Temporal Expression Dynamics of Helicobacter pylori 26695 During Acid Stress
This study investigates the temporal expression dynamics of Toxin-Antitoxin (TA) systems in the human gastric pathogen Helicobacter pylori (strain 26695) in response to acid stress conditions. H. pylori must continuously adapt to the harsh, acidic environment of the stomach to establish and maintain infection. By analyzing transcriptomic data, this project aims to evaluate the genome-to-function roles of uncharacterized TA systems and determine how their expression fluctuates over time under acidic pressure. The ultimate goal is to better understand the regulatory mechanisms, survival strategies, and pathogenesis of H. pylori within its ecological niche, providing valuable insights into its stress adaptation pathways.