Effects of indirubin on gut microbiota in DSS-induced ulcerative colitis mice
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with increasing global incidence. Gut microbiota dysbiosis plays a critical role in UC pathogenesis. Indirubin, a bioactive compound derived from Indigo naturalis, has demonstrated therapeutic effects against UC. However, its impact on the gut microbiome remains to be fully elucidated. This study aims to investigate the effects of indirubin on gut microbial community structure and diversity in dextran sulfate sodium (DSS)-induced UC mice. Mice were randomly divided into control, DSS-induced UC model, and indirubin treatment groups. Fecal samples were collected and subjected to 16S rRNA gene amplicon sequencing using the Illumina platform. The raw sequence data are deposited here to facilitate public access and further analyses of the microbial composition changes associated with indirubin intervention in UC.