Noise exposure drives intestinal inflammation and limits responsiveness to anti-TNF therapy
Environmental noise is an increasingly prevalent stressor that may influence systemic inflammation, but its effects on intestinal inflammatory responses remain poorly understood. To investigate the molecular changes associated with noise-exacerbated colitis, we performed RNA sequencing of colonic tissues from mice with dextran sulfate sodium-induced colitis with or without concurrent noise exposure. This dataset provides a transcriptomic resource for identifying noise-responsive genes and pathways involved in intestinal inflammation and may help clarify the mechanisms linking environmental noise exposure to inflammatory bowel disease progression.