GSE127876
Transcriptomic changes driven by oncogenic kinases
Transcriptomic changes were compared by RNA-seq in human mammary epithelial cells (HMECs) with or without ectopic expression of oncogenic kinase HER2, PI3KCA(mut), or SHP(mut). Overall design: RNA seq were performed in four engineered cell lines: HMEC-DD-pBABE, HMED-DD-pbabe-HER2; HMEC-DD-PI3KCA(H1047R), and HMEC-DD-SHP2(E76A). Three independent experiments were performed In each cell line.