GSE110564
Mycobacterium tuberculosis cording in lymphatic endothelial cells (hLEC)
Mycobacterium tuberculosis (Mtb) displayed cording phenotypes during intracellular infection. RNA-Seq was used to identify transcriptional programmes expressed by hLEC that actviates pathways relating to cellular pro-survival and cyosolic surveillance of intracellular Mtb. Mtb cording was found to be a mechanism to evade xenophagy in the cytosol of endothelial cells. Overall design: A total of 6 samples were sequenced: 3 samples of Mtb-infected hLEC and 3 samples of uninfected hLEC