GSE75472
Genome-wide analysis of differential gene expression after treatment of the PLCe inhibitor U73122 in colorectal CD110+TICs
Analysis of PLCe-regulation of tyrosine metabolism at gene expression level. The hypothesis tested in the present study was that the PLCe pathway-directed transcriptional control play a key role for metabolic reprogramming in CD110+TICs after Kras extinction. Results provide important information of the response of colorectal CD110+TICs to inhibition of the PLCe pathway, such as specific stress-responsive genes, up- or down-regulated specific anabolic/catabolic cellular functions. Overall design: Total RNA obtained from isolated CD110+TICs subjected to 24 hours in vitro U73122 (1µM) treatment compared to untreated control cells.