GSE174490
Mechanism for Cortical Bone Stem Cell-Derived Exosomes' Therapeutic Effect on Myocardial Ischema Reperfusion and Remodeling
The goal of this study was to understand the effect of human cortical bone stem cells on human cardiac fibroblast activation. We treated normal human cardiac fibroblasts +/-  50 ng/mL TGFBeta +/- 2,000,000 human cortical bone stem cell-derived exosome particles per fibroblast treated for 72 hours and then isolated RNA for RNA-sequencing. Overall design: Normal Human Cardiac Fibroblasts +/- TGFBeta +/- human cortical bone stem cell-derived exosomes