GSE200842
Transcriptomic analysis of injured and uninjured knee joints from Trem2 KO mice [bulk RNA-seq]
Trem2 is a single-pass transmembrane receptor of the immunoglobulin superfamily and is primarily expressed in myeloid cells. Cells from injured and uninjured knee joints of wildtype C57BL/6 mice and Trem2 KO mice were sequenced to determine if Trem2 plays a role in macrophage differentiation or function after joint injury. Overall design: Right knee joints of 10-week-old C57BL/6 and Trem2 KO mice were injured using a tibial compression injury model. Uninjured and 7-day post-injury joints were collected and cells were analyzed using bulk RNA-seq.