GSE168174
Global Gene Expression Changes in Cholangiocytes Treated with P300 inhibitor SGC-CBP30 (10 µM; Selleckchem, #S7256)
Histone modification is a critical epigenetic regulatory mechanism that is under-explored in cholestatic liver disease. Lysine 27 on histone 3 (H3K27) is a key regulatory residue that can be acetylated by the histone acetyltransferase (HAT) p300, which acts as a transcriptional coactivator. Overall design: Cholangiocyte cell line, HiBEC,  were treated with DMSO or SGC-CBP30 (10uM)  to look at the gene expression changes due to pharmacological inhibition of P300