PRJNA797941
Barn Swallow DNA methylation study
This project aims to jointly investigate genome-wide patterns of 5-methyl-cytosine (5mC) DNA methylation (RRBS data) and genetic variation (WGS data) in the barn swallow (Hirundo rustica). A global sampling design across all six described subspecies and two key hybrid zones will help untangle the contribution of genetic and environmental factors mediating observed patterns of methylome variation. Using population (epi)genetic techniques to decompose the evolutionary signal contained in both methylome and genetic variation and quantify the degree of covariation. Further, exploration of the relative contributions of both genetic (cis- and trans- acting) effects and environmental effects will be evaluated. We hope to uncover the parameters shaping methylation patterns in natural populations and consequently assess its potential relevance to evolution.