Mouse DBA/2J Genome Sequencing Project
A Second Mouse Genome:  De Novo Assembly of  Strain DBA/2J
Genetic reference panels of inbred mice, such as the large family of BXD strains (n = 80 member strains), have been used to investigate differences in susceptibility to a large numbers of pervasive and common diseases (see www.genenetwork.org for data access). The genome of one parent (C57BL/6J) of the BXD family has been sequenced and serves as a reference genome for virtually all mouse biology. In this project we have generated complete sequence data for the genome of the other parent of the BXD family--the DBA/2J strain. DBA/2J is one of the oldest inbred lines of mice with ancestry that traces back almost precisely 100 years. Our consortium has used Solexa and ABI SOLiD sequencing platforms to generate approximately 12 and 26x whole-genome shotgun per platform, respectively.  These sequence data and compendium of the sequence variants will be used to community of researchers who study complex traits in mouse models.
Whole Genome Sequencing of Mouse DBA/2J by Robert W. Williams, Xusheng Wang, William Taylor, Donald Thomason, Daniel Ciobanu, Stanley F Nelson, Zugen Chen, Deanna Church, Richa Agarwala, and colleagues