PRJNA664271
DA-DRD5 signaling controls colitis by regulating M1M2 colonic macrophage polarization
Previous studies have suggested that the dynamic shifts in gut microbiota play a significant role during the development of colitis. To evaluate whether the increased severity in colitis observed in DRD5-/- mice is also driven by colitogenic microbiota, we cohoused littermate WT mice [WT (DRD5-/-)] and DRD5-/- mice [DRD5-/- (WT)] for six weeks to equalize bacterial community before the administration of DSS