Human-associated microbial communities from stool and oropharyngeal swab samples collected longitudinally from infants with cystic fibrosis and age- and sex-matched healthy controls. Metagenome
This project investigates the longitudinal development of the gut and respiratory microbiome in Brazilian infants with cystic fibrosis (CF) and age- and sex-matched healthy controls during the first two years of life. Stool and oropharyngeal swab samples were collected prospectively at regular intervals to characterize microbial community composition and diversity over time. The study aims to identify microbiome alterations associated with cystic fibrosis during early life and to improve the understanding of host-microbiome interactions that may contribute to disease progression and support future microbiome-based therapeutic strategies.