Spatiotemporal single-cell atlas of suture stem cell dynamics in craniosynostosis (Spatial)
The cellular mechanisms underlying craniosynostosis remain poorly defined. To characterize spatiotemporal SuSC dynamics in this disease, we performed Visium HD spatial transcriptomics in Fgfr2(C342Y/+) and wild-type mouse coronal sutures across key developmental stages (E14.5, E18.5, and P3).