Altered histone modifications H3K4me3 and H3K27ac associated with abnormal clonality of peripheral B-cells in cattle with bovine leukemia virus
B-cell clonality in bovine peripheral blood fluctuate dynamically between polyclonal and oligoclonal in persistent lymphocytosis (PL) and progresses to monoclonal expansion in enzootic bovine leukosis (EBL); however, the mechanisms remain poorly understood. In this study, ChIP-seq analysis of histone modifications H3K4me3 and H3K27ac in peripheral blood mononuclear cells (PBMCs) was performed across polyclonal, oligoclonal, and monoclonal B-cell states.