GSE185226
MYDGF Deficiency Exacerbates Mitotic Catastrophe of Podocytes in Glomerular Disease
Podocytes, highly differentiated glomerular epithelial cells, are essential for the maintenance of glomerular filtration barrier. Podocyte dysfunction in podocytes is a major determinant of proteinuric kidney disease. By RNA sequencing analysis in ADR-treated podocytes with or without MYDGF overexpression, we observed the significant changes of genes important in regulating cell cycle in podocytes with ADR treatment. Overall design: The gene expression of 4 samples from a 24 h Adriamycin (ADR) induced NC-MYDGF or AD-MYDGF podocyte cell line was compared to 4 untreated samples by RNA sequencing.