ena-STUDY-NORWEGIAN INSTITUTE OF PUBLIC HEALTH-17-11-2017-12:06:35:918-833
Norwegian-African large Lineage 3 M. tuberculosis cluster
Immigrants from the Horn of Africa constitute the largest group of TB patients in Norway, making up a third of all TB cases in the country over the last decade. One particular genotype-cluster strongly associated with people originating in this region has been identified regularly over a 20-year period. Here we apply  transmission modeling methods to whole-genome sequence data to estimate the times at which individual patients were originally infected. By contrasting these estimates with time of arrival in Norway, we estimate on a case-by-case basis whether individual patients were likely to have been infected before or after arrival.
Immigrants from the Horn of Africa constitute the largest group of TB patients in Norway, making up a third of all TB cases in the country over the last decade. One particular genotype-cluster strongly associated with people originating in this region has been identified regularly over a 20-year period. Here we apply  transmission modeling methods to whole-genome sequence data to estimate the times at which individual patients were originally infected. By contrasting these estimates with time of arrival in Norway, we estimate on a case-by-case basis whether individual patients were likely to have been infected before or after arrival.