GSE108352
Cleavage Factor 25 Deregulation Contributes to Pulmonary Fibrosis through Alternative Polyadenylation
The purpose of this experiment is to identify the APA targets of CFIm25 in human lung fibroblasts.   Following the knockdown of CFIm25 in normal human lung fibroblasts, we identified 808 genes with shortened 3'UTRs, including those involved in the transforming growth factor-beta signaling pathway, the Wnt signaling pathway, and cancer pathways. Overall design: mRNA profiles of primary human lung fibroblasts transfected with control or CFIm25 siRNA were generated by RNA-Seq using Illumina GAIIx