GSE174691
Altered Intercellular Communication and Extracellular Matrix Signaling as a Disease Mechanism in Human Hypertrophic Cardiomyopathy
To understand the interplay between cardiomyocyte and nonmyocyte cell types in human hypertrophic cardiomyopathy, single nuclei RNA-sequencing was performed on 9 myectomy specimens from HCM patients Overall design: Myectomy specimens (samples 5-13) were sampled for single nuclei transcriptomic sequencing. Sample 5 was generated and sequenced on its own with NextSeq 550. Samples 6-13 were generated and sequenced togheter on a NovaSeq S4 run.