ena-STUDY-University of Saarland-20-10-2017-12:45:30:124-4
Identification of transcribed HERV-K(HML-2) loci in amyotrophic lateral sclerosis
Transcribed HERV-K(HML-2) loci were identified in ALS-derived and normal control tissue samples by means of RT-PCR, cloning, Sanger sequencing and assignment of cDNA sequences to HERV-K(HML-2) loci. Several HERV-K(HML-2) loci were identified as transcribed. An alternatively spliced transcript most likely originating from a HERV-K(HML-2) locus in human chromosome 3q21.2 (HGNC-approved gene symbol ERVK-4) was identified.
Transcribed HERV-K(HML-2) loci were identified in ALS-derived and normal control tissue samples by means of RT-PCR, cloning, Sanger sequencing and assignment of cDNA sequences to HERV-K(HML-2) loci. Several HERV-K(HML-2) loci were identified as transcribed. An alternatively spliced transcript most likely originating from a HERV-K(HML-2) locus in human chromosome 3q21.2 (HGNC-approved gene symbol ERVK-4) was identified.