E-MTAB-9079
Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia
Our study illustrates the leukemic role of deregulated NKL homeobox genes HMX2 and HMX3 revealing molecular mechanisms of differentiation arrest in AML.Whole genome sequencing of EOL-1 identified two mutations in the regulatory upstream regions of HMX2/3 resulting in the generation of a novel ETS-site and transformation of a former NFkB-site into an SP1-site.
Our study illustrates the leukemic role of deregulated NKL homeobox genes HMX2 and HMX3 revealing molecular mechanisms of differentiation arrest in AML.Whole genome sequencing of EOL-1 identified two mutations in the regulatory upstream regions of HMX2/3 resulting in the generation of a novel ETS-site and transformation of a former NFkB-site into an SP1-site.