88cc9433-1f48-46bd-813e-6c3b11639837
Gut dysbiosis contributes to NASH in a pig model
Eight weeks of CDAHFD resulted in a significantly altered colon microbiota mainly driven by the bacterial families Lachnospiraceae and Enterobacteriaceae, being decreased and increased in abundance, respectively. CDAHFD decreased colon content of SCFA and increased colonic pH. In addition, serum imidazole propionate was significantly elevated as a consequence of CDAHFD feeding. Hepatic gene expression analysis indicated upregulation of ras homolog enriched in brain and mechanistic target of rapamycin (mTOR) and downregulation of insulin receptor substrate 1 and insulin receptor substrate 2 in CDAHFD fed minipigs. Furthe consequences of CDAHFD was increased serum cholesterol, increased serum bile acids (BA) and hyperglucagonemia, but not hyperaminoacidemia.
Eight weeks of CDAHFD resulted in a significantly altered colon microbiota mainly driven by the bacterial families Lachnospiraceae and Enterobacteriaceae, being decreased and increased in abundance, respectively. CDAHFD decreased colon content of SCFA and increased colonic pH. In addition, serum imidazole propionate was significantly elevated as a consequence of CDAHFD feeding. Hepatic gene expression analysis indicated upregulation of ras homolog enriched in brain and mechanistic target of rapamycin (mTOR) and downregulation of insulin receptor substrate 1 and insulin receptor substrate 2 in CDAHFD fed minipigs. Furthe consequences of CDAHFD was increased serum cholesterol, increased serum bile acids (BA) and hyperglucagonemia, but not hyperaminoacidemia.