snRNA-seq of cortices from a MCT8-OATP1C1-deficient Allan-Herndon-Dudley Syndrome mouse model
Allan-Herndon-Dudley syndrome (AHDS) is a rare disorder caused by faulty thyroid hormone transport to the brain, leading to severe movement problems and intellectual disability. Our study in a murine model of the AHDS used snRNAseq to gain deep insights into individual cortical cells, aiming to unravel novel pathologies of the AHDS. Organism: Mus Musculus Tissue: cortical hemispheres and attached cerebral nuclei Groups: 3 x WT, 3x dKO (global, MCT8 & OATP1C1) Mouse Info: age at cortex extraction was 21 days, mice were on a pure C57BL/6J background. Animals were pooled from multiple litters to minimize litter effects. All mice were group-housed on a 12:12-h light-dark cycle at 23°C and fed standard chow diet ad libitum Technology: 10x Genomics
Allan-Herndon-Dudley syndrome (AHDS) is a rare disorder caused by faulty thyroid hormone transport to the brain, leading to severe movement problems and intellectual disability. Our study in a murine model of the AHDS used snRNAseq to gain deep insights into individual cortical cells, aiming to unravel novel pathologies of the AHDS. Organism: Mus Musculus Tissue: cortical hemispheres and attached cerebral nuclei Groups: 3 x WT, 3x dKO (global, MCT8 & OATP1C1) Mouse Info: age at cortex extraction was 21 days, mice were on a pure C57BL/6J background. Animals were pooled from multiple litters to minimize litter effects. All mice were group-housed on a 12:12-h light-dark cycle at 23°C and fed standard chow diet ad libitum Technology: 10x Genomics