The impact of environmental exposure to heavy metal arsenic (AS) on the development of human neural tube organoids
The concentration of heavy metal As (approximately 0.2 uM) detected in the placenta of the aborted fetus was used to expose the embryonic stem cells during the induction of neural tube organoids. The exposure was conducted at 9 days and 17 days respectively. After the experiment, total RNA was collected for transcriptome sequencing. The differences between the exposed group and the control group were compared.