GSE163413
Terminally differentiated CD4+ T cells promote myocardial inflammaging
We generated a xenograft transplantation model in which young humanized mice were treated to harbor a senescent-like human CD4+ T cell compartment. Our data uncover a role for terminally differentiated T cells in promoting cardiac inflammaging. Overall design: Whole transcriptome profiles of hearts of NSG-DR1 mice comparing the control condition with the condition after human CD4+ T-cell transplantation. RNA was sequenced on the NextSeq-500 platform with ~55 million reads per sample in paired-end mode with 75 nt read length