GSE173454
The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis
We found that Keap1-Nrf2 signaling pathway mediates UBR7 to regulate HK2 expression through the modification of histone H2BK120 monoubiquitination, thereby inhibiting glycolysis and HCC tumorigenesis. Overall design: The promoter regions of genes that bind to H2BK120ub in wild-type and Alb; Cre-UBR7fl/fl mouse liver primary cells were detected by ChiP-seq.