PRJNA720270
Directing an evolutionary trade-off in Salmonella via intestinal antibodies
A rationally induced IgA response blocking all of escape trajectories selected for Salmonella mutants carrying deletions of the O-antigen polymerase wzyB. Due to their short O-antigen, evolved mutants were susceptible to environmental stressors (detergents, complement), to predation (bacteriophages), and were impaired in gut colonization and virulence.