Transmission_of_C__difficile_in_the_Netherlands-sc-5211
Transmission_of_C__difficile_in_the_Netherlands
Patients asymptomatically colonized by C. difficile are thought to play a role in the epidemiology of Clostridium difficile infections (CDI). Patients who are colonized on admission can spread the bacterium to other patients, who might eventually develop CDI. The relatedness between strains of asymptomatic carriers and CDI patients can indicate how many of the new CDI cases should be attributed to spread from asymptomatic carriers.    This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
In this study, whole genome sequencing (WGS) will be performed on the cultured isolates from CDI cases and asymptomatic carriers. This data will be compared using single nucleotide variants (SNVs), to determine relatedness of all samples. A statistical analysis will be performed to evaluate if any of the metadata parameters is a strong predictor of the relatedness (e.g. treatment in the same ward).