GSE163422
A combinatorial atlas of RNA Polymerase III subunit occupancy in human THP-1 cells
We present a genome-wide map of RNA Polymerase III subunit localization in human THP-1 monocytes and THP-1 derived macrophages after 72 hr exposure to PMA, as well as profiles of POLR3G and POLR3GL occupancy in THP-1 monocytes after 4 hr exposure to Pol III drug inhibitor ML-60218; 27 uM Overall design: Chromatin IP (ChIP) experiments were performed against specific RNA Polymerase III subunits, including POLR3A, POLR3B, POLR1D, POLR3C, POLR3G, POLR3GL, POLR3D, and POLR3E, as well as TFIIIB subunit BRF1, and TFIIIC subunit GTF3C1