Liver X Receptor Drives Plasma Cell Resilience to Chronic Proteostatic Stress
Liver X receptor (LXR) is a key transcription factor regulating lipid metabolism. However, its role in plasma cells remains poorly understood. To investigate the function of LXR in plasma cells, we performed transcriptomic profiling on B cells (CD19+), plasma cells (B220-CD138+), LXR agonist-treated plasma cells, and LXR knockout-derived plasma cells. Our data revealed that plasma cell differentiation is accompanied by significant alterations in lipid metabolism and induction of LXR expression. These findings suggest that LXR is intrinsically linked to lipid metabolic pathways and stress response mechanisms, thereby supporting plasma cell survival under chronic proteostatic stress.