GSE129045
YAP and AP-1 cooperate to initiate rapid pancreatic cancer development from the ductal cell population in mice
Purpose: We aimed to elucidate the unique consequences of YAP/TAZ activation in pancreatic ductal cells. Methods: We isolated RNA from Lats1 and Lats2 double knockout ductal cells from Lats1fl/fl; Lats2fl/fl; Sox9-CreER mice. Results: Oncogenic activation of YAP in ductal cells lead to the rapid development of carcinoma in situ with microinvasion. Overall design: mRNA profiles of pancreatic duct cells from control and Lats1/2 knockout mice were created by mRNA-sequencing.