GSE135590
mRNA-seq data for mouse ovarian tumors arising from oviduct with combinations of (Tamoxifen-inducible) inactivation of Brca1, Trp53, Rb1, and Nf1, or Apc and Pten, and normal ovaries and oviducts.
We engineered mice to have Ovgp1 promotor-driven expression of a tamoxifen-inducible Cre recombinase (iCre-ERT2), which inactivated the function of combinations of engineered floxed alleles of combinations of tumor suppressor genes in mouse oviducts (Fallopian tube) when mice were treated with tamoxifen. 21 samples were from oviductal tumors from mice with combinations of floxed alleles of Brca1, Trp53, Rb1, and/or Nf1 (BPRN mice), of which we analyzed 19. 6 samples were from oviductal tumors of mice with floxed alleles of Apc and Pten. 4 control samples were from pooled ovaries from BPRN mice that were not tamoxifen treated, and 4 other control samples were similar pools from mouse oviducts. Our goal was to investigate the similarity of these mouse models of ovarian cancer with different subgroups of human ovarian cancer. We provide raw read data, mapped count data for genes and transcripts, several normalizations of the count data, and supplementary files that contain our first analyses, and may be convenient for consumers wanting to investigate details about their favorite genes. The supplementary files are briefly described in our supplementary file Readme_GEOsupplements_s0.txt. Overall design: We engineered mice to have Ovgp1 promotor-driven expression of a tamoxifen-inducible Cre recombinase (iCre-ERT2), which inactivated the function of combinations of engineered floxed alleles of combinations of tumor suppressor genes in mouse oviducts (Fallopian tube) when mice were treated with tamoxifen. 21 samples were from oviductal tumors from mice with combinations of floxed alleles of Brca1, Trp53, Rb1, and/or Nf1 (BPRN mice), of which we analyzed 19. 6 samples were from oviductal tumors of mice with floxed alleles of Apc and Pten. 4 control samples were from pooled ovaries from BPRN mice that were not tamoxifen treated, and 4 other control samples were similar pools from mouse oviducts.