GSE191123
The Mediator Kinase Complex Cooperates with Swi/Snf to Regulate Lineage-Resolved Enhancers and Differentiation [RNA-Seq]
To identify novel functions of Mediator kinases CDK8 and CDK19 in the intestinal epithelium, we generated novel genetic mouse model enabling the individual and compound deletion of CDK8 and CDK19. RNA-sequencing was performed on primary intestinal epithelial cells and murine small intestinal organoids at different time points after CDK8/19 deletion. Overall design: 1) RNA samples from some control and CDK8/19-deficient IECs; 2) RNA samples from triplicates of organoids with the indicated genotypes, treatements collected at the indicated time points.