Multi-niche microbiome profiling reveals alterations of oral-gastric microbial communities associated with Helicobacter pylori infection
Helicobacter pylori infection is a major risk factor for gastric diseases and may influence microbial ecosystems beyond the stomach. In this study, we performed 16S rRNA gene sequencing of saliva, dental plaque, and gastric mucosal biopsy samples collected from individuals undergoing upper gastrointestinal endoscopy. This multi-niche microbiome dataset was generated to characterize microbial composition, diversity, and shared microbial features between oral and gastric ecosystems under different H. pylori infection statuses. The dataset provides resources for investigating the ecological impact of H. pylori infection on oral-gastric microbial communities.