GSE201678
Dissecting genetic components associated with eye disease using integrative genomic analysis [Capture HiC]
GWAS studies have revealed thousands of variants strongly associated with AMD, yet connecting these variants to their cognate genes has not been explored. In this study we fine-mapped AMD risk loci and examined long-range cis chromatin interactions at essential genes of RPE function and disease-associated variants in iPSC-induced retinal pigmented epithelium (RPE) and primary RPE. Overall design: Capture HiC from iPSCs (2 replicates), iPSC-induced RPE (2 replicates).