ena-STUDY-EUROPEAN RESEARCH INSTITUTE FOR THE BIOLOGY OF AGEING, UNIVERSITY OF GRONINGEN, UNIVERSITY MEDICAL CENTER GRONINGEN-01-09-2017-12:25:43:568-105
Chip-seq study for the genome-wide identification of CBX7 binding sites in CBX7 overexpressing CD34+ cellChip-seq study for genome-wide mapping of H3K9me3 and H3K27me3 in CD34+ cord blood cells upon overexpression of Polycomb CBX7 and Polycomb CBX8
Our study indicates that CBX7 regulates self-renewal of human HSC and is essential for leukemic cells suggesting that CBX7 qualifies as a new target protein in AML. CBX proteins have been described as readers of H3K27me3. Our identification of CBX7 binding H3K9 writers containing a trimethylated lysine suggests a novel role for CBX proteins, allowing crosstalks with other epigenetic repressing pathways.
Our study indicates that CBX7 regulates self-renewal of human HSC and is essential for leukemic cells suggesting that CBX7 qualifies as a new target protein in AML. CBX proteins have been described as readers of H3K27me3. Our identification of CBX7 binding H3K9 writers containing a trimethylated lysine suggests a novel role for CBX proteins, allowing crosstalks with other epigenetic repressing pathways.