ena-STUDY-TEAGASC-04-07-2018-20:50:49:130-1840
Moderate-intensity aerobic and resistance exercise is safe and favourably influences body composition in patients with quiescent Inflammatory Bowel Disease. A randomized cross-over trial
Background and Aims: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. Therefore, we aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.     Methods: A randomized, cross-over trial of 8-weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age (?Standard Deviation) of 25 (?6.5) years and Body Mass Index of 28.9 (?3.8) were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota composition determined using metagenomic sequencing.  Results: Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline estimated VO2max: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p=0.03). Improvement in body composition was achieved by the intervention group (n=13) with a median decrease of 2.1% body fat compared with the non-exercising group (n=7) (0.1% increase; p=0.022). Lean tissue mass increased by a median of 1.59kg and fat mass decreased by a median of 1.52kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. Minimal alterations in the ?- and ?-diversity of gut microbiota and associated metabolic pathways were evident.  Conclusions: Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects.
Background and Aims: Overweight and metabolic problems now add to the burden of illness in patients with Inflammatory Bowel Disease. Therefore, we aimed to determine if a program of aerobic and resistance exercise could safely achieve body composition changes in patients with Inflammatory Bowel Disease.     Methods: A randomized, cross-over trial of 8-weeks combined aerobic and resistance training on body composition assessed by Dual Energy X-ray Absorptiometry was performed. Patients in clinical remission and physically inactive with a mean age (?Standard Deviation) of 25 (?6.5) years and Body Mass Index of 28.9 (?3.8) were recruited from a dedicated Inflammatory Bowel Disease clinic. Serum cytokines were quantified, and microbiota composition determined using metagenomic sequencing.  Results: Improved physical fitness was demonstrated in the exercise group by increases in median estimated VO2max (Baseline estimated VO2max: 43.41mls/kg/min; post-intervention: 46.01mls/kg/min; p=0.03). Improvement in body composition was achieved by the intervention group (n=13) with a median decrease of 2.1% body fat compared with the non-exercising group (n=7) (0.1% increase; p=0.022). Lean tissue mass increased by a median of 1.59kg and fat mass decreased by a median of 1.52kg in the exercising group. No patients experienced a deterioration in disease activity scores during the exercise intervention. Minimal alterations in the ?- and ?-diversity of gut microbiota and associated metabolic pathways were evident.  Conclusions: Moderate-intensity combined aerobic and resistance training is safe in physically unfit patients with quiescent Inflammatory Bowel Disease and can quickly achieve favourable body compositional changes without adverse effects.