ena-STUDY-LEIDEN UNIVERSITY MEDICAL CENTER-18-12-2017-20:22:26:838-55
PIGA mutations in T-cell clones isolated from recipients who received alemtuzumab-based T-cell depleted allogeneic stem cell transplantation and from a healthy donor
PIGA mutations in T-cell clones isolated from recipients who received alemtuzumab-based T-cell depleted allogeneic stem cell transplantation and from a healthy donor. A highly polyclonal mutational landscape in the PIGA gene results in loss of CD52 expression from the T-cell membrane due to loss of GPI-anchor expression.
PIGA mutations in T-cell clones isolated from recipients who received alemtuzumab-based T-cell depleted allogeneic stem cell transplantation and from a healthy donor. A highly polyclonal mutational landscape in the PIGA gene results in loss of CD52 expression from the T-cell membrane due to loss of GPI-anchor expression.