GSE137277
DNA methylation in aging BXD mouse strains
We performed affinity-based enrichment with methyl-CpG binding domain protein followed by high-throughput sequencing (MBD-seq) to assay DNA methylation in mouse liver tissue. Overall design: A total of 70 liver samples from 12 BXD mouse strains maintained on either normal laboratory chow or high fat diet (60% calories from fat) were processed for next gen sequencing after affinity capture with methyl-CpG binding protein.