PRJNA760234
FREQ-Seq2 E. coli
Understanding how allele frequencies change over time in population samples is important for understanding their evolutionary dynamics. An accurate determination of allele frequencies is crucial across a wide range of problems in genetics, such as developing accurate models of population genetics, inferences in genome-wide association studies, determining genetic risk for diseases, as well as other scientific and medical applications. FREQ-Seq^2 is a precise, efficient, and economical method for quantifying the relative frequencies of different alleles at loci of interest in mixed population samples.