GSE172026
RNA-sequence on testes of wild type C57BL/6J, ARLmon/Y and AR-/Y mice
We generated a mouse model (ARLmon/Y) with disrupted dimerization of the ligand-binding domain 25 (LBD) of the androgen receptor (AR). These mice exhibit an external female phenotype with undescended testes. Histological analysis of the testes of ARLmon/Y mice revealed some residual spermatogenesis. Hormone measurements in serum of the ARLmon/Y mice showed significantly high levels of androgens. To further explore the ARLmon/Y testicular phenotype, we performed RNA-sequencing on while testis of five mice per genotype. Overall design: 5 samples per genotype: wild type C57BL/6J, ARLmon/Y and AR-/Y mice