GSE121212
Atopic Dermatitis, Psoriasis and healthy control RNA-seq cohort
To gain a deeper understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic study of AD with deeply-sequenced RNA-seq samples using long (125b) paired-end reads. By integrating deep sequencing-based skin transcriptome profiling with systems biology analysis, we are able to provide deep characterization for the expression signatures for AD, and by including psoriasis samples in the analysis, we can reveal the distinct molecular features of uninvolved and lesional skin of AD that have not been previously described. Overall design: We performed high-depth sequencing of 147 skin transcriptomes obtained from a carefully matched and tightly defined cohort of 27 AD patients, 28 PSO patients, and 38 healthy controls, whom were recruited within an ongoing investigator-initiated clinical study to identify shared and distinct disease mechanisms of AD and Psoriasis.