PRJNA392413
Extrachromosomal circular DNA and RNA sequencing of 16 healthy men
We purified and sequenced eccDNA from muscle and blood of 16 healthy men, detecting 170,000 eccDNAs from 16 million nuclei, covering 13% of the human genome. Furthermore, in order to assess if eccDNA correlates with gene expression we extracted and sequenced total RNA from muscle tissue of the 16 healthy men.