GSE202634
The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma [RNA-Seq]
To compare the function of endogenous ASCL1 in different neuroblastoma cell contexts, we have used CRISPR-mediated deletion to compare the effects of ASCL1 deletion in a MYCN-amplified and an ALK-driven neuroblastoma line and assessed the transcriptome wide impact of ASCL1 knockout using RNA-seq Overall design: RNA-seq in parental, ASCL1 knockout lines and rescue lines where ASCL1 has been re-expressed in ASCL1 knockout lines