Shotgun metagenomic analysis of the vaginal microbiome according to HPV vaccination status in women with cervical lesions
This study investigated associations between human papillomavirus (HPV) vaccination status and the vaginal microbiome in women with cervical lesions. Vaginal samples were collected from participants undergoing gynecological evaluation, and microbial community composition and functional profiles were characterized using shotgun metagenomic sequencing. The analysis focused on differences in vaginal microbial structure, including Lactobacillus-dominant community patterns, according to HPV vaccination status and high-risk HPV infection. Because this was an observational cross-sectional study, the data are intended to evaluate microbiome associations rather than establish causal effects of HPV vaccination. Human-derived sequencing reads were removed before submission, and the deposited data consist of host-depleted metagenomic sequencing reads.
This study investigated associations between human papillomavirus (HPV) vaccination status and the vaginal microbiome in women with cervical lesions. Vaginal samples were collected from participants undergoing gynecological evaluation, and microbial community composition and functional profiles were characterized using shotgun metagenomic sequencing. The analysis focused on differences in vaginal microbial structure, including Lactobacillus-dominant community patterns, according to HPV vaccination status and high-risk HPV infection. Because this was an observational cross-sectional study, the data are intended to evaluate microbiome associations rather than establish causal effects of HPV vaccination. Human-derived sequencing reads were removed before submission, and the deposited data consist of host-depleted metagenomic sequencing reads.