GSE128748
RNA-seq analysis of dolastatin 15 treatment in HCT116 cells
Dolastatin 15 is a known tubulin binding agent and shows remarkable differential cytotoxicity against a panel of colorectal HCT116 isogenic cells. The compound causes anti-vascularization effect in human endothelial cells (HUVEC) in a dose dependent manner. Antiangiogenic effect was further validated in a zebrafish genetic model with activated HIF Overall design: Examination of Dolastatin 15 effect on HCT116 cells relative to solvent controls using two different concentrations of 20 nM and 100 nM at 16 and 24 hour time points