GSE121782
Transcriptome Data of SREBP2(N) Overexpression in Human Umbilical Vein Endothelial Cells
Sterol regulatory element-binding protein 2 (SREBP2) is a transcription factor that has been recently discovered to mediate vascular endothelial cell (EC) dysfunction. We therefore investigated the role of SREBP2 in EC function through comparing the transciptional profiling of human umbilical vein endothelial cells (HUVECs) that were infected with adenovirus overexpressing SREBP2 (Ad-SREBP2) or with empty vector (Ad-null) control.  Gene ontology analysis revealed that SREBP2 not only regulates cholesterol biosynthesis, but also mediates the TGF, WNT, and cytoskeleton remodeling pathways.  Among the responsive genes, SREBP2 exhibited the induction of mesenchymal transition. Overall design: Transcriptome data of HUVECs overexpressing SREBP2 using adenovirus followed by deep sequencing, in biological duplicate, using Illumina NextSeq 500.