PRJNA675665
CircRNA expression profile unites WGCNA to reveal key genes associated with immune cell infiltrates in different TNM stages of colorectal cancer
To investigate the circRNA expression pattern in colorectal cancer (CRC) and explore the key circRNA in lymphatic infiltrated in CRC. A total of 314 DEcircRNAs were obtained, among them, 177 circRNAs differentially expressed between early-stage (I, II) and advanced stage (III, IV). The has_circ_0001647, has_circ_0087960, has_circ_0000745 were down-regulation in CRC and significantly correlated with several immune cell infiltrates level. Especially, hsa_circ_0087960 expression was positively correlated with infiltration level of NK, Th17, B cell, and Tfh cells, while negatively correlated with infiltration level of nTreg, Tr1, Tgd and iTreg. The hsa_circ_0000745 expression was respective positively and negatively correlated with infiltration level of Th17and Tgd cells. The hsa_circ_0001647 expression negatively correlated with infiltration level of nTreg and positively correlated with infiltration level of NK, B cell, and Tfh cells.