GSE183487
Context-defined cancer co-dependency mapping identifies a functional interplay between PRC2 and MLL-MEN1 complex in lymphoma
This work highlights the versatility of combining genetic screens with molecular profiling of cancer cells for high-throughput genetic interaction discovery that will not only offer critical insight into basic regulatory mechanisms of cancer epigenome progression, but also lead to new therapeutic targets for genetically defined and epigenetically perturbed cancers. Overall design: 32 RNA-seq samples; 41 CUT&Tag samples; 4 CRISPR screen samples