HIF3A regulates chondrogenic differentiation of mesenchymal stem cells via the PI3K/AKT-Mediated Wnt/beta-Catenin-Sox9 signaling pathway
Mesenchymal stem cell-induced cartilage development is regulated by oxygen-lacking signaling routes. Hypoxia-inducible factor 3A (HIF3A) is a comparatively less-explored variant of the HIF family. The impact of HIF3A on MSC chondrogenesis, oxidative equilibrium, and related signaling pathways in a dose-related way remains to be fully characterized.