GSE195891
Single cell RNA-seq of immune cells in multiple mouse models of outer retinal degeneration
The goal of this study focues on comparing the molecular signatures of immune cells, primarily microglia, in ectopically distinct mouse models of outer retinal degeneration. These models include the sodium iodate induced RPE injury model, rhodopsin-P23H knockin mice, an advanced aging model of 2-year-old mice and young (2-month old) wild-type control mice. Overall design: Profiling of retinal immune cells in mouse models of outer retinal degeneration