GSE193588
Expression analysis in Carm1 and Pax3 mutant embryos
We have found that Coactivator-associated Arginine Methyltransferase 1 (Carm1) mutant mice have highly penetrant heart defects. These are similar to those found in Pax3 mutant mice and PAX3 is a target of CARM1-mediated methylation. We analyzed gene expression at mid-gestation in both mutant lines. Overall design: RNA was obtained from E12.5 Carm1 and Pax3 mutant embryos and sequenced by a commercial provider (Novogene).