GSE114051
Discovery of a Drug Candidate for GLIS3-Associated Diabetes
Through development and use of a minimal component protocol for derivation of late stage pancreatic progenitors and beta-like cells, we compared WT and GLIS3-/- pancreatic cells at different stages and discovered that GLIS3-/- cells show an ectopic activation of TGF-beta signaling. Overall design: Comparison of WT and GLIS3-/- cells at various stages of human pancreatic differentiation