PRJNA510917
Germline panel sequencing of breast cancer patients
The aim of our study was to set up a panel for targeted sequencing of chemoresistancegenes and the main transcription factors driving their expression and to evaluate their predictive and prognostic value in breast cancer patients. Coding and regulatory regions of 509 genes, selected from PharmGKB and Phenopedia, were sequenced using massive parallel sequencing in blood DNA from 105 breast cancer patients in the testing phase.