PRJNA527717
Rattus norvegicus Raw sequence reads
Nowadays, sepsis and septic shock have become major public health problems, which are the main cause of death among patients admitted to the intensive care units. Notably, myocardial dysfunction during sepsis, usually called sepsis-induced myocardial depression, is common in septic shock patients whose incidence is about 70% and leads to a high mortality. However, the mechanism underlying the septic myocardial depression is still unclear. Recent studies suggested noncoding RNAs (ncRNAs) could regulate the process of sepsis-induced myocardial depression. But the role of transcriptome in myocardial depression is unknown, and all kinds of ncRNAs as well as messenger RNAs (mRNAs) present in sepsis-induced myocardial depression have never been sequenced. Therefore, we performed the rat models of sepsis-induced myocardial depression and investigated ncRNAs and mRNAs expression profiles in heart tissue between sepsis and control group using whole-genomic next-generation sequencing.