Tumourigenesis_in_E_cigarette_exposed_Mice___WES-sc-6170
Tumourigenesis_in_E_cigarette_exposed_Mice___WES
Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use is gaining popularity. Previously, we found that ECS induces DNA damage and inhibits DNA repair in the mouse lungs and bladder urothelium. Nicotine induces the same types of DNA adducts and has a similar effect on DNA repair inhibition in human cells. Nicotine also enhances human cells' mutation and tumorigenic transformation susceptibility. In this project we have sequenced tumour that have developed in mice exposed to ECS so as to understand the processes of tumourigenesis.
Electronic-cigarette smoke (ECS) is designed to deliver nicotine, and its use is gaining popularity. Previously, we found that ECS induces DNA damage and inhibits DNA repair in the mouse lungs and bladder urothelium. Nicotine induces the same types of DNA adducts and has a similar effect on DNA repair inhibition in human cells. Nicotine also enhances human cells' mutation and tumorigenic transformation susceptibility. In this project we have sequenced tumour that have developed in mice exposed to ECS so as to understand the processes of tumourigenesis.