GSE192578
Small Noncoding RNAome Changes during Human Bone Marrow Mesenchymal Stem Cells Senescence
The proliferation capability and functionality of BMSCs are known to decline with aging, which severely impairing the extensive applications of BMSCs-based therapies. In this study, replicative senescence model of hBMSCs was established and the expression changes of small noncoding RNAs during senescence was detected by small RNA high-throughput sequencing analysis and qPCR. Overall design: We subcultured hBMSCs and collected P1 and P10 hBMSCs respectively.The small RNA sequence detected expression of small RNA in P1 and P10 hBMSCs