PRJNA486551
Loss of FOXO3 facilitates inflammatory colon cancer: transcriptome profiling of the immune landscape and novel targets
Loss of FOXO3 transcription function, associated with human IBD and colon cancer progression, facilitates development of inflammatory colon cancer in mice. Transcriptome profiling of FOXO3 deficient colon and tumors revealed an immune landscape and novel targets similarly dysregulated in IBD and colon cancer.