Transcriptomic Analysis of Sheng DiHuang and HuangQi Herbal Pair in a STZ-Induced Type 2 Diabetes Rat Model
This project investigates the therapeutic mechanism of the traditional Chinese herbal pair Sheng DiHuang (Rehmannia glutinosa) and HuangQi (Astragalus membranaceus) in treating type 2 diabetes mellitus (T2DM). Using a streptozotocin (STZ)-induced T2DM rat model, liver tissues were collected for transcriptomic profiling after treatment with different doses of the SDH-HQ combination. High-throughput RNA sequencing was performed to explore gene expression changes and pathway regulation involved in glucose metabolism, insulin signaling, lipid synthesis, and inflammation. The study aims to elucidate the multi-target effects of the SDH-HQ herbal pair and provide a molecular basis for its antidiabetic action.