Linoleic Acid-LysoPG Axis Promotes Lipid Droplet-Mitochondria Tethering by Stabilizing Noncanonical Mitochondrial PPAR beta/delta to Ameliorate Microglial Dysfunction after Subarachnoid Hemorrhage
This bulk RNA-sequencing study investigates the molecular mechanisms by which the linoleic acid-lysophosphatidylglycerol (LA-LysoPG) axis restores primary microglial function after hemoglobin-induced in vitro modeling of subarachnoid hemorrhage. Primary mouse microglial cells were assigned to untreated control, 25 uM hemoglobin for 24 h, hemoglobin plus 1 uM linoleic acid, and hemoglobin plus 50 nM LysoPG groups.