GSE210533
Transcriptome data of bone marrow regulatory T cells (Tregs) with aging
Bone marrow (BM) is normally maintained in an immune-privileged and anti-inflammatory state, kept in check principally by regulatory T cells (Tregs). Thus, it is reasonable to expect that Tregs will help shield hematopoietic stem cells (HSCs) from excessive inflammation and thereby counteract HSC aging. Understanding how BM Tregs are adapted to the aged BM and whether they are endowed with unique functions to modulate HSC aging will identify targets for prevention of HSC aging. To identify the phenotype switching and function variation in BM Tregs with aging, we performed RNA-seq of Tregs from the bone marrow of mice at 2 mouths old (2 mo) and 12 mouths old (12 mo). Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of BM Tregs (CD3+CD4+NK1.1–Foxp3+) of mice at 2 mo or 12 mo.