PRJNA875097
CSDE1 promotes miR-451 biogenesis
miR-451 is a highly conserved miRNA in vertebrates which bypasses Dicer processing and instead relies on AGO2 for its maturation. miR-451 is highly expressed in erythrocytes and regulates the differentiation of erythroblasts into mature red blood cells. However, the mechanistic details underlying miR-451 biogenesis in erythrocytes remains obscure. We report that CSDE1 promotes biogenesis of miR-451 in erythroid progenitors.