GSE99442
Genome-wide nuclesome occupancy following HDAC1,2 inhibitor treatment
The goal of this study is to identify nucleoosme occupancies in leukemic cells treated with HDAC1,2 inhibitor Overall design: SupB15 cells were treated with 2uM ACY0135 for 62hr. SupB15 cells were mixed with Drosophila S2 cells at a ratio of 4:1. Mnase digestion was performed as described in the manuscript. The sequencing was perfomed with 3 DMSO control samples and 3 ACY1035 treated samples.