GSE184232
Investigate the effect of gain of HAND2 on chromatin accessibility.
The overexpression of HAND2 in IMR32 cells results in a increase of chromation accessibility at the HAND2 and MYCN common binding sites. Overall design: In the HAND2 stably transfected IMR32 cells (IMR32tetHAND2), HAND2 expression is Doxcycline (Dox) inducible. The IMR32tetHAND2 cells were treated with or without Dox for 36 hr and ATAC seq was performed.