GSE168417
Transcripitonal analysis of genes in the mouse liver that regulated by extracellular nanoparticles by Next-Generation Sequencing
We examined the effects on the liver following systemic delivery of extracellular nanoparticles exomeres and supermeres. Mice were injected with supermeres or exomeres via tail vein.To discern possible differences in the effects of supermeres and exomeres, we performed RNA-seq analysis of the liver tissue.GSEA analysis revealed that there were pathways significantly downregulated by both nanoparticles including cholesterol homeostasis, fatty acid metabolism, oxidative phosphorylation and adipogenesis. However, despite these overall similarities, there were significant differences in gene expression between the two groups. Overall design: mRNA profiles of mouse liver tissue treated with PBS control, exomeres and supermeres