GSE134608
RNA-seq analysis of the effects of single and compound deletion of Moz (Kat6a) and/or Dlx5 during mouse craniofacial development
The purpose of these data is to investigate the genetic perturbations which underlie the cleft palate phenotype in Kat6a and Dlx5 mutant mouse embryos. The palate develops from the maxillary portion of the first pharyngeal arches, commencing between E10.5 and E11.5 of mouse gestation. Overall design: The pharyngeal arches were taken from E10.5 female mouse embryos for each of the following genotypes: wild type (WT), Kat6a heterozygous knockout (KO), Dlx5 heterozygous KO, Kat6a and Dlx5 heterozygous KO, Dlx5 homozygous KO, Kat6a homozygous KO. There are four biological replicates for each genotype, giving a total of 24 samples. Batch effects, which were corrected for, arose from samples being derived from two different mouse facilities.