E-MTAB-9538
RNA-Seq analysis of E18.5 mouse Zfp800 knockout vs wild-type
Zfp800 was identified by Gene Co-expression Network analysis to be an interesting candidate gene involved in endocrine specification and ß-cell maturation. We found that Zfp800 null mice exhibited early post-natal lethality, and at E18.5 their pancreata exhibited a reduced number of pancreatic endocrine cells, alterations in exocrine cell morphology, and marked changes in genes involved in protein translation, hormone secretion, and developmental pathways in the pancreas.
Zfp800 was identified by Gene Co-expression Network analysis to be an interesting candidate gene involved in endocrine specification and ß-cell maturation. We found that Zfp800 null mice exhibited early post-natal lethality, and at E18.5 their pancreata exhibited a reduced number of pancreatic endocrine cells, alterations in exocrine cell morphology, and marked changes in genes involved in protein translation, hormone secretion, and developmental pathways in the pancreas.