GSE98579
RNAseq for Tfam knock under NKX2.5 promoter
Tfam inactivation by Nkx2.5Cre caused embryonic lethal myocardial hypoplasia. Tfam inactivation was accompanied by elevated production of reactive oxygen species (ROS) and reduced cardiomyocyte proliferation. Mosaic embryonic Tfam inactivation confirmed that the block to cardiomyocyte proliferation was cell autonomous. Transcriptional profiling by RNA-seq demonstrated activation of the DNA damage pathway. Overall design: E13.5 TFAM KOx3; E13.5 TFAM CONx3;