Foal Immunodeficiency Syndrome Sequence Capture and Sequencing
Identification of a mutation related to fatal Foal Immunodeficiency Syndrome in the Fell and Dales pony
Study designed by School of Veterinary Science, University of Liverpool and the Animal Health Trust, Newmarket and funded by the Horse Trust. Samples provided by the Fell and Dales Pony Societies and their members. Sequencing performed by Centre for Genomic Research, University of Liverpool.
The lethal Mendelian disease Foal Immunodeficiency Syndrome (FIS), which manifests as B-lymphocyte immunodeficiency and progressive anaemia (Scholes et al. 1998), is a substantial threat to Fell and Dales ponies. We have mapped and sequenced the underlying locus in five individuals.