GSE162550
Anti-fibrosis effects of dihydroartemisinin on primary skin fibroblast from healthy people
The objective of this study was to determine whether Dihydroartemisinin (DHA), a drug highly effective in treating malaria infection with good safety, could be repurposed for the treatment of skin fibrosis in systemic sclerosis (SSc). mRNA-seq of primary human fibroblast cultures from healthy donors treated with DHA or vehicle were performed. By KEGG and Reactome analysis, we identified autophagy was one of the most significantly enriched terms. Overall design: Transcriptomes from primary human skin fibroblast of 3 DMSO-treated and 3 Dihydroartemisinin (DHA) treated cultures.