GSE130538
Distruption of TOX and TOX2 transcription factors in CAR T cells limits T cell exhaustion [RNA-Seq]
We comapre mRNA expression level TOX and TOX2 CAR TILS and WT CAR TILs Overall design: 5x105 B16-OVA-huCD19 tumor cells were inoculated into C57BL/6N mice, the mice were adoptively transferred with the indicated CAR T cells (1.5x106) 12 days later, and GFP+CD8+Thy1.1+ CAR T cells were sorted on day 24 from tumors