GSE184628
T-bet Suppresses TGF-b-independent Gut-resident Memory CD8+ T Cell Differentiation [ATAC-seq]
TGF-beta signaling is required for the differentiation of gut-resident memory CD8 T cells. Here, we showed that the deficiency of transcription factor T-bet partially rescued the differentiation of TGF-beta receptor deficient gut-resident memory CD8 T cells. Overall design: Congenically marked naïve P14 TCR transgenic CD8 T cells were adoptively transferred into sex-matched C57BL/6 recipients followed by LCMV Armstrong infection. P14 T cells with different phenotypes were FACS sorted from both spleen and small intestine intraepithelial lymphocyte compartment. Please note that processed data was generated from all replicates and is linked to the corresponding rep1 sample records.