RNASeq_of_mouse_DDD_models_Phase_II-sc-4771
RNASeq_of_mouse_DDD_models_Phase_II
We will be sequencing adult tissues and embryonic time points for both mutant and WT mice This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute please see http://www.sanger.ac.uk/datasharing/
Exome sequencing in children with developmental disorders has identified numerous causative mutations in novel disease genes.  Using engineered loss of function alleles, we are modelling these disorders in mice. To understand the molecular and cellular mechanisms underpinning these neurodevelopmental disorders, we are carrying out RNA-sequencing of several distinct brain regions in adult animals, as well as brains from embryonic time points.