GSE203131
NIMA Related Kinase 7 reduction mediates acetaminophen-induced acute liver injury: role of impaired cell cycle regulation
Explored and demonstrated a new function of NEK7 in the liver against APAP-induced acute liver injury probably by dysregulating cyclins and disturbing cell cycle progression. Overall design: Comparative gene expression profiling analysis of RNA-seq data for liver tissue from NEK7 whole body knockout mice with tamoxifen inducibility (iKO_1, iKO_2, iKO_3) and wild type mice (Ctrl1, Ctrl2, Ctrl3).