RNA-seq of liver transcriptome of  UCP1+ cell-ablated mice at room temperature and upon acute cold exposure
UCP1-expressing brown and beige adipocytes are known to play an important role in thermogenic adaptation in mammals. Recent studies have proposed that these cells also exert beneficial effects on metabolic health. Therefore, we aimed to identify the consequences of UCP1+ cell loss on the metabolism of adult mice under standard conditions and upon cold challenge. In this study, UCP1+ cells were ablated in adult mice, and liver tissue was collected at room temperature or following acute cold exposure. We intended to compare the transcriptional profile of the liver between control and UCP1+ cell-ablated mice in order to identify liver-specific adaptations to severe UCP1+ cell loss under basal conditions and during acute cold stress.
UCP1-expressing brown and beige adipocytes are known to play an important role in thermogenic adaptation in mammals. Recent studies have proposed that these cells also exert beneficial effects on metabolic health. Therefore, we aimed to identify the consequences of UCP1+ cell loss on the metabolism of adult mice under standard conditions and upon cold challenge. In this study, UCP1+ cells were ablated in adult mice, and liver tissue was collected at room temperature or following acute cold exposure. We intended to compare the transcriptional profile of the liver between control and UCP1+ cell-ablated mice in order to identify liver-specific adaptations to severe UCP1+ cell loss under basal conditions and during acute cold stress.