phs001663
Analysis of Histological, Genomic, Molecular, and Clinical Factors in CNS Cancer: The Neuro-Oncology Group
Whole genome and exome-based DNA sequencing of germline and tumor specimens from serial samples of patients with glioblastoma. The data set includes several metastases and recurrences from a patient with germline POLE-deficiency. The data reveal extensive tumor heterogeneity, clonal evolution, and genomic responses to immunotherapy.