PRJNA284574
Mouse metagenome
In this study, we set out to test this hypothesis by analyzing the changes in intestinal T cells induced by feeding mice with a HFD and demonstrated their causal role through T cell adoptive transfer. We further report evidences that dysbiotic ileum microbiota impart changes in intestinal innate immune and CD4 T cell homeostasis – notably, a loss of Th17 cells. These changes precede the onset of metabolic disease and they are sufficient to induce glucose intolerance and insulin resistance features of T2D.