GSE210439
Quiescent ovarian cancer cells, in response to chemotherapy, secrete follistatin to induce chemotherapy resistance in surrounding cells.
We sought to identify mechanism of NFATC4 quiescence-driven chemoresistance. RNA-Seq identified upregulation of follistatin (FST) in quiescent OvCa cells. Overall design: Comparative gene expression profiling analysis of HEY1 and SKOV3 cell lines expressing the IcNFATC4 or ILUC constructs were treated for 24, 48 and 96h with 100 ng/mL doxycyclin