PRJNA482747
Alpha-Synuclein Induces the Unfolded Protein  Response in Parkinson's Disease SNCA Triplication  iPSC-Derived Neurons
The alpha Synuclein (SNCA) gene is one of the most commonly implicated mediator of Parkinson Disease (PD), changes in dosages are directly associated severity of PD. Here we aim to compare expression within induced pluripotent stem cells derived from a patient with a triplication of the SNCA locus to an isogenic IPSC line with normalized gene dosage through CRISPR/Cas9 mutagenesis.