GSE107678
Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration [RNA-seq]
To identify the potential microRNAs (miRNAs) involved in the regulation of cardiomyocyte (CM) proliferation during homeostasis and injury, RNA sequencing (RNA-seq) in mouse cardiac ventricles was performed on postnatal day 1, 7, and 28 (P1, P7, and P28). Significant upregulation of MiR-128 was found in P7 hearts as compared to P1. To further specify the effect of miR-128 in the heart, RNA-Seq was performed in control mice (Ctrl) and miR-128 overexpression mice (miR-128OE) on P7. These data provide novel insights into the mechanisms by which adult CMs exit the cell cycle arrest and is fundamental for therapeutic manipulation to stimulate endogenous CM proliferate in cardiac regeneration. Overall design: RNA-seq profilig of heart tissues from wild type mice on postanatal day 1, 7, and 28 (P1, P7, and P28), RNA-seq of hearts from control (Ctrl) and miR-128 overexpression transgenic mice (miR-128OE) at P7.