Transcriptomic Profiling of NCI-H157 Cells Treated with 11-Oxo-Mogroside V: Identification of Differential Gene Expression and Pathway Analysis
This study investigated the transcriptional effects of 11-oxo-mogroside V on NCI-H157 cells compared to untreated controls. Total RNA was extracted, quality-checked (NanoDrop, agarose gel), and sequenced on the DNBSEQ-T7 platform. Bioinformatics analysis (Trimmomatic, edgeR) identified differentially expressed genes (DEGs), followed by KEGG pathway enrichment (KOBAS) to elucidate molecular mechanisms. Data provide insights into the compound's potential regulatory roles in cancer-related pathways.