GSE195632
The METTL3 RNA methyltransferase regulates gene expression in castrate resistant LNCaP:C42 prostate cancer cells
RNA sequencing was used to determine the effect of the STM2457 METTL3 inhibitor on prostate cancer cell gene expression. Overall design: Enzalutamide sensitive LNCaP:C42 were treated with vehicle control (DMSO) or STM2457 (10µM) for 48 hours and the effect on basal gene expression and alternative splicing determined using RNA sequencing.