GSE138618
Impact of ZFAND3 knockdown on whole-genome gene expression in GBM cells
ZFAND3 was beforehand identified to be invasion essentiel in GBM cells using genome-wide shRNA library screen to identify invasion-defective and invasion-essentiel genes. The knockdown of ZFAND3 decreases invasion behaviour of GBM cells. To determine the differences in gene expression upon knockdown, whole-genome RNA sequencing was performed. Overall design: Control GBM cell line vs two different ZFAND3 knockdown cell lines