GSE110426
Small Molecule PCSK9 Inhibitors: Hit to lead optimization
Ribosome profiling is used to demonstrate improved selectivity of compounds that promote PCSK9 translational stalling Overall design: IEC6 cells were treated with 4 µM PF-06446846 (7f), 4  µM PF-06649492 (7l) or vehicle for  60 minutes, and subjected to ribosome profiling.