E-MTAB-11292
mitoRibo-seq and RNA-seq of parental and MRM2 knockout HEK 293T Flp-In T-REx cells
Methyltransferase MRM2 methylates the 2'-hydroxyl group of ribonucleotide U1369 of human 16S mt-rRNA. Mutations in MRM2 have been implicated in human mitochondrial-related disease. This study investigates the role of MRM2 in the biogenesis and function of human mitochondrial ribosomes. Absence of MRM2 leads to a severe defect in mitochondrial translation, with the mtLSU being trapped in immature assembly states.
Methyltransferase MRM2 methylates the 2'-hydroxyl group of ribonucleotide U1369 of human 16S mt-rRNA. Mutations in MRM2 have been implicated in human mitochondrial-related disease. This study investigates the role of MRM2 in the biogenesis and function of human mitochondrial ribosomes. Absence of MRM2 leads to a severe defect in mitochondrial translation, with the mtLSU being trapped in immature assembly states.