ena-STUDY-Pfizer-University of Granada-Junta de Andalucia Centre for Genomics and Oncological Research (GENYO)-31-05-2021-17:53:47:908-531
DNA Methylation signature in mononuclear cells and proinflammatory cytokines in Meniere Disease
Meniere Disease (MD) is a rare inner ear disorder characterised by episodic vertigo associated with sensorineural hearing loss, tinnitus and/or aural fullness. Two subtypes are described regarding the patient's IL-1ß basal levels: high (MDH) or low (MDL), which suggests different disease mechanisms. The DNA methylation is involved in stable programming of gene regulation and in mediating long-term effects on genome function.In this study, Whole Genome Bisulfite Sequencing (WGBS) was performed using peripheral blood mononuclear cells (PBMC) from 7 MDH, 7 MDL and 6 healthy controls to identify MD methylation patterns and potential disease mechanisms.
Meniere Disease (MD) is a rare inner ear disorder characterised by episodic vertigo associated with sensorineural hearing loss, tinnitus and/or aural fullness. Two subtypes are described regarding the patient's IL-1ß basal levels: high (MDH) or low (MDL), which suggests different disease mechanisms. The DNA methylation is involved in stable programming of gene regulation and in mediating long-term effects on genome function.In this study, Whole Genome Bisulfite Sequencing (WGBS) was performed using peripheral blood mononuclear cells (PBMC) from 7 MDH, 7 MDL and 6 healthy controls to identify MD methylation patterns and potential disease mechanisms.