Anti-6xHis ChIP seq of HpaB from Haloferax volcanii
Chromosome segregation are tightly regulated in all domains of life. However, in prokaryotic archaea it is not entirely understood how multi-partite genomes maintain and segregate their secondary chromosomes.  We investigate partitioning of the secondary chromosome pHV3 of the polyploid archaeon Haloferax volcanii by a ParA-like protein HpaA, and a specific DNA adaptor HpaB which binds to pHV3.
Chromosome segregation are tightly regulated in all domains of life. However, in prokaryotic archaea it is not entirely understood how multi-partite genomes maintain and segregate their secondary chromosomes.  We investigate partitioning of the secondary chromosome pHV3 of the polyploid archaeon Haloferax volcanii by a ParA-like protein HpaA, and a specific DNA adaptor HpaB which binds to pHV3.