synonymous mutations, the numbers of indels and non-synonymous SNVs were calculated. In addition to some previously reported mutations, such as those in TP53, APC, KRAS, and PIK3CA5, we identified a lot of point mutations only existed in large cell lung cancer.