GSE195714
Breast cancer plasticity is restrictedby a LATS1-NCOR1 repressive axis [ATAC-seq]
The tumor suppressor LATS1, whose expression is often downregulated in human breast  cancer,  helps  maintain  luminal  breast  cancer  cell  identity  by  keeping  basal-specific genes in a closed chromatin state, preventing their spurious activation. This is achieved via interaction of LATS1 with the NCOR1 nuclear corepressor and  recruitment  of HDAC1,driving  histone H3K27  deacetylation near NCOR1-repressed “basal” genes. Consequently, decreased expression of LATS1 elevates the expression of such “basal” genes and promotes luminal-to-basal slippage. Overall design: 4 samples X 2 replicates = 8 samples total