GSE135318
DOT1L-mediated Murine Neuronal Differentiation associates with H3K79me2 Accumulation and preserves SOX2-Enhancer Accessibility
To study whether acute inhibition of DOT1L induces global chromatin states alterations, we profile and compare the transcriptome, chromatin accessibility and epigenome (H3K4me3, H3K4me1, H3K27ac, H3K27me3, H3K36me3, H3K9me3, H3K79me2) of mESC and ES-derived NPC, treated with DMSO or EPZ5676. Overall design: full epigenome (duplicates), transcriptome (triplicates) and chromatin acceccibility profiling (duplicates) of mouse embryonic stem cells and in-vitro differentiated neurons, treated with DMSO and EPZ5676