GSE191115
ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to suppress stress-related ferroptosis
The goal of this study is to provide the liver metabolic changes in the liver specific Atf4 knockout MUP-uPA (MUP-uPA/Atf4?hep) mice and understand the function of ATF4 in the stressed liver Overall design: RNAs were extracted from livers of 6 week-old Wild Type (Atf4F/F), Atf4?hep, MUP-uPA/Atf4F/F, and MUP-uPA/Atf4?hep for RNA-seq analysis.