RNA-seq of IBD mice with DNA hydrogel microcapsules treatment.
DNA-based nanomedicines have shown significant therapeutic potential for various diseases; however, efficiently utilizing DNA nanomedicines without chemicals or small-molecule drugs is still a major challenge. Herein, we present programmed activated DNA hydrogel microspheres (HAMs) specifically designed for inflammatory bowel disease (IBD) treatment. To dissect the molecular mechanisms of the therapeutic effect of HAMs on IBD, RNA-seq was performed to analyze the treatment effect of HAMs on intestinal tissues of IBD model.