PRJNA802395
Tracing the Origin and Evolution of Mycophenolic Acid Biosynthesis in Fungi
Mycophenolic acid (MPA) is a natural meroterpenoid well documented for inhibiting inosine monophosphate dehydrogenase involved in de novo purine synthesis. Because of this critical metabolic effect in human T and B lymphocytes, MPA is used as an immunosuppressive agent, mostly in the framework of solid organ transplantations.