GSE109765
The Transgenerational Effects of Prenatal Synthetic Glucocorticoids on the Hippocampus Cortex
First generation animals (F1) were exposed to multiple courses of synthetic glucocorticoids in utero. Animals were then bred to produce second (F2) and third (F3) generation offspring. These animals underwent behavioural assessmenets before sacrifice. In this experiment the prefrontal cortex for F1, F2, and F3 female animals, as well as F1 males (Control and sGC) have been extracted via micro-punch and RNA has been extracted. Overall design: Methylation Analyses: F1: Control N=6, sGC N=6; F2: Control N=6, sGC N=6; F3: Control N=7, sGC N=5; RNA-Seq Analyses: F1: Control N=6, sGC N=5; F2: Control N=6, sGC N=6; F3: Control N=6, sGC N=7