GSE107608
Expression difference between stem cell Krt6a+ and differentiated cell WAP+ in mammary precancerous early lesions
The stem cell hierarchy of normal tissues has been studied extensively for cancer origin, but the stem cell hierarchy of precancerous lesions and its contribution to tumorigenesis remain elusive.  Here, we report that in MMTV-Wnt1 transgenic mice, mammary precancerous lesions harbor both keratin 6a+ precancerous stem cells (pcSC) and more differentiated whey acidic protein (WAP)+ cells. The goal of these data was to understand expression differences between different subsets of cells in mammary precancerous early lesions. There are two cell lines Krt6a+ cells (stem cells) and WAP+ cell (more differentiated cells) from hyperplastic mammary glands in MMTV-Wnt1 mice. Overall design: Compare the expression between Krt6a+ cells and WAP+ cells.