GSE124422
RNA-seq of HL-60 cells following treatment with different compounds
We investigate the effects of GCN5 and LSD1 inhibition in acute myeloid leukemia. Therefore, we characterized gene expression changes by RNA-seq in AML cells (AML M2 cell line HL-60) following treatment with ATRA, MB3, GSK-LSD1 and their combinations. Overall design: 21 samples in 7 groups: Untreated (3 samples), ATRA (3 samples), ATRA+MB3 (3 samples), ATRA+GSK-LSD1 (3 samples), ATRA+GSK-LSD1+MB3 (3 samples), MB3 (3 samples) and GSK-LSD1 (3 samples)