GSE161475
High dose IFN-?? activates GAF to enhance expression of ISGF3 target genes in epithelial cells
GAF is transcriptionally inactive in epithelial cells but enhances expression of ISGF3 target genes, thus functioning as a dose-sensitive amplifier of the IFN-?? response. Overall design: Sequencing data from MLE-12 murine lung epithelial cell line, stimulated with interferon ?? or ??: STAT1 ChIP-seq (19 samples), mRNA-seq (53 samples).