GSE200889
Transit-amplifying lineage states convey the susceptibility of PTEN and P53 loss to gliomagenesis [PPO1_and PPO1_Cells_RNA-seq]
To investigate the glioma mouse model by knocking out Pten and Trp53 in embryonal Olig2 and Olig1 positive cells in glioma pathogenesis. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 PPO2, 4 PPO1 and 2 OPN cell lines. Overall design: Comparative gene expression profiling analysis of RNA-seq data for PPO1 & PPO2 cell lines with Oligodendrocyte progenitor Cells and neural stem cells tissue from publically available datasets. And also explore transcriptomic changes of Nf1 and Trp53 knocl out in OPC with PPO1