GSE116302
Core TF Foxc1/2 reinforce differentiation of adult podocyte in glomeruli
We identified Fox1 and Foxc2 core transcription factors in kidney glomeruli. To investigate their transcriptional regulatory roles in glomeruli, we performed ChIPseq of Foxc1 and Foxc2 in adult mouse kidney glomeruli. The genome wide distribution of Foxc1/2 binding sites revealed they regulated the differentiation and mature state of adult podocyte to maintain kidney homeostatis. Overall design: Mouse kidney glomeruli were isolated by perfusion of magenetic beads and collection with MPC. ChIP-seq was performed with specific antibody.