DRP007014
Euglena gracilis stimulates Faecalibacterium and contributes to increased defecation
The alga Euglena gracilis (E. gracilis) has recently gained attention as a health food, but its effects on human gut microbiota remain unknown. This study aimed to determine the effect of E. gracilis on gut microbiota and defecation due to modulation of microbiota composition in vitro and in vivo. The in vitro model simulating human colonic microbiota revealed that E. gracilis administration stimulated the growth of commensal Faecalibacterium. In addition, E. gracilis administration enhanced butyrate production by Faecalibacterium prausnitzii. Paramylon, an insoluble dietary fibre that accumulates in E. gracilis and is the main component of E. gracilis, did not stimulate Faecalibacterium growth in vitro. Daily oral administration of 2 g of E. gracilis in 28 human participants for 30 days increased bowel movement frequency as well as stool volume. Collectively, these findings indicate that E. gracilis components other than paramylon, stimulate the growth of a key commensal organism Faecalibacterium to improve digestive health as well as promote defecation by increasing butyrate production.