GSE208759
DNA methyltransferases are complementary in maintaining DNA methylation in embryonic stem cells
To investigate the cooperative function DNMTs in the maintenance of DNA methylation at the ICRs, we established mutant ES clones lacking three major DNA methyltransferases (DNMTs). Overall design: We performed WGBS for a series of D1911 mouse embryonic stem cells: wildtype (WT),DNMT1 knockout,UHRF1 knockout, DNMT3A and DNMT3B double knockout (DKO), DNMT triple knockout (TKO), We perform WGS with the 129SvEv maouse tail DNA.