PRJNA673083
Transcriptional profiling of macrophages in Blau syndrome
We aimed to characterize the transcriptional profiles of macrophages generated from peripheral blood monocytes of Blau syndrome patients, untreated or treated with anti-TNF antibodies. Given our previous finding that IFNg stimulation is a key priming signal for Blau syndrome-associated inflammatory responses, we conducted RNA-seq with or without IFNg stimulation. Moreover, we generated patients' iPSC-derived macrophages and compared the transcriptional profiles with WT counterparts.