Transverse colon tissue proteome and microbiome alterations in Alzheimers Disease
Alzheimers Disease (AD) has long been regarded as a brain first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. We conducted a microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and control cases. Our findings underscore the guts possible involvement in AD pathogenesis and provide new insights into potential biomarkers and therapeutic targets.