ena-STUDY-MHH-24-09-2020-14:01:53:956-235
Genome sequencing and comparison of representatives of Pseudomonas aeruginosa clone ST235 strains
In the 2010 years, the Pseudomonas aeruginosa clonal lineage ST235 has emerged as the most prevalent international high-risk clone of this species. The ExoU-positive clone ST235 has been associated with nosocomial acute P. aeruginosa infections of poor clinical outcome worldwide, and the isolated strains typically displayed high-level multi drug resistance due to the presence of resistance cassettes bound to mobile genomic elements included in the bacterial chromosome. We selected older clone ST235 isolates not displaying multi-drug-resistance traits from our strain collection for genome sequencing and comparisons to search for individual and clone-specific genomic traits that might have contributed to the development of the acute infection- and MDR-associated phenotypes in more recent isolates of this clonal lineage. In this context, genomic traits of clone ST235 were compared with clone ST253, another widespread ExoU-positive P. aeruginosa clone.
In the 2010 years, the Pseudomonas aeruginosa clonal lineage ST235 has emerged as the most prevalent international high-risk clone of this species. The ExoU-positive clone ST235 has been associated with nosocomial acute P. aeruginosa infections of poor clinical outcome worldwide, and the isolated strains typically displayed high-level multi drug resistance due to the presence of resistance cassettes bound to mobile genomic elements included in the bacterial chromosome. We selected older clone ST235 isolates not displaying multi-drug-resistance traits from our strain collection for genome sequencing and comparisons to search for individual and clone-specific genomic traits that might have contributed to the development of the acute infection- and MDR-associated phenotypes in more recent isolates of this clonal lineage. In this context, genomic traits of clone ST235 were compared with clone ST253, another widespread ExoU-positive P. aeruginosa clone.