GSE173810
RNA-seq analysis of Igf2's function in the differentiation of mouse embryonic stem cells
We report the function of IGF2 in regulating the differentiation of ESCs, and then we performed RNA-seq for the wild-type and Igf2 knockout ESCs and embryoid bodies collected at different time points to analyze the transcriptomes. The results showed a significant difference between wild-type and Igf2 knockout groups in transcriptomes, and we performed a series experiments to study the function of Igf2 in the differentiation of ESCs. Overall design: Examination of RNA-seq for wild-type and Igf2 knockout embryonic stem cells and embryoid bodies and exploration of the role of Igf2 in ESC differentiation.