Homo sapiens Raw sequence reads
There have been no major breakthroughs in the treatment of small cell lung cancer (SCLC) in recent decades. It is thus essential to explore new or adjuvant treatment options for SCLC. Oridonin, a well-known traditional Chinese herbal medicinal product isolated from Isodon rubescens (Hemsl.). Previous study demonstrated that the anti-cancer effect of oridonin was proved in SCLC, however, the underlying mechanisms remain unclear.Oridonin suppressed SCLC cell proliferation and induce apoptosis in a concentration-dependent manner. Further analysis revealed that oridonin significantly hindered the transduction of JAK2/STAT3 pathway to promote apoptosis. We also found that oridonin induced the protein and mRNA level of SOCS1. Furthermore, deletion of SOCS1 gene by siRNA suppressed the induction of SOCS1, and reversed the inhibition of JAK2/STAT3 signaling pathway and apoptosis process. In xenograft model of SCLC, oridonin increased SOCS1 expression and reduced phospho-JAK2 and phospho-STAT3 levels, inducing apoptosis.