GSE202990
Evidence for a unique RNA motif in orchestrating Orthomyxoviridae splicing
Our laboratory has generated evidence that Archaean L7Ae serves as a unique inhibitor of orthomyxovirus splicing, and as such, can inhibit replication of this class of viruses. Here, we utilize RNA-sequencing to analyze how Archaean L7Ae impacts the transcriptome of a human cell line. Results showed that L7Ae had minimal impact on host transcriptonal response despite retaining its properties to inhibit orthomyxovirus replication. Overall design: Comparative differential expression data between 293T cells that were transfected with pCAGGS-eGFP (control) or pCAGGs-L7ae (experimental) and harvested 24 hours post transfection