GSE125201
In vivo Genome-scale CRISPR-Cas9 knockout screening
To identify essential gene responding to anti-PD-1 immunotherapy, we performed in vivo Genome-scale CRISPR-Cas9 knockout screening. We found that cohesin complex invovled in regulation of anti-PD-1 immunotherapy. Overall design: We performed two rounds of in vivo screening in two cell types.