GSE116013
Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells
Innate lymphoid cells (ILCs) play critical roles in mucosal barrier defense and tissue homeostasis. While ILCs are depleted in HIV-1 infection, this phenomenon is not a generalized feature of all viral infections.  Here we show in untreated SIV-infected rhesus macaques (RMs) that ILC3s are lost rapidly in mesenteric lymph nodes (MLN) yet preserved in SIV+ RMs with pharmacologic or natural control of viremia.  In healthy uninfected RMs, experimental depletion of CD4+ T cells in combination with DSS is sufficient to reduce ILC frequencies in the MLN.  In this setting and in chronic SIV+ RMs, IL-7R alpha chain expression diminishes on ILC3s in contrast to the IL-18R alpha chain expression which remains stable. In HIV-uninfected patients with durable CD4+ T cell deficiency, deemed idiopathic CD4+ lymphopenia, similar ILC deficiencies in blood were observed, collectively identifying determinants of ILC homeostasis in primates and potential mechanisms underlying their depletion in HIV/SIV infection. Overall design: There are 12 samples, 3 healthy, 8 SIV infected of which there are 4 acute and 4 chronic SIV infected.