ena-STUDY-Roche Innovation Center Copenhagen A/S-30-03-2017-12:15:26:168-148
RNase H Sequence Preferences
A massive parallel-sequencing-based method for determining RNase H sequence preferences was developed and applied on human RNase H1, E. coli RNase HI and the HIV-1 reverse transcriptase. Obtained sequence preferences of those enzymes were used to investigate their relevance for the action of antisense therapeutics and for the HIV replication.
A massive parallel-sequencing-based method for determining RNase H sequence preferences was developed and applied on human RNase H1, E. coli RNase HI and the HIV-1 reverse transcriptase. Obtained sequence preferences of those enzymes were used to investigate their relevance for the action of antisense therapeutics and for the HIV replication.