GSE174283
Dissecting the interface between ARID1A and mRNA translation in bladder cancer (Polysome)
Chromatin remodeling and protein synthesis are tightly regulated processes that impact gene expression and cellular phenotypes. However, it is unknown if these two regulatory mechanisms are linked or exert independent effects in normal epithelial physiology and disease states. We have uncovered a new functional relationship between the chromatin remodeler ARID1A and mRNA translation elongation that is involved in cancer initiation and progression. Overall design: Polysome to Subpolysome Profiling and RNASeq of samples