Exome_sequencing_of_the_pinky_mouse-sc-2011-01-11
Exome_sequencing_of_the_pinky_mouse
Exome sequencing of the pinky mouse. We have isolated a mouse line that features corpus callosum agenesis. In this experiment we will sequence the exome of this mouse in an attempt to discover the causal mutation.. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
The pinky mouse was detected during a neuroanatomical screen of ENU mutagenised pedigrees focusing on defects of the hippocampus, cortex, corpus callosum and ventricles. The aim of this screen is to find novel mutations associated with mental retardation and other disorders with a neuroanatomical and ultimately genetic pathological basis. The pinky mouse features agenesis of the corpus callosum making it a candidate. Identifying mutation will potentially inform as to the molecular etiological basis of the malformation during brain development.