GSE210054
DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy [Bulk RNAseq]
To investigate immunoediting at the primary tumour, we used DNA barcoding combined with NGS to identify individual cancer cells wthin the 4T1 murine model of cancer. We isolated two highly immune evasive clones from the parental population and carried out buk RNA sequencing Overall design: We sequenced bulk RNA derived from 4 biological replates of the bulk parental population, immune evasive clone 1, clone 2, and two non target clones (1 and 2).