PRJNA562984
To explore the mechanism of Paeonol to prevent inflammatory injury of murine ALD based on intestinal fungal flora (mycobiota) and its mediator Dectin-1 / IL-1b signaling pathway
The purpose of this study was to investigate the mechanism of Paeonol against inflammatory injury of ALD based on regulating intestinal fungal flora (mycobiota) and its mediated Dectin-1 / IL-1b signaling pathway. In order to verify whether Paeonol can improve the intestinal fungal flora (mycobiota) disorder of ALD mice, thereby inhibiting the translocation of 1, 3-b-D-Glucan to the liver and mediating the occurrence of inflammation by binding to the receptors Dectin-1 on the surface of liver macrophages.