GSE161077
CD49f defines a subset of dysfunctional regulatory T cells circulating in the human peripheral blood
Integrin CD49f has been reported to modulate various aspects of T cell biology including cell differentiation, migration and functionality.  Here we define CD49f as a marker for a subset of dysfunctional human effector Tregs expressing a Th17-like profile in the blood of patients with active inflammatory bowl disease. Overall design: RNA profiles of CD49f high and low Tregs extracted from healthy donor peripheral blood mononuclear cells (PBMC).