GSE115531
Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans
Purpose: We found that mutations in microtubule regulating factors lead to altered lifespan. In order to understand the mechnaisms, we carried out RNA-seq analyses to identify genes with differential expression in microtubule regulator mutants. Overall design: Genetic mutants of efa-6, hdac-6, ptl-1 and ptrn-1 were compared to wildtype control. Synchronized Day 1 young adults were used for RNA extraction.