Single cell sequencing of ocular and blood cells from individuals with uveitis
In this study, we compared the ocular infiltrating immune cells in non-infectious and viral uveitis by single-cell RNA sequencing (scRNA-seq) with paired T cell receptor (TCR) and B cell receptor (BCR) sequencing. This is the first comprehensive comparison between non-infectious and infectious uveitis for the differences in infiltrating immune cells and the pro-inflammatory pathways that are activated. We also compared TCR and BCR sequences to identify shared specificity across patients. This cohort contains 73 eye and blood samples across 41 participants with ~500,000 cells in the dataset.