PRJNA549711
ZNF529 knockdown in HEPG2
In our genome-wide association studies, a novel loss-of-function variant in ZNF529 was associated with decreased levels of circulating LDL-C. To experimentally assess the consequence of ZNF529 loss-of-function, we transiently knocked-down expression of ZNF529 in human hepatoma HepG2 cells using siRNA and performed RNA sequencing