GSE173537
Blood cells with trisomy 21 overreact to heat shock stress [PRO-seq]
Lymphoblastoid cells trisomic for chromosome 21 activate the heat shock response more robustly than disomic cells. Overall design: D21 and T21 lymphoblastoid cells derived from EBV infection of B cells from two brothers were assayed before and after heat shock using ATAC-seq, PRO-seq and scRNA-seq. Heat shock was 42C for 1 hour. This dataset includes the PRO-seq data.