ena-STUDY-Department of Dental Medicine (DENTMED), OF, Karolinska Institutet-04-06-2018-11:08:51:878-56
Salivary Oral Microbiome Signatures in Severe Congenital Neutropenia
Severe congenital neutropenia (SCN), is a rare autosomal recessive genetic disorder that is characterized by low absolute neutrophil counts (ANC) (<0.5×10E9/l) in the peripheral blood which can be managed by treatment with recombinant granulocyte-colony stimulating factor (G-CSF). Although, the most patients benefit from G-CSF therapy, they frequently present with recurrent infections including periodontal disease. The aim of the present study was to evaluate salivary oral microbiome in patients with SCN.
Severe congenital neutropenia (SCN), is a rare autosomal recessive genetic disorder that is characterized by low absolute neutrophil counts (ANC) (<0.5×10E9/l) in the peripheral blood which can be managed by treatment with recombinant granulocyte-colony stimulating factor (G-CSF). Although, the most patients benefit from G-CSF therapy, they frequently present with recurrent infections including periodontal disease. The aim of the present study was to evaluate salivary oral microbiome in patients with SCN.