GSE184552
Engineering CAR-NK cells to secrete IL15 sustains their anti-AML functionality, but is associated with systemic toxicities
Chronic stimulation with Acute Myeloid Leukemia can induce dysfunction in NK and CAR-NK cells. We evaluated transcriptomic differences on the day 10 of chronic antigen stimulation in NK cells secreting IL15 compared to non-secreting NK cells Overall design: Bulk RNAseq of  4 engineered NK cell conditions (2B4.? - 2B4.?.sIL15- sIL15-untransduced (UTD)) from 3 different donors Contributor: SKCCC RNAseq core