GSE135510
Gene expression analysis following depletion of LOXL2 in esophgeal cancer cells
Esophageal cancer is the sixth most common cause of cancer death globally, of which esophageal squamous cell carcinoma (ESCC) is the most common histological subtype. High level expression of LOXL2 has been shown to be associated with tumor metastasis and poor clinical outcome in ESCC. To determine whether there are genes whose expression in ESCC cells is regulated by LOXL2, next generation RNA sequencing analysis was used to compare the RNA expression profile of KYSE510 cells before and after silencing LOXL2 expression. Overall design: RNA-sequencing of LOXL2 silencing and control ESCC KYSE510 cells was performed in triplicate using the BGISEQ-500 platform.