GSE121425
LSD1 pharmacological inhibition in SET-2 containing wild type and mutant LSD1 [RNA-Seq]
We characterized the effect of GSK-LSD1 treatment on gene expression for both wt SET-2 and drug-resistant SET-2 LSD1 (Leu659_Asn660insArg) Overall design: For RNA-seq preparation, SET-2 cells were treated in triplicated with either DMSO (0.1% v/v) or 250 nM GSK-LSD1 for 48 after which RNA was harvested and prepared for RNA sequencing to assess transcriptional changes