GSE115181
Gene expression analysis of wild type and Lats1/2-mutated uveal melanoma
Lats1/2 kinases are the core Hippo pathway kinases. In this study, we use RNAseq to analyze the gene expression profiles of adult mouse uveal tract cells and mouse uveal melanoma generated by Lats1/2 deletion induced by AAV-based Cre injection into mouse uveal tract. Overall design: Total RNA obtained from freshly isolated wild type uveal tissue and eye tumors from AAV-Cre-injected Lats1/2 fl/fl mice