GSE135177
Bulk RNAseq Analysis of Murine Thoracic Aortas with Tsc1+/+ and Tsc1-/- Smooth Muscle Cells
We characterized the transcriptomic effects of chronic mTOR activation in aortic SMCs using a conditional genetic model to delete Tsc1 under control of a smooth muscle-specific Myh11 promoter Overall design: Myh11-CreERT2.mT/mG (Tsc1+/+) and Tsc1fl/fl.Myh11-CreERT2.mT/mG (Tsc1-/-) male mice were treated with tamoxifen at 1.5 wk and the thoracic aortas were analyzed by bulk RNAseq at 24 wk.