GSE158477
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation [MPRA]
A deep-learning framework interprets multi-omic data across epidermal differentiation, identifying cooperative DNA sequence rules that regulate gene modules. Massively parallel reporter analysis validates temporal dynamics and cis-regulatory logic. Overall design: Lentiviral MPRA of selected genomic constructs in primary keratinocyte differentiation with reporter RNA collected on days 0, 3, and 6