Schistosoma_mansoni_sex_specific_genome_sequencing-sc-4278
Schistosoma_mansoni_sex_specific_genome_sequencing
The Z and W chromosomes of the Schistosoma mansoni genome have consistently assembled into a haploid mosaic consensus that doesn't represent the true sequence of either chromosome.  This is due to many regions of near-identical sequences, plus large numbers of complex repeats.  The published draft had 294 Mb (81%) of the data assigned to chromosomes. Information from a genetic map has enabled some of the genome to be assigned to ZW.  However, ZW remains largely undifferentiated in the assembly, and the repetitive W-specific regions remain largely unassembled.  This study aims to isolate genomic DNA from male and female adults and generate seperate female and male-specific PacBio libraries.  This data will be used to improve the ZW chromosomes.  This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Elucidating the sex chromosomes of Schistosoma mansoni using Pacbio sequencing.