ILC Cell Line Encyclopedia (ICLE)
ICLE project provides a multi-omic atlas of ILC cell lines, integrating WES, SNP arrays, DNA methylation, mRNA-seq, RPPA, and optical genome mapping. By benchmarking ICLE against patient datasets, we confirm these models conserve hallmark ILC patterns, including CDH1 alterations and TFAP2B epigenetic activation. Optical mapping further identified novel chromothripsis and rearrangements at the CDH1 locus. Through functional RNAi integration and a multi-omic concordance framework, we nominate high-fidelity models and identify druggable vulnerabilities in cytoskeletal and cell-cycle pathways.