GSE201641
RNA Seq analysis of WT vs rv3249c mutant
We report the characterization of an Mtb transcriptional regulator Rv3249c (AlkX). Combined, our results define the primary role of AlkX as a transcriptional repressor of the alkBrubAB operon and suggests the operon contributes to intracellular survival of the pathogen and potential persistence phenotypes. Overall design: RNAseq analysis of was performed on the wild-type H37Rv and mutant strains of M. tuberculosis grown planktonically