Ultrasmall Manganese Oxide Nanozymes Reprogram Redox-Microbiota Homeostasis in IBD
This project investigates how nanocrystal-confined ultrasmall manganese oxide nanozymes regulate redox balance and gut microbiota homeostasis in inflammatory bowel disease. Fecal metagenomic sequencing and colonic tissue RNA sequencing were performed on male C57BL/6J mice from the Health, DSS, MN3O4, and 5-ASA groups to characterize microbiota composition, microbial functional potential, and host transcriptomic responses associated with nanozyme-mediated protection.