ena-STUDY-UNIVERSITY OF BASEL-25-06-2018-08:02:39:137-1068
Detection of Circulating Tumor Cell Clusters in Human Glioblastoma
Background: Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularized malignant brain cancer. Individual circulating tumor cells (CTCs) are sporadically found in GBM patients, yet, it is unclear whether multicellular CTC-clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier. We assessed CTC presence and composition at multiple time-points in 13 patients with progressing GBM during an open-label phase-1/2a study with the microtubule inhibitor BAL101553.
Background: Human glioblastoma (GBM) is a highly aggressive, invasive and hypervascularized malignant brain cancer. Individual circulating tumor cells (CTCs) are sporadically found in GBM patients, yet, it is unclear whether multicellular CTC-clusters are generated in this disease and whether they can bypass the physical hurdle of the blood-brain barrier. We assessed CTC presence and composition at multiple time-points in 13 patients with progressing GBM during an open-label phase-1/2a study with the microtubule inhibitor BAL101553.