PRJNA799590
Disrupted CEP128 function impairs spermatogenesis
The centrosome is a conserved eukaryotic organelle essential to the reproductive process, and centrosomal proteins are necessary components of the centrosome. However, few centrosomal proteins have been genetically linked to fertility, and the related molecular mechanisms remain unknown. Herein we identified a homozygous missense variant of CEP128 in two infertile males with cryptozoospermia from a consanguineous family.Altogether, our findings unveil in unprecedented fashion a crucial role for CEP128 in male fertility and provide new insights into the functions of centrosomal proteins in reproductive biology.