ena-STUDY-AMSTERDAM UMC-29-08-2020-16:54:55:996-649
Illumina and Nanopore whole-genome sequencing data from ESBL-positive Escherichia coli collected in the COMBAT study
International travel contributes significantly to the spread of AMR. In this study, we selected travellers included in the COMBAT study that acquired ESBL-positive Escherichia coli (ESBL-Ec) during international travel and were colonised for at least 12 months since return from travel. Using Illumina WGS data, we identified travellers that carried the same ESBL-Ec strain for 12 months. We matched short-term carriers (<1 month carriage) to the long-term carriers (>=12 months) and compared bacterial characeristics. This showed that specific lineages of E. coli are more likely to persist in the gut long-term. Notably, these lineages are typically recognised as extraintestional pathogenic E. coli (ExPEC) lineages.
International travel contributes significantly to the spread of AMR. In this study, we selected travellers included in the COMBAT study that acquired ESBL-positive Escherichia coli (ESBL-Ec) during international travel and were colonised for at least 12 months since return from travel. Using Illumina WGS data, we identified travellers that carried the same ESBL-Ec strain for 12 months. We matched short-term carriers (<1 month carriage) to the long-term carriers (>=12 months) and compared bacterial characeristics. This showed that specific lineages of E. coli are more likely to persist in the gut long-term. Notably, these lineages are typically recognised as extraintestional pathogenic E. coli (ExPEC) lineages.