Sex-specific variations in Drosophila microbiota and metabolome influence disease model selection
Fruit flies are widely used in experiments, but their gender factors are often ignored. Sex-specific genes not only directly affect the metabolism of fruit flies, but also often affect the life characteristics of fruit flies by affecting their metabolites and microbial composition. These factors may interfere with the experimental results. Therefore, it is of great significance to clarify the specific microbial and metabolic differences caused by gender factors for the selection of Drosophila disease models in the experiment. This project explores the differences in microbial species and diversity between male and female Drosophila melanogaster, and then studies the influence of gender factors in the selection of Drosophila disease models.