Genomic_variation_in_a_global_set_of_Salmonella_Paratyphi_A_isolates-sc-2011-04-11T17:15:27Z-225
Genomic_variation_in_a_global_set_of_Salmonella_Paratyphi_A_isolates
Global survey of genomic variation in the Paratyphi A population.  http://www.sanger.ac.uk/resources/downloads/bacteria/salmonella.html This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Salmonella Paratyphi A is the causative agent of paratyphoid fever, a disease virtually indistinguishable from typhoid fever. Over the past decade the incidence of paratyphoid fever caused by Salmonella Paratyphi A has increased dramatically, and in some areas has surpassed typhoid fever incidence. Salmonella Paratyphi A is genetically monomorphic, with the first two finished genome sequences differing by fewer than 200 single nucleotide polymorphisms and very few insertions or deletions. Very few molecular typing tools are able to differentiate among Salmonella Paratyphi A isolates at all, with phage typing, ribotyping and PFGE showing limited discriminatory power. In order to identify sequence polymorphisms within the global Salmonella Paratyphi A population, a total of 155 novel isolates of Paratyphi A were assembled for whole genome sequencing using multiplex Illumina/Solexa sequencing. http://www.sanger.ac.uk/resources/downloads/bacteria/salmonella.html