MyoD
Genome-wide MyoD binding in mouse skeletal muscle cells
We have used chromatin immunoprecipitation and high throughput sequencing to identify genomewide  binding of MyoD in several skeletal muscle cell types. As anticipated, MyoD preferentially binds  to a VCASCTG sequence that resembles the in vitro selected site for a MyoD:E-protein heterodimer,  and MyoD binding increases during differentiation at many of the regulatory regions of genes  expressed in skeletal muscle. Unanticipated findings were that MyoD was constitutively bound to  thousands of additional sites in both myoblasts and myotubes, and that the genome-wide binding of  MyoD was associated with regional histone acetylation. Therefore, in addition to regulating muscle  gene expression, MyoD binds genome-wide and has the ability to broadly alter the epigenome in myoblasts and myotubes.
Genome-wide MyoD binding in mouse skeletal muscle cells