Mus musculus Raw sequence reads
Sunitinib (SUNI), a multi-targeted tyrosine kinase inhibitor, is approved for the treatment of multiple advanced solid tumors. However, its clinical application is severely limited by cardiotoxicity, particularly myocardial fibrosis.This study aimed to investigate the protective effects of oridonin, a diterpenoid compound derived from Rabdosia rubescens, against SUNI-induced cardiotoxicity and to elucidate its potential mechanism of myocardial fibrosis inhibition.A mouse model of SUNI-induced cardiotoxicity was established by oral SUNI administration (40 mg/kg/day) for 8 weeks. Concurrently, oridonin (2.5, 5, or 10 mg/kg/day) was administered via intraperitoneal injection. Heart tissues underwent single nucleus RNA sequencing (snRNA-seq) for transcriptomic analysis.