GSE109827
Gut Microbiota from Human Autism Spectrum Disorder Induces Behavioral Deficits in Mice
We transplanted gut microbiota via fecal transfer from TD and ASD children into germ-free wild-type mice, and reveal that colonization with ASD microbiomes induces hallmark changes in sociability, vocalization, and stereotypies. The brains of mice receiving gut microbiota from ASD individuals display alternative splicing patterns for genes dysregulated in the human ASD brain. Overall design: Offspring of colonized mice (3 TD and 5 ASD donors) were saccrificed at P45 and striatum and prefrontal cortex were dissected.