GSE115999
Gene expression changes upon depletion of H3K36 methylation by mutating met-1 and RNAi depleting mes-4 in worm L1 larvae
We compared wild type N2 fed L4440 control RNAi to met-1 mutants fed mes-4 RNAi food. Genes tend to be upregulated rather than downregulated in these mutants. Comparison to available ChIPseq datasets indicates that the upregulated genes are heterochromatic and are not enriched for H3K36 methylation, indicating that H3K36me loss derepresses heterochromatin indirectly. Overall design: Comparison of 2 independent biological replicas