human saliva metagenome Raw sequence reads
Aim: To investigate the dysrhythmic circadian rhythms of salivary microbiota and metabolites. Methods: Six MPA patients with sleep disorder (MPASD) and the same number of healthy controls were recruited by the mobile phone addiction tendency scale (MPATS) and Pittsburgh sleep quality index (PSQI). Saliva samples were collected every 4 h in a 72-h constant routine (18 samples for each subject). Each sample was divided into two aliquots and subjected to 16S rRNA sequencing and nontarget metabolome analysis. The circadian rhythm of salivary bacteria and metabolites was determined by JTK_cycle.