Unveiling Fusobacterium nucleatum's role in colorectal cancer: the inflammatory microenvironment connection.
Fusobacterium nucleatum (Fn), a Gram-negative oral anaerobe, promotes the progression of colorectal cancer (CRC) by modulating the inflammatory tumor microenvironment. Gut microbiota imbalance is critical in CRC development, with Fn demonstrating pro-tumorigenic effects in the intestine. Using MC38 subcutaneous and AOM-DSS orthotopic mouse models, it was demonstrated that Fn administration significantly increased tumor growth