PRJNA176191
Homo sapiens Transcriptome of PABPN1-deficient HeLa cells
The poly(A)-binding protein nuclear 1 (PABPN1) is a ubiquitously expressed protein that is thought to function during mRNA poly(A) tail synthesis in the nucleus. Despite the predicted role of PABPN1 in mRNA polyadenylation, little is known about the impact of PABPN1 deficiency on human gene expression. This experiment address by high-throughput transcriptome sequencing the global impact of a PABPN1 deficiency on human gene expression.