Profiling of systemic IgG-targeted gut microbiota in ulcerative colitis.
We aimed to profile systemic IgG-targeted gut microbiota in patients with ulcerative colitis (UC). Using fecal samples and autologous sera from 37 patients with UC and 4 healthy controls, we profiled IgG-targeted bacteria under in vitro conditions using 16S rRNA gene sequencing. We also attempted to identify the specific IgG-targeted microbes that correlate with the clinical activity of UC or systemic inflammatory markers utilizing the IgG+ Probability Score (IPS) and machine learning models.