Genetic_diversity_of_Cryptosporidium_hominis_in_a_Bangladeshi_community_as_revealed_by_whole_genome_sequencing-sc-5144
Genetic_diversity_of_Cryptosporidium_hominis_in_a_Bangladeshi_community_as_revealed_by_whole_genome_sequencing
We studied the genetic diversity of Cryptosporidium hominis infections in slum dwelling infants from Dhaka over a two-year period. C. hominis infections were common during the monsoon, and were genetically diverse as measured by gp60 genotyping and whole genome resequencing. Recombination in the parasite was evidenced by the decay of linkage disequilibrium in the genome over less than 500 bp. Regions of the genome with high levels of polymorphism were also identified. Yet to be determined is if genomic diversity is responsible in part for the high rate of reinfection, seasonality and varied clinical presentations of cryptosporidiosis in this population. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
Genetic diversity of Cryptosporidium hominis in a Bangladeshi community as revealed by whole genome sequencing