Proanthocyanidins inhibit neuroinflammation in high-fat-induced obese mice by modulating intestinal flora and their metabolites
The effect of proanthocyanidins (PAS) on neuritis by the modulation of colon microbe and their metabolites was conducted in fat mice induced by high-fat diet. Thirty healthy male mice with similar body weights were selected and randomly divided into control, high-fat and PAS groups, with 10 mice in each group. The high-fat and PAS groups were fed a high-fat diet, and the control group was fed basic diet at first 8 weeks. Then the control and high-fat groups were given with equal doses of saline and the PAS group was given with PAS (100 mg/kg/d), respectively every day. The samples were collected at the 16th week. Conclusion, PAS have a role in modulating neuritis, colon microbe, and colon metabolites in mice, and they also have a mitigating effect on cognitive decline in fat mice induced by high-fat.