GR FAIRE signatures
Analysis of FAIRE signal at GR binding locations
FAIRE was utilized to assess chromatin structure at GR binding locations in A1-2 cells.  Cells were treated for 1 hour with ethanol (absence of ligand) and FAIRE analysis performed on DNA.  GR binding locations demonstrate a signicant FAIRE enrichment in the absence of activating ligand suggesting an open chromatin structure prior to receptor binding.